• Journal of Environmental Health Sciences
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• v.22 no.4
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• pp.16-24
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• 1996

This study was performed to investigate the effect of co-existence of carbaryl and chlorothalonil on the short-term bioconcentration factor in Carassius auratus(goldfish). The fishes were exposed to the combined treatment of carbaryl and chlorothalonil(0.05 ppm+0.005 ppm, 0.05 ppm+0.010 ppm, 0.10 ppm+0.005 ppm) for 1, 3 and 5 days, respectively. Carbaryl and chlorothalonil in fish and in test water were extracted with n-hexane and acetonitrile. GC-ECD was used to detect and quantitate carbaryl and chlorothalonil. 1-day, 3-day and 5-day bioconcentration factors($BCF_1, BCF_3$ and $BCF_5$) of each pesticide were calculated from the quantitation results. The depuration rate of each pesticide from the whole body of fish was determined over the 72-h period after combined treatment. The results were as follows: $BCF_1$ values of carbaryl were 3.521, 3.802 and 3.587, respectively, when the concentration of carbaryl and chlorothalonil in combined treatment were 0.05+0.005, 0.05+0.010 and 0.10+0.005 ppm. BCF3 values of carbaryl were 4.825, 4.556 and 3.828, respectively, and $BCF_5$ values of carbaryl were 3.974, 3.921 and 4.186, respectively, under the conditions. While $BCF_1$ of chlorothalonil were 0.829, 0.829 and 1.540, respectively, under the same condition of pesticide concentrations $BCF_3$ of chlorothalonil were 2.040, 2.208 and 3.633, respectively, and $BCF_5$ of chlorothalonil were 6.222, 6.667 and 7.095, respectively, under the conditions. Depuration rate constants of carbaryl were 0.022, 0.022 and 0.152, respectively, when the concentration of carbaryl and chlorothalonil in combined treatment were 0.05+0.005, 0.05+0.010 and 0.10+0.005 ppm. While depuration rate constants of chlorothalonil were 0.004, 0.004 and 0.006, respectively, under the same condition of pesticide concentrations. It was observed that no significant differences of carbaryl and chlorothalonil concentration in fish extracts, test water and $BCF_s$ of carbaryl and chlorothalonil between combined treatment and single treatment. It was considered that no appreciable interaction at experimental concentrations was due to low concentrations, 0.005~0.1 ppm. Co-existence of carbaryl and chlorothalonil had no effect on excretion of each pesticide and depuration rate of chlorothalonil was investigated 1/8 slower than that of carbaryl in combined treatment. Therefore, it is considered that the persistence of chlorothalonil in fish body would be higher than that of carbaryl.

• Journal of Environmental Health Sciences
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• v.39 no.1
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• pp.90-98
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• 2013

Objectives: Many studies have shown that air pollution and temperature have adverse effects on mortality and morbidity. But the interactive effect between air pollution and temperature on mortality has been rarely investigated. This study aims to explore whether temperature modifies the associations between ambient particulate matter less than $10{\mu}m$ in diameter ($PM_{10}$) and mortality in Seoul, Korea. Methods: The time-series analysis examined the effect of the interaction between $PM_{10}$ and temperature on mortality from 1999 to 2010 in Seoul. In order to examine the interactive effect between $PM_{10}$ and temperature on mortality, we fitted a response surface model controlling the time-trends and meteorological variables. The effects of $PM_{10}$ were stratified by temperature stratum to quantitatively estimate the $PM_{10}$-health outcome associations. Results: When temperature was low (below the threshold temperature), the percentage increases per $10{\mu}g/m^3$ increase of $PM_{10}$ increased 0.38% (95% Confidence Interval[CI]: 0.09~0.68%) and 0.31% (95% CI: - 0.07~0.68%) of mortality in the all age group and ${\geq}65$ year age group, respectively. When temperature was high (above the threshold temperature), the percentage increases per $10{\mu}g/m^3$ increase of $PM_{10}$ increased 1.09% (95% CI: 0.47~1.72%) and 1.35% (95% CI: 0.65~2.06%) for mortality in the all age group and ${\geq}65$ year age group, respectively. Conclusion: The results of this study showed strong modification by temperature in the association between $PM_{10}$ and mortality. We recommend that public health strategies to minimize adverse health impact of heat and $PM_{10}$ should be considered in control and prevention measures for air pollution and weather-related health impacts.

