• 한국식품저장유통학회지
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• 제20권5호
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• pp.602-607
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• 2013

포장 콩나물의 유통 중 품질향상을 위한 기초연구를 실시하고자 포장 필름의 종류 및 산소투과도에 따른 저장 중 포장 콩나물의 품질 변화를 조사하였다. 시판 중인 비포장 벌크 콩나물(제조일로부터 1일) 각 $320{\pm}20g$을 산소투과율 $3,000cc/m^2{\cdot}day{\cdot}atm$ 범위의 다양한 포장 필름으로 밀봉포장하고 $5^{\circ}C$에서 7일간 저장하면서 품질변화를 측정하였다. 품질유지에 적합한 산소투과도 선정을 위한 예비 실험 결과 산소유지율이 높은 $10,000cc/m^2{\cdot}day{\cdot}atm$의 산소투과도를 가지는 OPP 필름(대조구)과 $15,000cc/m^2{\cdot}day{\cdot}atm$의 산소투과도를 가지는 OPP (OP15) 및 CPP (CP15) 필름을 선정하였고, 이들 필름으로 포장한 콩나물의 저장 중 중량감소율, pH, 산소, 이산화탄소 및 관능적 품질변화를 조사하였다. 저장 중 중량감소율은 모든 구에서 10% 미만으로 OP15의 중량감소율이 가장 작게 나타났다. 저장 중 pH는 저장일의 증가에 따라 증가하고 있으며 유의적인 차이는 없으나 CP15에서 더 크게 나타났다. 저장에 따른 포장 내부의 산소함량은 감소하고 이산화탄소의 함량은 증가하고 있는데, 산소투과율이 높을수록 저장 중 높은 산소유지율을 나타내었다. 이산화탄소의 축적률은 저장 7일경 대조구와 OP15, CP15 각각에서 15.6%, 15.4% 및 14.3%로 대조구에서 가장 높은 수준의 축적률을 나타내었다. 저장 중의 관능품질은 저장 7일경 상업적 품질이 상실되어 OP15의 경우 강한 이취가 CP15에서 강한 녹변이 발생하였다.

• 한국컴퓨터정보학회논문지
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• 제18권1호
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• pp.167-175
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• 2013

본 연구는 G광역시 지역주민들을 대상(n=299)으로 운영되는 건강가정지원센터의 가족지원관련 5개 프로그램(가족상담프로그램, 가족교육지원사업, 가족친화문화지원사업, 돌봄지원사업, 다양한가족지원사업)이 가족가치관, 가족간 의사소통, 가족관계성 수준을 반영한 차별화된 프로그램 개발과 활성화가 필요하다는 인식에서 출발하였다. 이러한 연구목적을 달성하기 위해 첫째, 지역주민의 가족가치관, 가족간 의사소통, 가족관계성 수준은 어떠한가? 둘째, 지역주민의 가족가치관, 가족간 의사소통, 가족관계성에 따라 가족지원사업 프로그램 요구도에 차이가 있는가?라는 연구문제를 설정하였다. 연구결과 첫째, 지역주민의 가족가치관(M=3.55, S.D.=.664), 가족간 의사소통(M=3.65, S.D.=.669), 가족관계성(M=3.69 S.D=.584) 정도는 모두 평균이상(5점만점)으로 분석되었다. 둘째, 가족의 가치관, 의사소통, 가족관계성 수준이 평균미만집단이 평균이상집단과 비교하여 가족상담프로그램을 제외하고 가족교육지원사업, 가족친화문화지원사업, 돌봄지원사업, 다양한가족지원사업 등에서 필요도가 유의미하게 높게 나타났다. 따라서 건강가정지원센터의 프로그램 참여도를 높이고 활성화시킬 수 있는 방안은 각 프로그램별도 가족의 가치관, 의사소통, 가족관계성 수준을 사전에 파악하여 집단별 프로그램 목표도를 차별화하거나, 프로그램 참여 우선순위를 결정할 때 프로그램 필요도 욕구가 높은 평균미만집단에게 우선권을 주는 방안도 고려해야 할 것이다.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.4112-4112
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• 2001

