• 제목/요약/키워드: MD&A

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Draft Genome Sequence of Mycobacterium abscessus Treated with a Fluoroquinolone in a Time-Dependent Manner

  • Du-Gyeong Han;Ji-A Jeong;Sung-Kyoung Lee;Seong-Han Kim;Se-Mi Jeon
    • Microbiology and Biotechnology Letters
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    • 제52권2호
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    • pp.211-214
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    • 2024
  • This study aimed to confirm the induction of resistance to other drug classes by treating Mycobacterium abscessus with moxifloxacin, a fluoroquinolone used for treating nontuberculous mycobacteria infection, and to obtain genetic data for improving treatment. The reads were assembled and analyzed using reference strain sequence data, and the whole-genome and transcriptome sequences of four strains (MD2, MD4, MD6, and MD8) were reported. Antibiotic resistance was not induced by moxifloxacin treatment; however, transcriptomic analysis revealed that the expression of genes responding to stress was upregulated.

Clinical Features of Deep Neck Infections and Predisposing Factors for Mediastinal Extension

  • Kang, Shin-Kwang;Lee, Seok-Kee;Oh, Hyun-Kong;Kang, Min-Woong;Na, Myung-Hoon;Yu, Jae-Hyeon;Koo, Bon-Seok;Lim, Seung-Pyung
    • Journal of Chest Surgery
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    • 제45권3호
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    • pp.171-176
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    • 2012
  • Background: Deep neck infections (DNI) can originate from infection in the potential spaces and fascial planes of the neck. DNI can be managed without surgery, but there are cases that need surgical treatment, especially in the case of mediastinal involvement. The aim of this study is to identify clinical features of DNI and analyze the predisposing factors for mediastinal extension. Materials and Methods: We reviewed medical records of 56 patients suffering from DNI who underwent cervical drainage only (CD group) and those who underwent cervical drainage combined with mediastinal drainage for descending necrotizing mediastinitis (MD group) from August 2003 to May 2009 and compared the clinical features of each group and the predisposing factors for mediastinal extension. Results: Forty-four out of the 56 patients underwent cervical drainage only (79%) and 12 patients needed both cervical and mediastinal drainage (21%). There were no differences between the two groups in gender (p=0.28), but the MD group was older than the CD group (CD group, $44.2{\pm}23.2$ years; MD group, $55.6{\pm}12.1$ years; p=0.03). The MD group had a higher rate of co-morbidity than the CD group (p=0.04). The CD group involved more than two spaces in 14 cases (32%) and retropharyngeal involvement in 12 cases (27%). The MD group involved more than two spaces in 11 cases (92%) and retropharyngeal involvement in 12 cases (100%). Organism identification took place in 28 cases (64%) of the CD group and 3 cases of (25%) the MD group (p=0.02). The mean hospital stay of the CD group was $21.5{\pm}15.9$ days and that of the MD group was $41.4{\pm}29.4$ days (p=0.04). Conclusion: The predisposing factors of mediastinal extension in DNI were older age, involvement of two or more spaces, especially including the retropharyngeal space, and more comorbidities. The MD group had a longer hospital stay, higher mortality, and more failure to identify causative organisms of causative organisms than the CD group.

Full-Endoscopic versus Minimally Invasive Lumbar Interbody Fusion for Lumbar Degenerative Diseases : A Systematic Review and Meta-Analysis

