• BMB Reports
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• v.54 no.6
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• pp.317-322
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• 2021

CCCTC-binding factor (CTCF), a zinc finger protein, is a transcription factor and regulator of chromatin structure. Forebrain excitatory neuron-specific CTCF deficiency contributes to inflammation via enhanced transcription of inflammation-related genes in the cortex and hippocampus. However, little is known about the long-term effect of CTCF deficiency on postnatal neurons, astrocytes, or microglia in the hippocampus of adult mice. To address this, we knocked out the Ctcf gene in forebrain glutamatergic neurons (Ctcf cKO) by crossing Ctcf-floxed mice with Camk2a-Cre mice and examined the hippocampi of 7.5-10-month-old male mice using immunofluorescence microscopy. We found obvious neuronal cell death and reactive gliosis in the hippocampal cornu ammonis (CA)1 in 7.5-10-month-old cKO mice. Prominent rod-shaped microglia that participate in immune surveillance were observed in the stratum pyramidale and radiatum layer, indicating a potential increase in inflammatory mediators released by hippocampal neurons. Although neuronal loss was not observed in CA3, and dentate gyrus (DG) CTCF depletion induced a significant increase in the number of microglia in the stratum oriens of CA3 and reactive microgliosis and astrogliosis in the molecular layer and hilus of the DG in 7.5-10-month-old cKO mice. These results suggest that long-term Ctcf deletion from forebrain excitatory neurons may contribute to reactive gliosis induced by neuronal damage and consequent neuronal loss in the hippocampal CA1, DG, and CA3 in sequence over 7 months of age.

• Structural Engineering and Mechanics
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• v.30 no.6
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• pp.713-732
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• 2008

Serviceability and durability of the concrete members can be seriously affected by the corrosion of steel rebar. Carbonation front and or chloride ingress can destroy the passive film on rebar and may set the corrosion (oxidation process). Depending on the level of oxidation (expansive corrosion products/rust) damage to the cover concrete takes place in the form of expansion, cracking and spalling or delamination. This makes the concrete unable to develop forces through bond and also become unprotected against further degradation from corrosion; and thus marks the end of service life for corrosion-affected structures. This paper presents an analytical model that predicts the weight loss of steel rebar and the corresponding time from onset of corrosion for the known corrosion rate and thus can be used for the determination of time to cover cracking in corrosion affected RC member. This model uses fully the thick-walled cylinder approach. The gradual crack propagation in radial directions (from inside) is considered when the circumferential tensile stresses at the inner surface of intact concrete have reached the tensile strength of concrete. The analysis is done separately with and without considering the stiffness of reinforcing steel and rust combine along with the assumption of zero residual strength of cracked concrete. The model accounts for the time required for corrosion products to fill a porous zone before they start inducing expansive pressure on the concrete surrounding the steel rebar. The capability of the model to produce the experimental trends is demonstrated by comparing the model's predictions with the results of experimental data published in the literature. The effect of considering the corroded reinforcing steel bar stiffness is demonstrated. A sensitivity analysis has also been carried out to show the influence of the various parameters. It has been found that material properties and their inter-relations significantly influence weight loss of rebar. Time to cover cracking from onset of corrosion for the same weight loss is influenced by corrosion rate and state of oxidation of corrosion product formed. Time to cover cracking from onset of corrosion is useful in making certain decisions pertaining to inspection, repair, rehabilitation, replacement and demolition of RC member/structure in corrosive environment.

• The Journal of Internal Korean Medicine
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• v.43 no.6
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• pp.1134-1148
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• 2022

Purpose: We evaluated whether Spatholobus suberectus extract (SSE) can be used as a means of preventing and treating osteoporosis by measuring its effect on osteoclast differentiation, gene expression, and bone resorption. Methods: SSE was used to examine the effect on RAW 264.7 cells stimulated with RANKL to induce bone resorption. The inhibitory effect of TRAP formation and the expression of the bone resorption factors TRAP, cathepsin K, and MMP-9 during differentiation were measured. The effects on the differentiation-related factors NFATc and TRAIL and on the expression of OC-STAMP, DC-STAMP, ATP6v0d2, MITF, c-Fos, and inflammation-related factors were also evaluated. The effect on bone resorption was evaluated by culturing RANKL-treated osteoclasts on artificial bone fragments and observing the resulting resorption traces. The effect on bone damage in experimental animals was also measured. Results: SSE inhibited the differentiation of RANKL-stimulated osteoclasts into osteoclasts and suppressed the expression of cathepsin K, TRAP, MMP-9, NFATc1, TRAIL, MITF, OC-STAMP, DC-STAMP, ATP6v0d2, and c-Fos genes. Bone pore formation due to osteoclast action was also inhibited, and LPS-induced bone loss was suppressed in animal experiments. Conclusions: SSE could be useful for the prevention or treatment of osteoporosis by inhibiting osteoclast differentiation and bone resorption and suppressing bone loss induced in experimental animals. However, studies of larger populations are required.

