• Journal of Genetic Medicine
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• v.4 no.1
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• pp.53-63
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• 2007

Purpose : Tandem mass spectrometry (MS/MS) is effective screening test for inherited metabolic diseases. In this study, we estimate potential costs and benefits of using tandem mass spectrometry (MS/MS) to screen new borns for inherited metabolic diseases (phenylketonuria, BH4 deficiency, citrullinemia, maple syrup urine disease, propionic aciduria, isovaleric aciduria, glutaric aciduria type 1, LCHAD deficiency) in Korea. Methods : From April 2001 to March 2004, 79,179 new borns were screened for amino acid disorders, organic acid disorders, and fatty acid oxidative disorders. Twenty-eight new borns were diagnosed with one of the metabolic disorder and the collective estimated prevalence amounted to 1 in 2,800 with a sensitivity of 97.67%, a specificity of 99.28%, a recall rate of 0.05%, and a positive preditive value of 6.38%. We calculated and compared the total costs in case when neonatal screening on pheny lketonuria, BH4 deficiency, citrullinemia, maple syrup urine disease, propionic aciduria, isovaleric aciduria, glutaric aciduria type 1, LCHAD deficiency is implemented, and when not. Results : If the neonatal screening on pheny lketonuria, BH4 deficiency, citrullinemia, maple syrup urine disease, propionic aciduria, isovaleric aciduria, glutaric aciduria type 1, LCHAD deficiency is implemented, total benefits far exceed costs at a ratio of 1.40:1. Conclusion : Although, this study only concerns the monetary aspects of the neonatal screening, tandem mass spcetrometry for neonatal screening is cost-effective compared with not screening. The study appears to support the introduction of tandem mass spectrometry into a Korea neonatal screening programme for inherited metabolic diseases.

• Journal of the Korean Society of Radiology
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• v.15 no.2
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• pp.265-271
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• 2021

The pattern of the tree's internal swelling depends on many causes. Since it is difficult to detect these various causes of swelling with a general method, if the state of swelling for a long time cannot be confirmed, serious damage to the trees may occur due to enlargement of the swelling area. In the method of acquiring a tree tomography image, an impulse passing through the tree is generated by tapping the sensor with a rubber mallet, and the moving speed is recorded. In this paper, to measure cracks, cavities, and swelling due to physical damage, we developed a 3D viewer that can know the internal state of a tree using a tree cross-section image acquired from Arbotom to determine the degree of swelling inside the tree. Based on this, we tried to present data that can be referred to when surgical operation of trees is required. In order to acquire a tomographic image of a tree, 6 sensors were attached to the three Yangpala and Maple trees, and a 1 m-long tree was measured using the Arbotom program, and a 3D image was implemented through the 3D Viewer created using MATLAB. In addition to simply acquiring images, the cross-sectional length and volume of the tree were measured. In the actually produced 3D Viewer, the length of the part where the swelling of the maple tree occurred was 33.12 cm, and the swelling of the yangpala tree was measured as 21.41 cm. The volume of the maple tree was measured to be 78.832 ㎤. As a result of comparing the cross-sectional image of the Arbotom and the 3D image, the same result as the real aspect of the tree was obtained, so it can be judged that the reliability of the manufactured software is also secured, and data to be applied to the surgical tree operation through the created Viewer is provided. It is believed that the damage will be minimized.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.18 no.2
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• pp.43-49
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• 2018

Maple syrup urine disease (MSUD, OMIM#248600) is a rare and autosomal recessively-inherited metabolic disorder that is caused by mutations in the branched-chain ${\alpha}$-ketoacid dehydrogenase (BCKDH) genes. It prevents the normal breakdown of branched-chain amino acids (BCAAs), such as leucine, isoleucine, and valine, and leads to poor feeding, lethargy, abnormal movements, seizure, and death if untreated. Here, we report the case of a Korean newborn of biochemically- and genetically-confirmed MSUD manifesting lethargy and central apnea, the acute state of which was successfully treated. The molecular genetic investigation revealed two novel heterozygous mutations (p.Ala32Phefs*48 and p.Val 130Phe) in BCKDHB, and both parents were confirmed as carriers. We emphasize the importance of early diagnosis and prompt introduction of specific treatment for MSUD in life saving and prognosis.