  • Son, Seong;Yoo, Byung Rhae;Lee, Sang Gu;Kim, Woo Kyung;Jung, Jong Myung
    • Journal of Korean Neurosurgical Society
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    • 제65권4호
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    • pp.539-548
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    • 2022
  • Objective : Although full-endoscopic lumbar interbody fusion (Endo-LIF) has been tried as the latest alternative technique to minimally invasive transforaminal lumbar interobody fusion (MIS-TLIF) since mid-2010, the evidence is still lacking. We compared the clinical outcome and safety of Endo-LIF to MIS-TLIF for lumbar degenerative disease. Methods : We systematically searched electronic databases, including PubMed, EMBASE, and Cochrane Library to find literature comparing Endo-LIF to MIS-TLIF. The results retrieved were last updated on December 11, 2020. The perioperative outcome included the operation time, blood loss, complication, and hospital stay. The clinical outcomes included Visual analog scale (VAS) of low back pain and leg pain and Oswestry disability index (ODI), and the radiological outcome included pseudoarthosis rate with 12-month minimum follow-up. Results : Four retrospective observational studies and one prospective observational study comprising 423 patients (183 Endo-LIF and 241 MIS-TLIF) were included, and the pooled data analysis revealed low heterogeneity between studies in our review. Baseline characteristics including age and sex were not different between the two groups. Operation time was significantly longer in Endo-LIF (mean difference [MD], 23.220 minutes; 95% confidence interval [CI], 10.669-35.771; p=0.001). However, Endo-LIF resulted in less perioperative blood loss (MD, -144.710 mL; 95% CI, 247.941-41.478; p=0.023). Although VAS back pain at final (MD, -0.120; p=0.586), leg pain within 2 weeks (MD, 0.005; p=0.293), VAS leg pain at final (MD, 0.099; p=0.099), ODI at final (MD, 0.141; p=0.093) were not different, VAS back pain within 2 weeks was more favorable in the Endo-LIF (MD, -1.538; 95% CI, -2.044 to -1.032; p<0.001). On the other hand, no statistically significant group difference in complication rate (relative risk [RR], 0.709; p=0.774), hospital stay (MD, -2.399; p=0.151), and pseudoarthrosis rate (RR, 1.284; p=0.736) were found. Conclusion : Relative to MIS-TLIF, immediate outcomes were favorable in Endo-LIF in terms of blood loss and immediate VAS back pain, although complication rate, mid-term clinical outcomes, and fusion rate were not different. However, the challenges for Endo-LIF include longer operation time which means a difficult learning curve and limited surgical indication which means patient selection bias. Larger-scale, well-designed study with long-term follow-up and randomized controlled trials are needed to confirm and update the results of this systematic review.

An Efficient TCP Mechanism for Mobile IP Handoffs (Mobile IP 핸드오프를 위한 효율적인 TCP 방식)

  • Kwon, Jae-Woo;Park, Hee-Dong;Cho, You-Ze
    • Journal of KIISE:Information Networking
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    • 제29권5호
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    • pp.501-509
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    • 2002
  • When using TCP over a mobile network, TCP responds to a handoff by invoking a congestion control algorithm, thereby resulting in a degraded end-to-end performance in a mobile network. In this paper, two schemes are proposed, TCP-MD and TCP-R. TCP-MD can detect the movement of s mobile host early on, whereas TCP-R can force the source to freeze data transmission during registration. The proposed schemes maintain end-to-end TCP semantics, making it possible to fully interoperate with the existing infrastructure. Only a small change is required in the mobile host, plus the implementation is simple because some Mobile IP messages are used to notify the handoff, eliminating the need for any additional messages. Simulations confirmed that the proposed schemes give an excellent performance under various environments.

A study on the prediction of the mechanical properties of Zinc alloys using DV-Xα Molecular Orbital Method (DV-Xα분자궤도법을 이용한 Zn alloy의 기계적 성질 예측)

  • Na, H.S.;Kong, J.P.;Kim, Y.S.;Kang, C.Y.
    • Korean Journal of Materials Research
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    • 제17권5호
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    • pp.250-255
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    • 2007
  • The alloying effects on the electronic structures of Zinc are investigated using the relativistic $DV-X{\alpha}molecular$ orbital method in order to obtain useful information for alloy design. A new parameter which is the d obital energy level(Md) and the bonder order(Bo) of alloying elements in Zinc was introduced and used for prediction of the mechanical properties. The Md correlated with the atomic radius and the electronegativity of elements. The Bo is a measure of the strength of the covalent bond between M and X atoms. First-principles calculations of electronic structures were performed with a series of models composed of a MZn18 cluster and the electronic states were calculated by the discrete variational- $X{\alpha}method$ by using the program code SCAT. The central Zinc atom(M) in the cluster was replaced by various alloying elements. In this study energy level structures of pure Zinc and alloyed Zinc were calculated. From calculated results of energy level structures in MZn18 cluster, We found Md and Bo values for various elements of Zn. In this work, Md and Bo values correlated to the tensile strength for the Zn. These results will give some guide to design of zinc based alloys for high temperature applications and it is possible the excellent alloys design.

