• 한국수학교육학회지시리즈E:수학교육논문집
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• 제28권3호
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• pp.321-338
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• 2014

본 원고에서는 수학자 족보 프로젝트(MGP, Mathematics Genealogy Project)의 과거와 현재에 대해 소개하고, 힐베르트와 저자의 경우를 예를 들어, 우리가 MGP를 어떻게 활용할 수 있을지 연구한다. MGP를 통하여 한국의 주요 수학자들(한국 수학사에 기여한 5명, 역대 한국과학상 수학부문 수상자, 대한수학회 학술상 수상자 등)의 뿌리에 대해 조사해 본 결과 MGP의 데이터베이스에는 그들의 기록이 누락되었거나 부실한 경우가 대부분이었다. 따라서 본 논문에서는 자신의 수학적 뿌리에 대한 정보를 프로젝트에 입력하는 방법을 구체적으로 소개하였다. 이 작업은 한국인 수학자들 자신의 학문적 뿌리를 정리하고 또한 한국 근대 수학사의 이해 및 한국 수학의 미래를 전망하는 데 도움이 된다.

• 대한약침학회지
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• 제13권1호
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• pp.5-14
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• 2010

Objectives : This study was performed to examine the anticancer effect of mountain ginseng Pharmacopuncture(MGP) to the nude mouse of lung carcinoma induced by NCI-H460 human nonsmall lung cancer cells. Methods : Human lung cancer (NCI-H460) cells were cultured and applied to evaluate anti-tumor activity in nude mice. After confirmed tumor growth in mice, MGP was treated per 0.1ml/kg dose to intraperitoneal and intravenous injection everyday for four weeks. And checked the changes in body weights, tumor volume, mean survival time and percent, increase in life span, histo-pathological findings, organ weights, and blood chemistry levels. Results : The results of in vivo study showed that MGP may have potential as growth inhibitor of solid tumor induced NCI-H460 without marked side effects. MGP inhibited dosage-dependently the growth of NCI-H460 cell-transplanted solid tumor compared with the control group. And mean survival time of MGP treated group was prolonged comparing with control group. Generally the group of intravenous injection is more effective than intraperitoneal injection. Conclusion : These results were suggested that MGP may be a useful anticancer agent for therapy of human lung cancer. And follow study need for the certain evidence.

• 대한약침학회지
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• 제13권4호
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• pp.119-128
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• 2010

Objectives : The objective of this study is to report the change of progress in symptoms and various scales after treated with Mountain Ginseng Pharmacopuncture(MGP) on the patients of Amyotrophic Lateral Sclerosis(ALS). Methods : The three ALS patients who treated with MGP, were checked the change of progress by ALS Functional Rating Scale(ALSFRS), ALS Severity Score(ALSSS), grasping power on both arms and circumference of both thighs and calves. Results : After MGP treatment on three ALS patients, first case did not grow worse during MGP treated whereas she got worse rapidly during none treated period. Second case did not grow worse during treated period and third case got worse in progress by slow degrees despite of MGP treatment. Conclusions : Although MGP could not control the progress of ALS completely, MGP may help the improving of quality of life(QOL) in ALS patients and have the effect of delayed ALS progression.

• 대한약침학회지
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• 제17권3호
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• pp.50-56
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• 2014

Objectives: Mountain ginseng pharmacopuncture (MGP) is an extract distilled from either mountain cultivated ginseng or mountain wild ginseng. This is the first intravenous injection of pharmacopuncture in Korea. The word intravenous does not discriminate between arteries, veins, and capillaries in Oriental Medicine, but only the vein is used for MGP. The aim of this study is to evaluate the intravenous injection toxicity of MGP through a single-dose test in Sprague-Dawley (SD) rats. Methods: Male and female 6-week-old SD rats were injected intravenously with MGP (high dosage of 20 mL/kg or low dosage of 10 mL/kg). Normal saline was injected into the rats in the control group by using the same method. After the rats has treated, we conducted clinical observations, body-weight measurements and histological observations. Results: In this study, no mortalities were observed in any of the experimental groups. Also, no significant changes by the intravenous injection of MGP were observed in the body weights, or the histological observations in any of the experimental groups compared to the control group. The lethal dose for intravenous injection of MGP was found to be over 20 mL/kg in SD rats. Conclusion: Considering that the dosage of MGP generally used each time in clinical practice is about 0.3 mL/kg, we concluded with confidence that MGP is safe pharmacopuncture.

