• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2001년도 추계학술대회 및 정기총회
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• pp.100-100
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• 2001

Hypoxia is a pathophysiological condition that occurs during injury, ischemia, and stroke. Hypoxic stress induces the expression of genes associated with increased energy flux, including the glucose transporters Glutl and Glut3, several glycolytic enzymes, nitric oxide synthase, erythropoietin and vascular endothelial growth factor. Induction of these genes is mediated by a common basic helix-loop-helix PAS transcription complex, the hypoxia-inducible factor-l${\alpha}$ (HIF-1${\alpha}$)/ aryl hydrocarbon receptor nuclear translocator (ARNT). Insulin plays a central role in regulating metabolic pathways associated with energy storage and utilization. It triggers the conversion of glucose into glycogen and triglycerides and inhibits gluconeogenesis. Insulin also induced hypoxia-induced genes. However the underlying mechanism is unestablished. Here, we study the possibility that transcription factor HIF-1${\alpha}$ is involved in insulin-induced gene expression. We investigate the mechanism that regulates hypoxia-inducible gene expression In response to insulin We demonstrate that insulin increases the transcription of hypoxia- inducible gene. Insulin-induced transcription is not detected in Arnt defective cell lines. Under hypoxic condition, HIF- l${\alpha}$ stabilizes but does not under insulin treatment. Insulin-induced gene expression is inhibited by presence of PI-3 kinase inhibitor and Akt dominant negative mutant, whereas hypoxia-induced gene expression is not. ROS inhibitor differently affects insulin-induced gene expressions and hypoxia-induced gene expressions. Our results demonstrate that insulin also regulates hypoxia-inducible gene expression and this process is dependent on Arnt. However we suggest HIF-l${\alpha}$ is not involved insulin-induced gene expression and insulin- and hypoxia- induces same target genes via different signaling pathway.

• 전자공학회논문지SC
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• 제45권3호
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• pp.32-41
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• 2008

본 논문에서는 blu-ray 디스크 드라이버의 트랙킹 서보시스템에 대하여 플랜트와 제어기의 불확실성을 보상하는 견실비약성 $H^{\infty}$ 상태궤환 제어기 설계방법을 제안한다. 플랜트와 제어기의 불확실성을 매개변수화 선형행렬부등식(PLMI: parameterized linear matrix inequality)을 이용하여 구조화된 불확실성의 형태로 표현하며, Lyapunov 함수를 이용하여 구조적인 제어기의 이득섭동을 고려한 견실비약성 $H^{\infty}$ 상태궤환 제어기가 존재할 충분조건 및 제어기 설계방법을 PLMI의 형태로 제안한다. 또한, 완화기법(relaxation technique)을 통하여 PLMI를 유한개의 LMI의 형태로 변환하여 견실하고 최적화된 제어기 이득과 제어기 섭동 범위를 계산하고, 모의실험을 통해서 제시된 제어기의 타당성 및 견실성(robustness)과 비약성(non-fragility)을 검증한다.

• 수산해양기술연구
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• 제34권2호
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• pp.212-222
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• 1998

Heat transfer performance improvement by fin and groovs is studied for condensation of R-11 on integral-fin tubes. Eight tubes with trapczodially shaped integral-fins having fin density from 748 to 1654fpm(fin per meter) and 10, 30 grooves are tested. A plain tube having the same diameter as the finned tubes is also used for comparison. R-11 condensates at saturation state of 32 $^{\circ}C$ on the outside tube surface coded by inside water flow. All of test data are taken at steady state. The heat transfer loop is used for testing singe long tubes and cooling is pumped from a storage tank through filters and folwmeters to the horizontal test section where it is heated by steam condensing on the outside of the tubes. The pressure drop across the test section is measured by menas pressure gauge and manometer. The results obtained in this study is as follows : 1. Based on inside diameter and nominal inside area, overall heat transfer coefficients of finned tube are enhanced up to 1.6 ~ 3.7 times that of a plain tube at a constant Reynolds number. 2. Friction factors are up to 1.6 ~ 2.1 times those of plain tubes. 3. The constant pumping power ratio for the low integral-fin tubes increase directly with the effective area to the nominal area ratio, and with the effective area diameter ratio. 4. A tube having a fin density of 1299fpm and 30 grooves has the best heat transfer performance.

