• Title/Summary/Keyword: Loss Ratio

검색결과 3,138건 처리시간 0.029초

The Impact of Surgical versus Transcatheter Aortic Valve Replacement on Postprocedural Acute Kidney Injury in Patients with Chronic Kidney Disease

  • Eun Chae, Kim;Sue Hyun, Kim;Yeiwon, Lee;Suk Ho, Sohn;Jae Woong, Choi;Jeehoon, Kang;Jung Kyu, Han;Kyung Hwan, Kim;Hyo-Soo, Kim;Ho Young, Hwang
    • Journal of Chest Surgery
    • /
    • 제55권6호
    • /
    • pp.435-441
    • /
    • 2022
  • Background: This study aimed to evaluate the impact of the treatment modality on post-procedural acute kidney injury (AKI) and other clinical outcomes in patients with advanced chronic kidney disease who underwent surgical or transcatheter aortic valve replacement (AVR). Methods: A total of 147 patients with advanced chronic kidney disease (stage 3 to 5) who underwent isolated surgical AVR (SAVR group; n=70) or transcatheter AVR (TAVR group; n=77) were retrospectively studied. Postprocedural AKI was defined according to the RIFLE definition (an acronym corresponding to the risk of renal dysfunction, injury to the kidney, failure of kidney function, loss of kidney function, and end-stage kidney disease). Factors associated with postoperative complications and mortality were analyzed using multivariable logistic regression models and Cox proportional hazard models. Results: Postprocedural AKI occurred in 17 (24.3%) and 6 (7.8%) patients in the SAVR and TAVR groups, respectively (p=0.006). Multivariable analyses demonstrated that the SAVR group had higher risks of AKI (odds ratio [OR], 5.63; 95% confidence interval [CI], 1.85-17.73; p=0.002) and atrial fibrillation (OR, 16.65; 95% CI, 4.44-62.50; p<0.001), whereas the TAVR group had a higher risk of permanent pacemaker insertion (OR, 5.67; 95% CI, 1.21-26.55; p=0.028). The Cox proportional hazard models showed that the occurrence of AKI, contrary to the treatment modality, was associated with overall survival. Conclusion: In patients with chronic kidney disease, the risk of postprocedural AKI might be higher after SAVR than after TAVR.

Effect of Saccharomyces cerevisiae boulardii on sows' farrowing duration and reproductive performance, and weanling piglets' performance and IgG concentration

  • Sun, Haiqing;de Laguna, Fernando Bravo;Wang, Shuai;Liu, Fengju;Shi, Liang;Jian, Haidi;Hu, Xiaoxia;Qin, Peng;Tan, Jiajian
    • Journal of Animal Science and Technology
    • /
    • 제64권1호
    • /
    • pp.10-22
    • /
    • 2022
  • We studied the effects of Saccharomyces cerevisiae boulardii CNCM I-1079 (LSB) supplemented to lactating sows on reproductive traits and farrowing duration and to piglets from day 7 of life on post-weaning performance and IgG concentration. Ninety-six Landrace × Yorkshire sows started the trial 5 days before the expected farrowing date. Sows were distributed into 2 groups according to parity number and backfat thickness: control (CON: regular lactation diet) and LSB (CON + LSB at 2 × 109 colony forming units [CFU]/kg of feed). Seven days after birth, litters were randomly selected from each group and supplemented creep feed with or without LSB at 2 × 109 CFU/kg. At weaning, piglets from CON sows were shifted to a commercial farm and allocated to 14 pens in groups of 25 piglets/pen according to the creep feed supplemented during lactation. Piglets followed a 3-phase feeding program: creep, pre-starter and starter, with or without LSB at 2 × 109 CFU/kg LSB in creep and pre-starter, and 1 × 109 CFU/kg LSB in starter. The piglets were vaccinated against classical swine fever on days 41 and 72 of life. One day before each vaccination and at the end of the trial, blood samples were collected from 15 randomly selected piglets per treatment and assessed for total IgG. Supplemented sows with non-supplemented litters displayed the lowest backfat thickness loss during lactation (p < 0.05). The LSB supplementation shortened farrowing duration (p < 0.05) and increased feed intake (p < 0.05) during the first week of lactation. The LSB-fed piglets were heavier at the end of creep (p < 0.05), pre-starter (p < 0.05), and the trial (p < 0.05); grew faster during creep (p < 0.05), starter (p < 0.05), and overall (p < 0.05); and displayed an improved feed conversion ratio during creep (p < 0.05). Total IgG content was higher at days 40 (p < 0.05) and 71 (p < 0.05) in LSB-fed piglets. We conclude that supplementing sows with Saccharomyces cerevisiae boulardii CNCM I-1079 from late gestation until weaning shortens farrowing duration, increases feed intake, and minimizes backfat losses during lactation. When supplemented to piglet diet, post-weaning performance is improved. This improvement observed could be linked to a better immune status, as suggested by the higher IgG.

