• 대한지역사회영양학회지
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• 제10권1호
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• pp.3-11
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• 2005

The purpose of this study was to examine the long term effects of breast feeding on growth, bone development and nutrient intakes in preschool children. Subjects were 62 preschool children. Anthropometric characteristics and bone mineral density of carpus were measured using DEXA. The questionnaire was composed of health status, life style, dietary behaviors, and dietary intakes and was completed by the children's mothers. The average age of the boys was 62.4 months and that of the girls was 62.1 months. Average birth height and weight of the subjects was 50.9 cm and 3.4 kg for boys and 50.3 cm and 3.3 kg for girls, respectively. The average height, weight, $\%$ body fat, and obesity index were 111.7 cm, 19.6 kg, $15.0\%$, $-2.1\%$ in boys and 109.4 em, 18.7 kg, $17.5\%$, $0.2\%$ in girls, respectively. Forty children were fed colostrum, 21 were fed breast milk, 29 were fed formula, and 12 were fed mixed milk. There was no significant difference in growth status between children who were fed colostrum and those who were not. Children who had mixed feedings were significantly taller than those who did not (p <0.001), and children who had colostrum had significantly higher bone mineral density than those who did not ($0.25 \pm 0.04 g/ cm^2$ vs. $0.23 \pm 0.04 g/cm^2$, p < 0.05). However, the different feeding methods did not show any difference in bone mineral density. Except vitamin $B_6$, folic acid and vitamin E, vitamin, mineral and calorie intakes did not meet the Korean RDAs. Calcium intake was especially lower than recommendations by as much as $62\%$ and $70\%$ in boys and girls, respectively. There was no significant difference in nutrient intakes between children who had colostrum and those who did not. However, children who were formula consumed significantly more animal fat than those who did not (p < 0.05). Neonatal feeding and breast or formula feeding seems to associate with height, bone mineral density and animal fat intakes in preschool children, based on the results of this study. A longitudinal study is needed to clarify this relationship.

• Preventive Nutrition and Food Science
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• 제16권2호
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• pp.110-116
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• 2011

This study examined the growth effects of yeast hydrolysate (YH) and a traditional Korean herbal mixture (HM, a mixture of safflower seed and gasiogapi extract). Three-week old male SD rats were divided into the following five groups: negative control (saline), positive control (foremilk 0.5 g/kg/day), YH (YH 0.5 g/kg/day), HM (HM 0.2 g/kg/day), and YH+HM (YH 0.5 g/kg/day and HM 0.2 g/kg/day). Tibia bone length was 9.22 mm in the normal control rats, while both the YH and YH+HM groups had significantly longer tibia bones than the control rats (9.75 mm and 10.46 mm, respectively). The proximal epiphyses of YH, HM, and YH+HM measured 0.75, 0.70, and 0.75 mm, respectively, while the length in the control group was 0.50 mm. Plasma insulin growth factor-1 (IGF-1) level was slightly higher in the YH group (1.36 mg/mL) than in the control rats (1.29 mg/mL), but the difference was not significant. Plasma IGF-1 level was significantly increased in the HM (1.49 mg/mL) and YH+HM (1.53 mg/mL) groups compared to the control group (1.29 mg/mL). Growth hormone (GH) levels in YH (17.45 ng/mL), HM (15.49 ng/mL), and YH+HM (16.07 ng/mL) were significantly different compared to the control group (3.63 ng/mL).

• 대한치과의사협회지
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• 제19권2호통권141호
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• pp.167-174
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• 1981

The purpose of this study was observing the annual growth increment in cephalogram. The cephalograms of 29 boys & 23 girls were analized by method of Downs & Steiner, range from 7 to 8 years in Korean children. the results were as follows; 1. The craniofacial complex of Korean children grew downward and fordward. 2. The pronounced linear and angular growth changes were in the upper central incisors and lower central incisors. 3. The SN Plane to Mandibular plane angle was reduced. 4. The SNA and SNB was almost constant in male.

• 대한치과의사협회지
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• 제19권7호통권146호
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• pp.615-623
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• 1981

The purpose of this study was observing the annual growth increment in Cephalogram. The Cephalograms of 28 boys & 22 girls were analized by method of Downs & Steiner, range from 7 to 9 years in Korean children. The results were as follows. 1. The change of gonial angle in both male and female is not presented in this age. 2. The most significant linear change of both male and female is the facial depth (Na-Go) and that of both male and female is the interincisal angle in this age. 3. The increment of the mandibular body length (Go-Me) and the anterior facial height (Na-Me) is presented in this age. 4. The change of SNA and SNB in both male and female is negligible is negligible in this age.