• Journal of the Korean Data and Information Science Society
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• v.25 no.5
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• pp.1057-1067
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• 2014

Many genetic variants have been identified to be associated with complex diseases such as hypertension, diabetes and cancers throughout genome-wide association studies (GWAS). However, there still exist a serious missing heritability problem since the proportion explained by genetic variants from GWAS is very weak less than 10~15%. Gene-gene interaction study may be helpful to explain the missing heritability because most of complex disease mechanisms are involved with more than one single SNP, which include multiple SNPs or gene-gene interactions. This paper focuses on gene-gene interactions with the survival phenotype by extending the multifactor dimensionality reduction (MDR) method to the accelerated failure time (AFT) model. The standardized residual from AFT model is used as a residual score for classifying multiple geno-types into high and low risk groups and algorithm of MDR is implemented. We call this method AFT-MDR and compares the power of AFT-MDR with those of Surv-MDR and Cox-MDR in simulation studies. Also a real data for leukemia Korean patients is analyzed. It was found that the power of AFT-MDR is greater than that of Surv-MDR and is comparable with that of Cox-MDR, but is very sensitive to the censoring fraction.

• Journal of Life Science
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• v.15 no.4 s.71
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• pp.542-547
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• 2005

Hypersensitivity of cells lacking Brcal to DNA interstrand .ross-link (ICL) agents such as cisplatin and mitomycin C(MMC) implicates the important role of Brcal in cellular response following ICL treatment. Brca1 plays an essential role in DNA double-strand break (DSB) repair through homologous recombination (HR)-dependent and -independent process. Recently, our group has been reported that Brca1 involves in cellular ICL response through HR-dependent repair process (Yun J. et at., Oncogene 2005). In this report, the involvement of Brca1 protein in HR-independent repair process is examined using isogenic $p53^{-/-}\;and\;p53^{-/-}\;Brcal^{-/-}$ mouse embryonic fibroblast (MEF) and psoralen cross-linked reporter reactivation assay. Brcal-deficient MEFs showed significantly low HR-independent repair activity compare to Brca1-proficient MEFs. Hypersensitivity to MMC and ICL reporter repair activity were restored by the reconstitution of Brca1 expression. Interestingly, MEFs expressing exon 11-deleted isoform of Brca1 $(Brca1^{\Delta11/\Delta11})$ showed high resistance to MMC and ICL reporter repair activity comparable to Brca1-reconstituted MEFs. Taken together, these results suggest that Brca1 involves in ICL repair through not only HR-dependent process but also HR-independent process using N-terminal RINC finger domain or C-terminal BRCT domain rather than exon 11 region which mediate interaction with Rad50.

• The KIPS Transactions:PartD
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• v.18D no.3
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• pp.179-184
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• 2011

Current mobile devices have surpassed its boundaries as a more communication tool to a smart device which provides additional features. These features have supported the smart life of its users, but have reached its limit from low-performance processors and short-battery time. These issues can be resolved b implementing higher performing hardware, but they come with a burden of high cost. This paper introduces a new way of managing computing resources in a mobile device by enhancing the quality of human-computer interaction. The real-speed felt by users are mainly influenced by the time it takes form a user's input to the device to display the completed result on the screen. Since the size of the screen for mobile devices are small, if the processor only fetch data to be used for displaying on screen, the time can be significantly reduced. MVC+Prefetch Controller pattern accomplished this goal by using the minimum amount of data from DB to fetch display and still manages to support high-speed data transfer to achieve seamless display. This idea has been realized by practice using Samsung mobile phone S8500, which demonstrated the superior performance on user's perspective.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.2
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• pp.398-404
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• 2017