복소 전기비저항 3차원 역산 알고리듬 개발 (Development of Three-dimensional Inversion Algorithm of Complex Resistivity Method)

  • 손정술;신승욱;박삼규
    • 지구물리와물리탐사
    • /
    • 제24권4호
    • /
    • pp.180-193
    • /
    • 2021
  • 복소 전기비저항 탐사기법은 진동수 영역에서 전기비저항과 위상을 측정하여 지하 매질의 다양한 특성정보를 획득할 수 있는 탐사기법으로 최근 그 활용성이 증가하고 있다. 이 논문에서는 복소 전기비저항 탐사기법의 활용성을 높이기 위하여 획득한 자료에 대한 3차원 역산 알고리듬을 개발하였다. 이를 위한 모델링에는 전자기 커플링 효과를 무시하는 경우에 적용할 수 있는 포아송 방정식을 적용하였으며, 역산에는 기존의 평활화된 역산법을 복소수로 확장하는 방법으로 알고리듬을 개발하였다. 역산의 안정성 및 현장자료의 적용성을 높이기 위하여 라그랑지 곱수를 역산 과정에서 오차 벡터와 모델 증분 벡터의 크기에 따라 자동적으로 조정되도록 하는 기법을 도입하였다. 또한, 잡음이 많이 포함된 위상자료로 인한 자료의 손실을 보완하기 위하여 역산반복 단계에서 초반부는 전기비저항 자료만을, 후반부는 전기비저항 자료와 위상 자료를 모두 역산하는 두 단계로 구성된 역산기법을 제시하였다. 수치 모형실험에 대한 역산 시험결과 안정적인 역산 결과를 얻을 수 있었으며, 개발된 3차원 역산 알고리듬을 국내 천열수 광산 인근에서 수행한 복소 전기비저항 탐사자료 해석에 적용하여 그 타당성을 확인하였다.

필라테스 매트운동이 근위축 비만 노인의 심혈관질환 위험요인과 염증반응지표에 미치는 영향 (The Effect of Pilates Mat Exercise on Cardiovascular Disease Risk Factors and Inflammation Markers in Sarcopenic Obesity Elderly)

  • 김현태;김남정
    • 한국체육학회지인문사회과학편
    • /
    • 제51권4호
    • /
    • pp.407-417
    • /
    • 2012
  • 본 연구는 근위축 비만 노인여성을 대상으로 12주간 규칙적인 필라테스 매트 운동을 수행하였을 때 심혈관질환 위험요인 및 염증반응지표에 미치는 영향을 알아보고자 하였다. 연구대상자는 근육감소증 기준(팔, 다리, 사지근육량에 대한 신장의 비가 각각 1.16kg/m2, 4.31kg/m2, 5.21kg/m2 이하)과 체지방율이 30% 이상인 노인여성으로, 운동집단은 필라테스 매트 운동을 12주, 주3회, 일일 60분간 실시하고 심혈관질환 위험요인과 염증반응지표를 살펴보았다. 그 결과 체중과 체지방량은 감소하고 근육량은 증가하였으며 심혈관질환과 염증반응지표에서는 혈중지질과 Fibrinogen, CRP는 유의하게 감소하고 Adiponectin은 유의하게 증가하였다. 따라서 필라테스 매트 운동의 수행은 근위축 비만 노인여성의 심혈관질환과 염증반응지표의 개선으로 노인의 신체적 기능의 저하를 야기한 비만과 근력의 감소를 예방하는 효과적인 운동방법이 될 수 있을 것으로 생각된다.