MBR technology for textile wastewater treatment: First experience in Bangladesh

  • Saha, Pradip;Hossain, Md. Zakir;Mozumder, Md. Salatul I.;Uddin, Md. Tamez;Islam, Md. Akhtarul;Hoinkis, Jan;Deowan, Shamim A.;Drioli, Enrico;Figoli, Alberto
    • Membrane and Water Treatment
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    • 제5권3호
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    • pp.197-205
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    • 2014
  • For the first time in Bangladesh, a bench scale membrane bioreactor (MBR) unit was tested in treating a textile wastewater in the industry premises of EOS Textile Mills LTD, Dhaka for three months. The performance of the unit was compared with that of the conventional activated sludge treatment plant, which is in operation in the same premises. The COD and BOD removal efficiency of the MBR unit reached to around 90% and 80% respectively in 20 days whereas the removal efficiency of the conventional treatment plant was as low as 40-50% and 38-40% respectively. The outlet COD and the BOD level for the MBR unit remained stable in spite of the fluctuation in the feed value, while the conventional effluent treatment plant (ETP) failed to keep any stabilized level. The performance of the MBR unit was much superior to that of the functional ETP and the water treated by the MBR system can meet disposal standard.

Conductive line manufacturing method and evaluation using a metal jet (메탈젯을 이용한 전도성 배선 형성 방법과 평가)

  • Kim, Tae-Hoon;Lee, Young-Il;Seo, Young-Kwuan;Jeon, Byung-Ho;Lee, Kwi-Jong;Kim, Dong-Hoon
    • Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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    • 한국전기전자재료학회 2008년도 추계학술대회 논문집 Vol.21
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    • pp.391-392
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    • 2008
  • 최근 나노 금속의 대량 생산에 대한 기술이 확보됨에 따라, 메탈젯을 이용한 연구가 활발히 진행되고 있다. 메탈젯의 연구 범위는 RFID, PCB, MLCC 전극, 태양전지전극, PDP 전극, EMC용재료 등 그 응용 범위를 넓혀 가고 있다. 이러한 응용 기술 대표적인 배선형성 기술인 PCB 제조에 대한 연구는 40um 이하의 고해상도 기판 개발을 요구하고 있다. 선폭은 40um 이하를 유지하면서, 두께는 10um 이상으로 CCL을 대체 하기 위한 기판 형성 기술은 응용기술은 가장 어려운 난이도의 기술이다. 메탈젯 기술은 매우 복합적인 연구분야로 나노 재료의 개발, 인쇄공정의 개발, 기재 표면처리 기술, 헤드 기술의 개발을 동시에 만족할 때 가능하다. 배선 형성을 위하여 나노 잉크를 이용하여 직접 인쇄를 진행하고, 소결하여 전도성을 얻게 된다. 본 연구에서는 미세노즐에 토출 가능한 잉크젯용 잉크 조성을 결정하고, 기판과의 신뢰성을 확보하기 위하여 접착력의 평가, 전도도의 평가, 건조 시간 조절을 통한 Crack 문제 해결, 미세 선폭의 균일성 조절에 관한 실험을 진행하였다.

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Scalants removal from synthetic RO brine using natural zeolite (막증류 공정의 전처리 공정으로서 천연 제올라이트 컬럼 적용)

  • Jeong, Seongpil;Chung, Hayoon;Yoon, Teakgeun;Lee, Seockheon
    • Journal of Korean Society of Water and Wastewater
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    • 제30권3호
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    • pp.279-284
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    • 2016
  • Membrane distillation (MD) is the thermally driven water separation process based on the vapor pressure difference across the membrane. In order to increase the water recovery of the conventional RO process, the additional MD-PRO pocess was suggested. In this study, the syntheric RO brine was used as a feed solution of the MD process. Due to the high salinity of the RO brine, the MD membrane could be fouled by the scalants. In order to mitigate the scaling on the MD membrane surface, the pre-treatment process using the column filled by natural zeolite was applied. The roughing filter was installed between the pre-treatment process and MD system in order to prevent possible particulate fouling by the debries of the natural zeolite. Moreover, in order to enhance the CEC of the natural zeolite, the NaCl soaking was conducted. The flux and electronic conductivity were monitored under given experimental conditions. And the membrane morphology and the chemical compositions were analyzed by using the SEM-EDX.