The feasibility of NIR spectroscopy as a quick and nondestructive method for quality control of uniformity of coating thickness of pharmaceutical tablets was investigated. Near infrared spectra of a set of pharmaceutical tablets with varying coating thickness were measured with a diffuse reflectance fiber optic probe connected to a Broker IFS 28/N FT-NIR spectrometer. The challenging issues encountered in this study included: 1. The similarity of the formulation of the core and coating materials, 2. The lack of sufficient calibration samples and 3. The non-linear relationship between the NIR spectral intensity and coating: thickness. A peak at 7184 $cm^{-1}$ was identified that differed for the coating material and the core material when M spectra were collected at 2 $cm^{-1}$ resolution (0.4 nm at 7184 $cm^{-1}$). The study showed that the coating thickness can be analyzed by polynomial fitting of the peak area of the selected peak, while least squares calibration of the same data failed due to the lack of availability of sufficient calibration samples. Samples of coal powder and solid pieces of coal were analyzed by FT-NIR diffuse reflectance spectroscopy with the goal of predicting their ash content, percentage of volatile components, and energy content. The measurements were performed on a Broker Vector 22N spectrometer with a fiber optic probe. A partial least squares model was constructed for each of the parameters of interest for solid and powdered sample forms separately. Calibration models varied in size from 4 to 10 PLS ranks. Correlation coefficients for these models ranged from 86.6 to 95.0%, with root-mean-square errors of cross validation comparable to the corresponding reference measurement methods. The use of FT-NIR diffuse reflectance measurement techniques was found to be a significant improvement over existing measurement methodologies in terms of speed and ease of use, while maintaining the desired accuracy for all parameters and sample forms.(Figure Omitted).

• Toxicological Research
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• 제34권2호
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• pp.111-125
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• 2018

Solvents can be used in the manufacture of medicinal products provided their residual levels in the final product comply with the acceptable limits based on safety data. At worldwide level, these limits are set by the "Guideline Q3C (R6) on impurities: guideline for residual solvents" issued by the ICH. Diisopropyl ether (DIPE) is a widely used solvent but the possibility of using it in the pharmaceutical manufacture is uncertain because the ICH Q3C guideline includes it in the group of solvents for which "no adequate toxicological data on which to base a Permitted Daily Exposure (PDE) was found". We performed a risk assessment of DIPE based on available toxicological data, after carefully assessing their reliability using the Klimisch score approach. We found sufficiently reliable studies investigating subchronic, developmental, neurological toxicity and carcinogenicity in rats and genotoxicity in vitro. Recent studies also investigated a wide array of toxic effects of gasoline/DIPE mixtures as compared to gasoline alone, thus allowing identifying the effects of DIPE itself. These data allowed a comprehensive toxicological evaluation of DIPE. The main target organs of DIPE toxicity were liver and kidney. DIPE was not teratogen and had no genotoxic effects, either in vitro or in vivo. However, it appeared to increase the number of malignant tumors in rats. Therefore, DIPE could be considered as a non-genotoxic animal carcinogen and a PDE of 0.98 mg/day was calculated based on the lowest No Observed Effect Level (NOEL) value of $356mg/m^3$ (corresponding to 49 mg/kg/day) for maternal toxicity in developmental rat toxicity study. In a worst-case scenario, using an exceedingly high daily dose of 10 g/day, allowed DIPE concentration in pharmaceutical substances would be 98 ppm, which is in the range of concentration limits for ICH Q3C guideline class 2 solvents. This result might be considered for regulatory decisions.