근래의 신장이식 임상성적과 관련인자들: 단일기관 연구 (Clinical Outcomes and Contributors in Contemporary Kidney Transplantation: Single Center Experience)

  • 안재성;박경선;박종하;정현철;박호종;박상준;조홍래;이종수
    • 대한이식학회지
    • /
    • 제31권4호
    • /
    • pp.182-192
    • /
    • 2017
  • Background: In recent years, introduction of novel immunosuppressive agents and its proper implementation for clinical practice have contributed to improving clinical outcomes of kidney transplantation (KT). Here, we report clinical outcomes of KTs and related risk factors. Methods: From July 1998 to June 2016, 354 KTs (182 from living and 172 from deceased donors) have been performed at Ulsan University Hospital. We retrospectively reviewed the clinical characteristics and outcomes of KT recipients, then estimated graft and patient survival rate were estimated and analyzed risk factors using Cox-regression. Results: The median follow-up period was 53 months (range; 3 to 220 months). The mean ages of recipients and donors were 45.0 years (SD, 12.5) and 44.7 years (SD, 13.6) years, respectively. During follow-up, 18 grafts were lost and 5- and 10-year death-censored graft survival was 96.7% and 91.5%, respectively. Biopsy-proven acute rejection (BPAR) occurred in 71 patients (55 cases of acute cellular rejection and 16 of antibody-mediated rejection). Cox-regression analysis showed that BPAR was a risk factor related to graft loss (hazard ratio [HR], 14.38; 95% confidence interval [CI], 3.79 to 54.53; P<0.001). In addition, 15 patients died, and the 5- and 10-year patient survival was 97.2% and 91.9%, respectively. Age ≥60 years (HR, 6.03; 95% CI, 1.12 to 32.61; P=0.037) and diabetes (HR, 6.18; 95% CI, 1.35 to 28.22; P=0.019) were significantly related to patient survival. Conclusions: We experienced excellent clinical outcomes of KT in terms of graft failure and patient survival despite the relatively high proportion of deceased donors. Long-term and short-term clinical outcomes have improved in the last two decades.

Differences in Clinical Characteristics and Surgical Outcomes of Patients with Ischemic and Hemorrhagic Pituitary Adenomas

  • Jingpeng, Liu;Peng, Huang;Xiaoqing, Zhang;Yong, Chen;Xin, Zheng;Rufei, Shen;Xuefeng, Tang;Hui, Yang;Song, Li
    • Journal of Korean Neurosurgical Society
    • /
    • 제66권1호
    • /
    • pp.72-81
    • /
    • 2023
  • Objective : Ischemia and hemorrhage of pituitary adenomas (PA) caused important clinical syndrome. However, the differences on clinical characteristics and surgical outcomes between these two kinds apoplexy were less reported. Methods : A retrospective analysis was made of patients with pituitary apoplexy between January 2013 and June 2018. Baseline and clinical characteristics before surgery were reviewed. All patients underwent transsphenoidal surgery and were followed up at least 1 year. Results : Total 67 cases (5.8%) among 1147 pituitary tumor patients were enrolled, which consisted of 28 (~2.4%) ischemic PA and 39 (~3.4%) hemorrhagic PA. There were more male patients in the ischemic group compared with hemorrhagic group (78.6% vs 53.8%, p=0.043). However, the mean age, tumor size and functional tumor ratio were significant higher in the hemorrhagic group. Headache was more common in ischemic PA (82.1%) than that of hemorrhagic PA (51.3%, p=0.011). Magnetic resonance imaging findings found that mucosal thickening and enhancement of the sphenoid sinus was observed in 15 ischemic PA patients (n=27, 55.6%), but none in patients with hemorrhagic PA (n=38, p<0.0001). It was worth noting that the rate of pre-surgical hypopituitarism in ischemic PA patients were seemed higher than that in hemorrhagic PA patients, but not significant. The two groups got a total tumor resection rate at 94.1% and 92.9%, independently. No significant difference on the operative time, blood loss in operation and complications in perioperative period was observed in two groups. After operation, cranial nerve symptoms recovered to normal at 81.8% of ischemic PA patients and 82.6% of hemorrhagic PA patients. Importantly, the incidence of postoperative hypopituitarism partially decreased in both groups, among which the rate of hypothyroidism in ischemic PA patients significantly decreased from 46.4% to 18.5% (p=0.044). Conclusion : Patients with ischemic PA presented different clinical characteristics to the hemorrhagic ones. Transsphenoidal surgery should be considered for the patients with neuro-ophthalmic deficits and might benefit for pituitary function recovery of the apoplectic adenoma patients, especially pituitary thyroid axis in ischemic PA patients.

