• Title/Summary/Keyword: MEMBER MANAGEMENT

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Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions

  • Yang, Yanyan;Lee, Jongsung;Rhee, Man Hee;Yu, Tao;Baek, Kwang-Soo;Sung, Nak Yoon;Kim, Yong;Yoon, Keejung;Kim, Ji Hye;Kwak, Yi-Seong;Hong, Sungyoul;Kim, Jong-Hoon;Cho, Jae Youl
    • Journal of Ginseng Research
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    • v.39 no.1
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    • pp.61-68
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    • 2015
  • Background: Korean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and anti-inflammatory activities. Only a few studies have explored the molecular mechanism of KRG-mediated anti-inflammatory activity. Methods: We investigated the anti-inflammatory mechanisms of the protopanaxadiol saponin fraction (PPD-SF) of KRG using in vitro and in vivo inflammatory models. Results: PPD-SF dose-dependently diminished the release of inflammatory mediators [nitric oxide (NO), tumor necrosis factor-${\alpha}$, and prostaglandin $E_2$], and downregulated the mRNA expression of their corresponding genes (inducible NO synthase, tumor necrosis factor-${\alpha}$, and cyclooxygenase-2), without altering cell viability. The PPD-SF-mediated suppression of these events appeared to be regulated by a blockade of p38, c-Jun N-terminal kinase (JNK), and TANK (TRAF family member-associated NF-kappa-B activator)-binding kinase 1 (TBK1), which are linked to the activation of activating transcription factor 2 (ATF2) and interferon regulatory transcription factor 3 (IRF3). Moreover, this fraction also ameliorated HCl/ethanol/-induced gastritis via suppression of phospho-JNK2 levels. Conclusion: These results strongly suggest that the anti-inflammatory action of PPD-SF could be mediated by a reduction in the activation of p38-, JNK2-, and TANK-binding-kinase-1-linked pathways and their corresponding transcription factors (ATF2 and IRF3).

The Economic Effects of Oil Tariff Reduction of Korea-GCC FTA based on VAR Model (VAR모형을 활용한 한-GCC FTA 체결 시 원유관세 인하의 경제적 효과 분석)

  • KIM, Da-Som;RA, Hee-Ryang
    • International Area Studies Review
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    • v.20 no.1
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    • pp.23-51
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    • 2016
  • This study analyzed the expected economic effects of the Korea-GCC FTA and sought strategies for industrial cooperation. To see the economic effects of Korea-GCC FTA, we analysed the effect of the oil tariff reduction of economy by Vector Autoregression(VAR) model. The estimation results shows that following the abolishment of the tariff on crude oil imports, GDP, GNI and consumption are expected to grow by 0.212%, 0.389% and 0.238%, respectively. Meanwhile, investment, export and import are estimated to drop by 0.462%, 0.413% and 0.342%, respectively. As for prices, producer prices are to rise by 6.356%p, whereas consumer prices fall by 2.996%p. In short, the Korea-GCC FTA and resultant abolishment of the tariff on crude oil imports followed by the decline in crude oil prices will result in declining prices whilst macroeconomic indices, such as GDP, GNI and consumption, will increase exerting positive effects on domestic economic growth. Also, it is necessary to proactively respond to GCC member states' industrial diversification policies for FTA-based industrial cooperation to diversify the sources of crude oil and natural gas imports for further resource risk management.

A Basic Analysis on the Operation of the Cultural Heritage Committee (부록 1. 문화재위원회의 역할에 관한 기초적 분석)

  • Kim, Hong-real
    • Korean Journal of Heritage: History & Science
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    • v.38
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    • pp.421-474
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    • 2005
  • The Cultural Heritage Committee is an advisory committee established under the Cultural Heritage Administration with the aim of carrying out examination and deliberation on preservation, management and use of cultural properties. The Cultural Heritage Administration is responsible for Korean cultural properties. It was found to produce and execute policies on cultural properties, which involves in-depth investigation and consultation of experts in the fields of cultural properties. In here the Cultural Heritage Committee plays an important role in policy-making on Korean cultural properties. Governmental committees in Korea are largely divided into consultation committees and administrative commissions. Consultation committees are subdivided into consultation, deliberation and legislative committees. The Korean government established the Bureau of Cultural Properties in October 1961, and enacted provisions (as a presidential decree) on March 27, 1962, by the Cultural Properties Act, January 10, 1962. The Cultural Heritage Committee was opened as a deliberation committee which covers the entirety of cultural properties, including designation and cancellation of cultural properties, on which currently 120 members serve in 9 subcommittees. The committee member hold two years membership. This analysis contains a frame and scheme of the committee, function and statue of the current operation and study on role of a deliberation committee.

