• 한국응용곤충학회지
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• 제47권4호
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• pp.407-411
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• 2008

봄 배추 생육초기에 복숭아혹진딧물의 접종밀도에 따른 진딧물의 밀도 증가가 배추의 수량에 미치는 영향을 조사하여 경제적 피해수준과 요방제 수준을 설정하고자 하였다. 복숭아혹진딧물을 배추정식 후 10일에 포기당 2, 5, 10, 15 및 20마리 접종한 경우 접종 후 18일의 복숭아혹진딧물의 밀도는 각각 92.3, 177.4, 406.9, 440.4, 471.3마리로 증가하였으며, 배추의 생체중은 복숭아혹진딧물의 무처리, 2, 5, 10, 15 및 20마리 접종구에서 각각 602.0, 264.2, 262.0, 109.3, 151.0, 67.3 g으로 접종밀도가 높을수록 배추의 생체중은 현저하게 감소하였다. 복숭아혹진딧물의 발생밀도와 배추의 생체중과의 관계를 구명하기 위하여 진딧물의 누적발생일수(cumulative aphid days)와 배추 생체중과의 관계식을 구한 결과 비선형의 대수모형에 잘 적용되었다. 이 관계식에서 경험적인 수익한계(gain threshold) 5%와 봄 배추 상품율(92%)을 감안하여 복숭아혹진딧물 5마리가 5일 동안 흡즙하여 13%의 수량감소를 유발시킨 경제적 피해수준을 추정한 결과 CAD 값이 25가 되었다. 또한 요방제밀도는 경제적 피해수준의 80%가 되는 CAD 값이 20으로 추정되었다. 따라서 본 결과는 봄 배추 생육초기에 복숭아혹진딧물의 요방제 밀도 설정에 유용하게 활용될 수 있을 것으로 여겨진다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권11호
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• pp.4637-4642
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• 2014

Background: Hypoxia-inducible factor $1{\alpha}$ (HIF-$1{\alpha}$) plays an important role in regulating cell survival and angiogenesis, which are critical for tumor growth and metastasis. Genetic variations of HIF1A have been shown to influence the susceptibility to many kinds of human tumors. Increased expression of HIF-$1{\alpha}$ has also been demonstrated to be involved in tumor progression. However, the prognostic value of single nucleotide polymorphisms (SNPs) inthe HIF1A gene remains to be determined in most cancer types, including colorectal cancer (CRC). In this study, we sought to investigate the predictive role of HIF1A SNPs in prognosis of CRC patients and efficacy of chemotherapy. Materials and Methods: We genotyped two functional SNPs in HIF1A gene using the Sequenom iPLEX genotyping system and then assessed their associations with clinicopathological parameters and clinical outcomes of 697 CRC patients receiving radical surgery using Cox logistic regression model and Kaplan Meier curves. Results: Generally, no significant association was found between these 2 SNPs and clinical outcomes of CRC. In stratified analysis of subgroup without adjuvant chemotherapy, patients carrying CT/TT genotypes of rs2057482 exhibited a borderline significant association with better overall survival when compared with those carrying CC genotype [Hazard ratio (HR), 0.47; 95% confidence interval (95% CI): 0.29-0.76; P < 0.01]. Moreover, significant protective effects on CRC outcomes conferred by adjuvant chemotherapy were exclusively observed in patients carrying CC genotype of rs2057482 and in those carrying AC/CC genotype of rs2301113. Conclusions: Genetic variations in HIF1A gene may modulate the efficacy of adjuvant chemotherapy after surgery in CRC patients.

• 수면정신생리
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• 제21권2호
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• pp.61-68
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• 2014

목 적 : 본 연구에서는 한국의 청소년을 대상으로 자살사고 고위험군의 비율과 청소년에서 자살사고와 관련된 예측인자에 대해서 조사해 보았다. 방 법 : 일 도시지역 중고등학생 3,691명(남자 2,159명, 여자 1,532명, 평균연령 $15.31{\pm}1.46$)을 대상으로 하였다. 대상자들은 사회인구학적 정보를 비롯한 학급성적, 신체적 혹은 정신 질환유무, 평일 평균수면시간, 평일과 주말 사교육시간, 주관적인 상담의 필요성, Beck 우울척도(Beck depression inventory, 이하 BDI), Reynolds 자살생각척도(Reynolds' suicide ideation questionnaire, 이하 SIQ)에 대한 자가보고식 설문지를 작성하였다. 결 과 : 전체 대상자 중 168명(4.6%)이 SIQ 62점 이상의 자살사고 고위험군으로 분류되었다. 다중로지스틱 회귀분석에서는 여성(p = 0.002), 더 어린나이(p < 0.001), 낮은 학교성적(p = 0.043), 높은 BDI 척도 점수(p < 0.001)가 자살사고 고위험군의 예측인자로 나타났다. 자살사고 고위험군에서는, 더 어린나이(p = 0.045)와 높은 BDI 점수(p < 0.001)가 높은 SIQ 점수와 연관된 것으로 나타났다. 결 론 : 본 연구 결과는 여성, 어린나이, 낮은 학교성적, 우울감이 청소년 자살사고의 고위험군의 예측인자였고, 특히 자살사고 고위험군 중에서는 어린나이와 우울감이 심한 청소년들에게 더 많은 관심을 기울여야함을 보여주었다. 따라서 청소년 자살을 예방하기 위해서는, 이러한 위험요인을 가지고 있는 청소년들에 대해 적극적인 관심과 개입이 필요할 것으로 생각된다.