• Journal of Pharmaceutical Investigation
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• 제30권3호
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• pp.151-158
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• 2000

Gel and cream containing 5% and 10% ketonic fraction (KF) of Leptospermum scoparium, respectively were formulated. Antimicrobial activity, stability, anti-inflammatory effect, rheological properties, drug release and acute toxicity for these topical efficacy were evaluated. Gel and cream containing neomycin or gentamycin in combination with KF has potent antimicrobial activity. Gel and cream were physically stable and did not show any creaming for 6 months storage. Gel showed plastic flow with yield value and cream showed pseudoplastic flow with hysteresis loop. The gel and cream containing KF showed higher viscosity than control or commercial one. The viscosity increased as the concentration of KF increased. Both 10% gel and cream showed a significant decrease in swelling when applied to the carrageenan- injected paw, suggesting local antiinflammatory activity. Particularly, 10% gel preparation showed similar antiinflammatory activity when compared with commercially available drugs. Percent of drug released and diffusion coefficient were in the order of 5% gel, 10% gel, 5% cream, and 10% cream, respectively. There were no significant changes of body weight in rats percutaneously administered with 10% cream and gel when compared with control. There were no induced acute toxicity when 10% cream or gel was applied to rats. Leptospermum scoparium could be practicaly used in topical preparations.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2015년도 추계학술대회
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• pp.224-227
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• 2015

일반적으로 자동차드라이버의 스마트폰을 통한 데이터전송은 자동차운전자의 핸드폰은 데이터를 실시간으로 원격데이터 센터에 전송하는 경우에 용량 의존적인 순위를 가지고 있다. 생성되는 진단보드 데이터들은 드라이버의 폰에서의 모바일 진단 어플리케이션에 임시적으로 저장하고, 인터넷에 연결 되었을 때 데이터 센터에 전송한다. 클라우드에서 실행에 방해하는 다른 태스크들이 없는 원격 자동차 어플리케이션 사용방법을 위한 node.js는 모바일 네트워크을 통한 클라우드에서 데이터 저장업무를 다루기 위하여 적합하다. 우리는 외부 어플리케이션으로부터 driver inputs and delivers output을 패스하는 원격 유저와 운용하는 스마트폰 어플리케이션에서 자동차와의 어플리케이션 interface 방법을 사용하는 실시간 분석 안드로이드 어플리케이션 반응을 시뮬레이션 통해 제안된 아키텍쳐의 유효성을 입증한다. 이 논문에서, 우리는 이벤트 루프 접근을 기반으로 하는 이것은 웹서버 구조를 특징으로 하는 원격 자동차 결함 진단 시스템 연구를 제안한다.

• 한국전자통신학회논문지
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• 제16권6호
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• pp.1183-1194
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• 2021

전통적으로 전력시스템은 공급체계의 말단에 있는 소비자의 위치에서 보면 중앙집중화된 구조를 갖고 있다. 그러나 최근 수 십년간 지붕형 태양광, 영농형 태양광, 소형 풍력터빈, 배터리저장장치 및 스마트 가전품과 같은 분산에너지원의 등장을 보아왔다. 분산에너지원의 등장에 따라 배전계통 운전원의 역할도 확장된다. 확장된 분산전원의 진출은 배전망이나 송전망의 전통적인 계획과 운영에 영향을 주는 전력계통의 역조류와 예측성을 어렵게 할 수 있다. 이는 전형적인 계통계획, 정비 및 망관리, 정전할당 등 배전계통 운전원이 갖는 기능이 변경되어야 할 필요성을 증폭시킨다. 이 연구의 목적은 다중 분산전원을 갖는 미래 배전운전시스템을 설계하고 제안된 배전시스템 모델을 HILS로 구현 및 검증하는 것이다. 시험결과를 보면 제안된 배전시스템이 정상 영역에서 운전되고 배전선로 손실이 감소된다는 것을 보여준다.