Studies on the biochemical characteristics and plasmid profiles of Salmonella typhimurium isolated from pigeons and aquatic birds (비둘기 및 수생조류(水生鳥類) 유래(由來) Salmonella typhimurium의 생물화학적(生物化學的) 특성(特性)과 plasmid profile에 관(關)한 연구(硏究))

  • Park, No-chan;Choi, Won-pil
    • Korean Journal of Veterinary Research
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    • 제30권2호
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    • pp.203-214
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    • 1990
  • A total of 166 strains of Salmonella (S) typhimurium var copenhagen isolated from pigeons (164 strains) and aquatic birds (2 strains) were examined for the biochemical characteristics and plasmid profiles. All the strains were sensitive to ampicillin, chloramphenicol, gentamicin, kanamycin and sulfadimethoxine. But 13 strains(7.8%) were resistant to streptomycin (Sm), 2 (1.2%) to tetracycline, 2 (1.2%) to rifampicin, and 1 (0.6%) to nalidixic acid. Among drug resistant strains, only one strain resistant to Sm contained conjugative R plasmid which was fertility inhibition and incompatibility group $I_{\alpha}$. All the strains were sensitive to cobalt chloride, cupric sulfate, lead nitrate, mercuric chloride and silver nitrate. Of 166 isolates, 6 (3.6%) were resistant to sodium arsenate and 1 (0.6%) to potassium tellurite. Among 166 isolates, 1 (0.6%) was colicinogenic, 12 (7.2%) sucrose fermenters, and 166 (100%) maltose fermenters. Plasmid profiles were confirmed as being 4 or 5 plasmids, and their molecular weight ranged 3.2 to 60 megadalton (MD). All the strains harbored 60 Md plasmid. There are three patterns by the plasmid profile, 150 isolates (90.4%) were pattern I (3.2, 3.5, 33, 60Md), 14 (8.4%) pattern II (3.2, 3.5, 29, 60Md), and 2 (1.2%) pattern III (4.2, 7.8, 8.5, 15, 60Md). S typhimurium var copenhagen strains containing 60Md plasmid were resistant to killing by 90% normal guinea pig serum.

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A ROENTGENOCEPHALOMETRIC STUDY FOR THE ACCEPTABLE PROFILE IN KOREAN ADULTS (한국성인의 측모에 관한 두부방사선학적 연구)

  • Lee You Dong;Lee Sang Rae
    • Journal of Korean Academy of Oral and Maxillofacial Radiology
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    • 제20권1호
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    • pp.19-27
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    • 1990
  • The primary objective of this study was to analyze the hard and soft tissue profile and comparison of the both sexes in Korean adults using roentgenocephalometry. The subjects were 122 males and 116 females from 18 to 22 years of age selected on the basis of their excellent occlusion and harmonious profile. It was an investigation about the interrelationships in the angles which consisted of Frankfort horizontal plane (FH plane), Sella Nasion plane (SN plane), Nasal floor plane (NF plane) and Mandibular plane (Md plane) as reference planes, and of the axial inclinations of the upper anterior tooth to Nasal floor plane (NF Plane) and of the lower anterior tooth to Mandibular plane (Md Plane). Among the 14 categories estabilishied on the soft tissue land marks, the 6 categories were studied for the relationship to Frankfort horizontal plane (FH Plane), and the 8 categories were studied for the soft tissue contour. The results were as follows: 1. Among 8 measured angles in the hard tissue, the angle of FH-Md, NF-Md and SN-Md were greater in females than in males. 2. The axial inclinations of the anterior teeth to NF Plane and Md plane were slightly greater in males than In females. 3. Among 14 measured angles in the soft tissue, the angles of G-Sn-P and E-Pog-Sn were greater in males, and FH-G-Sn, GㆍSn-Sn. Pog and Pog-Sn-P were greater in females. 4. In males, the variability of measured values in both lips region were high.

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