• 한국환경보건학회지
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• 제41권5호
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• pp.335-348
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• 2015

Objectives: We aimed to assess the risk of metabolic syndrome one year after the 2007 Hebei Spirit oil spill in Taean, Korea among people exposed to spilt oil during clean-up work. Methods: A total of 6,923 adults, including 3,019 males and 3,904 females, participated in the study. Health examinations and blood tests (total cholesterol, triglycerides, HDL, fasting blood sugar) were performed. A logistic regression model adjusting for age, gender, smoking history, drinking history, income, education, and marital status was used to estimate the risk of metabolic syndrome associated with the level of oil spill exposure. Results: The prevalence of metabolic syndrome was 24.9% among males and 18% among females. Compared with people living within 20 km of the coastline, the risk of metabolic syndrome among people living within 0.8 km of the coastline was significantly higher (male OR=1.696, 95% CI=1.320-2.178, female OR=1.992, 95% CI=1.549-2.561), including a significant dose-response relationship for distance from early contaminate coastline (p<0.001). The risk of metabolic syndrome was higher according to the increase of duration of cleaning work. The risk of metabolic syndrome among people who participated in the clean-up work for more than 116 days, compared with people who participated in the cleaning work for or less 14 days, was significantly higher (male OR=1.845, 95% CI=1.448-2.353, female OR=1.752, CI=1.378-2.228), with a significant dose-response relationship for days of clean-up work (p<0.001). Conclusion: This study showed that there is a significant association between exposure to the oil spill during the clean-up work, distance from early contaminate coastline and the risk of metabolic syndrome in a doseresponse manner.

• 한국산업보건학회지
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• 제25권3호
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• pp.405-417
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• 2015

Objectives: The aim of this study is to evaluate the association between physical factors, working conditions and occupational injuries among Korean workers. Methods: We used data from the 2nd Korean Working Conditions Survey, conducted in 2010. A total of 7,114 workers over 15 years of age were selected from among 10,019 Korean workers. The participants were interviewed using questionnaires. A multiple logistic regression model was used to analyze the associations among physical factors, working conditions and occupational injuries. Results: After the adjustment of socio-demographic factors, the odds ratio of injuries through physical factors such as vibration (adjusted Odds Ratio [aOR] 4.037, 95% CI 2.30-7.09), noise (aOR 4.562, 95% CI 2.64-7.89), high temperature (aOR 3.262, 95% CI 1.86-5.73), and low temperature (aOR 3.358, 95% CI 1.76-6.41) were greater in the exposed group than in the non-exposed group. The odds ratios of occupational injury(aOR 5.272, 95% CI 3.19-8.7 for very high speed work, aOR 3.303, 95% CI 1.95-5.60 for tight deadlines, and aOR 3.641, 95% CI 1.72-7.70 for not enough time to work) increased with increased work demands. Conclusions: In this study, physical factors such as vibration, noise, and high and low temperatures were significantly correlated with occupational injuries according to the increase in exposure intensity(p for trend <0.001). Also, working conditions such as high-speed work, tight deadlines and insufficient time to work showed significant associations with occupational injuries(p for trend<0.001).

