• 한국임상수의학회:학술대회논문집
• /
• 한국임상수의학회 2009년도 추계학술대회
• /
• pp.254-254
• /
• 2009

• Biomolecules & Therapeutics
• /
• 제8권4호
• /
• pp.338-348
• /
• 2000

The present study was attempted to determine the effect of 5'-(N'-ethylcarboxamido) adenosine (NECA), which is an potent $A_2$-adenosine receptor agonist, on catecholamine (CA) secretion evoked by cholinergic stimulation, membrane depolarization and calcium mobilization from the isolated perfused rat adrenal gland. NECA (20 nM) perfused into the adrenal vein for 60 min produced a time-related inhibition in CA secretion evoked by ACh (5.32x10$^{-3}$ M), high $K^{+}$(5.6x10$^{-2}$ M), DMPP (10$^{-4}$ M for 2 min), McN-A-343 (10$^{-4}$ M for 2 min), cyclopiazonic acid (10$^{-5}$ M for 4 min) and Bay-K-8644 (10$^{-5}$ M for 4 min). Also, in the presence of $\beta$,${\gamma}$-methylene adenosine-5'-triphosphate (MATP), which is also known to be a selective $P_{2x}$-purinergic receptor agonist, showed a similar inhibition elf CA release evoked by ACh, high potassium, DMPP, McN-A-343, Bay-K-8644 and cyclopiazonic acid. However, in adrenal glands preloaded with 20$\mu$M NECA for 20 min under the presence of 20$\mu$M 3-isobutyl-1-methyl-xanthine (IBMX), an adenosine receptors antagonist, CA secretory responses evoked by ACh, high potassium, DMPP, McN-A-343, Bay-K-8644 and cyclopiazonic acid were much recovered in comparison to the case of NECA-treatment only. Taken together, these results indicate that NECA causes the marked inhibition of CA secretion evoked by stimulation of cholinergic (both nicotinic and muscarinic) receptors as well as by membrane depolarization. This inhibitory effect may be mediated by inhibiting influx of extracellular calcium and release in intracellular calcium in the rat adrenomedullary chromaffin cells through the adenosine receptor stimulation. Therefore, it is suggested that the inhibitory mechanism of adenosine receptor stimulation may play a modulatory role in regulating CA secretion.n.n.

• 한국정보처리학회논문지
• /
• 제6권3호
• /
• pp.699-709
• /
• 1999

This paper is aimed at defining items of analysis using SNMP MIB-II for the purpose of managing the Internet based network running on TCP/IP protocol, and then utilize these items, in conjunction with various Web technology and JAVA to design and implement a Web based interface of a management system to analyze the performance and status of the Internet. Among the required items in order to accomplish this task are utilization, interface packet transmission rate, I/O traffic ratio, and so on. Based on these items, the actual analysis is carried out by the Web interface according to the type of analysis. For instance, the interface executes the function of real-time analysis, collection processing, elementary analysis and detailed analysis. The demand of the user is fed into the Web interface which carried out a real-time analysis with the client system which in turn will eventually produce the results of the analysis. In order words, the interface acts as a mediator server for the analysis system. Furthermore, a protocol for exchange of data and messages between the server and the analysis system, the MATP protocol, was also designed. Finally, the results obtained through the system presented in this paper were displayed on screen according to the type of analysis. The system realized in this paper uses We technology and is independent of platform and allows the user to determine the performance of Internet at his/her own host according to the selected items of analysis.