• Journal of Dental Anesthesia and Pain Medicine
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• v.17 no.1
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• pp.29-35
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• 2017

Background: No study has compared lidocaine with articaine, each at a concentration of 4% and combined with epinephrine. The purpose of this study was to compare the effectiveness of 4% lidocaine with that of 4% articaine, with a concentration of 1:100,000 epinephrine added to each, in an inferior alveolar nerve block for surgery on impacted lower third molars. Method: This study was conducted at the Faculty of Dentistry, Mahidol University in Bangkok, Thailand. The randomized, single-blind, comparative split-mouth study was carried out in patients with symmetrically impacted lower third molars, as identified on panoramic radiographs. Each patient underwent surgery for the removal of the lower third molars by the same surgeon under local anesthesia at two separate visits, 3 weeks apart. The onset and duration of local anesthesia, intra-operative pain, surgical duration, and number of additional anesthetics administered were recorded. Results: The subjective and objective onset of action for the local anesthetics showed statistically significant differences (P < 0.05). However, the intra-operative pain, surgical duration, duration of local anesthesia, and number of additional anesthetics administered did not show statistically significant differences. Conclusion: The use of 4% articaine for the inferior alveolar nerve block was clinically more effective in the onset of subjective and objective anesthesia as compared with the use of 4% lidocaine. Based on the pain scores from the visual analogue scale, 4% lidocaine provided more analgesia during the procedure, and patients noted less intra-operative pain than with 4% articaine; however, the difference was not clinically significant.

• Journal of Dental Anesthesia and Pain Medicine
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• v.22 no.6
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• pp.419-426
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• 2022

Topical anesthetics are routinely used in dental practice for various purposes. They are usually available at higher dosages and have serious potential adverse reactions, such as seizures, anaphylaxis, and acquired methemoglobinemia. To date, the scope of application of herbal plants and their extracts, which have medicinal properties, has been elaborated in the field of dentistry. The growing interest in herbal medication can be attributed to the increased safety profile of herbal agents, in contrast to synthetic preparations that have a higher risk of systemic complications. Herbal preparations can induce topical anesthesia with minimal side effects. Recently, many studies have reported the use of topical herbal preparations. The current review aimed to evaluate data from various articles comparing the capacity of herbal topical anesthetic formulations and conventional synthetic anesthetics in reducing pain perception when used as local anesthesia before dental procedures.

• Journal of Pharmaceutical Investigation
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• v.25 no.3
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• pp.33-35
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• 1995

Microspheres containing tetracaine or bupivacaine with poly-lactic-glycolic acid were prepared with a range of compositions. Using the rat scicatic nerve model in vivo it was found that prolonged blockade for periods of 2-7 days. depending on composition variables. Polymer-local anesthetics microspheres are feasible delivery vehicle for prolonged regional nerve blockade.

• Journal of Dental Anesthesia and Pain Medicine
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• v.19 no.1
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• pp.1-10
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• 2019

Periodontal procedures require adequate anesthesia not only to ensure the patient's comfort but also to enhance the operator's performance and minimize chair time. In the maxilla, anesthesia is often achieved using highly traumatic nerve blocks, apart from multiple local infiltrations through the buccal vestibule. In recent years, anterior middle superior alveolar (AMSA) field block has been claimed to be a less traumatic alternative to several of these conventional injections, and it has many other advantages. This critical review of the existing literature aimed to discuss the rationale, mechanism, effectiveness, extent, and duration of AMSA injections for periodontal surgical and non-surgical procedures in the maxilla. It also focused on future prospects, particularly in relation to computer-controlled local anesthetic delivery systems, which aim to achieve the goal of pain-free anesthesia. A literature search of different databases was performed to retrieve relevant articles related to AMSA injections. After analyzing the existing data, it can be concluded that this anesthetic technique may be used as a predictable method of effective palatal anesthesia with adequate duration for different periodontal procedures. It has additional advantages of being less traumatic, requiring lesser amounts of local anesthetics and vasoconstrictors, as well as achieving good hemostasis. However, its effect on the buccal periodontium appears highly unpredictable.

• Journal of Korean Academy of Nursing
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• v.5 no.1
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• pp.87-92
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• 1975

This study was performed from July to December 1974 to investigate the rates of contamination of distilled water for injection and local anesthetics. 222 vials were sampled from 7 different places of St. Mary's Hospital The samples were cultured for isolation of microorganisms. The results were as follows; 1. Of 222 vials, 11 were Contaminated by 6 types: Staphylococcus epidermis, Bacillus subtilis, Mima polymorph a, Alcaligenes faecalis, Herellea vaginicala and pepto- streptococcus. 2. 5(9.1 %) of 55 vials from surgical wards, 2 (4.2 %) of 48 vials from surgical OPD, and 4 (12,l %) of 33 vials from pediatric wards were contaminated 3. Between rates of contamination of distilled water for injection and local anesthetics and the number of punctures, there was no significant relationship. (CR=1.42 P〉0.1) 4. There was no significant relationship (CR=1.02 P〉0.1) between the rates of contamination of vials and the duration of the first and the last punctures. 5. The ratios of contamination between 75% alcohol and 2% phenol used for disinfection of rubber lids of vials did not show significant difference.