The aim of this study was to determine the effect of a non-elastic fixation belt on the balance ability and fall prevention in elderly women. Elderly women experience reduced balance ability and an increased risk of falls due to a weakening of the surrounding sacroiliac joint and pelvic muscles during childbirth and menopause. On the other hand, specific studies are still needed. The subjects were allocated randomly to two groups: control (n=20) and experimental (n=20). The experimental group used a non-elastic fixation belt, whereas the control group had no fixation belt. The balance ability and the fall index were measured in all subjects using a balance measurement device, and the low abdominal muscle thickness was determined in the experimental group using ultrasound imaging for the exact application of the non-elastic fixation belt. The following statistical analysis was performed: an independent t-test for the general characteristics of the subjects, $2{\times}2$ analysis of variance with repeated measures for the balance and fall index score, and a paired t-test for the abdominal muscle thickness. The group ${\times}$ time interaction effect showed significant improvement in the General Stability Index (F1,38=47.24, p=0.001), Fourier Harmony Index (F1,38=88.83, p=0.001), Weight Distribution Index (F1,38=50.21, p=0.001), and Fall Index (F1,38=21.59, p=0.001). The thicknesses of the transverse abdominal (p=0.001) and internal oblique (p=0.001) muscles were increased significantly in the experimental group after using the non-elastic fixation belt. Overall, the application of a non-elastic fixation belt could be effective in improving the balance ability and fall prevention in elderly women.

• Journal of Soil and Groundwater Environment
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• v.19 no.2
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• pp.7-15
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• 2014

This study was conducted to understand the chemical characteristics of groundwater in carbonate areas of Korea. In this study, data on pH, electric conductivity (EC), $Ca^{2+}$, $Mg^{2+}$, $Na^+$, $K^+$, $Cl^-$, $SO_4{^{2-}}$, and $HCO_3{^-}$ were collected from 97 wells which were installed in various carbonate rock regions of Korea. The pH values ranged from 5.7 to 9.9, and the average value was 7.3. The concentration range showed differences between the maximum value of $HCO_3{^-}$ and the medium to minimum values of $Ca^{2+}$, $Mg^{2+}$, $Na^+$, $Cl^-$, $SO_4{^{2-}}$, and $K^+$ in the study area. The average value of EC was $374{\mu}S/cm$, higher than in granite and gneiss areas, where the value is $176{\mu}S/cm$. Most of the groundwater was type $Ca-HCO_3$, and some was type $Mg-HCO_3$. The relationship between $Ca^{2+}$, $Cl^-$, and $HCO_3{^-}$, respectively, and EC showed relatively significant positive correlations compared to the other dissolved components. However, the determination coefficients for $Mg^{2+}$, $Na^+$, $SO_4{^{2-}}$, and $K^+$ were very low less than 0.2. These results indicate that the source of $Ca^{2+}$ and $Mg^{2+}$ is relatively simple (carbonate dissolution) compared to other sources. The sources of $Na^+$, $K^+$, $Cl^-$, $SO_4{^{2-}}$, and $HCO_3{^-}$ might be not only water-rock interactions, but also irrigation return flow, because many groundwater wells had been developed for irrigation purposes. Subsequently, the influence of agriculture on groundwater chemistry was evaluated using a cumulative plot of $SO_4{^{2-}}$. The threshold value of $SO_4{^{2-}}$ calculated from the cumulative frequency curve was 29.2 mg/L. Therefore, 12.4% of all the groundwater wells were affected by agricultural activity.

• Archives of Plastic Surgery
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• v.38 no.4
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• pp.359-368
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• 2011

