• 대한방사선기술학회지:방사선기술과학
• /
• 제39권4호
• /
• pp.501-507
• /
• 2016

본 연구는 손, 머리, 허리측방향 등에 대한 X선 촬영조건(kVp, mAs)으로 SID 50cm, 1m, 2m에서 발생되는 1차 X선이 보호앞치마를 어느 정도 투과하는지를 알아보았고, 그 결과는 다음과 같다. 첫째, 손 X선 촬영조건의 1차X선은 0.3mmPb 보호앞치마로 차폐할 경우 선량을 약 270배 줄일 수 있으나 SID 50cm, 1m, 2m에서 보호앞치마를 각각 0.120, 0.043, 0.012mR 수준으로 투과한다. 둘째, 머리 X선 촬영조건의 1차X선은 0.3mmPb 보호앞치마로 차폐할 경우 선량을 약 22배 줄일 수 있으나 SID 50cm, 1m, 2m에서 보호앞치마를 각각 13.191, 4.821, 1.388mR 수준으로 투과한다. 셋째, 허리측방향 X선 촬영조건의 1차X선은 0.3mmPb 보호앞치마로 차폐할 경우 선량을 약 13배 줄일 수 있으나 SID 50cm, 1m, 2m에서 보호앞치마를 각각 77.844, 27.406, 8.606mR 수준으로 투과한다. 따라서 X선 검사 시 촬영실 내에 있는 관계자들은 1차X선이 도달하는 모든 공간에서 보호앞치마만을 착용한 채 머물러 있어서는 안 되며, 부득이하게 촬영실 안에 머물러 있어야 할 경우 보호앞치마 착용과 함께 두꺼운 납이 내장된 차폐칸막이 뒤에 안전하게 피해야 한다.

• 대한전자공학회:학술대회논문집
• /
• 대한전자공학회 1998년도 추계종합학술대회 논문집
• /
• pp.731-734
• /
• 1998

A scalable parallel algorithm is proposed for efficient image component labeling with local operatos on a mesh connected SIMD computer. In contrast to the conventional parallel labeling algorithms, where a single pixel is assigned to each PE, the algorithm presented here is scalable and can assign m$\times$m pixel set to each PE according to the input image size. The assigned pixel set is converted to a single pixel that has representative value, and the amount of the required memory and processing time can be highly reduced. For N$\times$N image, if m$\times$m pixel set is assigned to each PE of P$\times$P mesh, where P=N/m, the time complexity due to the communication of each PE and the computation complexity are reduced to O(PlogP) bit operations and O(P) bit operations, respectively, which is 1/m of each of the conventional method. This method also diminishes the amount of memory in each PE to O(P), and can decrease the number of PE to O(P2) =Θ(N2/m2) as compared to O(N2) of conventional method. Because the proposed parallel labeling algorithm is scalable, we can adapt to the increase of image size without the hardware change of the given mesh connected SIMD computer.

• Biomolecules & Therapeutics
• /
• 제30권3호
• /
• pp.257-264
• /
• 2022

Colorectal cancer (CRC) is one of the most common malignant tumor. 5-FU is commonly used for the treatment of CRC. However, the development of drug resistance in tumor chemotherapy can seriously reduce therapeutic efficacy of 5-FU. Recent data show that FoxM1 is associated with 5-FU resistance in CRC. FoxM1 plays a critical role in the carcinogenesis and drug resistance of several malignancies. It has been reported that urushiol V isolated from the cortex of Rhus verniciflua Stokes is cytotoxic to several types of cancer cells. However, the underlying molecular mechanisms for its antitumor activity and its potential to attenuate the chemotherapeutic resistance in CRC cells remain unknown. Here, we found that urushiol V could inhibit the cell proliferation and induced S-phase arrest of SW480 colon cancer cells. It inhibited protein expression level of FoxM1 through activation of AMPK. We also investigated the combined effect of urushiol V and 5-FU. The combination treatment reduced FoxM1 expression and consequently reduced cell growth and colony formation in 5-FU resistant colon cancer cells (SW480/5-FUR). Taken together, these result suggest that urushiol V from Rhus verniciflua Stokes can suppress cell proliferation by inhibiting FoxM1 and enhance the antitumor capacity of 5-FU. Therefore, urushiol V may be a potential bioactive compound for CRC therapy.

• 한방비만학회지
• /
• 제1권1호
• /
• pp.33-42
• /
• 2001

Objectives: This study was to investigate the reductive effects of oriental medicine on the body fat and abdominal obesity, Methods: The subject were selected among the patients who were treated with 4weeks total program, visited our obesity clinic from October 1999 to August 2000, We practiced combined therapy such as herbal medicine, acupuncture therapy, moxibution therapy, negative therapy, auricular acupuncture, electrolipolysis, colon hydrotherapy, heat therapy, Chuna therapy, low-calorie diet teaching, exercise teaching, and correcting life style for 4 weeks. Results and Conclusion: 1. Body weight, RBW, and BMI were significantly reduced each by 5.4kg, 10.4% and $2.2kg/m^2$ (p<0.01). 2. % Body fat was significantly reduced by 3.3%. Fat mass was reduced by 4.0kg(17.0%) and soft lean mass was reduced by 1.5kg(3.7%), thus it was acknowledged that fat mass was significantly reduced compared to soft lean mass by oriental medicine treatment for obesity. 3. WHR was significantly reduced by 0.02. Waist circumference was reduced by 6cm(6.6%) and hip circumference was reduced by 4.5cm(4.6%), thus it was acknowledged that waist fat was significantly reduced compared to hip circumference by oriental medicine treatment for obesity.