• Journal of Gastric Cancer
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• 제13권4호
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• pp.214-225
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• 2013

Purpose: Peritoneal lavage cytology is part of the routine staging workup for patients with advanced gastric cancer. However, no quality assurance study has been conducted to show variations or biases in peritoneal lavage cytology results. The aim of this study was to demonstrate a test execution variation in peritoneal lavage cytology between investigating surgeons. Materials and Methods: A prospective cohort study was designed for determination of the positive rate of peritoneal lavage cytology using a liquid-based preparation method in patients with potentially curable advanced gastric cancer (cT2~4/N0~2/M0). One hundred thirty patients were enrolled and underwent laparotomy, peritoneal lavage cytology, and standard gastrectomy, which were performed by 3 investigating surgeons. Data were analyzed using the chi-square test and a logistic regression model. Results: The overall positive peritoneal cytology rate was 10.0%. Subgroup positive rates were 5.3% in pT1 cancer, 2.0% in pT2/3 cancer, 11.1% in pT4a cancer, and 71.4% in pT4b cancer. In univariate analysis, positive peritoneal cytology showed significant correlation with pT stage, lymphatic invasion, vascular invasion, ascites, and the investigating surgeon. We found the positive rate to be 2.1% for surgeon A, 10.2% for surgeon B, and 20.6% for surgeon C (P=0.024). Multivariate analysis identified pT stage, ascites, and the investigating surgeon to be significant risk factors for positive peritoneal cytology. Conclusions: The peritoneal lavage cytology results were significantly affected by the investigating surgeon, providing strong evidence of test execution variation that could be related to poor diagnostic accuracy and stage migration in patients with advanced gastric cancer.

• Genomics & Informatics
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• 제8권4호
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• pp.206-211
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• 2010

The Fas (TNF receptor superfamily, member 6) (FAS)/FAS ligand (FASLG) interaction plays a central role in the regulation of programmed cell death. FAS and FASLG polymorphisms in promoter regions affect transcriptional activities. To investigate whether FAS and FASLG polymorphisms are associated with the development and clinical phenotypes of stroke, 2 promoter single nucleotide polymorphisms (SNPs) in FAS (rs1800682, -670C/T) and FASLG (rs763110, -844C/T) were selected and genotyped by direct sequencing in 220 stroke patients [107 ischemic stroke (IS), 77 intracerebral hemorrhage (ICH), and 36 subarachnoid hemorrhage (SAH)] and 369 control subjects. For the analysis of clinical symptoms, all stroke patients were divided into 3 clinical phenotypes according to the respective results of the National Institutes of Health Stroke Survey (NIHSS) and the Modified Barthel Index (MBI) and the presence or absence of complex regional pain syndrome (CRPS). The SNPStats, SNPAnalyzer, and Helixtree programs were used to analyze the genetic data. Multiple logistic regression models (codominant, dominant, and recessive) were used to estimate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. The promoter SNP rs1800682 was associated with stroke in the codominant (OR=0.48, 95% CI=0.25-0.94, p=0.04) and dominant models (OR=0.51, 95% CI=0.30-0.87, p=0.011). However, a FASLG SNP (rs763110) was not in Hardy-Weinberg equilibrium (p<0.05). In the analysis of stroke types, rs1800682 was associated with IS in the codominant (OR=0.30, 95% CI=0.12-0.74, p=0.025), dominant (OR=0.44, 95% CI=0.23-0.88, p=0.018), and recessive models (OR=0.45, 95% CI=0.21-0.99, p=0.042). The genotype frequencies of rs1800682 were different between ICH and controls in the dominant model (OR=0.49, 95% CI=0.26-0.94, p=0.031) but not between SAH and controls. In the analysis of clinical symptoms, however, rs1800682 was not related to the 3 clinical phenotypes (NIHSS, MBI, and CRPS). These results suggest that a promoter SNP (rs1800682, -670C/T) in FAS may be associated with the development of stroke in the Korean population.

• 한국사회복지학
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• 제64권2호
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• pp.273-298
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• 2012

본 연구는 나눔행동이 선택적으로 혹은 결합적으로 전개될 수 있다는 사실에 기반하여 나눔행동을 네 가지(비참여, 기부에만 참여, 자원봉사에만 참여, 기부와 자원봉사 모두 참여)로 세분화 한 후 다양한 형태의 나눔행동에의 영향 요인을 탐색해 보았다. 분석을 위해서는 다항로지스틱 회귀분석을 활용하였고, 자료로는 서울복지패널 1차 및 2차 자료를 활용하였다. 다양한 나눔행동에의 참여여부 및 정기적 참여를 구분하여 분석한 결과, 전반적으로 과거의 나눔경험과 종교활동은 현재의 나눔행동과 밀접한 관련성을 지니는 것으로 밝혀졌다. 인구사회학적 변수중, 성별(여성), 소득수준(+), 교육수준(+), 취업상태 등은 기부와 관련된 나눔행동과 밀접한 관련성을 지니는 것으로 나타났는데, 취업상태의 경우 미취업은 자원봉사행동과, 취업은 기부행동과 보다 큰 관련성을 지니는 것으로 나타났다. 또한 개인의 주관적 행복감 역시 기부와 자원봉사 모두에의 정기적 참여를 이끌어내는데 영향을 끼치는 것으로 나타났다. 본 연구는 지금까지 간과되어온 질문인 '누가 각기 다른 형태의 나눔행동에 참여하는가?'와 관련해서 이의 영향 요인을 종합적으로 밝히고 있다는 점에서 연구의 의미를 지닌다.