• Journal of Biosystems Engineering
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• v.28 no.5
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• pp.403-410
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• 2003

To enhance the performance of a rice seed pelleting machine and the quality of rice-seed pellets made, improvement of the rice seed pelleting machine developed previously(Park, 2002) was tried and its performance was evaluated. As compared with the previous pelleting machine, a feeding mechanism of pellet materials to the forming rolls was changed from screw conveyor to hydraulic cylinder for proper feeding, rings were installed among rows of semi-spherical forming grooves on the forming rolls for reducing pellet materials loss and seeds damage, and discharging air nozzles were added for complete discharging of the pellets made. Through performance tests, capacity, pelleting ratio, and seed loss ratio of the pelleting machine were investigated at the mixing ratios of soil to rice seed of 6 : 1, 7 : 1, and 8 : 1, and rotating speeds of the forming rolls of 7 rpm, 10 rpm, and 13 rpm. As results of performance evaluation, pelleting ratios were in the range of 77 ∼ 89 ％, and maximum pelleting ratio increased by 18 % in comparison with that of the previous machine. Maximum capacity was about 110 kg/h(about 63,000 pellets/h), which was increased by 70 % in comparison with that of the previous machine. But, ratios of seed loss were in the range of 24 - 49 ％, which were not improved.

• Steel and Composite Structures
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• v.27 no.6
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• pp.727-745
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• 2018

The design criteria and the corresponding performance levels characterize the response of extended stiffened end-plate beam-to-column joints. In order to guarantee a ductile behavior, hierarchy criteria should be adopted to enforce the plastic deformations in the ductile components of the joint. However, the effectiveness of thesecriteria can be impaired if the actual resistance of the end-plate material largely differs from the design value due to the potential activation of brittle failure modes of the bolt rows (e.g., occurrence of failure mode 3 in the place of mode 1 per bolt row). Also the number and the position of bolt rows directly affect the joint response. The presence of a bolt row in the center of the connection does not improve the strength of the joint under both gravity, wind and seismic loading, but it can modify the damage pattern of ductile connections, reducing the gap opening between the end-plate and the column face. On the other hand, the presence of a central bolt row can influence the capacity of the joint to resist the catenary actions developing under a column loss scenario, thus improving the joint robustness. Aiming at investigating the influence of these features on both the cyclic behavior and the response under column loss, a wide range of finite element analyses (FEAs) were performed and the main results are described and discussed in this paper.

• Journal of the Korean Society for Nondestructive Testing
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• v.35 no.1
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• pp.39-45
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• 2015

Applications of smart sensors have been extended to safety systems in the aerospace, transportation and civil engineering fields. In particular, structural health monitoring techniques using smart sensors have gradually become necessary and have been developed to prevent dangers to human life and damage to assets. Generally, smart sensors are based on electro-magnets and have several weaknesses, including electro-magnetic interference and distortion. Therefore, fiber optic sensors are an outstanding alternative to overcome the weaknesses of electro-magnetic sensors. However, they require expensive devices and complex systems. This paper proposes a new, affordable and simple sensor system that uses a single fiber to monitor pressures at multiple-points. Moreover, a prototype of the sensor system was manufactured and tested for a feasibility study. Based on the results of this experimental test, a relationship was carefully observed between the bend loss conditions and light-intensity. As a result, it was shown that impacts at multiple-points could be monitored.

• Physical Therapy Korea
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• v.18 no.1
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• pp.18-27
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• 2011

This study was to investigate the positive effects of specially designed trunk-stabilization exercise program on lower extremity balance of elderly with history of leprosy. In this participants, lower extremity functions has been undermined by the development of damage in peripheral nerves. A total of 40 elderly with history of leprosy were divided into 2 groups of equal size ($n_{1,\;2}=20$): a group that participated in the exercise program, and a control group that did not exercise but did continue to engage in normal daily activities (including walking). The exercise group exercised for 60 minutes 2 days a week for 12 weeks. Static balance ability was measured by asking study participants to a one leg standing test: dynamic balancing ability was measured with a tandem walking test and a timed up-and-go test. The participants in the exercise program and the control group were tested before and after completion of the exercise program for comparison, and then divided according to their ability to feel sensory in the soles of their feet into the categories of normal sensory group: group with sensory loss in one foot: and group with sensory loss in both feet. The participants in the exercise program showed a positive, statistically significant difference in static balance compared with the control group (p<.05) as measured using the one leg standing test. Similarly, the participants in dynamic balance (p<.05) as measured using the tandem walking and timed up-and-go tests. Finally, these improvements were related to the severity of sensory loss in the soles of the feet for all study participants.

