• 제목/요약/키워드: Low-level lasers

검색결과 37건 처리시간 0.023초

Stability and Effectiveness of Laser and Liquiband Treatments in the Rat Model of Oral Ulcer

  • Kang, Ji Won;Ryu, Hyun Seok;Abueva, Celine;Chung, Phil-Sang;Woo, Seung Hoon
    • Medical Lasers
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    • 제10권4호
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    • pp.207-213
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    • 2021
  • Background and Objectives This study was undertaken to assess the stability and efficacy of laser therapy (808 nm), Liquiband (a commercial topical skin adhesive product), and a combination treatment, for application in oral ulcers. Materials and Methods The oral ulcer rat animal model was used to determine the efficacy of photobiomodulation, Liquiband, or combination therapy. Ulcers were induced by injecting 60% acetic acid in the oral mucosa. Three days after ulcer confirmation, the chemically induced ulcers were treated with either laser (808 nm), Liquiband, or a combination of both, every two days for 8 days (4 sessions). Combination therapy was performed by first treating with laser followed by application of the Liquiband. Reduction in ulcer area size was subsequently determined, and animals were sacrificed at 5 and 10 days after the last administration, for histological observation of the extracted oral ulcer tissue samples. Results In this study, treatment with either laser (808 nm) or commercial Liquiband product as well as the combined treatment significantly enhanced oral ulcer healing in the rat animal model. The effect of laser treatment is mainly attributed to collagen synthesis, whereas application of the Liquiband promotes vascularization and formation of granulation tissue. Our results indicate that further optimization of the combined therapy could synergistically and significantly enhance oral ulcer healing. Conclusion Laser or Liquiband treatment of oral ulcer in the rat animal model exert different outcomes, but both methods confirm significant effects relative to the untreated group. The combined treatment group with laser and Liquiband showed marked oral ulcer healing, but further optimization is required to get highly significant results and establish the potential synergistic effect of the combination therapy, as compared to the individual enhancing effects of healing oral ulcers.

대상포진성 신경통에 대한 저출력 레이저 치료 (Effects of Low Level Laser Therapy on Herpetic Neuralgia)

  • 문원배;김해규;백승완;김인세;정규섭
    • The Korean Journal of Pain
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    • 제3권2호
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    • pp.139-143
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    • 1990
  • 대상포진성 신경통 환자의 통증을 조정하기 위한 목적으로 본원 통증치료실을 내원한 환자 26명을 대상으로 저출력 레이저 치료를 시행한 결과는 아래와 같다. 1) 통증완화 효과에 대한 평가로서 LLLT는 통증환자에게 비침습적이고 안전하게 시행할 수 있었다. 2) 저출력 레이저 조사후 VAS의 변화는 치료전 $7.57{\pm}1.81$, 5회후 $4.01{\pm}2.01$ 10회후 $3.28{\pm}1.85$ 15회후 $2.82{\pm}1.95$이었다(p<0.01). 3) 15회의 LLLT후 VAS의 개선율은 63%였다. 4) 가장 현저한 VAS의 개선율은 1회 LLLT후의 24%였고 VAS의 개선율은 7회 LLLT후에 나타났다. 5) 대상포진후 신경통으로의 이환은 60세 이상군에서 나타난 1명(3.8%)이었다. 60세 이하 군에서 VAS의 변화는 치료전 $7.67{\pm}2.31$, 5회후 $3.42{\pm}1.77$, 10회후 $2.88{\pm}1.33$, 15회후 $2.22{\pm}1.63$이었으며 VAS의 개선율은 각각 55%, 62%, 71%였다. 60세 이상 군에서는 VAS의 변화는 치료전 $7.49{\pm}1.44$, 5회후 $4.51{\pm}2.20$, 10회후 $3.76{\pm}2.38$, 15회후 $3.47{\pm}2.32$이고 VAS의 개선율은 각각 40%, 50%, 54%로 유의한 차이가 없었다(p>0.05). 7) LLLT중이나 후에 특이한 합병증은 없었다. 이상에서 볼 때 대상포진성 신경통 환자에서 LLLT는 초기에 통증을 조절할 뿐만 아니라 대상포진후 신경통으로의 이환을 줄이며 환자의 전신상태와 비교적 무관하게 치료를 적용할 수 있는 방법으로 사료된다.

