• Toxicological Research
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• 제35권2호
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• pp.119-129
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• 2019

As the use of cosmetics has greatly increased in a daily life, safety issues with cosmetic ingredients have drawn an attention. Drometrizole [2-(2'-hydroxy-5'-methylphenyl)benzotriazole] is categorized as a sunscreen ingredient and is used in cosmetics and non-cosmetics as a UV light absorber. No significant toxicity has been observed in acute oral, inhalation, or dermal toxicity studies. In a 13-week oral toxicity study in beagle dogs, No observed adverse effect level (NOAEL) was determined as 31.75 mg/kg bw/day in males and 34.6 mg/kg bw/day in females, based on increased serum alanine aminotransferase activity. Although drometrizole was negative for skin sensitization in two Magnusson-Kligman maximization tests in guinea pigs, there were two case reports of consumers presenting with allergic contact dermatitis. Drometrizole showed no teratogenicity in reproductive and developmental toxicity studies in which rats and mice were treated for 6 to 15 days of the gestation period. Ames tests showed that drometrizole was not mutagenic. A long-term carcinogenicity study using mice and rats showed no significant carcinogenic effect. A nail product containing 0.03% drometrizole was nonirritating, non-sensitizing and non-photosensitizing in a test with 147 human subjects. For risk assessment, the NOAEL chosen was 31.75 mg/kg bw/day in a 13-week oral toxicity study. Systemic exposure dosages were 0.27228 mg/kg bw/day and 1.90598 mg/kg bw/day for 1% and 7% drometrizole in cosmetics, respectively. Risk characterization studies demonstrated that when cosmetic products contain 1.0% of drometrizole, the margin of safety was greater than 100. Based on the risk assessment data, the MFDS revised the regulatory concentration of drometrizole from 7% to 1% in 2015. Under current regulation, drometrizole is considered to be safe for use in cosmetics. If new toxicological data are obtained in the future, the risk assessment should be carried out to update the appropriate guidelines.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2010년도 춘계학술대회
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• pp.371-392
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• 2010

Since the 21st century, to the worldwide computer, broadcasting, communications and other technologies have be developed. because of the Internet allows real-time information delivery, Information Society that was done quickly. In this study, using information technology, Active measures to enable e-commerce in agriculture is discussed. agricultural e-commerce to the consumer satisfaction surveys were conducted, too. In addition to, as a e-commerce features, informance, convenience, interface presented. After research results, I think information, convenience, interface is important to consumers. Consumers will be spent on activities having a new value. To respond to these consumers, Companies must evaluate the internal capabilities. and outside the assessment continuously. E-commerce will give an effective way to companies. And e-commerce will develop further in the future. Therefore, e-commerce will be done by the long-term plan.

• 한국안전학회지
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• 제25권6호
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• pp.155-160
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• 2010

In this study, detailed assessment for durability performance were performed on the chloride protected concrete structures to investigate the effectiveness of chloride protection. And economical efficiency for the chloride protected concrete structures were studied by LCC(Life Cycle Cost) analysis. In the comparison result of the first section repair time, it was found that the chloride protected concrete structures was economical better than the non-protected concrete structures in the long term. According to the analysis result of the accumulated chloride concentration by used time and chloride ion concentration by depth, it can be seen that the permeation through time from chloride has increased two times in the chloride protected concrete structures.

• 한국가스학회지
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• 제7권2호
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• pp.1-6
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• 2003

본 연구에서는 이미 개발되어 있는 부식결함의 잔존강도를 평가식을 이용하여 파단, 대누출, 소누출의 손상모드 예측하는 절차를 제시하였다. 또한 이 손상모드에 따라 손상확률을 예측할 수 있는 방법을 제시하고 여기에 부식속도 정보를 결합하면 일정기간 경과 후 손상확률도 예측할 수 있음을 보였다. 이 결과는 노후배관의 수명 또는 교체주기의 예측에 매우 유용하게 활용될 수 있을 것이라 판단된다.

