• The Korean Journal of Zoology
• /
• v.36 no.3
• /
• pp.347-352
• /
• 1993

N-ethylmaleimide at low concentrations is known to interact specifically with 2 sulfhydryl residues in myosin heavy chain. Calpain, a Ca$^2$+-dependent neutral protease isolated from chick skeletal muscle, was found to preferentially degrade the alkylated protein but much less significantly the unmodified protein. Exposure of myosin to KMnO$_4$, which is also known to interact with sulthydryl groups, also caused the rapid degradation of the myosin heavy chain. Furthermore, treatment of each agent with increasing concentrations results in a greater loss of the myosin ATPase activity, indicating that the modification occurred at the reactive site sulfhydryl residues. These results suggest that the covalent modification at the reactive site salfhydryl residues in the myosin heavy chain may mark the protein for degradation by intracellular proteases such as calpain.

• Journal of Korean Academy of Nursing Administration
• /
• v.8 no.3
• /
• pp.373-380
• /
• 2002

Purpose : The purpose of this study is to analyze the history of nursing and medicine as phenomena of knowledge/power from the viewpoint of Foucault. Method : The present study adopts the genealogical method by Foucault, which tries to unite languages and knowledge. Foucault who attempted to show that the basic ideas which people normally take to be permanent truths about human nature and society change in the course of history. Results : It has been emphasized that the development of modern health care has been due to the progressive efforts of medicine and to medical discoveries. Foucault examines the institutionalization of knowledge and the power exerted thereby, with special reference to the devices of social regulation and their function over the madness, the disease, the crime, and the sexuality. The concept of power is that it is exerted spontaneously in verbal behaviors of individuals through knowledge of everyday life such as definition of body or mind. Therefore as to the problem of knowledge/power, this study tries to understand the meaning of history of nursing and medicine through an analysis of the formation of text of history. In order to have authority in a power relation, the medical professional asserts that medical discourse is the most scientific knowledge. Conclusion : According to the above findings, it can be concluded that the body is also directly invested in a political field: power relations have an immediate hold upon it; they invest it, mark it, train it, torture it, force it to carry out tasks, to perform ceremonies, to emit signs. Therefore the devaluation of nursing care is reinforced by the medicine which has the legitimate authority through use of the political skills about the body.

• Journal of The Korean Society of Grassland and Forage Science
• /
• v.21 no.3
• /
• pp.109-114
• /
• 2001

The object of this experiment was to evaluate nutritive value of roughage which was collected by Woosung Feed Co., Ltd. in Korea in 1999-2000. Nineteen kinds of roughage(l32 samples) were collected by Woosung Feed Co., Ltd. and their chemical composition, ADF, NDF, Ca and P. were analysed. In addition, their DMD, DMI, WV and hay grades were calculated based on analysed values. The CP content of roughage was ranged from 17.35%(alfalfa hay) to 4.00%(Italian ryegrass hay), and ten kinds of roughage under six percentages were observed. The NDF content of roughage was ranged from 47.50%(sugarcane leaf) to 78.84%(orchardgrass hay), and eight kinds of roughage above seventy percentages were observed. The DMD of roughage was ranged from 66.38%(beet pulp) to 50.95%(orchardgrass hay). The WV of roughage was ranged from 60.1 l(orchardgrass hay) to 125.07(sugarcane leaf). In hay grade of roughage, the first grade was assigned to sugarcane leaf only and the third grade and fourth grade were assigned to four kinds of roughage each. Bermudagrass straw received the fifth grade, and the nine kinds of roughage received the poor grades. As shown in the above results, nineteen kinds of roughage were mostly low in crude protein contents and dry matter digestibility, but they were high in fibrous contents. Futhermore, while only one kind of roughage was evaluated as obtaining the first grade, nine kinds of roughage were evaluated as the poor grade. Hence, we know that roughage which was collected in Korea was mostly low in their quality and that there was significant difference in their feed value among those roughage(P<0.05). Therefore, it is necessary to mark the hay quality for purpose of distributive circulation of roughage. (Key words : Roughages, Nutritive value, DMD. RFV. Hay grade)

• The Journal of the Korean dental association
• /
• v.56 no.2
• /
• pp.94-102
• /
• 2018