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ZnO nanostructures for e-paper and field emission display applications

  • Sun, X.W.
    • 한국정보디스플레이학회:학술대회논문집
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    • 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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    • pp.993-994
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    • 2008
  • Electrochromic (EC) devices are capable of reversibly changing their optical properties upon charge injection and extraction induced by the external voltage. The characteristics of the EC device, such as low power consumption, high coloration efficiency, and memory effects under open circuit status, make them suitable for use in a variety of applications including smart windows and electronic papers. Coloration due to reduction or oxidation of redox chromophores can be used for EC devices (e-paper), but the switching time is slow (second level). Recently, with increasing demand for the low cost, lightweight flat panel display with paper-like readability (electronic paper), an EC display technology based on dye-modified $TiO_2$ nanoparticle electrode was developed. A well known organic dye molecule, viologen, was adsorbed on the surface of a mesoporous $TiO_2$ nanoparticle film to form the EC electrode. On the other hand, ZnO is a wide bandgap II-VI semiconductor which has been applied in many fields such as UV lasers, field effect transistors and transparent conductors. The bandgap of the bulk ZnO is about 3.37 eV, which is close to that of the $TiO_2$ (3.4 eV). As a traditional transparent conductor, ZnO has excellent electron transport properties, even in ZnO nanoparticle films. In the past few years, one-dimension (1D) nanostructures of ZnO have attracted extensive research interest. In particular, 1D ZnO nanowires renders much better electron transportation capability by providing a direct conduction path for electron transport and greatly reducing the number of grain boundaries. These unique advantages make ZnO nanowires a promising matrix electrode for EC dye molecule loading. ZnO nanowires grow vertically from the substrate and form a dense array (Fig. 1). The ZnO nanowires show regular hexagonal cross section and the average diameter of the ZnO nanowires is about 100 nm. The cross-section image of the ZnO nanowires array (Fig. 1) indicates that the length of the ZnO nanowires is about $6\;{\mu}m$. From one on/off cycle of the ZnO EC cell (Fig. 2). We can see that, the switching time of a ZnO nanowire electrode EC cell with an active area of $1\;{\times}\;1\;cm^2$ is 170 ms and 142 ms for coloration and bleaching, respectively. The coloration and bleaching time is faster compared to the $TiO_2$ mesoporous EC devices with both coloration and bleaching time of about 250 ms for a device with an active area of $2.5\;cm^2$. With further optimization, it is possible that the response time can reach ten(s) of millisecond, i.e. capable of displaying video. Fig. 3 shows a prototype with two different transmittance states. It can be seen that good contrast was obtained. The retention was at least a few hours for these prototypes. Being an oxide, ZnO is oxidation resistant, i.e. it is more durable for field emission cathode. ZnO nanotetropods were also applied to realize the first prototype triode field emission device, making use of scattered surface-conduction electrons for field emission (Fig. 4). The device has a high efficiency (field emitted electron to total electron ratio) of about 60%. With this high efficiency, we were able to fabricate some prototype displays (Fig. 5 showing some alphanumerical symbols). ZnO tetrapods have four legs, which guarantees that there is one leg always pointing upward, even using screen printing method to fabricate the cathode.

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Effects of Photobiomodulation Therapy on Glycemic and Lipid Profiles In Vitro

  • Hakami, Abdulrahim R.;Alasmari, Sultan;Makkawi, Mohammed;Mansour, Adel Abo;Ahmad, Irfan;Shahrani, Mesfer Al;Alkhathami, Ali;Dera, Ayed A.;Tedla, Jaya Shanker;Almane, Saleh;Abudahish, Abdulaziz;AbuHadhyah, Jawaher;Alshehri, Majed;Mansour, Hanan Abo;Saad, Manar
    • Medical Lasers
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    • 제9권2호
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    • pp.172-178
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    • 2020
  • Background and Objectives This study aimed at examining the effects of photobiomodulation therapy (PBMT) on glucose, cholesterol, triglycerides, and low- and high-density lipoprotein (LDL and HDL, respectively) levels in vitro. Materials and Methods A total of 38 serum samples collected in plain (n=10) and heparinized tubes (n=28) were subjected to PBMT at 60 Joules (J)/cm2 for 2 min at 810 nm. The glucose and lipid profiles, cholesterol, triglycerides, LDL, and HDL of each sample was measured before and after PBMT. Results A statistically significant increase in glucose levels was observed in the PBMT-sera in 8 out of 10 samples in plain tubes. However, only two samples that were prepared in heparinized tubes showed an increase in glucose levels. The remaining heparinized samples that were exposed to PBMT presented lower glucose values. The treated sera exhibited a fluctuation in the lipid profiles after PBMT. However, high cholesterol levels were evident following PBMT. Similar trends with HDL and LDL in heparinized tubes were evident. Conclusion Together, the findings suggest that photobiomodulation exhibits an effect on glycemic and lipid profiles in vitro. Hence, the use of low-level laser therapy could have therapeutic potential. However, the differences between individual responses appear to indicate that the impact of PBMT may not always be beneficial.