• Culinary science and hospitality research
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• v.18 no.1
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• pp.15-26
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• 2012

The objective of this study is to optimize enzymatic hydrolysis of cooked krill by using Alcalase. To optimize krill hydrolysis on such dependent variables as TCA, DPPH-scavenging, and Fe-chelating activities by using Alcalase, independent variables of hydrolysis pH and temperature were investigated Their formulas and three dimensional graphs were obtained by using SAS and Maple softwares, respectively. For comparison of general composition of raw krill, its contents of moisture, crude protein, crude fat, and ash were 17.48%, 53.74%, 15.66%, and 10.21%, respectively, and for cooked krill, its contents were 4.80%, 71.84%, 5.26%, and 15.09%, respectively. The composition of fatty acids for cooked krill was similar to that of raw krill. The most abundant fatty acid was palmitic acid(16:0) and the following order was oleic acid(18:1), eicosapentaenoic acid (20:5), palmitoleic acid(16:1), and docosahexaenoic acid(22:6). For DH optimization of hydrolysates from cooked krill, its result was pH 8.5 and $66.6^{\circ}C$ hydrolysis temperature for the maximum DH of 29.4% For DPPH-antioxidative optimization of hydrolysates from raw krill, its maximum result of 27.1% was obtained in the hydrolysis condition of pH 7.4 and $67.5^{\circ}C$. For Fe-chelating optimization of hydrolysates from cooked krill, its maximum result of 24.9% was in the condition of pH 8.7 and $65.5^{\circ}C$. These results can be used for basic data for using krill products and other fish products as bioactive ingredients.

• Korean Journal of Remote Sensing
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• v.32 no.2
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• pp.155-169
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• 2016

In this study, we developed a multi-sensor blending short-term rainfall forecasting technique using radar and satellite data during extreme rainfall occurrences in Busan and Gyeongnam region in August 2014. The Tropical Z-R relationship ($Z=32R^{1.65}$) has applied as a optimal radar Z-R relation, which is confirmed that the accuracy is improved during 20mm/h heavy rainfall. In addition, the multi-sensor blending technique has applied using radar and COMS (Communication, Ocean and Meteorological Satellite) data for quantitative precipitation estimation. The very-short-term rainfall forecasting performance was improved in 60 mm/h or more of the strong heavy rainfall events by multi-sensor blending. AWS (Automatic Weather System) and MAPLE data were used for verification of rainfall prediction accuracy. The results have ensured about 50% or more in accuracy of heavy rainfall prediction for 1-hour before rainfall prediction, which are correlations of 10-minute lead time have 0.80 to 0.53, and root mean square errors have 3.99 mm/h to 6.43 mm/h. Through this study, utilizing of multi-sensor blending techniques using radar and satellite data are possible to provide that would be more reliable very-short-term rainfall forecasting data. Further we need ongoing case studies and prediction and estimation of quantitative precipitation by multi-sensor blending is required as well as improving the satellite rainfall estimation algorithm.

• Journal of Korean Society of Forest Science
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• v.90 no.3
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• pp.242-248
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• 2001

Changes in land-use can affect soil organic matter content and fertility. We compared total soil carbon and nitrogen concentrations, soil respiration, and nitrogen availability under three land-use types in central Korea; conversion of old rice field to natural willow-maple (Salix-Acer) forest, conversion of old field to artificial Korean pine (Pines koraiensis) forest, and indigenous oak (Quercus spp.) forest. After 20 years of fallow the area of rice field conversion to forest had higher soil carbon and nitrogen concentrations in the soil depth of 0-10cm and 10-20cm than the areas of field conversion to Korean pine forest and indigenous forest. In general, soil carbon and nitrogen concentrations decreased with soil depth. Organic matter accumulation as a balance of input and decomposition seemed to be higher in the soil of previous rice field, and carbon and nitrogen accumulation was largely confined to the topsoil. Soil respiration rates were greatest at the area of rice field conversion to forest, and appeared to be related to soil carbon and soil moisture. Soil nitrogen availability measured by the ion exchange resin bag method differed significantly among land-use types; soil inorganic nitrogen ($NH_4{^+}+NO_3{^-}$) and ammonium availability were highest in the soil under indigenous oak forest followed by conversion of old field to artificial Korean pine forest and conversion of old field to natural willow-maple forest.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.32 no.4
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• pp.73-84
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• 2014

