• 디지털융복합연구
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• 제13권9호
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• pp.333-339
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• 2015

본 연구의 목적은 호흡기 장애가 있는 제한성 폐질환 노인의 체간에 관절가동술과 스트레칭이 호흡기능, 자세, 신체피로감의 개선효과를 확인하는데 있다. 연구대상자는 총 10명으로 2014년 1월부터 동년 11월까지 8주간 비동시적으로 진행되었고, 주 3회, 1일 30분간 체간에 관절가동술과 스트레칭을 실시하였다. 연구 결과 FVC, FEV1, 체간자세, 체간움직임, 신체피로감이 유의하게 개선되었다(p<.05). 본 연구를 통해 관절가동술과 스트레칭이 호흡기장애 노인의 호흡기능, 체간자세, 체간움직임, 신체피로감을 동시에 개선시킬 수 있는 호흡정형물리치료가 될 수 있음을 확인하였다. 이후 연구들에서는 제한성 폐질환 노인을 대상으로 본 연구에서 적용한 호흡정형물리치료와 운동 분야들과의 치료적 융복합을 통한 지속적인 연구가 필요하겠다.

• 대한통합의학회지
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• 제4권2호
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• pp.23-28
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• 2016

Purpose : The purpose of this study was to investigate the effects of transverse abdominal muscle contraction on pulmonary function in supine position. Methods : 10 female and 10 male college students were recruited this study. Pulmonary Function test was measured with QUARK SPIRO. To check the changes in lung function with transverse abdominal muscle contraction, we tested pulmonary function in the supine, with and without transverse abdominal muscle contraction. While the transverse abdominis was activating, we investigate in the change of forced expiration. All statistical analyses were performed using SPSS Statistics VER.12.0 for window version p-values less than 0.05 were used to identify significant differences. Statistical analysis was used Paired t-test to know difference between activated and non-activated TrA of forced expiration. Results : The subject with transverse abdominal muscle contraction showed significant increments in variable of FVC, FEV1, PEF compared to the pre-intervention results (p<0.01). Conclusion : These results indicate that spontaneous contraction of the TrA helps pulmonary function. And the selective contraction of the transverse abdominis at the end of forced inspiration makes increases in the lung capacity.

• Journal of Trauma and Injury
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• 제24권2호
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• pp.155-158
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• 2011

Mechanical ventilation is usually the treatment of choice for severe respiratory failure associated with trauma. However, in case of severe hypoxia, mechanical ventilation may not be sufficient for gas exchange in lungs. Patients with Acute Respiratory Distress Syndrome (ARDS) undergo difficulties in oxygen and carbon dioxide exchange. Extracorporeal Membrane Oxygenation (ECMO) is the ideal therapeutic option for those patients with severe traumatic injuries. ECMO allows lungs to reserve their functions and decreases further lung injuries while increasing survival rate at the same time. We report two cases of patients with traumatic ARDS and Multiple Organ Failure including compromised heart function. The preservation of lung function was successful using ECMO therapy.

• Tuberculosis and Respiratory Diseases
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• 제79권3호
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• pp.121-126
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• 2016

Lung function reportedly declines with age and that this decline is accelerated during disease progression. However, a recent study showed that the decline might peak in the mild and moderate stage. The prognosis of chronic obstructive pulmonary disease (COPD) can be improved if the disease is diagnosed in its early stages, prior to the peak of decline in lung function. This article reviews recent studies on early COPD and the possibility of applying the U.S. Preventive Services Task Force recommendation 2008 and 2015 for early detection of COPD in Korea.

• 한국대기환경학회지
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• 제1권1호
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• pp.17-23
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• 1985

In order to study the effect of air pollution on the ventilatory function of lung, pulmonary function studies were carried out in middle school students (male) living isn Sasang industrial area more than 10 years, and were compared with those of control group. The following results were obtained; 1. Lung capacities were normal in observed & control group, and were not significantly different between two groups. 2. The respective parameters of ventilatory function test of observed group were smaller than that of control group, but FVC, $FEV_1$, $FEV_1/FVC$, FEF 25-75%, Vmax 50, MVV of two groups were normal. 3. PEFR, Vmax 25, Vmax 75 of observed group were significantly decreased, and there were statistically significant differences between two groups in FEF 25-75% (p < 0.01), Vmax 25 (p < 0.05), Vmax 50 (p < 0.01), Vmax 75 (p < 0.05), PEFR (p < 0.05) and MVV (p < 0.02).

• 보험의학회지
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• 제33권2호
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• pp.8-11
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• 2014

Pulmonary function test is a group of tests which are composed of measurement for lung function. Thy are spirometry, blood-gas analysis, lung volumes, exercise test, diffusion capacity, and bronchial challenge test. In this article, I will review the pulmonary function test and it's application in terms of clinical aspect and insurance medicine. The standard spirometric indicies are forced vital capacity(FVC), forced expiratory volume at 1 second(FEV1), and the ratio of FEV1 over FVC(FEV1/FVC). If the value of FEV1/FVC less than 70%, the examinee has obstructive ventilatory dysfunction.

