• Tuberculosis and Respiratory Diseases
• /
• 제77권4호
• /
• pp.167-171
• /
• 2014

Background: In Korea, patients with destroyed lung due to tuberculosis (TB) account for a significant portion of those affected by chronic pulmonary function impairment. The objective of our research was to evaluate the efficacy of inhaled tiotropium bromide in TB destroyed lung. Methods: We compared the effectiveness of inhaled tiotropium bromide for 2 months between pre- and post-treatment pulmonary function tests performed on 29 patients with destroyed lung due to TB. Results: The mean age of the total number of patients was $63{\pm}9$ years, where 15 patients were male. The pre-treatment mean forced expiratory volume in 1 second ($FEV_1$) was $1.02{\pm}0.31L$ ($44.1{\pm}16.0%$ predicted). The pre-treatment mean forced vital capacity (FVC) was $1.70{\pm}0.54L$ ($52.2{\pm}15.8%$ predicted). Overall, the change in $FEV_1%$ predicted over baseline with tiotropium was $19.5{\pm}19.1%$ (p<0.001). Twenty patients (72%) got better than a 10% increase in $FEV_1$ over baseline with tiotropium, but one patient showed more than a 10% decrease in $FEV_1$. Overall, the change in FVC% predicted over baseline with tiotropium was $18.5{\pm}19.9%$ (p<0.001). Seventeen patients (59%) experienced greater than a 10% increase in FVC over baseline with tiotropium; 12 (41%) patients had stable lung function. Conclusion: The inhaled tiotropium bromide therapy may lead to improve lung functions in patients with TB destroyed lung. However, the long-term effectiveness of this treatment still needs to be further assessed.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권3호
• /
• pp.761-766
• /
• 2012

Objective: Although various human cancer stem cells (CSCs) have been defined, their applications are restricted to immunocompromised models. Developing a novel CSC model which could be used in immunocompetent or transgenic mice is essential for further understanding of the biomolecular characteristics of tumor stem cells. Therefore, in this study, we analyzed murine lung cancer cells for the presence of CSCs. Methods: Side population (SP) cells were isolated by fluorescence activated cell sorting, followed by serum-free medium (SFM) culture, using Lewis lung carcinoma cell (LLC) line. The self-renewal, differentiated progeny, chemosensitivity, and tumorigenic properties in SP and non-SP cells were investigated through in vitro culture and in vivo serial transplantation. Differential expression profiles of stem cell markers were examined by RT-PCR. Results: The SP cell fraction comprised 1.1% of the total LLC population. SP cells were available to grow in SFM, and had significantly enhanced capacity for cell proliferation and colony formation. They were also more resistant to cisplatin in comparison to non-SP cells, and displayed increased tumorigenic ability. Moreover, SP cells showed higher mRNA expression of Oct-4, ABCG2, and CD44. Conclusion: We identified SP cells from a murine lung carcinoma, which possess well-known characteristics of CSCs. Our study established a useful model that should allow investigation of the biological features and pharmacosensitivity of lung CSCs, both in vitro and in syngeneic immunocompetent or transgenic/knockout mice.

• Journal of Chest Surgery
• /
• 제24권4호
• /
• pp.338-344
• /
• 1991

If the postoperative pulmonary function can be predicted in the patients undergoing pneumonectomy for lung cancer preoperatively, it will be helpful for identifying them as high or low risk candidates. Perfusion lung scan and spirometry were performed in 12 patients with lung cancer pre-operatively and the predicted postoperative Vital Capacity, FVC, FEV1.0, FEF25 - 75% and MVV were estimated by multiplying the preoperative values by the percentage of perfusion of the nonsurgical lung. Three months postoperation the patients were reinvestigated with spirometry and the obtained values were compared with the predicted values. The linear regression lines derived from the correlation between predicted values [X] and observed values [Y] were as follows; VC; R=0.532, Y=0.48X+1.28, P=0.075 FVC; R=0.566, Y=O 54X+1.15, P=0.055 FEV1.0; R=0.832, Y=0.68X+0.70, P=0.001 FEF25 ~ 75%; R=0.781, Y=0.68X+0.54, P=0.003 MVV; R=0.718, Y=0.67X+34.75, P=0.009 The prediction of postoperative FEV1.0, FEF25 ~ 75% and MVV in lung cancer patients undergoing pneumonectomy appear to be valid for evaluating preoperative pulmonary function.