• 대한소아치과학회지
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• 제38권2호
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• pp.161-169
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• 2011

상악 치조골은 상악골의 일부로 치근을 감싸고 지자하는 역할을 하며 치아의 결손 시 지지구조물로 치료에 중요한 역할을 하게 된다. 지금까지 치조골의 성장에 관한 연구는 교정적 치료의 관점에서 이루어져 영구치 결손을 위한 치료법을 위한 자료로 사용하기에는 한계가 있다. 따라서 본 연구에서는 성장기에 있는 한국인 여학생들의 측모두부규격방사선사진들을 연도 별로 수집하여 상악 치조골의 성장 양상을 분석하였다. 한국인 여학생들의 만 8세에서 만 14세까지 2년 간격으로 측모두부규격방사선 사진, 키, 역연령을 수집하였다. 여섯 항목을 계측하여 각 항목의 평균 최소값 및 최대값을 구하고 각 예측 항목과 역연령, 키 사이의 상관관계 및 동일 항목에서 나이 군사이의 상관관계를 분석하였으며 성장량 예측을 위한 선형회귀분석을 시행하였다. 상악 치조골은 14세까지 계속 성장하였으나 성장속도는 점차 감소하여 키의 성장 양상과 차이를 보였다. 역연령 및 키와 치조골 높이 사이의 상관 계수는 차이를 보이지 않았으며, 역연령 군 사이의 상관계수는 매우 높게 나타났다. 따라서 역연령을 기초로 하는 선형회귀분석을 시행하여 14세 때의 치조골 높이 예측 공식을 작성하였다. 이러한 결과는 소아 상악 치조골의 성장 양상 이해와 성장량을 예측을 가능하게 하여 임플란트 시술과 같은 적극적 치료에 도움을 줄 수 있을 것으로 기대된다.

• Molecules and Cells
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• 제43권8호
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• pp.739-748
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• 2020

Stringent regulation of the chondrocyte cell cycle is required for endochondral bone formation. During the longitudinal growth of long bones, mesenchymal stem cells condense and differentiate into chondrocytes. Epiphyseal chondrocytes sequentially differentiate to form growth-plate cartilage, which is subsequently replaced with bone. Although the importance of nuclear factor 1C (Nfic) in hard tissue formation has been extensively studied, knowledge regarding its biological roles and molecular mechanisms in this process remains insufficient. Herein, we demonstrated that Nfic deficiency affects femoral growth-plate formation. Chondrocyte proliferation was downregulated and the number of apoptotic cell was increased in the growth plates of Nfic^-/- mice. Further, the expression of the cell cycle inhibitor p21 was upregulated in the primary chondrocytes of Nfic^-/- mice, whereas that of cyclin D1 was downregulated. Our findings suggest that Nfic may contribute to postnatal chondrocyte proliferation by inhibiting p21 expression and by increasing the stability of cyclin D1 protein.

• 동아시아식생활학회지
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• 제5권1호
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• pp.41-51
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• 1995

Bone mass accretion during puberty appears to be critical in the development of peak bone mass. Although bone density of females in Korea has been studied, only a few studies have related bone mass with anthropometric patterns or puberty in the pubescent girls. This study was conducted as part of a study of major determinants of bone development during puberty. Subjects were aged 14∼16 yr(mean 14.97), and had no history of disorders or dedication use likely to influence bone or calcium metabolism. Bone mineral density and content were measured by dual energy X-ray absorptiometry using a Lunar DPX+Scanner (Lunar Madison, WI). Also, total body fat, and total lean body mass were assessed using a Lunar DPX dual-energy X-ray absorptiometer, Pubertal status was assessed according to the Marshall and Tanner guidelines. Serum levels of osteocalcin was measured by RIA using a commercial kit assay. Skinfold measurements were taken with a skinfold caliper(Lange Caliper, USA). Data were analyzed using the regression and GLM procedure of the statistical package SAS. The results indicated that the observed means for lumbar spine BMD and femoral BMD correspond to approximately 91% and 96% of the means for young adult females, respec tively. All subjects were menarchal, with the majority being in the middle to end stages of pubertal development. Total body BMD was positively related to fat mass(P<0.001), lean body mass and time since menarche, and negatively related to urine pyridinoline, serum alkaline phosphatase and osteocalcin. The data indicate that girls who reported lower age for menarche had significantly higher bone densities than girls who reported higher age for menarche. Attaining peak skeletal bone mass during puberty may reduce the incidence of osteoporosis in later life. this finding suggests that early menarche may augment peak bone mass, influencing the extent of bone loss later in adulthood. The results suggest that good nutrition in childhood appears to be needed not for growth and development, but possibly also to assure an optimal peak of bone mass and thus greater latitude for the maintenance or skeletal integrity in the face of bone losses. Troeps skinfold thickness was a better predictor of total BMD and total BMC than was any other skinfold thickness. The study did not find a relationship between total BMD and body fat %, but total fat was significantly positively related to total BMD(r=0.49) and total BMC(r=0.60). It supports earlier report that there was a significant correlation between TBMD and body weight. Conclusively, total fat, lean body mass and pubertal development could influence BMD in pubescent girls. Clearly, longitudinal studies are required to assess the effect of puberty on peak bone mass, and to define further the potential determinants of peak bone mass.

