• Journal of Gastric Cancer
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• 제3권1호
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• pp.50-55
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• 2003

Background: An aberrant function of the mismatch repair system has been reported to underlie carcinogenesis in several tumors, including colorectal and gastric carcinomas, and to induce the typical genotype of microsatellite instability (MSI). Purpose: We aimed to determine the frequency of MSI in early-onset sporadic gastric carcinoma and elucidate the role of promoter methylation in hMLH1 as the mechanism of MSI. Materials and Methods: Thirty-six early-onset sporadic gastric carcinomas were analyzed to determine the status of MSI and the frequency of methylation of the promoter region in hMLH1. MSI was determined using five markers recommended by NCI: MSI-H (high), MSI-L (low), and MSS (Microsatellite stable). Methylation specific PCR (MSP) and direct automated genomic sequencing analysis with DNA modified by sodium bisulfite have been performed to confirm promoter region methylation. All the data were analyzed regarding characteristics of molecular changes, and clinicopathologic variables. Results: The microsatellite status was determined as MSI-H in five cases ($13.8\%$), MSI-L in 13 cases ($36.1\%$), and MSS in 18 cases ($50.0\%$). hMLH1 was methylated in seven cases ($19.4\%$). In all cases of MSI-H, promoter of hMLH1 was methylated, and in two of the 13 cases of MSI-L, hMLH1 promoter methylation was identified. Methylation was not found in any cases of MSS. Promoter methylation in hMLH1 was significantly correlated with MSI status (P<0.001). We could not find any relationship between MSI and clinicopathologic parameters. Conclusion: These results suggest that an abnormal function of the mismatch repair system may be associated with gastric carcinogenesis in more than $10\%$ of early-onset gastric carcinomas and MSI appeared to be closely related to the promoter methylation in hMLH1.

• 한국소음진동공학회논문집
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• 제21권10호
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• pp.940-950
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• 2011

This paper reports a filtered velocity feedback(FVF) controller, which is an alternative to direct velocity feedback(DVFB) controller. The instability problems at high frequencies due to non-collocated sensor/actuator configuration with the DVFB can be alleviated by the proposed FVF controller. The FVF controller is designed to filter out the unstable high frequency response. The dynamics of a clamped plate under forces and moments and the FVF controllers are formulated. The stability of the control system and performance are investigated with the open loop transfer function(OLTF). It is found that the FVF controller has a higher gain margin than the corresponding DVFB controller owing to the rapid roll-off behavior at high frequencies. Although the gain margin cannot be fully utilized because of the enhancement at the high frequencies, the vibration at the modes lower than the tuning frequency is well controlled. This performance of the FVF controller is shown to be improved from that of the DVFB controller. It is, however, noted that the stability around the tuning frequency is very sensitive so that the enhancement in vibration level should be followed. The reduction performance at low frequencies using the FVF controller should be compromised with the enhancement in the vibration at high frequencies while designing the controller.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2587-2592
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• 2016

Background: Early onset sporadic colorectal cancer (CRC) is a biologically and clinically distinct entity hypothesized to exhibit differences in histological features and microsatellite instability (MSI) as compared to typical onset CRC. This study compared the MSI status, mismatch repair enzyme deficiency and clinicopathological features of early onset (aged ${\leq}45$ years) with controls (>45 years). Materials and Methods: A total of 30 cases and 30 controls were analyzed for MSI status using the Bethesda marker panel. Using antibodies against hMLH1, hMSH2 and hMSH6, mismatch repair protein expression was assessed by immunohistochemistry. Molecular characteristics were correlated with clinicopathological features. Results: The early onset sporadic CRCs were significantly more poorly differentiated tumors, with higher N2 nodal involvement and greater frequency of signet ring phenotype than the typical onset cases. MSI was observed in 18/30 cases, with 12/18 designated as MSI-high (MSI-H) and 6/18 designated as MSI-low (MSI-L). In the control group, 14 patients exhibited MSI, with 7 MSI-H and 7 MSI-L. MSI tumors in both cases and controls exhibited loss of hMLH1, hMSH2 and hMSH6. MSS tumors did not exhibit loss of expression of MMR proteins, except hMLH1 protein in 3 controls. No statistically significant difference was noted in MSI status or expression of MMR proteins in cases versus controls. Conclusions: Microsatellite status is comparable between early and typical onset sporadic CRC patients in Pakistan suggesting that differences in clinicopathological features between these two subsets are attributable to other molecular mechanisms.