• Asian-Australasian Journal of Animal Sciences
• /
• 제28권3호
• /
• pp.405-410
• /
• 2015

The objective of this study was to evaluate the effects of sequential applications of ${\varepsilon}$-polylysine (EPL) or lauramide arginine ethyl ester (LAE) sprays followed by an acidic calcium sulfate (ACS) spray on inoculated chicken carcasses to reduce Salmonella (Salmonella enterica serovars including Salmonella typhimurium and Salmonella enteritidis) contamination during 6 days of storage ($4.4^{\circ}C$). Secondly, reductions of the resident microflora were studied on uninoculated chicken carcasses following the sequential application of the treatments, chilling and 10 days of storage at $4.4^{\circ}C$. The treatment of Salmonella inoculated carcasses with 300 mg/L EPL followed by 30% ACS (EPL300-ACS30) sprays reduced Salmonella counts initially by 1.5 log cfu/mL and then by 1.2 log cfu/mL (p<0.05) following 6 days of storage at $4.4^{\circ}C$. Likewise, 200 mg/L LAE followed by 30% ACS (LAE200-ACS30) treatment reduced initial Salmonella counts on poultry carcasses by 1.8, 1.4 and 1.8 log cfu/mL (p<0.05), respectively, after 0, 3, and 6 days storage. Immediately after the treatments, EPL300-ACS30 and LAE200-ACS30 both reduced Escherichia coli counts significantly by 2.6 and 2.9 log cfu/mL, respectively. EPL300-ACS30 and LAE200-ASC30 were effective in lowering psychrotroph counts by 1 log cfu/mL on day 10 when compared to the control and distilled water treatments. This study demonstrated that EPL300-ACS30 and LAE200-ACS30 were effective in reducing Salmonella on inoculated chicken carcasses both after treatment and during the storage at $4.4^{\circ}C$ for up to 6 days. In addition, reductions in psychrotroph counts indicated that these treatments might have the potential to increase the shelf-life of poultry carcasses.

• 한국농공학회지
• /
• 제45권5호
• /
• pp.160-170
• /
• 2003

A pilot study was performed to examine the feasibility of intermittent slow sand filtration for agricultural reuse of reclaimed water. The effluent of biofilter for 16-unit apartment was used as influent to the slow sand filtration system at 0.6 $m^3$/day loading rate using 15 seconds spray in every 10 minutes on the about 1 $m^2$ surface area and 0.5 m depth. The influent concentrations of total coliform (TC), fecal coliform (FC) and E. coli were in the range of 10.000 MPN/100 mL. and they were reduced to less than 1,000 MPN/100 mL after filtration with average of 320, 270, and 154 MPN/100 mL, respectively, showing over 95 % removal. Turbidity and SS were improved effectively and their average concentration was reduced to 0.8 NTU and 1.7 mg/L, respectively, and removal rate was about 50 %. Average BOD and COD concentrations were also reduced substantially to 2.6 and 25.8 mg/L with about 55 and 21 % removal rate, respectively. Nutrients removal was relatively low and removal rate for T-N and T-P was low however, remaining nutrients might be beneficial and less concerned in case of agricultural reuse. The concentration of biofilter effluent used in this experiment was in the range of secondary treatment effluent but slightly stronger than the one from existing wastewater treatment plants (WWTPs). Therefore, intermittent slow sand filtration might be also applicable to the effluent from WWTPs as long as its agricultural reuse is available. Considering stable performance and effective removal of bacterial indicators as well as other water quality parameters, low maintenance, and cost-effectiveness, the intermittent slow sand filtration was thought to be an effective and feasible alternative for agricultural reuse of reclaimed water. This paper is a preliminary result from pilot study and further investigations are recommended on the optimum design parameters before full scale application.

