• The Korean Journal of Physiology and Pharmacology
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• v.27 no.4
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• pp.417-426
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• 2023

The TRPM4 gene encodes a Ca²⁺-activated monovalent cation channel called transient receptor potential melastatin 4 (TRPM4) that is expressed in various tissues. Dysregulation or abnormal expression of TRPM4 has been linked to a range of diseases. We introduced the hemagglutinin (HA) tag into the extracellular S6 loop of TRPM4, resulting in an HA-tagged version called TRPM4-HA. This TRPM4-HA was developed to investigate the purification, localization, and function of TRPM4 in different physiological and pathological conditions. TRPM4-HA was successfully expressed in the intact cell membrane and exhibited similar electrophysiological properties, such as the current-voltage relationship, rapid desensitization, and current size, compared to the wild-type TRPM4. The presence of the TRPM4 inhibitor 9-phenanthrol did not affect these properties. Furthermore, a wound-healing assay showed that TRPM4-HA induced cell proliferation and migration, similar to the native TRPM4. Co-expression of protein tyrosine phosphatase, non-receptor type 6 (PTPN6 or SHP1) with TRPM4-HA led to the translocation of TRPM4-HA to the cytosol. To investigate the interaction between PTPN6 and tyrosine residues of TRPM4 in enhancing channel activity, we generated four mutants in which tyrosine (Y) residues were substituted with phenylalanine (F) at the N-terminus of TRPM4. The YF mutants displayed properties and functions similar to TRPM4-HA, except for the Y256F mutant, which showed resistance to 9-phenanthrol, suggesting that Y256 may be involved in the binding site for 9-phenanthrol. Overall, the creation of HA-tagged TRPM4 provides researchers with a valuable tool to study the role of TRPM4 in different conditions and its potential interactions with other proteins, such as PTPN6.

• Journal of the Korean Institute of Landscape Architecture
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• v.51 no.3
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• pp.122-138
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• 2023

Today, fishing villages are on the verge of extinction due to severe aging within the population and outward migration. Recent projects and studies targeting fishing villages viewed the fishing villages from an outsider-centered perspective, without a local-centered understanding of the village as a daily living space. Therefore, to understand the settlement environment of fishing villages, this study analyzed empirical data on the usage behavior of fishing village residents to gain insight into the characteristics of the outdoor space uses of residents in fishing villages. In this regard, a face-to-face survey was conducted among residents, and a village map drawn by the villagers showedthe spatial perception of the villagers. Empirical data on the behavior of fishing villagers using the village space was collected and analyzed through GPS. The study results suggested that residents of fishing villages tend to focus on productive activities, such as fishing, leading to a lack of awareness of other leisure activities and spaces. This monotonous pattern of space utilization within the village appears to stem from an absolute lack of available facilities within the target area. Therefore, in future village regeneration projects aimed at improving the quality of life for residents in fishing villages, it is essential to consider the residents' perception and utilization of space as a priority. The results of this study can be considered valuable foundational data for understanding the utilization of spaces within fishing villages and can be effectively utilized in planning initiatives to enhance quality of life.

• Journal of the Korean Institute of Landscape Architecture
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• v.51 no.3
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• pp.139-152
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• 2023

Recently, there has been an increasing interest in the migration of young people to local areas. These young people are discovering and reinterpreting local resources to open local businesses while generating new value in local activities and businesses. This study was initiated with the recognition that fundamental solutions are needed for these young people to settle and sustain residence in the local area. Edward Relph stated that 'place' is a fundamental attribute that influences human existence in the world and is the source of stability and identity formation for individuals. This is deeply related to the psychology of young people who have migrated to local areas. These young people accept the unfamiliar 'space' as a 'place' to form stability and personal identity. Therefore, this study utilized PhotoVoice methodology to examine the process and key factors of place identity formation among migrant youths. As a result, the study identified factors that enable young people to settle in local areas and sustain residence while recognizing elements the local government should focus on to support and address the influx of young people. The results of this study can serve as a foundation for addressing the declining population in local areas through the formation of a relationship population and spur the inflow of young people to local cities in the future.