• Korea-Australia Rheology Journal
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• 제14권1호
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• pp.33-45
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• 2002

Recent results obtained for the port-pom model and the constitutive equations with time-strain separability are examined. The time-strain separability in viscoelastic systems Is not a rule derived from fundamental principles but merely a hypothesis based on experimental phenomena, stress relaxation at long times. The violation of separability in the short-time response just after a step strain is also well understood (Archer, 1999). In constitutive modeling, time-strain separability has been extensively employed because of its theoretical simplicity and practical convenience. Here we present a simple analysis that verifies this hypothesis inevitably incurs mathematical inconsistency in the viewpoint of stability. Employing an asymptotic analysis, we show that both differential and integral constitutive equations based on time-strain separability are either Hadamard-type unstable or dissipative unstable. The conclusion drawn in this study is shown to be applicable to the Doi-Edwards model (with independent alignment approximation). Hence, the Hadamardtype instability of the Doi-Edwards model results from the time-strain separability in its formulation, and its remedy may lie in the transition mechanism from Rouse to reptational relaxation supposed by Doi and Edwards. Recently in order to describe the complex rheological behavior of polymer melts with long side branches like low density polyethylene, new constitutive equations called the port-pom equations have been derived in the integral/differential form and also in the simplifled differential type by McLeish and carson on the basis of the reptation dynamics with simplifled branch structure taken into account. In this study mathematical stability analysis under short and high frequency wave disturbances has been performed for these constitutive equations. It is proved that the differential model is globally Hadamard stable, and the integral model seems stable, as long as the orientation tensor remains positive definite or the smooth strain history in the flow is previously given. However cautious attention has to be paid when one employs the simplified version of the constitutive equations without arm withdrawal, since neglecting the arm withdrawal immediately yields Hadamard instability. In the flow regime of creep shear flow where the applied constant shear stress exceeds the maximum achievable value in the steady flow curves, the constitutive equations exhibit severe instability that the solution possesses strong discontinuity at the moment of change of chain dynamics mechanisms.

• 한국직업건강간호학회지
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• 제17권2호
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• pp.146-154
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• 2008

Purpose: The purpose of this study is to investigate the degree of job stress and job satisfaction and the relationship between job stress and job satisfaction of Medical Aid Client Managers. Method: Data were collected from 185 Medical Aid Client Managers in 234 areas between April 2-15, 2007. Collected data was analyzed for the frequency, t-test, ANOVA, Pearson's Correlation Coefficient etc. Results: The average score of job stress was 2.6. Job instability was highest as 2.9 and job autonomy was lowest as 2.2. in eight items. When the job stress of Medical Aid Client Managers was converted to 100 point, the average was 51.7 and ranked in upper 50% of Korean woman workers' job stress. Among the eight items, because the relationship satisfaction and the instability of duty regime ranked in upper 25% of Korean woman workers' job stress, those items were identified to have high stress. The average score of job satisfaction was 2.3 out 4.0 which could be interpreted as unsatisfactory. The correlation between the job stress and the job satisfaction demonstrated significant difference. Decrease of the job satisfaction was associated with increase of the job stress. In regard to the eight items, the inverse correlation was demonstrated to be significant in organization, inappropriate compensation, and workplace culture. Conclusion: Medical Aid Client Managers have high stress in carrying out their duties. They have experienced very severe instability in their duty regime. Also, they have felt alienated from their organization and experienced unfair rewards. They had low duty satisfaction but got a heavy workload and experienced overtime work. To relieve job overburden of Medical Aid Client Managers. it was necessary to improve business system and also was necessary to relieve a regional disparity of business charge.

• 한국추진공학회지
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• 제8권3호
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• pp.10-16
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• 2004

원통 다발형 그레인의 연소시험 결과 저주파 불안정 현상이 나타났다. 그 원인은 원통 그레인 내면의 압력과 외면의 압력차(압력 비평형)가 주원인임을 알 수 있었으며, 그레인 반경방향으로 홀을 뚫어 그레인 내면에 상승된 압력을 외면으로 빠르게 확산되도록 하여 안정된 연소현상을 얻을 수 있었다. 그러나 고온 조건에서도 안정된 연소 현상을 얻기 위하여 직경 3mm 흘 7개를 뚫게 됨에 따라 가스발생량의 증가가 많이 둔화되어 격자를 사용하는 방법을 연구하게 되었다. 격자를 사용함으로써 큰 와류(large vorticity)를 소멸시켜 그레인에 홀을 뚫지 않고도 안정된 연소를 얻을 수 있었으며 가스 발생량도 점진적으로 증가시킬 수 있었다. 가로${\times}$세로 격자는 5${\times}$5, 그레인은 격자에 고정시키지 않을 때 가장 좋은 결과를 얻을 수 있었다.

• 대한지리학회지
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• 제41권2호
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• pp.168-187
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• 2006