• 보건교육건강증진학회지
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• 제12권2호
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• pp.48-61
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• 1995

This study attempted to analyze the health habits affecting health status of industrial workers. Data was collected from 57 industries of 900 workers at Inchon. The research has been carried out through self-administered questionnaire and from the analysis of the health examination records and the results were as follows: 1. Among 861 respondents, men were 81.2%, women were 18.8%, 42, 6% were of the 30-40 age group, the married were 65.7%, the single were 32.5%, the high school graduates were 62.4% and 37.3% were of people who worked between 1 and 5 years. 2. As far as the seven health habits, current smokers were 54.9%, people who regularly exercise was 31.7%, 7-8 hour of sleep, on the average were 74.0%, people eating breakfast nearly every day were 8.0%, and people eating between meals almost every day were 54.2%. Heavy drinkers who drink 3-4 times or more per week were 13.2%, 1-2 times per week were 26.8% and the obese were 4.6%, 3. Health status of A and B, estimated by doctors in the health examination were 81.7% and C, D1, D2, the unhealthy were 18.3%. Men were reported more than women in unhealthy groups and the results regarding health status reflect gender, educational level and age, That is to say that, lower educational level group and over 30 years of age group perceive their health to be worse than the higher educational level and under 30 age group, And these differences were statistically significant. 4. The relationship between health habits and health status, expressed in terms of the odds ratio. Current smokers had a consistently worse health status than a nonsmokers with a 1.36 odds ratio. The workers who reported eating breakfast rarely or never were more associated with the unhealthy group than the regular breakfast eating group with a 2.48 odds ratio. One or more drink per week had a worse health status than a never or a little drinker with a 1.42 odds ratio. 5, The Health habits score and duration of work were selected as significant factors influencing health status based on logistic analysis. According to the results of this model, the odds ratio of good health status was 2.06 for good health habit score, 1.55 for population who worked seven years or more duration of work. As we have seen, good practices were found to be associated with better health and the effect of the health habits was cummulative;those who followed 6-7 health habits were in better health, even though they were older than those who failed to do so. Therefore, in order to provide the health promotion of workers it is necessary to establish a health management plan for an effective health education and health service. If we use this type of study as a prospective study design, we can get a precise basic data for health promotion and a management plan for industrial workers.

• 감성과학
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• 제23권2호
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• pp.13-22
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• 2020

본 연구는 국민건강영양조사(2017) 자료를 이용하여 의사로부터 천식 진단을 받은 대상자의 자가 건강인지도, 스트레스, 2주 연속 우울감 등의 심리적 요인과 생리적 건강지표인 혈액 검사 자료를 비교하고 관련 위험요인들을 분석하였다. 연구에 사용된 국민건강영양조사(2017) 전체 대상자 수는 8,127명이며, 그 중의 성인(19세 이상) 5,852명을 대상으로 자료를 분석하였다. 일반적 특성 중 나이에 따른 천식 발생의 위험도는 65세 이상에서 높이 나타났으며(OR=1.48), 학력(OR=1.89)과 소득(OR=2.07)이 낮을수록 천식질환 발생 위험도가 증가하는 것으로 관찰되었다. 또한, 결혼 상태에서는 유배우자 동거와 비교하면 미혼(OR=1.62)과 무 배우자(사별, 이혼; OR=2.30)에서 천식 발생확률이 증가하였으며, 천식 진단군은 활동 제한(OR=2.39)이 높은 것으로 확인되었다. 심리적 요인에 있어서는 건강이 나쁘다고 인식할수록 천식 발생 유병률이 증가하였으며(OR=3.45), 우울감을 느끼는 경우도 증가하였지만(OR=1.78), 스트레스는 천식 발생 관련 위험요인이 아닌 것으로 확인되었다. 객관적 검사자료인 생리적 지표에서는 고감도 C-반응성 단백질 수치가 증가할수록 천식 발생 위험도가 증가함이 확인되었다(OR=1.12). 따라서 자가 건강인지도 및 우울감 같은 심리적 요인과 생리적 건강지표 중 하나인 고감도 C-반응성 단백질은 성인천식 질환의 잠재적 위험요인으로 인지되며, 이를 바탕으로 성인천식 질환 관리에 있어서 일반적 특성뿐만 아니라 심리적 요인 및 생리적 건강지표를 고려한 성인건강 관련 프로그램이 필요할 것으로 생각된다.