• Journal of the korean academy of Pediatric Dentistry
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• v.23 no.3
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• pp.609-614
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• 1996

Laser is getting more attention from increasing numbers of dental clinicians by its own several unique characteristics : precision, hemostasis, and bactericidal capacity. It also provides patients with several advantages of minimal tissue damage. faster healing with less postoperative pain and minimal use of local anesthetics. Labial or lingual frenectomies were performed successfully in three pediatric patients using Nd-YAG laser. When compared to the conventional scalpel method, less local anesthetics were needed and the bleeding control was so excellent that any suture was not necessary. The operation sites were completely healed without any infection or complication and discomfort from swelling or pain was not noted in all cases throughout the healing process.

• Proceedings of the KACD Conference
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• 2003.11a
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• pp.596-596
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• 2003

The purpose of this study were to evaluate the effect of epinephrine-containing local anesthetics on pulpal blood flow (PBF) and to compare the change of pulpal blood flow after cavity preparation between in non-anesthetized teeth and in anesthetized ones in cats. Nine cats were initially anesthetized with intra-muscular injection of keramine(75mg/kg) and acepromazine(2.5mg/kg). Periapical radiographs of canine teeth were taken, followed by intra-venous injection of alpha-chloralose(40mg/kg) and urethane (500mg/kg) through the femoral vein for the general anesthesia.(중략)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.410.1-410.1
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• 2002

Local anesthetics are used to reduce pain. but they are so frequently injected to patients. So we prepared lidocaine solid lipid nanopaticles for long acting subcutaneous injection to decrease the number of times of injection. Solid lipid nanoparticles were prepared by spray drying method. First. drug. lipid. plasticizer and surfactant were dissolved in methylene chloride. and we operated spray dryer using this solution at setting value. (omitted)

• Journal of the korean academy of Pediatric Dentistry
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• v.29 no.1
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• pp.69-75
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• 2002

A number of techniques may be employed to reduce the discomfort of syringe or needle for dental care. The use of topical anesthesia is one such method. Topical anesthetics are applied to alleviate pain during many clinical procedures, such as injection of local infiltration anesthetics, primary tooth extraction, X-ray taking of sensitive patients, reducing gag reflex prior to impression taking. In children, placement of a rubber dam clamp, however, may cause significant discomfort for purpose of pit and fissure sealant and preventive resin restoration(PRR). A topical anesthetic would be beneficial to aid in rubber dam placement for this purpose. It has been suggested that all intra-oral topical anesthetics are equally effective on reflected mucosa, however EMLA(an acronym for eutectic mixture of local anesthetics), which was developed in the 1980s and produces surface anesthesia of skin, has been shown to be more effective than conventional topical anesthetics when used on attached gingivae. This report is topical anesthesized 4 case by EMLA cream, who showed better effect in reducing the pain of infiltration anesthesia, extraction of deciduous teeth, rubber dam clamp placement and reducing the pain of preformed crown adaptation.

• The Korean Journal of Pain
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• v.8 no.2
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• pp.266-271
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• 1995

Recently, continuous epidural infusion of narcotics and local anesthetics have been used for postoperative pain relief. This study was designed to compare the analgesic efficacy and side effects of continuous epidural infusion of narcotics and local anesthetics with those of intramuscular administration of meperidine, for postoperative pain relief after cesarean section. Forty patients were divided into 2 groups of 20 patients each ; Continuous epidural group and control (IM meperidine) group. Before each operation, the epidural group had an epidural catheter placed (L1-2) and following each operation, a bolus of 1%~8ml of lidocaine was injected, followed by continuous infusion of morphine 3 mg/day, fentanyl 300g, 2% mepivacaine 20 ml, 0.5% bupivacaine 20 ml and normal saline 40 ml. The control group received meperidine 50mg IM injection as needed. We evaluated analgesic efficacy with VAS (Visual analogue scale) and side effect at 1, 6, 12, 24, 36 and 48 hour intervals after the operation. The results were as follows: 1) Continuous epidural group was superior to the control group with respect to postoperative analgesia. 2) Side effects (pruritus, nausea & vomiting) were more frequent in the epidural group.