• Asia pacific journal of information systems
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• v.6 no.2
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• pp.19-52
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• 1996

It has been argued theoretically and empirically that the analysis of business processes requires the decomposition of an integrated system. However, in order to innovate a business process, cognitive integration activities that try to understand the decomposed features of the business process as an integrated system are essential. This research aims at 1) empirically investigating the cognitive process of integrating multiple diagrams while using object-oriented methodologies in process modeling ; 2) identifying a cognitive integration strategy that supports the successful comprehension of business processes with the use of multiple diagrams ; and 3) proposing guidelines for developing supporting tools for effective business process engineering by using object-oriented process modeling.

• Proceedings of the KSCN Conference
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• 2004.05a
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• pp.439.2-439
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• 2004

Melatonin in mammals, produced by the pineal gland and elsewhere, has shown antioxidant and neuroprotective properties in neuronal cells. We investigated whether melatonin would increase newly-born cells (cell proliferation) in the dentate gyrus of maternally-separated rats. To examine the effect of melatonin on cell proliferation of the dentate gyrus in maternally-separated rats, 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry was performed.(omitted)

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.212.1-212.1
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• 2012

2010년 6월 성공적으로 발사된 천리안위성(COMS; Communication, Ocean, and Meteorological Satellite)의 기상영상기(MI; Meteorological Imager)를 통해 관측된 원시 기상영상은 지상국인 국가기상위성센터에서 지표기준과 위성궤도 및 자세 정보를 이용하여 영상위치보정 과정이 수행된다. 본 연구에서는 정규운영 초기 1년 동안의 운영 자료를 분석하여 계절 및 일변화를 나타내는 천리안위성 기상영상의 영상위치보정 성능 및 특성을 기술하였다. 이를 통하여 천리안위성 기상영상 가시 및 적외 채널의 영상위치결정 정확도 및 영상 위치유지 정확도는 기준값인 $56{\mu}rad$(약 2km) 이내로 유지되는 것을 확인하였다. 이는 천리안위성 기상영상이 우수한 품질의 위치정확도를 가지며 기상현상 분석 및 응용 연구에 높은 효용성을 가지는 것을 보여준다. 또한 본 연구의 결과는 후속 기상위성 영상위치보정 시스템 설계에도 유용하게 활용될 것이다.

• Journal of Navigation and Port Research
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• v.26 no.2
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• pp.227-233
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• 2002

Recently, the water pollution of coastal sea area including harbor, bay and inland sea has been very serious and it causes u\\various environmental impacts. In this study, water flow system of Danghnag Bay, which has the narrow and long topographical characteristics with the narrow bay mouth and its flow is influenced principally by the tidal current, is investigated experimentally and numerically. In order to understand the tidal system of Danghang Bay, harmonic analysis is performed based on measured tidal range and flow velocity. In addition, numerical model for tidal exchange is developed considering conditions of Danghang Bay. Calculated results show good agreement with measurement. Lastly, based on the proposed numerical model, exchange ratio of seawater volume in Danghang Bay is predicted.

• Molecules and Cells
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• v.37 no.3
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• pp.196-201
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• 2014

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by the vascular remodeling of the pulmonary arterioles, including formation of plexiform and concentric lesions comprised of proliferative vascular cells. Clinically, PAH leads to increased pulmonary arterial pressure and subsequent right ventricular failure. Existing therapies have improved the outcome but mortality still remains exceedingly high. There is emerging evidence that the seven-transmembrane G-protein coupled receptor APJ and its cognate endogenous ligand apelin are important in the maintenance of pulmonary vascular homeostasis through the targeting of critical mediators, such as Kr$\ddot{u}$ppel-like factor 2 (KLF2), endothelial nitric oxide synthase (eNOS), and microRNAs (miRNAs). Disruption of this pathway plays a major part in the pathogenesis of PAH. Given its role in the maintenance of pulmonary vascular homeostasis, the apelin-APJ pathway is a potential target for PAH therapy. This review highlights the current state in the understanding of the apelin-APJ axis related to PAH and discusses the therapeutic potential of this signaling pathway as a novel paradigm of PAH therapy.

• Bulletin of the Korean Chemical Society
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• v.16 no.3
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• pp.205-210
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• 1995

Catalytic effects of various Schiff base metal(II) complexes on the reduction of thionyl chloride at glassy carbon electrode are evaluated by determining the kinetic parameters from cyclic voltammetry technique. The charge transfer process is affected strongly by the concentration of catalysts during the reduction of thionyl chloride. The catalytic effects are shown by both a shift of the reduction potential for thionyl chloride toward more positive direction and an increase in peak current. The diffusion coefficient value, Do, of the 8.17 ${\times}$ 10-9 $cm^2/s$ was observed at the bare glassy carbon electrode, whereas larger values (0.9-1.09 ${\times}$ 10-8 $cm^2/s$) were observed at the catalyst supported glassy carbon electrode. Significant improvements in the cell performance have been noted in terms of both exchange rate constants and current densities at glassy carbon electrode.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.206.1-206.1
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• 2003