• International journal of advanced smart convergence
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• 제10권3호
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• pp.245-256
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• 2021

This study is significant in determining the reduction of safety accidents by applying PDCA's theory by subdividing it into a case analysis technique for construction sites by PDCA's theory. For this study, accidents accounted for the largest proportion of each type of disaster in the construction site were considered, and safety accidents were reduced through the PDCA theory through prior research. The analysis method of this study derived improvement plans by applying PDCA techniques to plan, implement, confirm, review, and improve disaster accidents at construction sites. The conclusions of this study are as follows. In the plan, first of all, measures shall be taken to prepare a safety management plan, to verify the implementation of the plan, and to verify the degree of implementation by the field manager. In the implementation, first of all, it is necessary to introduce a safety education history system to strengthen the safety education curriculum to suit the site, as long-term work is impossible for field workers depending on field conditions. First of all, it is necessary to strengthen the installation of safety facilities, including "work scaffolding" and "conducting prevention facilities" at construction sites. In management review and improvement, the risk assessment system for construction sites needs to be expanded first°.

• 환경영향평가
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• 제19권2호
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• pp.169-177
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• 2010

One of the most obvious climatic manifestations of urbanization in Korea is a trend towards higher air temperature. The trends of long-term annual temperature generally well describe the warming of urban areas. The increase of air temperature in urban area has been observed to the present since the meteorological observations in Korea began. The objective of this study is to explore the actual increase and the regional long-term trends of air temperature attributed to urbanization in the Korean Peninsula. Therefore, temperatures of the selected urban areas were compared with that of the surrounding rural areas, with the results varying by the application of the estimates of each region. The second objective is to separate the long-term trend of surface air temperature of global warming from urbanization and to find the actual temperature increase from urbanization in Korean peninsula. For the data analysis, daily air temperatures observed by the Korea Meteorological Administration (KMA) during between from 1961 and 2005 were used at five rural sites and cities. The re-analyzed surface air temperatures by the National Centers for Environmental Prediction (NCEP) was also carried out to compare the result from the observed air temperature in the Korean climate domain. In this study, the urban areas in Korea showed high increase rate of air temperature with $0.4^{\circ}C$ per decade during past 50 year period, while rural sites as Chupungryung with the $0.2^{\circ}C$ decadal increase rate. The analyses reflect that the urban area shows the high rate of temperature increase with $1.39^{\circ}C$ of regression value at the urban area, Seoul, and $0.43^{\circ}C$ at the rural site, Chupungnyeong during the period of 30 years. The temperature increas due to the urbanization only showed the increase range between $0.44^{\circ}C$ and $0.86^{\circ}C$, and the observed decrease in diurnal temperature range at five urban areas during the 30 years period.

• 터널과지하공간
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• 제33권4호
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• pp.228-243
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• 2023

벤토나이트는 팽윤 능력과 낮은 투수율 등의 유리한 특성으로 인해 고준위방폐물처분장에서 완충재로 널리 인정받고 활용되고 있으며, 낮은 투수율로 인해 방사성 핵종이 주변 암반으로 이동하는 것을 효과적으로 방지하여 방사성 폐기물의 안전한 처분을 보장하는 데 중요한 역할을 한다. 그러나 벤토나이트 완충재의 장기적인 성능은 여전히 지속적인 연구의 대상으로 남아 있으며, 주요 우려 사항 중 하나는 벤토나이트의 팽윤과 지하수 흐름에 의한 완충재의 침식이다. 벤토나이트 완충재의 침식은 완충재의 무결성을 손상시키고 지하수를 통한 방사성 핵종의 이동을 촉진할 수 있는 콜로이드 형성을 초래하여, 결과적으로 방사성 핵종 이동 위험을 높임으로써 처분장 안전에 중대한 영향을 미칠 수 있다. 따라서 벤토나이트 완충재의 침식 메커니즘과 침식 정도를 수치 해석적으로 정량화하여 장기적인 벤토나이트 완충재의 성능 및 콜로이드 형성 정도를 평가하는 것이 고준위방폐물처분장의 안전성 평가에 매우 중요하다. 본 기술 보고에서는 동적 벤토나이트 확산 모델을 기반으로 거동이 유사한 영역을 두 개로 분류하여 벤토나이트의 균열 침투 및 콜로이드 형성을 모사할 수 있도록 제안된 모델인 Two-region 모델을 소개하였으며, 이 모델을 이용해 벤토나이트 완충재 침식 정도를 정량적으로 평가하였다.