• Korean Journal of General Education
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• v.4 no.1
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• pp.237-254
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• 2010

For years, poor research and working conditions in the field of science and engineering in Korea led to the migration of gifted students to seek a better academic environment. The primary reason for such a phenomenon is the lack of a coherent education system for gifted students. With the support from the Ministry of Education, Science and Technology and the Korea Foundation for the Advancement of Science & Creativity, Hanyang University launched an exploring project to introduce an Honors Program, aiming to provide specialized and systematic learning opportunities as well as supporting greater academic achievements for gifted students at university-level. Students admitted to this program were selected not by conventional standards but by competency-based selection process, assessed through an in-depth interview. The specific goal of this program is to prepare gifted and talented students not only for an academic pioneer with the highest caliber in the field of science, but also for a global leader equipped with a creative view as well as integrity and a convergent mind. Distinctive features of this program include emphasis on fundamental science and consilience, problem solving skills, first-hand education, interpersonal skills, and global communication skills as well as individualization of the learning experience, among many others. This paper provides a short glimpse of the focus and methodology Honors Program in Hanyang University offers.

• Journal of The Geomorphological Association of Korea
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• v.18 no.3
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• pp.37-51
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• 2011

Geomorphic changes and sedimentary changes are investigated by sediment analysis from estuarine tidal flat, Mosan Bay Estuary, which is a tide-dominated and rias estuary. Sediments separatedly deposited during the early Holocene and the late Holocene. There are unconformities between the early Holocene sediment unit and the late Holocene sediment unit. Developments of these unconformities were related with fluctuated sea level change during the mid Holocene. Three deposit zones are spatially classified, which are named "intermittent tide channel deposit zone"(A1, B1, D3), "flood-dominated deposit zone"(A3, B3, C1, C3), and "fluvial sediment deposit zone"(A2, B2). This classification is explained by three main effects; laterally restricted migration of a tidal channel, diffract flood effect and settling lag effect, and fluvial induced reworking. These effects are deserved as main factors which have formed estuarine geomorphology in tidedominated and rias estuary. This study suggests research directions in reconstructing estuarine geomorphic and sedimentary change in west coast of Korea. Furthermore, it gives useful data for making a "land-ocean interaction" model for west coast of Korea.

• Journal of Trauma and Injury
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• v.36 no.3
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• pp.196-205
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• 2023

Purpose: Surgical stabilization of rib fractures (SSRF) is widely used in patients with flail chests, and several studies have reported the efficacy of SSRF even in multiple rib fractures. However, few reports have discussed the hardware failure (HF) of implanted plates. We aimed to evaluate the clinical characteristics of patients with HF after SSRF and further investigate the related factors. Methods: We retrospectively reviewed the electronic medical records of patients who underwent SSRF for multiple rib fractures at a level I trauma center in Korea between January 2014 and January 2021. We defined HF as the unintentional loosening of screws, dislocation, or breakage of the implanted plates. The baseline characteristics, surgical outcomes, and types of HF were assessed. Results: During the study period, 728 patients underwent SSRF, of whom 80 (10.9%) were diagnosed with HF. The mean age of HF patients was 56.5±13.6 years, and 66 (82.5%) were men. There were 59 cases (73.8%) of screw loosening, 21 (26.3%) of plate breakage, 17 (21.3%) of screw migration, and seven (8.8%) of plate dislocation. Nine patients (11.3%) experienced wound infection, and 35 patients (43.8%) experienced chronic pain. A total of 21 patients (26.3%) underwent reoperation for plate removal. The patients in the reoperation group were significantly younger, had fewer fractures and plates, underwent costal fixation, and had a longer follow-up. There were no significant differences in subjective chest symptoms or lung capacity. Conclusions: HF after SSRF occurred in 10.9% of the cases, and screw loosening was the most common. Further longitudinal studies are needed to identify risk factors for SSRF failure.

• The Journal of Engineering Geology
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• v.33 no.4
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• pp.587-598
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• 2023

To assess the distribution and temporal changes in radon concentration within a region in Yeonpung-myeon, Goesan-gun, known for elevated groundwater radon levels, we conducted a series of analyses, measuring radon concentration and DTW (Depth to water table) at 2-month intervals over 12 cycles. The investigation covered 10 groundwater wells and one stream within the designated area. The groundwater in the central part of the region exhibited high radon concentrations, ranging from 37.0 to 2,675.2 Bq/L. Conversely, the peripheral zones displayed comparatively lower radon concentrations, ranging from 10.6 to 37.9 Bq/L. This variation is attributed to the presence of granite porphyry that intruded into the Okcheon Formation, forming a fracture zone and contributing to elevated radon levels in the central part. In contrast, the peripheral locations, located within the Okcheon Formation and away from the granite porphyry intrusion, demonstrated lower radon concentrations. The observed significant fluctuation in radon concentration in the central area is associated with its low-lying topography. The pronounced seasonal changes in groundwater levels contribute to the migration of shallow, low-radon groundwater into areas with higher radon concentrations, explaining the observed variations in radon levels within the central part of the studied area.