• BMB Reports
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• 제49권8호
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• pp.414-423
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• 2016

MG53 is a member of the TRIM-family protein that acts as a key component of the cell membrane repair machinery. MG53 is also an E3-ligase that ubiquinates insulin receptor substrate-1 and controls insulin signaling in skeletal muscle cells. Since its discovery in 2009, research efforts have been devoted to translate this basic discovery into clinical applications in human degenerative and metabolic diseases. This review article highlights the dual function of MG53 in cell membrane repair and insulin signaling, the mechanism that underlies the control of MG53 function, and the therapeutic value of targeting MG53 function in regenerative medicine.

• Tuberculosis and Respiratory Diseases
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• 제72권2호
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• pp.163-168
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• 2012

Background: Cigarette smoke induced release of iron could alter iron metabolism in the lungs of chronic smokers and contribute to the increase in the total oxidative burden on the lungs of smokers. In previous studies, ferritin levels of bronchoalveolar lavage fluid in smokers were elevated. The aim of the present study was to investigate the relationship between serum ferritin concentration, smoking and lung function in Korean people. Methods: This study was based on the data acquired in the second year (2008) of the Forth National Health and Nutrition Examination Survey that was conducted from 2007 to 2009. The analysis included 2,244 subjects who were older than 20 years and had complete data from both lung function test and serum ferritin concentration. Among participants, 1,076 were male and 1,168 were female. Results: Mean serum ferritin concentrations in males were $120.3{\pm}80.1{\mu}g/L$ and $47.9{\pm}39.8{\mu}g/L$ in females. There were no differences in serum ferritin concentrations between non-smokers and smokers after adjusting for age, body mass index, and amounts of alcohol. Serum ferritin concentrations were associated with smoking amounts by simple linear regression but not associated with smoking amounts after adjustment with age, body mass index, and amounts of alcohol in both males and females. Lung function was not associated with serum ferritin concentrations. Conclusion: Our data suggested that serum ferritin concentrations are not related with smoking and lung function.

• Asian Pacific Journal of Cancer Prevention
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• 제15권15호
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• pp.6009-6014
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• 2014

Aims: To investigate changes in cellular immune function of patients with lung cancer before and after cytokine-induced killer (CIK) cell therapy and to identify variation effects on overall survival (OS) and progression-free survival (PFS). Materials and Methods:A total of 943 lung cancer patients with immune dysfunction were recruited from January 2002 to January 2010, 532 being allocated to conventional therapy and 411 to CIK therapy after a standard treatment according to the NCCN Clinical Practice Guidelines. All the patients were investigated for cellular immune function before and after therapy every three months. and clinical prognostic outcomes were analyzed. Results: After six courses of treatment, immune function was much improved in patients receiving CIK cells therapy as compared to controls. The percentages of recurrence and/or metastases for patients undergoing CIK cell therapy was 56.2% and 49.1% respectively but 78.6% and 70.3% among controls (p<0.001). The median OS times for CIK cell therapy and control groups were 48 and 36 months respectively. The OS rates at 12, 36, 60, 84 months in CIK treated patients were 97.8%, 66.9%, 27.7%, and 4.1% while they were 92.3%, 44.5%, 9.2%, and 1.5% in controls. OS and PFS were significantly different by log rank test between the two groups and across the three immune improvement classes. Conclusions: The immune function of lung cancer patients was improved by CIK cell therapy, associated with an increase in the OS rate and extension of the time to recurrence and/or metastasis.

• 종양간호연구
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• 제9권2호
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• pp.77-85
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• 2009

Purpose: The purpose of this study was to identify symptom cluster experienced by patients with advanced non-small cell lung cancer (NSCLC) on gefitinib treatment. In addition, this study assessed the patterns in severity of the symptom cluster and differences in quality of life (QOL) and function among subgroups by the severity of symptom cluster. Methods: This study was conducted as a secondary analysis of symptoms of 72 patients from a mother study. Factor analysis was used to identify symptom clusters measured with EORTC QLQ-C30 and LC13 symptom related items. Results: Three symptom clusters were identified: cluster 1 was comprised of fatigue, anorexia and dysphagia; cluster 2 of dyspnea, cough and insomnia; and cluster 3 of pain, constipation and nausea/vomiting. These three symptom clusters were improved one week after gefitinib administration. The group with more severe symptom clusters showed significantly lower QOL and function than the group with less severe symptom clusters. Conclusion: Since symptom clusters experienced by the patients with advanced NSCLC influenced on the QOL and function, it is important for nurses to understand and observe their symptom clusters. In addition, there is an necessity to develop nursing interventions to effectively care patients with the symptom clusters.