여성노인의 허약 상태 예측을 위한 보행변동성 및 체력의 역할 검증 (Role of Gait Variability and Physical Fitness as a Predictor for Frailty Status in Older Women)

  • 진영윤;박진국;강현식
    • 한국체육학회지인문사회과학편
    • /
    • 제57권6호
    • /
    • pp.263-272
    • /
    • 2018
  • 본 연구는 여성노인의 허약 상태에 대한 보행 변동성과 체력의 역할을 검증하고자 하였다. 본 연구 기관의 지역사회에 거주하는 65세 이상 여성노인 168명(나이 75.07±5.40)을 대상으로 인구사회학적 특성, 신체조성, 보행 변인 및 변동성, 체력, 인지기능, 우울상태를 측정하였다. 그리고 Fried et al.(2001)의 허약진단 지표(체중감소, 정서적 고갈, 신체활동, 보행속도, 악력)를 기준으로 정상, 전-허약, 허약으로 구분하였다. 허약 상태 예측을 위한 보행 변인 및 변동성 그리고 체력의 역할을 검정하기 위해 로지스틱 회귀분석을 실시하였다. 그 결과, 나이, 교육수준, 보유한 질병 수, 일상생활수행능력 및 인지기능 점수와 우울점수를 통제 한 후 허약그룹은 정상그룹(OR=1)과 비교하였을 때, 두 다리 지지비율(OR=1.48, 95% CI=0.10-2.21, p=.049) 및 분당 보폭수(OR=2.06, 95%CI=1.20-3.43, p=.009)의 변동성이 통계적으로 높게 나타났으며, 상체근력(OR=0.49, 95%CI=0.31-0.77, p=.002)이 낮은 것으로 나타났다. 결론적으로 본 연구에서 허약의 예측인자로 나타난 두발 지지비율 및 분당 보폭수의 변동성 그리고 상체근력은 허약 상태를 예측하고 평가하는데 중요한 지표로 사용될 수 있을 것으로 판단된다.

Comparison of Laparoscopic and Open Gastrectomy for Patients With Gastric Cancer Treated With Neoadjuvant Chemotherapy: A Multicenter Retrospective Study Based on the Korean Gastric Cancer Association Nationwide Survey

  • Seul Ki Oh;Chang Seok Ko;Seong-A Jeong;Jeong Hwan Yook;Moon-Won Yoo;Beom Su Kim;In-Seob Lee;Chung Sik Gong;Sa-Hong Min;Na Young Kim;the Information Committee of the Korean Gastric Cancer Association
    • Journal of Gastric Cancer
    • /
    • 제23권3호
    • /
    • pp.499-508
    • /
    • 2023
  • Purpose: Despite scientific evidence regarding laparoscopic gastrectomy (LG) for advanced gastric cancer treatment, its application in patients receiving neoadjuvant chemotherapy remains uncertain. Materials and Methods: We used the 2019 Korean Gastric Cancer Association nationwide survey database to extract data from 489 patients with primary gastric cancer who received neoadjuvant chemotherapy. After propensity score matching analysis, we compared the surgical outcomes of 97 patients who underwent LG and 97 patients who underwent open gastrectomy (OG). We investigated the risk factors for postoperative complications using multivariate analysis. Results: The operative time was significantly shorter in the OG group. Patients in the LG group had significantly less blood loss than those in the OG group. Hospital stay and overall postoperative complications were similar between the two groups. The incidence of Clavien-Dindo grade ≥3 complications in the LG group was comparable with that in the OG group (1.03% vs. 4.12%, P=0.215). No statistically significant difference was observed in the number of harvested lymph nodes between the two groups (38.60 vs. 35.79, P=0.182). Multivariate analysis identified body mass index (odds ratio [OR], 1.824; 95% confidence interval [CI], 1.029-3.234; P=0.040) and extent of resection (OR, 3.154; 95% CI, 1.084-9.174; P=0.035) as independent risk factors for overall postoperative complications. Conclusions: Using a large nationwide multicenter survey database, we demonstrated that LG and OG had comparable short-term outcomes in patients with gastric cancer who received neoadjuvant chemotherapy.