• Journal of Korean Dental Science
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• v.16 no.2
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• pp.128-148
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• 2023

Dementia is an umbrella term that describes the loss of thinking, memory, attention, logical reasoning, and other mental abilities to the extent that it interferes with the activities of daily living. More than 50 million individuals worldwide live with dementia, which is expected to increase to 131 million by 2050. Recent research has shown that poor oral health increases the risk of dementia, while oral health declines with cognitive decline. In this narrative review, the literature was based on the "hypothesis" that dementia and oral health have a close relationship, and appropriate oral health and occlusal rehabilitation treatment can improve the quality of life of patients with dementia and prevent progression. We conducted a literature search in PubMed and Google Scholar databases, using the search terms "dementia," "major neurocognitive disorder," "dentition," "occlusion," "tooth loss," "dental prosthesis," "dental implant," and "occlusal rehabilitation" in the title field over the past 30 years. A total of 131 studies that scientifically addressed dementia, oral health, and/or oral rehabilitation were included. In a meta-analysis, the random effect model demonstrated significant tooth loss increasing the dementia risk 3.64-fold (pooled odds ratio=3.64, 95% confidence interval [2.50~5.32], P-value=0.0348). Tooth loss can be an important indicator of cognitive function decline. As the number of missing teeth increases, the risk of dementia increases. Loss of teeth can lead to a decrease in the ascending information to the brain and reduced masticatory ability, cerebral blood flow, and psychological atrophy. Oral microbiome dysbiosis and migration of key bacterial species to the brain can also cause dementia. Additionally, inflammation in the oral cavity affects the inflammatory response of the brain and the complete body. Conversely, proper oral hygiene management, the placement of dental implants or prostheses to replace lost teeth, and the restoration of masticatory function can inhibit symptom progression in patients with dementia. Therefore, improving oral health can prevent dementia progression and improve the quality of life of patients.

• Journal of the Korean Association of Geographic Information Studies
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• v.26 no.4
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• pp.173-187
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• 2023

In an era of population decline, depopulated regions facing challenges in attracting inbound population migration must enhance urban vitality through the attraction of living populations. This study focuses on Busan, a city experiencing population decline, comparing the spatiotemporal distribution characteristics of registered residents and living populations in various administrative districts (Eup-Myeon-Dong) using mobile communication big data. Administrative districts are typified based on population change patterns, and regional characteristics are analyzed using indicators related to urban decline and vitality. Spatiotemporal distribution analysis reveals generally similar density patterns between registered residents and living populations; however, a distinctive feature is observed in the city center areas where the density of registered residents is low, while the density of living populations is high. Divergent trends in spatial patterns of change between registered residents and living populations show clusters of registered population decline in low-density areas and clusters of living population decline in high-density areas. Areas adjacent to declining living populations exhibit large clusters of population changes, indicating a spillover effect from high-density to neighboring areas. Typification results reveal that, even in areas with a decline in registered residents, there is active population influx due to commuting or visiting. These areas sustain an increase in the number of businesses, confirming the presence of industrial and economic growth. However, approximately 47% of administrative districts in Busan are experiencing a decline in both registered residents and living populations, indicating ongoing regional decline. Urgent measures are needed for enhancing urban vitality. The study emphasizes the necessity of utilizing living population data as an urban planning indicator, considering the increasing limit distance of urban activities and growing interregional interaction due to advancements in transportation and communication.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.34 no.2
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• pp.263-279
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• 2024

With the increasing trend of Cloud migration, security threats in the Cloud computing environment have also experienced a significant increase. Consequently, the importance of efficient incident investigation through log data analysis is being emphasized. In Cloud environments, the diversity of services and ease of resource creation generate a large volume of log data. Difficulties remain in determining which events to investigate when an incident occurs, and examining all the extensive log data requires considerable time and effort. Therefore, a systematic approach for efficient data investigation is necessary. CloudTrail, the Amazon Web Services(AWS) logging service, collects logs of all API call events occurring in an account. However, CloudTrail lacks insights into which logs to analyze in the event of an incident. This paper proposes an automated analysis framework that integrates Cloud Matrix and event information for efficient incident investigation. The framework enables simultaneous examination of user behavior log events, event frequency, and attack information. We believe the proposed framework contributes to Cloud incident investigations by efficiently identifying critical events based on the ATT&CK Framework.