The present study was conducted to assess the growth changes of human chin in childhood and adolescence at various stages of skeletal maturation using metallic implant installed in mandibular body. Lateral cephalographs including 23 subjects (9 males and 14 females) between 7-18 years old were used, which had been taken at University of California in San Francisco and kept at University of the Pacific. Three lateral cephalographs were chosen for each subject according to CVM (Cervical Vertebral Maturation) method (CVM stage 1 to 2, CVM stage 3 to 4, and CVM stage 5 to 6) which assess the extent of the skeletal maturation using the second, third, and fourth cervical vertebrae. V-ceph was used in order to mark the 8 landmarks (S, N, A, B, Pog, Me, Go, Imp) on lateral cephalographs and obtain 8 angular and linear measurements(ANB, SNPog, SN-GoMe, Imp-B, Imp-Pog, B-Pog//GoMe, $GoMe{\bot}B$, $GoMe{\bot}Pog$). Among 8 measurements, ANB, SNPog, SN-GoMe, B-Pog//GoMe, $GoMe{\bot}B$ showed statistically significant growth changes at various stages of skeletal maturation according to CVM method, while there were no significant differences on Imp-B, Imp-Pog, $GoMe{\bot}Pog$. The results suggest that the increasing prominence of human chin is greatly influenced by the vertical growth of B point area, in addition to the change and growth in chin and mandible proper.

• Journal of the Institute of Convergence Signal Processing
• /
• v.5 no.3
• /
• pp.190-197
• /
• 2004

This paper presents automated prediction of transient ischemic episodes using neural networks(NN) based pattern matching method. The learning algorithm used to train the multilayer networks is a modified backpropagation algorithm. The algorithm updates parameters of nonlinear function in a neuron as well as connecting weights between neurons to improve learning speed. The performance of the method was evaluated using ECG signals of the MIT/BIH long-term database. Experimental results for 15 records(237 ischemic episodes) show that the average sensitivity and specificity of ischemic episode prediction are 85.71% and 71.11%, respectively. It is also found that the proposed method predicts an average of 45.53［sec］ ahead real ischemia. These results indicate that the NN approach as the pattern matching classifier can be a useful tool for the prediction of transient ischemic episodes.

• Korean Journal of Community Nutrition
• /
• v.18 no.1
• /
• pp.11-24
• /
• 2013

This study was conducted to provide basic data for development of a dietary education textbook and guidebook by investigating and analyzing eating behavior, nutrition knowledge and educational needs in elementary school students. Most of the subjects were eating three meals a day (71.5%) and breakfast (75.3%). The percentage of students who consumed proper amount of meals (49.2%) was low. The percentage of students consuming salty food and fatty foods was 28.6% and 42.1%, respectively. The consumption of meat, fish, egg, bean and tofu was high, while the consumption of vegetables, fruits and seaweed was low. The percentage of students consuming processed food was high, but the percentage reading nutrition labels (34.9%) and hazard analysis critical control point (HACCP) mark (26.9%) when buying processed foods was very low. Total scores of eating behavior and nutrition knowledge were significantly higher in female students than in male students (p < 0.05-p < 0.001). The desirable frequency of the education was once a week (60.5%). The most preferred educational method was 'experiment and cooking practice' (40.1%). The students wanted dietary information as 'cooking' (39.0%). As a result of this study, many problems were found in the eating behavior of students and nutritional knowledge was observed to be low as well. On the other hand, the demand for dietary education was very high. The findings of this study suggested the need for developing dietary education programs in order to encourage proper eating habits of students.

• The Journal of Korean Obstetrics and Gynecology
• /
• v.30 no.4
• /
• pp.45-58
• /
• 2017

Objectives: The aim of this trial is to investigate the effect of Ginseng and Wild Cultivated Ginseng to Heat pattern subject. Methods: Eighty-nine Subjects were diagnosed as heat pattern by Cold-Heat Patternization and divided into Ginseng group (n=30), Wild Cultivated Ginseng group (n=31) and Placebo group (n=28) in their 1 st visit. In each visit, The researchers measured the subject's facial temperature using the infrared thermometer (Testo 835-T1). After that, The subjects were asked to mark the current score of flushing on the Visual Analogue Scale (VAS) and to complete the Chalder-Fatigue Scale (CFS) in each visit. The subjects took the test drug for one week and returned the remaining drug on the 2nd visit. The trial result was analyzed with one-way ANOVA using SPSS for Windows version 18. Results: 1. Systolic blood pressure was significantly lower in the Ginseng group and Wild Cultivated Ginseng group than in the control group (p=0.021). 2. There was no significant difference in facial temperature between each groups. 3. The current score of flushing showed the greatest decrease in the Ginseng group compared to the other groups but there was no significant difference (p=0.205). 4. The score of Chalder-Fatigue Scale was decreased in all groups but not statistically significant (p=0.180). Conclusions: This study showed that taking Ginseng extract and Wild Cultivated Ginseng extract do not affect to heat-rising reaction to the subjects diagnosed as heat pattern.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• v.19 no.1
• /
• pp.12-19
• /
• 2016