• Journal of Animal Science and Technology
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• 제49권1호
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• pp.89-98
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• 2007

본 연구는 재래종 흑돼지육과 개량종 돼지육의 냉장저장중 향기성분 및 패턴을 비롯한 품질을 비교하고자 실시하였다. 사육기간이 모두 6개월인 70kg의 재래흑돼지 5두와 103kg의 개량종 돼지(Landrace×Yorkshire) 5두로부터 발골한 뒷다리육(M. Biceps femoris)을 진공 포장하여 2±0.2℃에 12일 동안 저장하였다. 일반성분을 보면 재래흑돼지육의 수분 함량이 개량종 돼지육 보다 낮았으나(p<0.05), 조단백질 및 조회분 함량은 높았다(p<0.05). pH는 재래흑돼지육이 낮았고(p<0.05), 그에 따라 가열감량은 높았다(p<0.05). 표면육색을 보면 저장기간 동안 재래흑돼지육의 a*, b* 값이 개량종 돼지육 보다 높았다(p<0.05). TBARS는 저장 8일부터, 전단력은 저장 8일까지 재래흑돼지육이 높았다(p<0.05). SPME-GC/MS에 의한 가열육의 향기성분에서 일부 차이를 보였으나, 전자코에 의한 향기패턴 차이는 없었다. 따라서 재래흑돼지육은 색깔이 붉고 짙으며, 가열감량이 높았고 조직감도 단단하였다. 또한 기계적으로 향기특성의 차이를 구별하지 못했지만, 관능검사상 재래흑돼지육이 우수한 기호도를 나타내었다.

• 대한약침학회지
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• 제17권4호
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• pp.27-35
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• 2014

Objectives: Mountain ginseng pharmacopuncture (MGP) is a pharmacopuncture made by distilling extract from mountain cultivated ginseng or mountain wild ginseng. This pharmacopuncture is injected intravenously, which is a quick, lossless way of strongly tonifying Qi function. The present study was undertaken to evaluate a 4-week, repeated, intravenous injection, toxicity test of MGP in Sprague-Dawley (SD) rats. Methods: Twenty male and female 6-week-old SD rats were used as subjects. We divided the SD rats into 4 groups: the high-dosage (10 mL/kg), medium-dosage (5 mL/kg), low-dosage (2.5 mL/kg) and control (normal saline) groups. MGP or normal saline was injected intravenously into the caudal vein of the rats once daily for 4 weeks. Clinical signs, body weights, and food consumption were monitored during the observation period, and hematology, serum biochemistry, organ weight, necropsy, and histological examinations were conducted once the observations had been completed. Results: No mortality was observed in any of the groups during the observation period. No changes due to MGP were observed in the experimental groups regarding clinical signs, body weights, food consumption, hematology, serum biochemistry, organ weight and necropsy. No histological changes due to MGP were observed in any of the male or female rats in the high-dosage group. Conclusion: During this 4-week, repeated, intravenous injection, toxicity test of MGP in SD rats, no toxic changes due to MGP were observed in any of the male or female rats in the high-dosage group. Thus, we suggest that the high and the low doses in a 13-week, repeated test should be 10 mL/kg and 2.5 mL/kg, respectively.

• 대한약침학회지
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• 제14권4호
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• pp.81-88
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• 2011

Objectives: The purpose of this report is to find out how Mountain Ginseng Pharmacopuncture(MGP) and Sweet Bee Venom(SBV) treatments are effective on prostate cancer patients by monitoring Prostate specific antigen(PSA) values. Methods: We treated two prostate cancer patients with MGP and SBV from October 2008 to April 2011. One patient had localized prostate cancer, the other was in the terminal stage of prostate cancer with lung and bone metastasis and both had been receiving western anticancer therapy. We had monitored the changes of PSA value. Results: In case 1, MGP and SBV treatments seemed to be helpful in preventing the recurrence of localized prostate cancer. In case 2, PSA value was decreased by MGP treatment. Conclusions: It is conceivable that MGP and SBV are effective treatments for patients with prostate cancer.