• Tuberculosis and Respiratory Diseases
• /
• 제71권5호
• /
• pp.341-348
• /
• 2011

Background: The aim of this study was to investigate annual changes in pulmonary function in workers who were exposed to inorganic dust. Methods: The subjects were 2,922 male patients who had been diagnosed with pneumoconiosis more than twice during 6 years from 2005 to 2010. Results: Of the 2,922 cases, forced vital capacity (FVC) decreased by 54 mL in 1 year. In contrast, the annual change of forced expiratory volume in one second ($FEV_1$) decreased by 56 mL. Conclusion: This is the first study that has investigated the annual change in pulmonary function in workers exposed to inorganic dust. The results will help estimate the pulmonary condition of patients who are unable to perform a pulmonary function test due to age or a disorder.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권14호
• /
• pp.5613-5618
• /
• 2015

Clinicians should looking for techniques that helps to early diagnosis of cancer, because early cancer detection is critical to increase survival and cost effectiveness of treatment, and as a result decrease mortality rate. Medical images are the most important tools to provide assistance. However, medical images have some limitations for optimal detection of some neoplasias, originating either from the imaging techniques themselves, or from human visual or intellectual capacity. Image processing techniques are allowing earlier detection of abnormalities and treatment monitoring. Because the time is a very important factor in cancer treatment, especially in cancers such as the lung and breast, imaging techniques are used to accelerate diagnosis more than with other cancers. In this paper, we outline experience in use of image processing techniques for lung and breast cancer diagnosis. Looking at the experience gained will help specialists to choose the appropriate technique for optimization of diagnosis through medical imaging.

• 국제물리치료학회지
• /
• 제9권1호
• /
• pp.1393-1397
• /
• 2018

The purpose of this study was to examine the effects of combined respiratory physical therapy on respiratory function, spinal curve and spinal mobility for community-dwelling elderlies with restrictive lung diseases. In total, 10 patients participated in an 8-week intervention program of thoracic cage mobilization and breathing exercise in combination. The results of the study are as follows: for respiratory function, the forced expiratory volume in 1 second (FEV1), forced vital capacity(FVC), and FEV1/FVC were significantly improved to $.30{\pm}0.31{\ell}$, $.46{\pm}.42{\ell}$, and $18.10{\pm}11.39%$, respectively (p<.05). For spinal curve, the thoracic curve and the lumbar curve were improved significantly to $-2.20{\pm}1.40^{\circ}$ and $-1.20{\pm}1.14^{\circ}$, respectively (p<.01). For spinal mobility, the thoracic flexion ($3.40{\pm}2.99^{\circ}$), thoracic extension ($3.50{\pm}1.43^{\circ}$), lumbar flexion ($4.50{\pm}4.74^{\circ}$), and lumbar extension($-1.50{\pm}1.84^{\circ}$) were all significantly improved (p<.05). These findings indicate that thoracic cage mobilization and breathing exercise in combination improve the respiratory function, spinal alignment, and spinal mobility in elderly people with restrictive lung diseases.