This research has conducted historical data analysis and on-site investigation on Chungam Pavilion and Seokchun Valley in Bonghwa. Based on the results, the original planting form was identified, and the vegetation management were drawn up. The results of this study can be summarized as follows. First of all, The Book of Seokchun states that there used to be forest trees such as pine tree, saw-leaf zelkova and maple tree, and flowering trees such as peony, royal azalea, rose, chrysanthemum, and lotus, planted around Chungamjeong. Around Seokchunjeongsa, there used to be boxwood, bamboo, maple, peach, gooseberry and peony planted in the area. Through this discovery it can be realized that the vicinity of Chungam Pavilion and Seokchunjeongsa provided not only the grand aesthetics of four clear seasons, but also planting landscapes with various symbolistic significance and meanings. The description of the planting situation in the historical records offers a useful reference for future vegetation management in Chungam Pavilion, Seokchunjeongsa and surrounding valleys. Furthermore, it holds critical value in the identification of planting pattern in late Chosun dynasty. Second, the planting landscape in and around Chungam Pavilion and Seokchunjeongsa will have to be maintained as described in the historical records The Book of Seokchun. Also, the once famous colony of pine trees in the area is gradually reducing in its scale, which calls for active management measures such as elimination of broadleaf trees.

• Journal of Korea Game Society
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• v.11 no.6
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• pp.127-138
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• 2011

The creation and interchange of information through the Internet network forms online community and makes Social Network Game (SNG) as a new entertainment by grafting it onto the most popular online games. SNG means the service which amalgamates social network service (e.g., Facebook, Twitter, etc) strong points and the fun of online game. It promotes the intimacy of relation between the friends above social network service and the gaming amusement for users. The domestic SNG market is currently fast changing according to the smart environment which is quickly shifted. The existing online game field will continuously maintain a market size. SNOG will be more developed because it is competitive from the business perspective of managing cost and production cost when compares with the existing online game. In relation to Facebook, Twitter, etc. overseas SNS platform base SNOG service, the domestic competition for launching SNG is expected to heat up as NHN, Daum and SK Communication introduce open type SNS. This study examines the successful factors and strategy for domestic SNOG by studying the case of MapleStory Adventures successful possibility. The possible successful factors are combing SNS on the existing popular online game, marketing through the existing users, and solving the platform problem of a failure factor of NexonStar. This case study is expected to contribute to the domestic SNOG industry development by providing several implications for the successful factors and strategy of SNOG which will be continuously developed.

• Journal of Korea Water Resources Association
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• v.53 no.3
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• pp.225-236
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• 2020

It is not easy to provide sufficient lead time for flood forecast in urban and small mountain basins using on-ground rain gauges, because the time concentration in those basins is too short. In urban and small mountain basins with a short lag-time between precipitation and following flood events, it is more important to secure forecast lead times by predicting rainfall amounts. The Han River Flood Control Office (HRFCO) in South Korea produces short-term rainfall forecasts using the Mcgill Algorithm for Precipitation-nowcast by Lagrangian Extrapolation (MAPLE) algorithm that converts radar reflectance of rainfall events. The Flash Flood Research Center (FFRC) in the Korea Institute of Civil Engineering and Building Technology (KICT) installed a flash flood forecasting system using the short-term rainfall forecast data produced by the HRFCO and has provided flash flood information in a local lvel with 1-hour lead time since 2019. In this study, we addressed the flash flood forecasting system based on the radar rainfall and the assessed the accuracy of the forecasting system for the recorded flood events occurred in 2019. A total of 31 flood disaster cases were used to evaluate the accuracy and the forecast accuracy was 90.3% based on the probability of detection.

• Journal of the Korean Wood Science and Technology
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• v.30 no.2
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• pp.87-94
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• 2002

This study was carried out to evaluate bending property on principal domestic species such as sargent cherry(Prunus sargentii), bitter wood(Picrasma quassioides), horn beam(Carpinus laxiflora), cork oak(Quercus variabilis), birch(Betula schmidtii), painted maple(Acer mono), basswood(Tilia amurensis), red pine(Pinus densiflora), pitch pine(Pinus rigtda), royal pawlonia(Paulownia tomentosa) by microwave heating. In this study, radius of curvature(ROC) for bending process was classified by radius of curvature(ROC) of bending plate such as 4 cm, 6 cm, and 10 cm, and thickness of metal-strap(TMS) was 0.6 mm and 0.8 mm. Bending process was successfully operated for 100 percent in bitter wood, horn beam, birch and painted maple. On the other hand, there was a success rate of 58 percent in sargent cherry and 83 percent in cork oak and 29 percent in basswood and 8 percent in royal pawlonia which is the worst bending property. All specimens of basswood and royal pawlonia were broken at 4 cm of ROC. Success rate of bending property was shown 44 percent in red pine and 56 percent in pitch pine. TMS has an effect on only drying speed in drying process than difficulty and facility of bending property. It was considered that the thinner TMS in drying process is the faster in drying speed of bent wood.