• 대한치과교정학회지
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• 제30권6호
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• pp.699-712
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• 2000

림프조직은 비인두 부위에서 Waldeyer's ring의 일부조직으로 tonsil을 이루며 정상적으로 존재한다. 이러한 림프조직이 임상적인 증상을 나타낼 정도로 과증식한 것을 'Adenoid vegetation or Adenoids'라고 이른다. 아데노이드는 일반적으로 유년기에 발생하며 $2\~12$세때 특징적인 증상을 보인다. 사춘기시기에 이르면 절대적인 아데노이드 크기 감소와 주변의 비인두의 성장으로 인한 상대적 크기 감소가 나타난다. 그리하여 성인이 되면 아데노이드는 퇴화된 상태로 변하게 된다. 아데노이드는 구호흡의 주요한 원인 중 하나이며, '아데노이드 얼굴'이라는 특징적인 안면형태를 야기한다고 알려져 있다. 아데노이드에 의한 구호흡이 안면 형태와 치열에 영향을 미칠 수 있다는 주장은 오래 전부터 제기되고 있으나, 여러 가지 복합적인 원인으로 이들간의 상호연관정도를 정확히 알기가 어려웠다. 이에 본 연구에서는 정상 교합 아동에서의 골 연령에 따라 아데노이드와 악골 크기의 정상치와 성장변화량을 제시하고 이들간의 상관관계를 알아보았으며 다음과 같은 결과를 얻었다. 1. 골 연령에 따른 남녀별 계측항목의 평균과 표준편차를 얻었다. 2. 같은 골연령을 비교시 남자는 여자보다 약 2년 가량 성장속도가 느렸다. 3. 비인두의 height과 depth는 남자에서는 CVMI 1과 2 때 많은 성장을 보이고, CVMI 4 이후에서는 성장을 보이지 않았으며, 여자에서는 모든 골 연령에서 유사한 정도의 성장이 나타났다. 4. 비인두의 상대적 면적은 남자에서 CVMI 1에서 2로 이행되는 시기에 유의한 증가를 보였다. 5. 비기도의 상대적 면적과의 상관분석에서 남녀 모두에서 아데노이드 항목중에서는 Ad2와 관련된 항목과 uppe pharynx가 높은 상관관계를 보였으며, 치열궁과 관련된 항목중에는 상$\cdot$하악의 견치간 너비, 상악의 대구치간 너비, 구개정 높이가 상관관계가 있었다.

• Journal of Korean Neurosurgical Society
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• 제49권1호
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• pp.8-12
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• 2011

Objective: Ossification of the posterior longitudinal ligament (OPLL) has a strong genetic component. Specific gene polymorphisms may be associated with OPLL in several genes which regulate calcification in chondrocytes, change of extracellular collagen matrix and secretions of many growth factors and cytokines controlling bone morphogenesis. Toll-like receptor 5 (TLR5) may playa role in the pathogenesis of OPLL by intermediate nuclear factor-kappa B (NF-${\kappa}B$). The current study focused on coding single nucleotide polymorphisms (SNPs) of TLR5 for a case-control study investigating the relationship between TLR5 and OPLL in a Korean population. Methods: A total of 166 patients with OPLL and 231 controls were recruited for a case-control association study investigating the relationship between SNPs of TLR5 gene and OPLL. Four SNPs were genotyped by direct sequencing (rs5744168, rs5744169, rs2072493, and rs5744174). SNP data were analyzed using the SNPStats, SNPAnalyzer, Haploview, and Helixtree programs. Multiple logistic regression analysis with adjustment for age and gender was performed to calculate an odds ratio (OR). Results: None of SNPs were associated with OPLL in three alternative models (codominant, dominant, and recessive models; p> 0.05). A strong linkage disequilibrium block, including all 4 SNPs, was constructed using the Gabriel method. No haplotype was significantly associated with OPLL in three alternative models. Conclusion: These results suggest that Toll-like receptor 5 gene may not be associated with ossification of the posterior longitudinal ligament risk in Korean population.

• 한국식품영양과학회지
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• 제37권12호
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• pp.1576-1582
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• 2008

기존 칼슘보충용식품의 성장촉진효능을 증진시키기 위하여 칼슘흡수 관여 물질인 $\gamma$-PGA를 다량 생산하는 Bacillus subtilis SE4 균주를 선발하였다. 선발된 B. subtilis SE4의 발효대사물을 기존 칼슘보충용식품에 첨가하여 성장기 수컷 흰쥐에 28일간 경구투여 한 결과 발효대사물이 첨가된 신규칼슘보충용식품군에서 혈청 내 IGF-I 함량이 대조군이나 기존칼슘보충용식품군에 비해 유의적으로 높게 나타났다(p<0.05). 일일증체량, 일일사료섭취량, 장골길이, 장골 무게, 장골폭 등의 성장관련 지표에서도 장골의 길이와 일부 부위별 두께에서의 유의적 결과를 포함하여 전반적으로 신규칼슘보충용식품군이 대조군과 기존칼슘보충용식품군에 비해 양호한 성적을 나타내었다. 이러한 결과는 기존칼슘 보충용 식품에 발효대사물을 첨가함으로써 나타난 칼슘의 생체흡수율 증대 및 성장호르몬의 분비활성화 등 여러 성장 관련요인들이 흰쥐 성장에 긍정적으로 작용한 때문으로 생각되어진다.