• Geomechanics and Engineering
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• v.31 no.3
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• pp.237-248
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• 2022

Nowadays, more and more subway tunnels were planed and constructed underneath the ground of urban cities to relieve the congested traffic. Potential damage may occur in existing tunnel if the new tunnel is constructed too close. So far, previous studies mainly focused on the tunnel-tunnel interactions with circular shape. The difference between circular and horseshoe shaped tunnel in terms of deformation mechanism is not fully investigated. In this study, three-dimensional numerical parametric studies were carried out to explore the effect of different tunnel shapes on the complicated tunnel-tunnel interaction problem. Parameters considered include volume loss, tunnel stiffness and relative density. It is found that the value of volume loss play the most important role in the multi-tunnel interactions. For a typical condition in this study, the maximum invert settlement and gradient along longitudinal direction of horseshoe shaped tunnel was 50% and 96% larger than those in circular case, respectively. This is because of the larger vertical soil displacement underneath existing tunnel. Due to the discontinuous hoop axial stress in horseshoe shaped tunnel, significant shear stress was mobilized around the axillary angles. This resulted in substantial bending moment at the bottom plate and side walls of horseshoe shaped tunnel. Consequently, vertical elongation and horizontal compression in circular existing tunnel were 45% and 33% smaller than those in horseshoe case (at monitored section X/D = 0), which in latter case was mainly attributed to the bending induced deflection. The radial deformation stiffness of circular tunnel is more sensitive to the Young's modulus compared with horseshoe shaped tunnel. This is because of that circular tunnel resisted the radial deformation mainly by its hoop axial stress while horseshoe shaped tunnel do so mainly by its flexural rigidity. In addition, the reduction of soil stiffness beneath the circular tunnel was larger than that in horseshoe shaped tunnel at each level of relative density, indicating that large portion of tunneling effect were undertaken by the ground itself in circular tunnel case.

• The Korean Society of Law and Medicine
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• v.20 no.1
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• pp.47-82
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• 2019

Inter-Korean exchanges and cooperation, in the process, will inevitably lead to various legal disputes, one of which is the issue of compensation for personal injury. The purpose of this study is to present the standards of settlement of disputes between the residents of North and South Korea by examining the North Korean compensation law on the calculation of damages due to personal injury and comparing it with the South Korean compensation law. Understanding the North Korean compensation law is a critical and urgent task, as exchanges and cooperation between the two Koreas are expected to increase in the future. For the South Korean compensation law does not have specific provisions on the estimation of damages, the specific methods and standards for estimating damages are determined by court precedents. The South Korean courts categorize the damages caused by personal injury into active property damages, passive property damages and emotional distress damages and calculate the amount of each damages. On the other hand, the North Korean Compensation for Damage Act stipulates the categories of damage by dividing the cases of personal injury into 1) infringement of health(§41), 2) disability due to infringement of health(§42), and 3) death resulting from human infringement(§44). In addition, the North Korea Compensation for Damage Act specifies the calculation of compensation for damages(§43, §51). Furthermore, South Korea widely acknowledges emotional distress damages for personal injury, whereas North Korea does not recognize emotional distress damages in principle.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.25 no.7
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• pp.757-766
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• 2014

In this paper, economic loss due to high power electromagnetic pulse is estimated and the methodology used for calculating its impacts is suggested using a macro approach. In order to investigate the most critical infrastructure for the high power electromagnetic pulse assault, the vulnerability assessment that provides information on the threats of concern is conducted. As a result, this study concentrates on the electric power networks. The presented assessment model is considered with gross domestic product (GDP) and energy consumption when the electric power networks are damaged due to high power electromagnetic pulse. In addition, economic losses are calculated by the extent of damages considering different types of the high power electromagnetic pulse assault generated by nuclear and man-made weapon. Through the estimation of these damages, the resulted economic loss will be compared with the protection cost. Consequently, protection of the vulnerable infrastructures can be prepared against electromagnetic pulse attack.