• 한국전산구조공학회논문집
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• 제27권5호
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• pp.385-392
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• 2014

면진장치는 지진력을 감소시키기 위하여 사용되어왔다. 원자력발전소에 면진장치가 적용된다면, 운영기간동안 구조물과 기기들은 동일한 내구성 및 성능이 확보되어야 한다. 본 연구에서는 면진된 원전의 지진에 대한 안전성을 확보하기 위하여 면진구조물의 장기거동을 해석적으로 분석하였다. 경년열화에 의한 면진장치 특성을 분석하였고, 다른 온도환경에서 면진장치의 경년열화에 의한 구조물의 지진응답을 분석하였다. 해석결과에 의하면 면진장치의 경년열화에 의하여 면진구조물의 고유진동수는 증가하였다. 그러나 면진 구조물의 최대가속도와 최대변위는 온도에 따라 크게 변하지 않았다. 면진장치의 열화에 의하여 구조물의 손상은 발생하지 않았지만 목표진동수 영역에서 스펙트럼가속도는 온도에 따라 증가하였다. 따라서 면진구조물에서 면진장치는 온도에 따른 지진응답의 증가를 고려하여 설치 및 제작해야 할 것으로 판단된다.

• Safety and Health at Work
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• 제2권1호
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• pp.39-51
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• 2011

Objectives: This study was designed to evaluate exposure levels of various chemicals used in wafer fabrication product lines in the semiconductor industry where work-related leukemia has occurred. Methods: The research focused on 9 representative wafer fabrication bays among a total of 25 bays in a semiconductor product line. We monitored the chemical substances categorized as human carcinogens with respect to leukemia as well as harmful chemicals used in the bays and substances with hematologic and reproductive toxicities to evaluate the overall health effect for semiconductor industry workers. With respect to monitoring, active and passive sampling techniques were introduced. Eight-hour long-term and 15-minute short-term sampling was conducted for the area as well as on personal samples. Results: The results of the measurements for each substance showed that benzene, toluene, xylene, n-butyl acetate, 2-methoxy-ethanol, 2-heptanone, ethylene glycol, sulfuric acid, and phosphoric acid were non-detectable (ND) in all samples. Arsine was either "ND" or it existed only in trace form in the bay air. The maximum exposure concentration of fluorides was approximately 0.17% of the Korea occupational exposure limits, with hydrofluoric acid at about 0.2%, hydrochloric acid 0.06%, nitric acid 0.05%, isopropyl alcohol 0.4%, and phosphine at about 2%. The maximum exposure concentration of propylene glycol monomethyl ether acetate (PGMEA) was 0.0870 ppm, representing only 0.1% or less than the American Industrial Hygiene Association recommended standard (100 ppm). Conclusion: Benzene, a known human carcinogen for leukemia, and arsine, a hematologic toxin, were not detected in wafer fabrication sites in this study. Among reproductive toxic substances, n-butyl acetate was not detected, but fluorides and PGMEA existed in small amounts in the air. This investigation was focused on the air-borne chemical concentrations only in regular working conditions. Unconditional exposures during spills and/or maintenance tasks and by-product chemicals were not included. Supplementary studies might be required.

• 대한조선학회논문집
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• 제30권4호
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• pp.74-82
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• 1993

본고에서는 type B 독립구형 방식 LNG 탱크의 피로균열 발생 및 진전에 대한 구조안전성 평가 기법을 연구하였다. 이는 다음과 같은 3단계의 검토과정으로 구성된다. 1) 탱크에 작용하는 파랑응력의 장기분포 평가 및 피로균열 발생수명해석 과정은 이미 제1보에서 상세히 다룬 바 있으며 2) 초기 결함이 탱크판을 관통할 수 없음을 표면균열 진전해석을 통하여 증명한다. 3) LBF(Leak Before Failure) 이론을 바탕으로 관통균열의 진전해석을 수행하여 급속 취성파괴에 대한 안전성을 검증한다.