Purpose: This study was performed to evaluate the quality of sleep in snoring obese children without obstructive sleep apnea (OSA); and to study the possible relationship between sleep interruption and gastroesophageal reflux (GER) in snoring obese children. Methods: Study subjects included 13 snoring obese children who were referred to our sleep lab for possible sleep-disordered breathing. Patients underwent multichannel intraluminal impedance and esophageal pH monitoring with simultaneous polysomnography. Exclusion criteria included history of fundoplication, cystic fibrosis, and infants under the age of 2 years. Significant association between arousals and awakenings with previous reflux were defined by symptom-association probability using 2-minute intervals. Results: Sleep efficiency ranged from 67-97% (median 81%). A total of 111 reflux episodes (90% acidic) were detected during sleep, but there were more episodes per hour during awake periods after sleep onset than during sleep (median 2.3 vs. 0.6, p=0.04). There were 279 total awakenings during the sleep study; 56 (20.1%) of them in 9 patients (69.2%) were preceded by reflux episodes (55 acid, 1 non-acid). In 5 patients (38.5%), awakenings were significantly associated with reflux. Conclusion: The data suggest that acid GER causes sleep interruptions in obese children who have symptoms of snoring or restless sleep and without evidence of OSA.

• Journal of Korean Neurosurgical Society
• /
• v.59 no.1
• /
• pp.26-36
• /
• 2016

Objective : This study investigated whether pyrosequencing can be used to determine the methylation status of the MGMT promoter as a clinical biomarker using relatively old archival tissue samples of glioblastoma. We also examined other prognostic factors for survival of glioblastoma patients. Methods : The available study set included formalin-fixed paraffin-embedded (FFPE) tissue from 104 patients at two institutes from 1997 to 2012, all of which were diagnosed histopathologically as glioblastoma. Clinicopathologic data were collected by review of medical records. For pyrosequencing analysis, the PyroMark Q96 CpG MGMT kit (Qiagen, Hilden, Germany) was used to detect the level of methylation at exon 1 positions 17-39 of the MGMT gene, which contains 5 CpGs. Results : Methylation of the MGMT promoter was detected in 43 (41.3%) of 104 samples. The average percentage methylation was $14.0{\pm}16.8%$ overall and $39.0{\pm}14.7%$ for methylated cases. There was no significant pattern of linear increase or decrease according to the age of the FFPE block (p=0.687). In multivariate analysis, age, performance status, extent of surgery, method of adjuvant therapy, and methylation status estimated by pyrosequencing were independently associated with overall survival. Additionally, patients with a high level of methylation survived longer than those with low methylation (p=0.016). Conclusion : In this study, the status and extent of methylation of the MGMT promoter analyzed by pyrosequencing were associated with overall survival in glioblastoma patients. Pyrosequencing is a quantitative method that overcomes the problems of MSP and a simple technique for accurate analysis of DNA sequences.

• Design & Manufacturing
• /
• v.13 no.3
• /
• pp.35-40
• /
• 2019

As the consumer market in the cosmetic, vehicle manufacturing and aerospace industries grows, the demand for manufacturing industries using on injection mold technology. Also, such manufacturing technology of metal machining is expensive, and the shape is limited. Cosmetic cushion fact products are divided into outer relevant to the exterior of the product and inner containers containing the actual contents. In the case of the inner container, it needs to be combined with the upper and lower cases. As environmental regulations are strengthened internationally, the use of a large number of component parts can result in significant losses in recycling and economics. Therefore, this study aims to perform injection molding analysis through injection molding simulation to develop a cushion fact container that can be recycled through the unification of products and materials using polypropylene to cope with environmental regulations. In the case of injection molding conditions, Injection Time(sec): 4.5, Cooling Time(sec): 13, Resin Temperature($^{\circ}C$): 240, and Pressure(MPa): 30 were determined. The results of injection molding simulation according to the two design methods were compared with the sync mark which shows the problem of filling and injection molding.