Analysis of Borrows Demand for Books in Public Libraries Considering Cultural Characteristics (문화적 특성을 고려한 공공도서관 도서 대출수요 분석 : 대구광역시 시립도서관을 사례로)

  • Oh, Min-Ki;Kim, Kyung-Rae;Jeong, Won-Oong;Kim, Keun-Wook
    • Journal of Digital Convergence
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    • v.19 no.3
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    • pp.55-64
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    • 2021
  • Public libraries are a space where residents learn a wide range of knowledge and ideologies, and as they are directly connected to life, various related studies have been conducted. In most previous studies, variables such as population, traffic accessibility, and environment were found to be highly relevant to library use. In this study, it can be said that the difference from previous studies is that the book borrow demand and relevance were analyzed by reflecting the variables of cultural characteristics based on the book borrow history (1,820,407 cases) and member information (297,222 persons). As a result of the analysis, it was analyzed that as the increase in borrows for social science and literature books compared to technical science books, the demand for book borrows increased. In addition, various descriptive statistical analyzes were used to analyze the characteristics of library book borrow demand, and policy implications and limitations of the study were also presented based on the analysis results. and considering that cultural characteristics change depending on the location and time of day, it is believed that related research should be continued in the future.

A Study on the Determination of Minimum Welding Condition Based on Structural Strength under Launching for Tandem Blocks (선체 블록 진수 시 필요한 최소 용접 구조 강도 평가에 관한 연구)

  • Myung-Su Yi;Joo-Shin Park
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.28 no.7
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    • pp.1267-1273
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    • 2022
  • Although the Korea shipbuilding industry has recently been receiving most of the orders for ships in the world, production processes are being disrupted due to a shortage of manpower at the production site. This is because the workers quit the shipyard as both work and wages were reduced due to the long slump in the shipbuilding industry. The main reason for the increase in orders was the large-scale orders for Qatar LNG carriers, and the situation in which the technical specifications required for ships are becoming more complex is also working to an advantage. Because the contract delivery time is of utmost importance for ships, the dock launch plan is the most important management item among the shipyard's major processes. The structure to be built in the dock may be a hull that has left the design work or a finished vessel, and in some cases, it is often at the level of some blocks of the hull. When launching, the hull is affected by the hogging or sagging moment due to the fluid force, and securing the safety of the structural strength of the block connection is of utmost importance. In a normal process, the connecting member launches after welding has been completed, but in actual shipbuilders, quick decision-making is needed on the conditions for securing structural safety to comply with the docking schedule. In this study, a detailed analysis method and applicability using a bending stress evaluation method and finite element analysis modelling were analyzed to rationally judge the above-mentioned problems from an engineering point of view. The main contents mentioned in the thesis can be used as good examples when conducting similar structural strength evaluations in the future.

Study on Self-worth and University Life Adaptation of Paramedicine Department Students (응급구조학과 학생들의 자기가치감과 대학생활적응)

  • Song-Yi Han;Hyo-Jin Won
    • Journal of Digital Policy
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    • v.2 no.3
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    • pp.17-24
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    • 2023
  • This study identified the degree of self-worth and college life adjustment of students in the department of paramedicine, and analyzed whether there was a difference according to the presence or absence of religion and the intimacy of family members. An online survey was conducted on 183 students in department of paramedicine students attending a university, and the subject's gender, religious affiliation, and intimacy with family members were analyzed by frequency and percentage. Self-worth and adjustment to college life according to the presence or absence of religion and intimacy with family members were analyzed by mean, standard deviation, t-test, and ANOVA. As a result, there was a difference in self-worth according to religion status and family closeness. According to intimacy with family members, there was a significant difference in academic adjustment among the sub-factors of college life adjustment. Through the results of this study, it is necessary to consider the existence of religion and intimacy with family members in setting up a counseling strategy tailored to the factors of personal self-worth improvement and college life adjustment. It is proposed to develop a college life adjustment promotion program to improve various self-worth, apply it to department of paramedicine students, and verify its effectiveness.