Purpose: Aquacel Ag$^{(R)}$ is a hydrofiber wound dressing integrated with ionic silver. Sorbact$^{(R)}$ is a hydrophobiccoated dressing that uses the hydrophobic interaction with microbes. In this study, we compared the wound healing effects and the antibacterial effects of Medifoam$^{(R)}$, Betadine soaked, Aquacel Ag$^{(R)}$ and Sorbact$^{(R)}$ dressings against MRSA-infected wounds. Methods: Eighty rats were divided into four groups: Medifoam$^{(R)}$; Betadine soaked; Aquacel Ag$^{(R)}$; and Sorbact$^{(R)}$. A $1.5{\times}1.5cm$ square full-thickness wound was made on the dorsum of each rat and infected with MRSA. Twenty-four hours thereafter, each dressing was applied to the wound and changed every other day. One, 3, 7, 11 and 15 days after the wound infection, swab culture grade, wound bed appearance score, and wound defect size change were evaluated, and 7 and 15 days after, histologic evaluation was compared between the groups. Results: The bacteria load of wounds in the Sorbact$^{(R)}$ group decreased earlier than in the other groups. The wound bed appearance score of the Sorbact$^{(R)}$ group also increased quicker, compared with the other groups. However, the size of wounds of the Aquacel Ag$^{(R)}$ group decreased more rapidly, compared with other groups. From the histologic point of view, there was no significant difference between Betadine soaked, Aquacel Ag$^{(R)}$ and Sorbact groups. Conclusion: The hydrophobic dressing using Sorbact$^{(R)}$ showed a more rapid reduction in the MRSA load and an elevation in the wound bed appearance score, but a slower decrease in wound size change due to detachment of wound bed tissue when the dressing was eliminated in the low exudate wound. The silver-containing hydrofiber dressing using Aquacel Ag$^{(R)}$ was more effective in ultimate wound size reduction, but some debris was trapped in the wound tissue and induced foreign body reaction in the high exudate wound. Thus, ongoing selection process of treatment based on the evaluation of the infectious wound state will be very important.

• Journal of Korea Water Resources Association
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• v.44 no.1
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• pp.9-22
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• 2011

A 1D numerical model for steady flow, based on the energy equation, was developed for natural rivers with emergent vegetations on floodplains and banks. The friction slope was determined by the friction law of Darcy-Weisbach. The composite friction factor of the each cross section was calculated by considering bottom roughness of the main channel and the floodplains, the flow resistance of vegetations, the apparent shear stress and the flow resistance caused by the momentum transfer between vegetated areas and non-vegetated areas. The interface friction factor caused by flow interaction was calculated by empirical formulas of Mertens and Nuding. In order to verify the accuracy of the suggested model, water surface elevations were calculated by using imaginary compound channels and the results of calculations were compared with that of the HEC-RAS. The sensitivity analysis was performed to confirm changed friction factors by vegetations density etc. The suggested model was applied to the reach of the Enz River in Germany, and estimated water surface elevations of the Enz River were compared with measured water surface elevations. This model could acceptably compute not only water surface elevations with low discharge but also that with high discharge. So, the suggested model in this study verified the applicability in natural rivers with emergent vegetations.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.91-91
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• 2013

Imagine a world where we could biomanufacture hybrid nanomaterials having atomic-scale resolution over functionality and architecture. Toward this vision, a fundamental challenge in materials science is how to design and synthesize protein-like material that can be fully self-assembled and exhibit information-specific process. In an ongoing effort to extend the fundamental understanding of protein structure to non-natural systems, we have designed a class of short peptides to fold like proteins and assemble into defined nanostructures. In this talk, I will talk about new strategies to drive the self-assembled structures designing sequence of peptide. I will also discuss about the specific interaction between proteins and inorganics that can be used for the development of new hybrid solar energy devices. Splitting water into hydrogen and oxygen is one of the promising pathways for solar to energy convertsion and storage system. The oxygen evolution reaction (OER) has been regarded as a major bottleneck in the overall water splitting process due to the slow transfer rate of four electrons and the high activation energy barrier for O-O bond formation. In nature, there is a water oxidation complex (WOC) in photosystem II (PSII) comprised of the earthabundant elements Mn and Ca. The WOC in photosystem II, in the form of a cubical CaMn4O5 cluster, efficiently catalyzes water oxidation under neutral conditions with extremely low overpotential (~160 mV) and a high TOF number. The cluster is stabilized by a surrounding redox-active peptide ligand, and undergo successive changes in oxidation state by PCET (proton-coupled electron transfer) reaction with the peptide ligand. It is fundamental challenge to achieve a level of structural complexity and functionality that rivals that seen in the cubane Mn4CaO5 cluster and surrounding peptide in nature. In this presentation, I will present a new strategy to mimic the natural photosystem. The approach is based on the atomically defined assembly based on the short redox-active peptide sequences. Additionally, I will show a newly identified manganese based compound that is very close to manganese clusters in photosystem II.