대류권 하부의 높은 대기 불안정도와 건조도에 의해 바람이 강한 조건하에 화재 연료도 건조해지면 산불 통제가 어렵고 대형산불에 의한 더 많은 산림자원과 계산의 손실을 초래할 수 있다. 본 연구에서 제시된 장기간(1979-2005)의 Haines Index는 한반도 상의 대기 불안정도와 건조도의 시공간적 패턴이 우리나라 산불 발생빈도에 중요한 영향을 미치고 있음을 잘 보여주고 있다. 산불 발생빈도와 Haines Index 사이의 지수회귀모델은 주요 산불 발생기간동안(12월-4월)의 Haines Index 일평균 값 혹은 월별 발생빈도가 우리나라 산불 발생빈도와 통계적으로 유의미하게 상관되어 있음을 보여준다. 지리정보시스템(GIS)에서 수치표고모델(DEM)을 고려하여 작성한 Haines Index 기후도에 따르면, 5 이상의 높은 Haines Index는 주로 해발고도 500m 이하의 한반도 북서 저지대를 중심으로 4-5월에 자주 발생하고 있다. 이러한 Haines Index의 발생빈도는 1990년대 중반 이후 한반도 전체적으로 증가하는 추세를 보이고, 특히 경상북도와 동해안 지역을 따라 산불기간 동안 가장 뚜렷하게 증가하는 패턴을 보였다. 연구기간 동안 높은 Haines Index가 2-3일 연속적으로 발생한 극사상(extreme events)이 나타나는 시기의 500hPa 종관 평균도에 따르면, 오흐츠크해에 발달한 한랭저기압이 한반도 중층대기의 기압경도력을 높여 동서의 강한 바람장을 형성하는데 도움을 주고 있음을 알 수 있다. 이러한 결과들은 현재 우리나라 산불 예보 시스템에 대기 불안정도나 건조도와 같은 대기의 수직적 요소들의 시 공간적 특성도 고려되어야 하는 필요성을 잘 보여준다.

• Smart Structures and Systems
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• 제22권1호
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• pp.41-55
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• 2018

Damping ratio and frequency have influence on dynamic serviceability or instability such as vortex-induced vibration and displacement amplification due to earthquake and critical flutter velocity, and it is thus important to make determination of damping ratio and frequency accurate. As bridges are getting longer, small scale model test considering similitude law must be conducted to evaluate damping ratio and frequency. Analysis conditions modified by similitude law are applied to experimental test considering different scale ratios. Generally, Nyquist frequency condition based on natural frequency modified by similitude law has been used to determine sampling rate for different scale ratios, and total time length has been determined by users arbitrarily or by considering similitude law with respect to time for different scale ratios. However, Nyquist frequency condition is not suitable for multimode system with noisy signals. In addition, there is no specified criteria for determination of total time length. Those analysis conditions severely affect accuracy of damping ratio. The focus of this study is made on the determination of minimum analysis conditions for different scale ratios. Influence of signal to noise ratio is studied according to the level of noise level. Free initial value problem is proposed to resolve the condition that is difficult to know original initial value for free vibration. Ambient and free vibration tests were used to analyze the dynamic properties of a system using data collected from tests with a two degree-of-freedom section model and performed on full bridge 3D models of cable stayed bridges. The free decay is estimated with the stochastic subspace identification method that uses displacement data to measure damping ratios under noisy conditions, and the iterative least squares method that adopts low pass filtering and fourth order central differencing. Reasonable results were yielded in numerical and experimental tests.

• Asian Pacific Journal of Cancer Prevention
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• 제14권9호
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• pp.5257-5261
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• 2013

The micronucleus frequency (MNF) in peripheral blood lymphocytes (PBL) is a biomarker of chromosomal damage and genome instability in human populations.The relationship of micronucleus frequency with prognosis of patients with acute leukemia is not clear. We therefore investigated MNF in mitogen-activated peripheral blood lymphocytes from patients with hematologic diseases and solid tumours. Patients included 50 with acute leukemia, 49 diagnosed with myelodysplastic syndrome (MDS), 54 with benign blood diseases, and 45 with solid tumours, examined with 50 healthy controls. The mean MNF was significantly higher in cases of hematologic diseases and solid tumor patients than in healthy controls (P<0.001). There was no evident difference between MNF in the acute leukemia ($7.15{\pm}2.18$) and solid tumor groups ($7.11{\pm}1.47$), but both were higher than in the MDS group ($5.12{\pm}1.29$) and benign blood diseases group ($3.08{\pm}1.08$). Taking 7.15‰, the average MNF of the acute leukemia group as standard, and dividing 50 cases of acute leukemia patients into high MNF group ($MNF{\geq}7.15$‰) and low MNF group (MNF<7.15‰). The overall response (complete remission + partial remission) rates of the low MNF group were significantly higher than in the high MNF group (P=0.001). The high MNF group further showed lower overall survival rates than the low MNF group. MNF expression and progression-free survival seemed to have a opposite relationship, with a correlation coefficient of -0.702. These data indicate that MNF in peripheral blood lymphocytes is important for evaluation of prognosis of acute leukemia patients, and it can reflect progression of disease to a certain degree.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2006년도 제33회 KOSCO SYMPOSIUM 논문집
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• pp.27-35
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• 2006

It has been observed in experiments that combustion instability of low frequency (${\sim}$ 10Hz) results form the modulation of equivalence ratio at fuel injection hole when a pressure fluctuation propagates upwards along the channel of the burner under an unchoked fuel flow condition. In this study, a commercial program was used to determine how the fuel flow rate changed with respect to the pressure, velocity of the fuel flow and the mass fraction in a choked and an unchoked condition. The calculation focus on the upstream of the dump plane to know how the forced pressure with the fuel injection conditions affects the modulation of the equivalence ratio. Therefore, it is found that pressure fluctuation leads to oscillation of mass flow rate and then results in equivalence ratio modulation under the unchoked fuel flow condition.