Prediction of Crack Distribution for the Deck and Girder of Single-Span and Multi-Span PSC-I Bridges (단경간 및 다경간 PSC-I 교량의 바닥판 및 거더의 균열분포 예측)

  • Hyun-Jin Jung;Hyojoon An;Jaehwan Kim;Kitae Park;Jong-Han Lee
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.27 no.6
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    • pp.102-110
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    • 2023
  • PSC-I girder bridges constitute the largest proportion among highway bridges in Korea. According to the precision safety diagnosis data for the past 10 years, approximately 41.3% of the PSC-I bridges have been graded as C. Furthermore, with the increase in the aging of bridges, preemptive management is becoming more important. Damage and deterioration to the deck and girder with a long replacement cylce can have considerable impacts on the service and deterioration of a bridge. In addition, the high rate of device damages, including expansion joints and bearings, necessitates an investigation into the influence of the device damage in the structural members of the bridge. Therefore, this study defined representative PSC-I girder bridges with single and multiple spans to evaluate heterogeneous damages that incorporate the damage of the bridge member and device with the deterioration of the deck. The heterogeneous damages increased a crack area ratio compared to the individual single damage. For the single-span bridge, the occurrence of bearing damage leads to the spread of crack distribution in the girder, and in the case of multi-span bridges, expansion joint damage leads to the spread of crack distribution in the deck. The research underscores that bridge devices, when damaged, can cause subsequent secondary damage due to improper repair and replacement, which emphasizes the need for continuous observation and responsive action to the damages of the main devices.

Difference Factors Analysis of between Quantity Take-off Using BIM Model and Using 2D Drawings in Reinforced Concrete Building Frame (건물 골조수량 산출 시 BIM모델 기반 수량과 2D도면 기반 수량 차이 요인 분석)

  • Kim, Gwang-Hee
    • Journal of the Korea Institute of Building Construction
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    • v.23 no.5
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    • pp.651-662
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    • 2023
  • Recently, research on the use of Building Information Modeling(BIM) for various construction management activities is being actively conducted, and interest in 3D model-based estimation is increasing because it has the advantage of being able to be automatically performed using the attribute information of the 3D model. Therefore, this study aimed that the difference in the quantities is calculated the quantity based on the 2D drawing of a building and is extracted from the 3D model created by the Revit software was compared and tried to find out the cause. The difference in the quantity calculated by the two methods was the largest in the formwork, followed by the smallest in the order of the quantity of rebar and concrete. The reason for this difference is that there is a part where the quantity extraction in the 3D model is not suitable for the quantity calculation standard, and in particular, in the case of formwork, it was difficult to separate only the quantity of the necessary part. In addition, since the quantity of rebar was not separated by member, it was impossible to accurately compare the quantity and identify the cause of the difference. Therefore, it is considered to be the most reasonable to use application software that imports only the numerical information necessary for quantity calculation from the 3D model and applies a separate calculation formula.

A Study on the Influence of Conflict on the Performance and Validity of Organization (갈등이 조직성과 및 조직 유효성에 미치는 영향에 대한 연구)