• 대한암한의학회지
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• 제20권2호
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• pp.51-59
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• 2015

Objective: This paper is to investigate the current evidence and clinical effectiveness of mountain ginseng pharmacopuncture (MGP) in cancer treatment. Methods: Along with hand searches, relevant literatures were searched from Korean medical database until November 2015 without language restriction and clinical researches were selected for this review. Results: Nine articles were searched. The MGP was generally prepared in the concentration of ten percent. Also, the MGP has been used by intravenous injection much more than acupoint injection. The clinical effects were the suppression of the cancer cell growth, the improvement the quality of life, the reduction of the side effect by chemotherapy and radiotherapy. Conclusion: This analysis suggests that the MGP can be used as a single therapy or a supportive therapy with conventional therapies, which are chemotherapy or radiotherapy.

• 한국식품저장유통학회지
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• 제14권3호
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• pp.247-255
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• 2007

본 연구는 재래종 및 개량종 돼지 등심의 일반 품질특성 과 SPME-GC/MS 및 전자코에 의한 신선육의 향기를 진공 포장 냉장저장중 비교하고자 실시하였다. 평균 출하체중 64 kg의 재래종 돼지(거세돈) 5두와 114 kg인 개량종 돼지($Landrace{\times}Yorkshire{\times}Duroc$, 거세돈) 5두를 도축하고 등심(M. longissimus) 부위를 진공포장한 다음 $2{\pm}0.3^{\circ}C$에서 12일 동안 저장하면서 품질을 분석하였다. 지방 함량은 재래종이 개량종보다 높았던 반면(p<0.05), 지방산 조성중 C14:0, C18:3, C20:5 함량은 개량종보다 낮았다(p<0.05). 저장기간동안 재래종의 pH와 보수력 모두 개량종보다 낮았으며(p<0.05), 표면육색은 재래종이 저장기간 동안 개량종보다 붉고 진하였다. TBARS 는 재래종에서 더 빨리 촉진되었으며, 조직감은 재래종이 저장기간 동안 개량종보다 단단하였다. SPME-GC/MS 및 전자코에 의해 저장 12일에 두 품종 간 hexanoic acid, 3-methyl-1-butanol, 2-ethyl hexanol, m-xylene의 성분 및 저장기간 동안 패턴 차이가 분별되었다.

• 한국축산식품학회지
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• 제27권1호
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• pp.1-7
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• 2007

본 연구는 해동후 냉장시킨 재래흑돼지육과 개량종 돼지육의 육질을 비교함으로서 재래흑돼지육에 대한 기초자료를 제시하고자 실시하였다. 생시체중이 65.3 kg인 재래흑돼지 거세돈 5두와 114.3 kg인 개량종 돼지 거세돈($Landrace{\times}Yorkshire{\times}Duroc$) 5두의 등심(M. longissimus)을 $-80^{\circ}C$에서 1개월 동안 냉동하고 해동한 후 $2{\pm}0.3^{\circ}C$에서 7일 동안 저장하였다. 도체중과 지육율은 재래흑돼지가 개량종 돼지보다 낮았다(p<0.05). 일반성분에서 수분 함량은 재래흑돼지육이 개량종 돼지육보다 낮았지만(p<0.05), 조지방 함량은 높았다(p<0.05). pH는 재래흑돼지육이 저장 5일까지 높았으며(p<0.05), 드립감량은 재래흑돼지육이 저장기간 동안 낮았다(p<0.05). TBARS는 재래흑돼지육이 저장 5일부터 유의적으로 높았다(p<0.05). 표면육색은 저장기간 동안 $L^*,\;h^0$ 값에서 재래흑돼지육이 낮았으며(p<0.05), $a^*,\;b^*,\;C^*$ 값에서는 높았다(p<0.05). 지방산 조성은 myristic acid, gamma-linolenic acid, linolenic acid, cis-5,8,11,14,17-eicosapentaenoic acid에서 재래흑돼지육이 개량종 돼지육보다 낮았으며(p<0.05), 신선육과 가열육의 관능적 기호도는 재래흑돼지육이 높았다(p<0.05). 따라서 재래흑돼지육은 개량종 돼지육보다 수분 및 일부 불포화지방산 함량이 낮고 저장중 지방산화가 촉진되었지만, 조지방 함량이 높고 보수력, 관능적 기호도 및 색택이 우수하였다.