발광 다이오드(Light Emitting Diode) 전동칫솔의 치은염에 대한 효과: 무작위 배정 임상시험 (The effect of Light Emitting Diode electric toothbrush on gingivitis: a randomized controlled trial)

  • 이성조
    • 구강회복응용과학지
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    • 제33권2호
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    • pp.119-126
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    • 2017
  • 목적: 이 논문의 목적은 발광 다이오드(Light Emitting Diode(LED))의 유무에 따른 전동칫솔의 항치태 및 항치은염 효과를 치은염 및 경도의 치주염 환자에서 관찰하는 것이었다. 연구 재료 및 방법: 30명의 환자를 실험군, 대조군으로 각각 15명씩 나누어 실험을 진행하였다. 실험군은 정상 작동의 LED 전동칫솔을 사용하였고 대조군은 LED가 나오지 않도록 개조된 동일 제품의 전동칫솔을 사용하였다. 기준(Baseline), 2주, 4주 후의 임상지표($L{\ddot{o}}e-Silness$ gingival index (GI), Quigley-Hein plaque index (PI))를 측정하여 Wilcoxon signed rank test, Mann-Whitney test를 통해 통계적 분석을 시행하였다. 결과: 실험군과 대조군 간의 시간에 따른 GI의 변화는 두 군 모두 시간에 따른 감소를 나타내었으나, 2주, 4주차에서 유의한 차이를 나타내었다. PI는 4주차에서 실험군에서 대조군보다 낮은 수치를 나타내었는데, 통계적으로 유의한 차이는 아니었다. 결론: 본 연구에서 LED가 장착된 전동 칫솔은 단기간의 연구에서 치은염의 감소효과를 보였고, 장기간의 관찰 시 치태의 축적을 감소시킬 수 있다 추측할 수 있었다.

WDM-PON 시스템용 저가형 Fiber Grating Laser의 제작 및 성능 분석 (Fabrication and performance analysis of cost-effective fiber grating lasers for WDM-PON systems)

  • 조승현;이우람;이지현;박재동;김병휘;강민호;신동욱
    • 한국광학회지
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    • 제16권1호
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    • pp.13-20
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    • 2005
  • 광섬유 브라그 격자를 외부 공진기로 사용하는 레이저 다이오드(이하 FGL : fiber grating laser 이라 약칭함)를 제작한 후 그 성능을 실험적으로 측정하고 분석하였다. FGL을 WDM기반의 수동형 광 가입자망 시스템에 적용하기 위해서는 저가 구현이 필수적이며, 이를 위해, TO-CAN 형태의 모듈로 패키징하였다. 제작된 FGL의 동작 전류 대 광 출력 특성을 측정한 결과, $25^{\circ}C$에서 60 mA일때 약 3.6 mW를 얻을 수 있었고 주입 전류 변화에 따른 발진 파장의 변화율은 5.2 pm/mA이었다. 또한, FGL의 온도 변화에 따른 발진 파장의 변화율은 30 pm/$^{\circ}C$로 주변 온도 변화에 대한 발진 파장의 안정도가 매우 우수함을 확인하였다. 문턱 전류 이상의 동작전류 영역에서 각각 30 dB 이상의 양호한 주변 모드 억압비(SMSR)를 얻을 수 있었고, 단일 종 모드 발진 특성을 유지함을 확인하였다. 제작된 FGL의 전송 성능을 분석하기 위하여 155 Mb/s의 NRZ 신호로 직접 변조 실험을 수행하였다. BER 성능을 측정한 결과. 단일 모드 광섬유 20 km를 통과하더라도 광경로 파워 페널티가 발생하지 않았고 수신파워가 -37.5 dBm 이상에서 BER<$10^{-9}$ 을 얻을 수 있었다.

유기발광다이오드를 이용한 Photobiomodulation 기반 스킨케어 효과 (Photobiomodulation-based Skin-care Effect of Organic Light-emitting Diodes)

  • 김홍빈;정혜정;진석근;이병일;안재성
    • 한국광학회지
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    • 제32권5호
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    • pp.235-243
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    • 2021
  • Photobiomodulation (PBM) 치료법은 특정 파장대역의 광원이 미토콘드리아에서 ATP 생성을 촉진하는 현상을 이용하는 치료법으로서 상처 치유, 염증 감소, 통증 완화 효과가 있는 것으로 알려져 생물 및 의학 분야에서 많은 관심을 받고 있다. PBM 치료법에 대한 연구는 주로 레이저, 발광다이오드(LED)를 광원으로 사용하였고, 유기발광다이오드(OLED)가 가지는 장점에도 불구하고 PBM 치료법에 사용된 사례는 제한적이다. 본 연구에서는 적색(λ = 620 nm), 녹색(λ = 525 nm), 청색(λ = 455 nm) OLED 조명모듈을 사용하여 PBM에 의한 피부관리 효과를 분석하고 LED에 의한 PBM 효과와 비교하였다. OLED 조명모듈의 PBM에 의한 피부미용효과는 적색 OLED 조명모듈에 의한 collagen type 1 합성량 증가, 녹색 OLED 조명모듈에 의한 melanin 합성 억제, 청색 OLED 조명모듈에 의한 nitric oxide 생성 억제를 각각 측정하여 입증되었다.