• Asian-Australasian Journal of Animal Sciences
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• 제28권7호
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• pp.936-942
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• 2015

The purpose of this study was to characterize genetic architecture of behavior patterns in Sapsaree dogs. The breed population (n=8,256) has been constructed since 1990 over 12 generations and managed at the Sapsaree Breeding Research Institute, Gyeongsan, Korea. Seven behavioral traits were investigated for 882 individuals. The traits were classified as a quantitative or a categorical group, and heritabilities ($h^2$) and variance components were estimated under the Animal model using ASREML 2.0 software program. In general, the $h^2$ estimates of the traits ranged between 0.00 and 0.16. Strong genetic ($r_G$) and phenotypic ($r_P$) correlations were observed between nerve stability, affability and adaptability, i.e. 0.9 to 0.94 and 0.46 to 0.68, respectively. To detect significant single nucleotide polymorphism (SNP) for the behavioral traits, a total of 134 and 60 samples were genotyped using the Illumina 22K CanineSNP20 and 170K CanineHD bead chips, respectively. Two datasets comprising 60 (Sap60) and 183 (Sap183) samples were analyzed, respectively, of which the latter was based on the SNPs that were embedded on both the 22K and 170K chips. To perform genome-wide association analysis, each SNP was considered with the residuals of each phenotype that were adjusted for sex and year of birth as fixed effects. A least squares based single marker regression analysis was followed by a stepwise regression procedure for the significant SNPs (p<0.01), to determine a best set of SNPs for each trait. A total of 41 SNPs were detected with the Sap183 samples for the behavior traits. The significant SNPs need to be verified using other samples, so as to be utilized to improve behavior traits via marker-assisted selection in the Sapsaree population.

• Asian Pacific Journal of Cancer Prevention
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• 제14권12호
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• pp.7221-7227
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• 2013

Background: Fascin, an actin-bundling protein forming actin bundles including filopodia and stress fibers, is overexpressed in multiple human epithelial cancers including esophageal squamous cell carcinoma (ESCC). Previously we conducted a microarray experiment to analyze fascin knockdown by RNAi in ESCC. Method: In this study, the differentially expressed genes from mRNA expression profilomg of fascin knockdown were analyzed by multiple bioinformatics methods for a comprehensive understanding of the role of fascin. Results: Gene Ontology enrichment found terms associated with cytoskeleton organization, including cell adhesion, actin filament binding and actin cytoskeleton, which might be related to fascin function. Except GO categories, the differentially expressed genes were annotated by 45 functional categories from the Functional Annotation Chart of DAVID. Subpathway analysis showed thirty-nine pathways were disturbed by the differentially expressed genes, providing more detailed information than traditional pathway enrichment analysis. Two subpathways derivated from regulation of the actin cytoskeleton were shown. Promoter analysis results indicated distinguishing sequence patterns and transcription factors in response to the co-expression of downregulated or upregulated differentially expressed genes. MNB1A, c-ETS, GATA2 and Prrx2 potentially regulate the transcription of the downregulated gene set, while Arnt-Ahr, ZNF42, Ubx and TCF11-MafG might co-regulate the upregulated genes. Conclusions: This multiple bioinformatic analysis helps provide a comprehensive understanding of the roles of fascin after its knockdown in ESCC.

• 한국대기환경학회지
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• 제33권6호
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• pp.593-604
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• 2017

The suspended particulate matter(PM) was measured in subway tunnel of Seoul Line 1 to 9 in order to evaluate the pollution degree and characteristics of the PM in the subway tunnel. Also, to analyze the effect of outdoor aerosol concentration on the PM concentration of subway tunnels, the ambient PM concentration around the subway station was extracted by spatial analysis using $PM_{10}$ data of Seoul air pollution monitoring network. Finally, in order to understand pollution pattern in the Seoul subway tunnels, cluster analysis was performed based on input data set such as PM levels in tunnel, tunnel depth, length, curvature radius, outdoor ambient air pollution levels and so on. The average concentration of $PM_{10}$, $PM_{2.5}$, and $PM_1$ on subway tunnels were $98.0{\pm}37.4$, $78.4{\pm}28.7$, and $56.9{\pm}19.2{\mu}g/m^3$, respectively. As a result of the cluster analysis, tunnels from Seoul subway Line-1 to Line-9 were classified into five classes, and the concentrations and physical properties of the tunnels were compared. This study can provide a method to reduce PM concentration in tunnel for each pollution pattern and provide basic information about air quality control in Seoul subway tunnel.