From methanol extract of Acanthopnanax senticosus, six platelet anti-aggregating compounds, chiisanogenin (1), chiisanoside (2), ursolic acid (3), oleanolic acid (4), b-sitosterol (5) and daucosterol (6) were isolated. All of the isolated compounds showed dose-dependent inhibitory activities to rat platelet aggregation induced by all the agonist employed. Compound 1 showed about 50 folds higher potency than acetylsalicylic acid (ASA) on U46619 induced platelet aggregation (IC$\sub$50/ : 6.21 ${\mu}$M) and 10 ∼ 20 folds higher effect than ASA on epinephrine and arachidonic acid (AA) induced aggregation (IC$\sub$50/ ; 2.50 and 4.81 ${\mu}$M, respectively). (omitted)

• The Korean Journal of Mycology
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• v.30 no.2
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• pp.142-146
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• 2002

In order to develop a new traditional liquor by using Paecilomyces japonica, alcohol fermentation condition was investigated. Ethanol was produced maximally when 1% P. japoniea and 10% koji were added into mash and fermented by Saccharomyces cerevisiae at $25^{\circ}C$ for 15 days. Sensory evaluation and physiological functionalities of P. japonica traditional liquors made by different addition ($0.1{\sim}2.0%$) of the fungus were also determined and compared. As 0.1% P. japonica was added to mash, the liquor was best acceptable, and its fibrinolytic activity and nitrite scavenging activity were 11.2U and 19.8%, respectively.

• Clinical and Experimental Pediatrics
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• v.45 no.8
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• pp.973-979
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• 2002

Purpose : Recently, a number of rapid antigen detection tests have been available to diagnose group A streptococcal pharyngotonsillitis. The purpose of this study was to determine the sensitivity, specificity and consistency of the two rapid antigen detection tests. Methods : Among the patients who visited our clinic from November 2001 to February 2002, 61 patients who had clinical findings of pharyngeal erythema or edema, pharyngeal exudates and soft palatine petechiae were enrolled in our study. A total of 61 patients were tested with rapid antigen detection tests and throat culture. BD $LINK2^{TM}$ Strep A(Becton, Dickinson & Company, U.S.A.) and $QuickVue^{(R)}$ $In-Line^{TM}$(Quidel Corporation, U.S.A.) were selected for rapid antigen detection tests. Results : Of the 61 patients tested, 22 patients were confirmed as group A streptococcal pharyngotonsillitis by throat culture. The BD $LINK2^{TM}$ Strep A had a sensitivity of 81.8% and a specificity 89.7%. The positive and negative predictive values were 81.8% and 89.7%, respectively. The $QuickVue^{(R)}$ $In-Line^{TM}$ had a sensitivity of 77.3% and a specificity of 100%. The positive and negative predictive values were 100% and 88.6%, respectively. The kappa values of BD $LINK2^{TM}$ Strep A and $QuickVue^{(R)}$ $In-Line^{TM}$ were 0.72 and 0.81, respectively. Conclusion : In addition to high sensitivity, specificity and consistency, both kits are easy to use and simple to interpret, and therefore have the potential to be used with backup throat culture for diagnosis of acute pharyngotonsillitis.

• Animal Bioscience
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• v.37 no.3
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• pp.509-521
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• 2024

Objective: It was shown that microRNAs (miRNAs) play an important role in milk protein synthesis. However, the post-transcriptional regulation of casein expression by exogenous miRNA (xeno-miRNAs) in ruminants remains unclear. This study explores the regulatory roles of alfalfa xeno-miR162 on casein synthesis in bovine mammary epithelial cells (bMECs). Methods: The effects of alfalfa xenomiR-162 and G protein subunit gamma 11 (GNG11) on proliferation and milk protein metabolism of bMECs were detected by 5-Ethynyl-2'-Deoxyuridine (EdU) staining, flow cytometry, cell counting kit-8 (CCK-8), enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot. Dual-luciferase reporter assay was used to verify the targeting relationship between GNG11 and xenomiR-162. Results: Results showed that over-expression of xenomiR-162 inhibited cell proliferation but promoted apoptosis, which also up-regulated the expression of several casein coding genes, including CSN1S1, CSN1S2, and CSN3, while decreasing the expression of CSN2. Furthermore, the targeting relationship between GNG11 and xenomiR-162 was determined, and it was confirmed that GNG11 silencing also inhibited cell proliferation but promoted apoptosis and reduced the expression of casein coding genes and genes related to the mammalian target of rapamycin (mTOR) pathway. Conclusion: Alfalfa xenomiR-162 appears to regulate bMECs proliferation and milk protein synthesis via GNG11 in the mTOR pathway, suggesting that this xeno-miRNA could be harnessed to modulate CSN3 expression in dairy cows, and increase κ-casein contents in milk.