• PNF and Movement
• /
• 제5권2호
• /
• pp.63-71
• /
• 2007

Objective : Respiratory muscle weakness and decreased chest mobility has been suggested to result from the deconditioning that accompanied activity level in chronic elderly stokes. The benefits of respiratory exercise programmes on exercise capacity and muscle strength in hemiplegia. This study aimed to determine the effects of selective inspiratory and expiratory muscles training and chest mobility exercise on patients with strokes to establish if an improved exercise capacity can be obtained in patients that are not limited in their daily activities. Methods & Intervention : Twelve patients were assigned to the intensive respiratory exercise group participated in a measures design that evaluated the subjects with pre-treatment and post-treatment. Thirteen subjects who were assigned to a control group received training with breathing exercise and resistance exercise of skeletal muscles. The subjects performed spirometry then undertook a 6-week programme of respiratory muscle and chest mobility training. Training for the two groups was carried out 2 times a week for 6 weeks. Measurements and Results : Spirometry(Forced Vital Capacity: FVC and Closed Circuit Spiromety: CCS) and thoracic mobility were measured before and after the 6 weeks. The experimental group improved significantly compared to control group in FVC, $FEV_1$, MVV, IRV and ERV, and upper chest wall expansion(p<0.05). No significant improvement was seen in thoracic mobility or lung function in control group(p>0.05). Conclusion : The major findings in this study were that a intensive 6week exercise programme of resistive breathing and chest mobility in patients with hemiplegia led to an increase in lung capacity. The resistive breathing exercise programme used here resulted in a significant increase in the chest excursion during breathing.

• 대한물리의학회지
• /
• 제18권3호
• /
• pp.31-37
• /
• 2023

PURPOSE: This study aimed to investigate the relationship between being underweight and respiratory function indicators such as pulmonary function, respiratory muscle strength, and diaphragm thickness in normal adults without lung disease. METHODS: The participants in this experiment were thirty young adults. To compare the respiratory function between the underweight and normal weight individuals, 15 participants were selected from each of the underweight and normal weight groups based on body mass index. Respiratory function tests were conducted through pulmonary function tests and respiratory muscle strength tests. Diaphragm thickness was measure with ultrasonography, and physical characteristics were obtained from grip strength and waist circumference. An independent t-test was used to compare the averages of the parameters measured in the two groups. RESULTS: In the respiratory function tests between the two groups, statistically significant differences (p < .05) emerged in the ratio of the predicted forced vital capacity (%FVC), the ratio of the predicted forced expiratory volume in one second (%FEV1), maximal expiratory pressure (MEP), and diaphragm thickness at the functional residual capacity (FRC). There was no statistically significant difference in the forced vital capacity, forced expiratory volume in one second, maximal inspiratory pressure, diaphragm thickness at the total lung capacity, and thickening ratio (p > .05). CONCLUSION: Decreases in some variables of respiratory function, such as the %FVC, %FEV1, MEP, and diaphragm thickness at the FRC were observed in underweight subjects. However, it is difficult to determine whether it affected the overall respiratory function. Future studies are needed to clearly identify the relationship between being underweight and respiratory function.

• Tuberculosis and Respiratory Diseases
• /
• 제49권1호
• /
• pp.30-36
• /
• 2000

연구배경 : 흉막박피술은 만성적인 농흉으로 인한 감염 병소의 제거와 감소된 폐기능의 향상을 도모할 목적으로 시행되어져 왔는데, 박피술 후 폐기능이 개선되지 않는 경우도 있어 어떤 군에서 박피술이 유용한 지에 대해 수술 전후의 폐기능 검사를 통해 이를 검토하였다. 방법 : 1990년부터 1996년까지 서울대 병원에서 결핵성 농흉으로 흉막 박피술을 시행받은 37명의 환자를 대상으로 수술 전후의 폐기능검사를 후향적으로 분석하였다. 결과 : 환자군의 남녀비는 29 : 8, 나이의 중앙값은 34세(15-68)였다. 농흉의 발생부터 수술까지의 기간은 1개월에서부터 30년까지 다양했으며, 수술 후 폐기능 검사는 평균 5.4$\pm$2.6 개월에 행해졌다. 1. 전체 환자에서 FVC는 수술 전 2.77$\pm$0.67(L)에서 2.95$\pm$0.81 (L)로 유의하게 증가했다(p=0.02). 2. 40세 이하의 환자 군에서 40세 이상의 환자 군보다 FVC가 유의하게 증가했다(p=0.01). 3. 진단후 4개월 이내 조기 흉막박피술을 시행받은 군에서 진단 4개월 이후 시행받은 군보다 더욱 큰 FVC의 증가를 보였다(p=0.007). 4. 수술 전 폐기능검사에서 FVC가 예상치의 60% 이하로 감소되어 있던 군이 예상치의 60% 이상이었던 군에 비해 수술 후 FVC 의 유의한 증가를 보였다 (p=0.047). 5. 수술 전 흉부 방사선학적 검사상 흉막에 석회화를 동반하지 않은 군이 석회화를 동반한 군에 비해 FVC의 증가가 유의했다(p=0.02). 결론 : 이상의 결과에서 흉막박피술은 전반적으로 환자의 폐기능의 증가를 가져왔으며, 특히 40세 이전의 젊은 환자, 농흉 발생 후 4개월 이내 흉막 박피술을 시행했을 경우, 수술 전 폐활량이 예상치의 60%이하로 감소되었던 경우와 흉막에 석회화를 동반하지 않았을 때가 도움이 되었다.