• 한국멀티미디어학회논문지
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• 제15권11호
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• pp.1330-1340
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• 2012

본 논문에서는 심음신호를 이용해 강한 심 잡음이 나타나는 심장판막협착 영역을 검출하는 새로운 알고리듬을 제안하였다. 심음의 주성분을 찾거나 심 잡음을 제거하기 위한 지금까지의 많은 연구들은 대동맥판막협착증이나 승모판막협착증과 같이 강한 심 잡음이 나타나는 비정상 심음의 경우, 강한 심 잡음으로 인해 좋은 결과를 보이지 못하였다. 본 논문에서는 구간 잡음강도함수를 이용한 잡음 검출 알고리듬을 제안하였다. 제안한 구간 잡음 강도 함수는 심음 신호에서 제 1심음과 제 2심음을 검출하여, 이를 이용한 심음 구간을 설정한 후 구간 자기상관변화량을 이용하여 도출할 수 있다. 제안한 구간 잡음강도함수를 이용하여 심 잡음의 강도를 판단하고 심 잡음 유무를 검출하였다. 제안한 알고리듬으로 실험한 결과, 심장판막협착 영역 검출에서 기존의 연구보다 뛰어난 성능을 가지는 것을 확인하였다.

• 대한한의학방제학회지
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• 제20권2호
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• pp.37-46
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• 2012

Objectives : Oyaksungi-san(Wuyaoshunqisan) has been used for treatment of stroke and rheumatoid arthritis in Korea. In this study, a simple and accurate high-performance liquid chromatography(HPLC) method was established for simultaneous determination of six main components, liquiritin, ferulic acid, naringin, hesperidin, neohesperidin, and glycyrrhizin in Oyaksungi-san, a traditional Korean herbal prescription. Methods : The analytical column for separation of six constituents was used a Gemini $C_{18}$ column maintained at $40^{\circ}C$. The mobile phase consisted of two solvent systems, 1.0% (v/v) acetic acid in $H_2O$ (A) and 1.0% (v/v) acetic acid in acetonitrile (B) by gradient flow. The flow rate was 1.0 mL/min and the detector was a photodiode array (PDA) set at 254 nm for glycyrrhizin, 280 nm for liquiritin, naringin, hesperidin, and neohesperidin, and 320 nm for ferulic acid. Results : Calibration curves were acquired with $r^2$ values ${\geq}0.9998$. The results of recovery test were 91.58%-105.90% with a relative standard deviations (RSDs, %) value less than 2.0%. The values of RSD for intra- and inter-day precision were 0.03%-1.72% and 0.03%-1.63%, respectively. The contents of the six compounds in Oyaksungi-san were 0.33-9.30 mg/g. Conclusions : The newly established HPLC method will be helpful to improve quality control of Oyaksungi-san.

• Asian Journal of Atmospheric Environment
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• 제11권1호
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• pp.33-36
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• 2017

China is suffering from severe air pollution especially fine $PM_{2.5}$ pollution. In 2015, the annual average $PM_{2.5}$ concentration of the 338 municipal cities was $50{\mu}g/m^3$, 78% cities at or above the prefectural level failed to comply with the $PM_{2.5}$ concentration standards. The $13^{th}$ Five-Year Plan for National Economic and Social Development set the goal that the annual average concentration of $PM_{2.5}$ in the municipal cities which failed to attain the ambient air quality standards shall be decreased by 18% by 2020 (CCCPC, 2016). In this study, an air pollution control scenario during the $13^{th}$ Five-Year Plan period was proposed and the $SO_2$, $NO_x$ and PM emission reductions in response to different measures in 31 provincial-level regions mainland China by 2020 were estimated. The air quality in the target year (2020) was simulated using the WRF-CMAQ model. The results showed that by 2020, the emissions of $SO_2$, $NO_x$ and primary PM in mainland China will be reduced by 4.19 million tons, 3.94 million tons and 4.41 million tons, a drop of 23%, 21% and 25% respectively compared with that in 2015, and the annual average concentration of $PM_{2.5}$ will decrease by 19%. Coal-fired power plant contributes the most pollutant emission reduction.