• Nuclear Engineering and Technology
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• 제56권3호
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• pp.1066-1080
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• 2024

SMART100 has a containment pressure and radioactivity suppression system (CPRSS) for passive containment cooling system (PCCS). This prevents overheating and over-pressurization of a containment through direct contact condensation in an in-containment refueling water storage tank (IRWST) and wall condensation in a CPRSS heat exchanger (CHX) in an emergency cool-down tank (ECT). The Korea Atomic Energy Research Institute (KAERI) constructed scaled-down test facilities, SISTA1 and SISTA2, for the thermal-hydraulic validation of the SMART100 CPRSS. Three separate effect tests were performed using SISTA1 to confirm the heat removal characteristics of SMART100 CPRSS. When the low mass flux steam with or without non-condensable gas is released into an IRWST, the conditions for mitigation of the chugging phenomenon were identified, and the physical variables were quantified by the 3D reconstruction method. The local behavior of the non-condensable gas was measured after condensation inside heat exchanger using a traverse system. Stratification of non-condensable gas occurred in large tank of the natural circulation loop. SISTA2 was used to simulate a small break loss-of-coolant accident (SBLCOA) transient. Since the test apparatus was a metal tank, compensations of initial heat transfer to the material and effect of heat loss during long-term operation were important for simulating cooling performance of SMART100 CPRSS. The pressure of SMART100 CPRSS was maintained below the design limit for 3 days even under sufficiently conservative conditions of an SBLOCA transient.

• Journal of Biosystems Engineering
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• 제28권3호
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• pp.217-224
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• 2003

To find out heating load and to determine the power of heat pump compressor for the Ondol room heating the COP of heat pump, the variation of Ondol room air temperature, the variation of ambient temperature and power consumption of heat pump are analyzed. The results from this study were summarized as follows: 1. The COP of the heat pump in close loop decreased as the ambient air temperature. The COP was 2.26 when the temperature difference of condenser was $20\pm3^{\circ}C$. 2. The Ondol surface temperature was $25\pm3^{\circ}C$ when the hot water of $40^{\circ}C$ was supplied from hot water storage tank to the Ondol and the temperature difference between the Ondol surface and the room air temperature was $7~8^{\circ}C$. 3. The ratio of thermal conduction heating load to total heating load in Ondol heating space was found to be 83% and ratio of ventilation heating load was 17%. Therefore, the thermal conduction heating load was confirmod to be a major heating load in Ondol heating space. 4. In case of the ambient temperature of $3.2^{\circ}C$, the efficiency of heat exchange of Ondol heating system was 85%. 5. The heating load per Ondol heating surface area and volume of Ondol room space were theoretically analyzed. In case of the room temperature of $20^{\circ}C$ and the ambient temperature of $-3.2~3.8^{\circ}C$, the heating load per Ondol surface area was 115.8~167.6kJ/h ㆍ㎥ and per Ondol mom space volume was 50.2~72.7kJ/h ㆍ㎥. 6. The compressor power of heat pump fur the Ondol room heating could be determined with the heating load analyzed in this study In case of the Ondol room air temperature of 17~2$0^{\circ}C$ and the ambient temperature of -5~3.8$^{\circ}C$, the compressor power of heat pump per Ondol surface area was analyzed to be $2.3\times10^{-2}psm^2$, and per volume of Ondol room space $1.0\times10^{-2}1.4\times10^{-2}ps/m^2$ps.