• 한국방사선학회논문지
• /
• 제17권5호
• /
• pp.767-773
• /
• 2023

본 연구에서는 폐용적에 영향을 미치는 관련 인자들과 폐기능 환기장애에 대한 유의성을 평가하고자 하였다. 실험대상으로는 저선량 흉부 CT검사와 폐활량검사를 동시에 수행한 정상 성인 남·여 206명을 선정하였으며 실험방법으로는 저선량 흉부 CT검사로 획득한 폐 CT 영상을 이용하여 폐용적을 딥러닝 기반의 AVIEW LCS 자동진단 프로그램을 이용하여 측정하였다. 그리고 폐활량계를 이용하여 폐기능을 측정한 결과를 획득하였으며 폐용적에 영향을 미치는 관련 인자로 성별 및 BMI를 선정하여 폐용적과의 독립표본 T-test를 통하여 유의성을 평가하고자 하였다. 실험결과 성별에 따른 폐용적의 평가에서 남성의 모든 폐용적이 여성의 모든 폐용적보다 크다는 것을 확인할 수 있었다. 성별 및 폐용적에 대한 각각의 평균값을 이용한 독립표본 T-test 결과 남성이 여성보다 모든 폐용적이 더 크다는 결과는 유의한 결과를 나타내었다(p<0.001). 그리고 BMI 지수에 따른 폐용적의 평가에서 BMI 지수 24 이상의 성인의 모든 폐용적이 BMI 지수 24 미만의 모든 폐용적보다 크다는 것을 확인할 수 있었다. 그러나 BMI 지수 및 폐용적에 대한 각각의 평균값을 이용한 독립표본 T-test 결과 BMI 지수 24 이상이 BMI 지수 24 미만보다 모든 폐용적이 더 크다는 결과는 유의한 결과를 나타내지 않았다(p<0.055). 폐기능 환기장애 유무에 따른 폐용적의 평가에서 폐기능 환기 정상성인의 모든 폐용적이 폐기능 환기 장애성인의 모든 폐용적보다 크다는 것을 확인할 수 있었다. 그리고 폐기능 환기장애 유무 및 폐용적에 대한 각각의 평균값을 이용한 독립표본 T-test 결과 폐기능 환기 정상성인이 폐기능 환기 장애성인보다 모든 폐용적이 더 크다는 결과는 유의한 결과를 나타내었다(p<0.001). 폐용적과 폐활량 검사 결과는 폐 건강을 평가하는데 가장 중요한 지표이며, 이 두 지표를 함께 사용하여 폐 기능을 평가하는 것이 가장 정확한 평가 방법이다. 그러므로 본 연구에서는 폐용적과 폐활량 검사에 대한 향후 유사 연구 시 폐기능 환기 정상 성인과 폐기능 환기 장애 성인에 대한 폐용적 평균값을 제시하여 기초자료로 활용될 것이라고 사료된다.