나노 MMT-폴리머 복합체를 이용한 폴리머 콘크리트의 강도 특성 (Properties on the Strength of Polymer Concrete Using Nano MMT-UP Composite)

  • 조병완;문린곤;박승국
    • 대한토목학회논문집
    • /
    • 제26권4A호
    • /
    • pp.761-766
    • /
    • 2006
  • 폴리머 복합체는 우수한 강도와 내구성으로 건설현장에서 프리캐스트 부재 및 보수, 보강재로서 널리 쓰이고 있어 폴리머 복합체의 경제성 및 성능 향상에 관한 연구가 이루어지고 있다. 폴리머 나노 복합체는 나노미터 수준의 크기를 가진 Clay 등의 무기 물질을 나노분산 상으로 폴리머에 균일 혼합시킨 것으로 산업적 응용가능성 면에서 뿐만 아니라 재료 및 공학분야에서도 많은 관심을 가지고 있다. 그리고 기존의 복합체 보다 1/10 혹은 그 이상의 낮은 함량의 분산상만으로도 더 우수한 강도와 역학적 특성 및 열안정성을 나타낸다. 본 실험에서는 폴리머 복합체의 성능을 향상시키고자 유기화된 몬모릴로나이트(MMT)와 유기화 되지 않은 몬모릴로나이트(MMT)를 사용하여 박리된 MMT-UP 나노 복합체를 제조하였다. XRD와 TEM실험결과, Cloisite 30B-UP 나노 복합체에서 층과 층 사이가 $100{\AA}$ 이상 떨어져 단일층으로 분산되었기 때문에 박리가 되었음을 알 수 있었다. 또한 역학적 특성은 기존복합체보다 인장강도와 인장탄성계수을 비교하였을 때 매우 향상됨을 알 수 있었고 열적 특성도 기존복합체보다 우수한 함을 나타내었다. 박리정도가 우수한 MMT-UP 복합체로 제조한 폴리머 콘크리트에서도 순수한 UP를 사용한 것보다 역학적 특성이 두드러졌다. 또한 폴리머 콘크리트의 강도와 탄성계수는 MMT-UP 복합체의 인장강도 및 인장탄성계수와 상관성을 갖는 것으로 판단된다.

SCP개량지반상에 성토시공 시 최적설계에 관한 연구 (Study on Optimum Design for Embankment Construction on Soft Ground Treated by SCP)

  • 채종길;박영목;정민수
    • 대한토목학회논문집
    • /
    • 제29권6C호
    • /
    • pp.251-258
    • /
    • 2009
  • 본 연구에서는 모래다짐말뚝 (SCP)로 개량된 연약점토지반상의 성토시공에 있어서 최적설계조건에 대해 현행 설계법과 손실평가함수 및 1차 근사 2계 모멘트법 (AFOSM)에 기초한 신뢰성 설계법으로 비교 검토하였다. 결과를 요약하면 다음과 같다. 1) 안전율(Fs)와 파괴확률($P_F$)는 심한 비선형 관계를 나타냈고, Fs가 1.2로 증가함에 따라 $P_F$는 약 1%까지 급격한 감소를 나타낸 후, 안전율의 증가와 더불어 $P_F$는 점진적으로 감소하였다. 현행 설계법상의 기준 안전율 1.2는 둘의 관계에 있어서 일종의 임계값이며, 이들의 관계가 적절히 고려되어 정립되었다고 판단된다. 2) 최소기대총비용을 나타내는 안전율은 1.15부근으로 현행설계기준 1.2에 다소 못미치는 값으로 나타났고, 파괴확률은 1% 정도로 다소 컸다. 3) 응력분담비 n과 모래의 내부마찰각 ${\phi}$의 민감도가 연약층의 초기비배수강도 관련 변수들의 민감도보다 더 크게 나타났다. 이것은 n과 ${\phi}$의 변동 특성이 보다 해석결과에 큰 영향을 준다는 것과 이들 변동 특성은 SCP 개량지반상의 성토안정해석에 반드시 고려되어야 함을 의미한다. 4) 설계기준안전율 1.2 이상(파괴확률 0.1-0.3% 이하)에서 New Failure Point는 평균치에서 표준편차의 1~2배 가량 떨어져 있는 값을 나타냈다.