  • 기호익
    • The Journal of Information Technology
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    • v.1 no.2
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    • pp.81-102
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    • 1998
  • It is common description that modern society is In the era of limitless competition. In order to challenge the change of economy and its management at home and abroad, organization should be changed anew, and in this case, there accompanies conflict or trouble whether the subject of change wants it or not. Therefore, according to change, we should concern with settlement of small troubles as well as big ones, and by managing the conflict or trouble productively and originally, it should be utilized as new fatality and chance to develop something in organization. In the system organized by people, there exist various conflicts in accordance with the target and want of the system, therefore giving no freedom to each Individual member of the system, and this is an unavoidable tate in consideration of the modem society where the survival of mankind and human systems should be guaranteed. Therefore, it determines the coordinates of success of any of organizations to manage conflict or trouble well, and so, when decreasing or increasing conflicts so that the organization exerts its full influence, it is note worthy that conflict itself should be rationally and efficiently managed. In a view point of the theory of organization and its behavior, relating job satisfaction with the performance and validity of organization, the influence of individual conflict is so great on the rate of job transfer within an organization or nonattendance, even on the productivity of the organization. So, the manager to cope with conflict within an organization should devise following three plans to manage conflict for job satisfaction and conflict settlement. In conclusion, it is suggested that in order to manage conflict within an organization well, some plans to control conflict should be well utilized while giving more efforts to improving management of individual conflict, job satisfaction, validity of organization, productivity, etc and all the members of organization should remember that the Issue of conflict within an organization be recognized ad an opportunity of new development and a way to settle a trouble within an organization, and a direction of conflict management should be suggested so that new innovation ca be created.

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The Gains To Bidding Firms' Stock Returns From Merger (기업합병의 성과에 영향을 주는 요인에 대한 실증적 연구)

  • Kim, Yong-Kap
    • Management & Information Systems Review
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    • v.23
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    • pp.41-74
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    • 2007
  • In Korea, corporate merger activities were activated since 1980, and nowadays(particuarly since 1986) the changes in domestic and international economic circumstances have made corporate managers have strong interests in merger. Korea and America have different business environments and it is easily conceivable that there exists many differences in motives, methods, and effects of mergers between the two countries. According to recent studies on takeover bids in America, takeover bids have information effects, tax implications, and co-insurance effects, and the form of payment(cash versus securities), the relative size of target and bidder, the leverage effect, Tobin's q, number of bidders(single versus multiple bidder), the time period (before 1968, 1968-1980, 1981 and later), and the target firm reaction (hostile versus friendly) are important determinants of the magnitude of takeover gains and their distribution between targets and bidders at the announcement of takeover bids. This study examines the theory of takeover bids, the status quo and problems of merger in Korea, and then investigates how the announcement of merger are reflected in common stock returns of bidding firms, finally explores empirically the factors influencing abnormal returns of bidding firms' stock price. The hypotheses of this study are as follows ; Shareholders of bidding firms benefit from mergers. And common stock returns of bidding firms at the announcement of takeover bids, shows significant differences according to the condition of the ratio of target size relative to bidding firm, whether the target being a member of the conglomerate to which bidding firm belongs, whether the target being a listed company, the time period(before 1986, 1986, and later), the number of bidding firm's stock in exchange for a stock of the target, whether the merger being a horizontal and vertical merger or a conglomerate merger, and the ratios of debt to equity capital of target and bidding firm. The data analyzed in this study were drawn from public announcements of proposals to acquire a target firm by means of merger. The sample contains all bidding firms which were listed in the stock market and also engaged in successful mergers in the period 1980 through 1992 for which there are daily stock returns. A merger bid was considered successful if it resulted in a completed merger and the target firm disappeared as a separate entity. The final sample contains 113 acquiring firms. The research hypotheses examined in this study are tested by applying an event-type methodology similar to that described in Dodd and Warner. The ordinary-least-squares coefficients of the market-model regression were estimated over the period t=-135 to t=-16 relative to the date of the proposal's initial announcement, t=0. Daily abnormal common stock returns were calculated for each firm i over the interval t=-15 to t=+15. A daily average abnormal return(AR) for each day t was computed. Average cumulative abnormal returns($CART_{T_1,T_2}$) were also derived by summing the $AR_t's$ over various intervals. The expected values of $AR_t$ and $CART_{T_1,T_2}$ are zero in the absence of abnormal performance. The test statistics of $AR_t$ and $CAR_{T_1,T_2}$ are based on the average standardized abnormal return($ASAR_t$) and the average standardized cumulative abnormal return ($ASCAR_{T_1,T_2}$), respectively. Assuming that the individual abnormal returns are normal and independent across t and across securities, the statistics $Z_t$ and $Z_{T_1,T_2}$ which follow a unit-normal distribution(Dodd and Warner), are used to test the hypotheses that the average standardized abnormal returns and the average cumulative standardized abnormal returns equal zero.

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