• 대한치과보철학회지
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• 제38권2호
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• pp.169-177
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• 2000

The purpose of this study was to compare the retention of complete cast crown over amalgam ores, composite resin cores, and cast gold cores when cemented with three different luting agents. Eighteen core specimens each of amalgam(Bestaloy, Dong Myung, Seoul, Korea), composite resin (Z100, 3M Dental product, st. Paul, Minn) and type IV gold alloy (Ba-4, Heesung Engelhard Corp., Korea) were made in a customized milling stainless steel die. A wax pattern with a loop attached to occlusal surface was made for each core and a type II gold alloy casting was fabricated. The castings which had clinically acceptable marginal fit were used as test samples. The following luting cements were used to cement cast crowns on each core material : (1) zinc phosphate cement (Confi-dental Products Co., USA) (2) glass-ionomer cement (Fuji Plus, GC Industrial Corp., Tokyo, Japan) (3) resin cement (Panavia 21, Kuraray Co., USA). All cements were mixed according to manufacturers' instructions. A static load of 5kg was then applied for 10 minutes on the crowns. All specimens were stored in saline solution for 24 hours at $37^{\circ}C$ and thermocycled for 500 cycles. After storage and cycling, the tensile bond strengths were measured by using a universal testing machine (Instron Corp., Canton, Mass.) at a crosshead speed of 0.5mm/min. The results were as follows 1. The retentive strength of resin cement was the highest of alt three types of cement for resin core (p<0.05). 2. There was no statistical difference among the retentive strengths of three cements for amalgam core (p>0.05). 3. The retentive strength of resin cement was higher than that of zinc phosphate for cast core, but there was no difference between the retentive strength of glass ionomer cement and those of rein and zinc phosphate cement. 4. The retentive strength of the zinc phosphate cement for amalgam core was the highest of all type of cores.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2012년도 제42회 동계 정기 학술대회 초록집
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• pp.250-250
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• 2012

Recently, multiferroic materials have attracted much attention due to their fascinating fundamental physical properties and potential technological applications in magnetic/ferroelectric data storage systems, quantum electromagnets, spintronics, and sensor devices. Among single-phase multiferroic materials, $BiFeO_3$, in particular, has received considerable attention because of its very interesting magnetoelectric properties for application to spintronics. Enhanced ferromagnetism was found by Fe-site ion substitution with magnetic ions. In this study, $BiFe_{1-x}Ni_xO_3$ (x=0 and 0.05) bulk ceramic compounds were prepared by solid-state reaction and rapid sintering. High-purity $Bi_2O_3$, $Fe_3O_4$ and NiO powders were mixed with the stoichiometric proportions, and calcined at $450^{\circ}C$ for 24 h to produce $BiFe_{1-x}Ni_xO_3$. Then, the samples were directly put into the oven, which was heated up to $800^{\circ}C$ and sintered in air for 20 min. The crystalline structure of samples was investigated at room temperature by using a Rigaku Miniflex powder diffractometer. The Raman measurements were carried out with a Raman spectrometer with 514.5-nm-excitation Ar+-laser source under air ambient condition on a focused area of $1-{\mu}m$ diameter. The field-dependent magnetization and the temperature-dependent magnetization measurements were performed with a vibrating-sample magnetometer. The x-ray diffraction study demonstrates the compressive stress due to Ni substitution at the Fe site. $BiFe_{0.95}Ni_{0.05}O_3$ exhibits the rhombohedral perovskite structure R3c, similar to $BiFeO_3$. The lattice constant of $BiFe_{0.95}Ni_{0.05}O_3$ is smaller than of $BiFeO_3$ because of the smaller ionic radius of Ni3+ than that of Fe3+. The field-dependent magnetization of $BiFe_{0.95}Ni_{0.05}O_3$ exhibits a clear hysteresis loop at 300 K. The magnetic properties of $BiFe_{0.95}Ni_{0.05}O_3$ were improved at room temperature because of the existence of structurally compressive stress.