• Clinical and Experimental Pediatrics
• /
• 제55권7호
• /
• pp.238-248
• /
• 2012

Purpose: Hypoxic-ischemic encephalopathy is an important cause of neonatal mortality, as this brain injury disrupts normal mitochondrial respiratory activity. Carnitine plays an essential role in mitochondrial fatty acid transport and modulates excess acyl coenzyme A levels. In this study, we investigated whether treatment of primary cultures of rat cortical neurons with L-carnitine was able to prevent neurotoxicity resulting from oxygen-glucose deprivation (OGD). Methods: Cortical neurons were prepared from Sprague-Dawley rat embryos. L-Carnitine was applied to cultures just prior to OGD and subsequent reoxygenation. The numbers of cells that stained with acridine orange (AO) and propidium iodide (PI) were counted, and lactate dehydrogenase (LDH) activity and reactive oxygen species (ROS) levels were measured. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and the terminal uridine deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assay were performed to evaluate the effect of L-carnitine (1 ${\mu}M$, 10 ${\mu}M$, and 100 ${\mu}M$) on OGD-induced neurotoxicity. Results: Treatment of primary cultures of rat cortical neurons with L-carnitine significantly reduced cell necrosis and prevented apoptosis after OGD. L-Carnitine application significantly reduced the number of cells that died, as assessed by the PI/AO ratio, and also reduced ROS release in the OGD groups treated with 10 ${\mu}M$ and 100 ${\mu}M$ of L-carnitine compared with the untreated OGD group (P<0.05). The application of L-carnitine at 100 ${\mu}M$ significantly decreased cytotoxicity, LDH release, and inhibited apoptosis compared to the untreated OGD group (P<0.05). Conclusion: L-Carnitine has neuroprotective benefits against OGD in rat primary cortical neurons in vitro.

• 대한본초학회지
• /
• 제32권4호
• /
• pp.61-68
• /
• 2017

Objectives : Jema-sunghyangjungkisan (JSGS, Jima Xingxiang Zhengqi san) and yeoldahanso-tang (YDHST, Reduo hanshao decoction) are traditional herbal formulas which commonly used to prevent and treat stroke in traditional korean medicine. However, JSGS and YDHST extracts have not been previously reported to have anti-inflammatory effects. Therefore, We measured the anti-inflammatory effects of JSGS and YDHST extracts on lipopolysaccharide (LPS)-stimulated murine macrophage cell line, RAW 264.7 cells. Methods : To investigate the anti-inflammatory activities of JSGS and YDHST extracts, tumor necrosis factor-alpha ($TNF-{\alpha}$), interleukin (IL)-6, nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) were examined in RAW 264.7 cells with LPS of $1{\mu}g/m{\ell}$. Results : JSGS and YDHST extracts did not have any cytotoxicity in RAW 264.7 cells. $TNF-{\alpha}$ concentration decreased 49.67% at $500{\mu}g/m{\ell}$ by JSGS but, YDHST has no statistically significant effect at all concentration. IL-6 accumulation on JSGS and YDHST extracts in LPS-stimulated RAW 264.7 cells reduced 22.03% and 41.44% at $500{\mu}g/m{\ell}$ respectively. In addition, JSGS has no inhibitory effects on NO accumulation and YDHST reduced 10.08% at $500{\mu}g/m{\ell}$. Moreover, JSGS and YDHST treatment does-dependently reduced the $PGE_2$ production. In particular, YDHST ($500{\mu}g/m{\ell}$) extract was more effective compared with $10ng/m{\ell}$ of indomethacin which is the $PGE_2$ positive control. Conclusions : Our results suggest that treatment of JSGS and YDHST extracts decreased the LPS-stimulated inflammation. Therefore, in the present study, we demonstrated that JSGS and YDHS may be used as a potential anti-inflammatory therapeutic agent.

• 한국건축시공학회지
• /
• 제13권3호
• /
• pp.291-305
• /
• 2013

This paper presents the continuous hoop reinforcement method as a means to overcome the difficulty of rebar construction due to the seismic detail of lateral reinforcement. Because the continuous hoop has no seismic hook, and there is less interference during the rebar work, rebar quantities and construction time can be reduced. Since the details of column and beam continuous hoops are different from those of conventional lateral reinforcements, the construction method should be developed through mock-up tests. The length of the beam mock-up is 8m and the section size is $500mm{\times}700mm$, the height of the column mock-up is 2.8m and 4m, and the section size is $800{\times}800mm$. The length and the size are determined based on the elements that are generally used in reinforced concrete basement parking lots and office buildings. The results of the mock-up test showed that the quantities of rebar could be reduced by 20% and the time could be reduced by up to 40% compared with conventional lateral reinforcements.

• 상하수도학회지
• /
• 제8권1호
• /
• pp.44-52
• /
• 1994

The purpose of this experimental research was focused to improve the quality of the effluent and the yielded sludge when the papermill wastewater was treated by the indirect aerated submerged biofilter as a second treatment method of papermill wastewater. Changing the various experimental factors(Nutrient additions or not, HRT, F/M ratio, recirculation ratio, etc) with indirect aerated biofilter, the results obtained are as follows. 1. Because of the microbes concentration could be sustained to $9,000mg/l$ in submerged biofilter and then the volumetric organic loads could be increased to $2.7kg-BOD/m^3/day$(that of activated sludge is $0.8kg-BOD/m^3/day$), the reactor volume can be reduced to one third of the activated sludge treatment. 2. Because of the yield coefficient(Y) and the endogenous decay coefficient(kd) were revealed 0.4 and 0.07/d, the yielded sludge volume was reduced by for compared with that of the activated sludgg process. 3. The concentration of the sloughed sludge in the reactor was 2.62~4.01%, so the thickener could be omitted in the papermill wastewater sludge treatment process. 4. When the operating was conducted at HRT of 4hrs, the treatment efficiencies of BOD and COD were obtained 80% and 70%, Therefore operating time can be reduced to one half of the activated sludge treatment.