• The Korean Journal of Physiology and Pharmacology
• /
• 제20권1호
• /
• pp.111-117
• /
• 2016

Vagal nerve activity has been known to play a crucial role in the induction and maintenance of atrial fibrillation (AF). However, it is unclear how the distribution and concentration of local acetylcholine (ACh) promotes AF. In this study, we investigated the effect of the spatial distribution and concentration of ACh on fibrillation patterns in an in silico human atrial model. A human atrial action potential model with an ACh-dependent $K^+$ current ($I_{KAch}$) was used to examine the effect of vagal activation. A simulation of cardiac wave dynamics was performed in a realistic 3D model of the atrium. A model of the ganglionated plexus (GP) and nerve was developed based on the "octopus hypothesis". The pattern of cardiac wave dynamics was examined by applying vagal activation to the GP areas or randomly. AF inducibility in the octopus hypothesis-based GP and nerve model was tested. The effect of the ACh concentration level was also examined. In the single cell simulation, an increase in the ACh concentration shortened $APD_{90}$ and increased the maximal slope of the restitution curve. In the 3D simulation, a random distribution of vagal activation promoted wavebreaks while ACh secretion limited to the GP areas did not induce a noticeable change in wave dynamics. The octopus hypothesis-based model of the GP and nerve exhibited AF inducibility at higher ACh concentrations. In conclusion, a 3D in silico model of the GP and parasympathetic nerve based on the octopus model exhibited higher AF inducibility with higher ACh concentrations.

• 농촌계획
• /
• 제18권3호
• /
• pp.1-11
• /
• 2012

This study postulates a study model to examine the effect on the local economy revitalization of a selection of local resources, the local innovation capability strengthening, the establishment of promotion system and the creation of revenues for the participant groups of the local industry promotion project. To accomplish study purposes, 169 response samples from 85 project groups which drive the local industry promotion project were verified using SPSS 12.0 and AMOS 5.0. The results showed that firstly, the selection of local resources had a significant effect on the local innovation capability strengthening. Secondly, the local innovation capability strengthening had a significant effect on the establishment of promotion system. Thirdly, the establishment of promotion system had a significant effect on the creation of revenues. Fourthly, the selection of local resources didn't have an effect on the revitalization of local economy. Fifthly, both the local innovation capability strengthening and the establishment of promotion system didn't have an effect on the revitalization of local economy. Sixthly, the creation of revenues had a significant effect on the revitalization of local economy. According to the verifications of study model, the revitalization of local economy is achieved by inducing creation of revenues through the local innovation capability strengthening and the establishment of promotion system after the selection of local resources. From these results, this study presents suggestions, limits of study and directions in the future study.

• 한국조경학회지
• /
• 제44권6호
• /
• pp.107-119
• /
• 2016

국내 관광지는 현재 230개소가 관광진흥법에 따라 지정, 조성, 운영되고 있으며, 선행연구 결과에 따르면 이중 30% 이상이 정체 쇠퇴단계에 이르고 있는 것으로 분석되었다. 이는 관광지를 운영, 관리하고 있는 지방자치단체에 부담으로 작용하고 있으며, 이에 대한 해결방안 모색이 필요한 실정이다. 이에 본 연구에서는 국내 정체 쇠퇴하고 있는 관광지에 대한 문제를 해결하고 합리적이고 지속가능한 관광지 재생을 위해 정체 쇠퇴 관광지 재생 활성화 요소에 대한 연구를 진행하였다. 본 연구는 선행연구에서 제시하고 있는 국내 정체 쇠퇴 관광지의 정체 쇠퇴 원인을 기준으로 전문가 설문조사를 실시하였으며, 설문 결과를 토대로 델파이 조사 분석 기법과 계층적 의사결정기법을 통해 정체 쇠퇴 관광지 재생 활성화 요소를 도출하였다. 관광지 재생의 합리적 사업 진행을 위해 도출된 정체 쇠퇴 관광지 재생 활성화 요소의 우선순위와 가중치를 분석하였다. 분석 결과, 정체 쇠퇴 관광지 재생 활성화 요소로 상위 속성 7개와 하위 속성 23개, 세부요소 66개가 도출되었다. 도출된 활성화 요소를 활용하여 향후 관광지 재생사업을 시행할 때 합리적 의사결정과 사업의 효율성을 높일 수 있을 것으로 판단된다. 또한, 본 연구 결과가 정체 쇠퇴하고 있는 국내 관광지가 지속가능성을 가지며 지역경제 활성화에 기여하고, 국내 관광 사업에 대한 무분별한 관광개발을 막고 관광자원의 효율적 활용을 위한 방안으로서 역할을 기대해 본다.

• 농촌계획
• /
• 제13권3호
• /
• pp.61-72
• /
• 2007

Natural resource of the island and coastal regions is one of the most important element of ecological network system in Korea. Currently, there is trend that natural and biological resources such as fishing and tidal wetland have been used to local economic activation in island and coastal regions. According to the 5-days work in a week, island and coastal regions become important amenity resource of citizen's recreation area. Korea is peninsula surrounded by maritime. Especially, South and West Sea surrounded by many islands and tidal flat wetlands are emerging marine ecosystem and seascape in the world. Natural resource is limited, so we have to sustain those resource to current tourism. In this study, I would like to suggest that importance of cultural resource as well as natural resource for 'eco-cultural tourism' in order to keep both biological diversity and cultural diversity as amenity resource for future island economic activation in Korea.

• Natural Product Sciences
• /
• 제5권1호
• /
• pp.33-38
• /
• 1999

Ethanolic extracts of different parts of 10 local traditional vegetables (ulam) (Amaranthus gangeticus, Jussiaea linifolia, Eugenia polyantha, Trapa incisa, Trichosanthes anquina, Mangifera indica, Pachyrrhirus erosus, Barringtonia mcarostachya, Carica papaya, and Coleus tuberosus) were screened for in vitro antitumor promoting activity using the inhibition test of Epstein-Barr virus (EBV) activation in Raji cells induced by phorbol 12-myristate 13-acetate and sodium-n-butyrate. All the extracts were found to have strong inhibition activity toward EBV-activation, except for leaf extract of T. anquina. The extracts were non-cytotoxic to the Raji cells except for the extracts of A. gangeticus (leaves), B. macrostachya (leaves), E. polyantha (young leaves), and J. linifolia (leaves) where the viability of the cells were decreased significantly.

• 대한의용생체공학회:학술대회논문집
• /
• 대한의용생체공학회 1995년도 춘계학술대회
• /
• pp.82-86
• /
• 1995

Using electrocardiography is a common method to diagnose heart disease, Modeling and simulation of activation process for the heart system is useful to understand electrocardiography. This paper proposes a two-dimensional cellular automata model for the activation process of the ventricles. The model represents the geometry of the ventricles by the ellipsoidal shape in two dimension. In the model, ventricles are divided into four layers, each of which has a set of cells with preassigned properties. The proposed model takes Into account the local orientation of the myocardial fibers and their distributed velocity, and refractory period. Simulation experiment is performed to measure activation potential for each cell in each layer within the ventricles.

• 한국환경과학회지
• /
• 제25권11호
• /
• pp.1531-1540
• /
• 2016

This research was intended to provide a method to improve competitiveness, based on the integration of basic municipalities by assessing changes in their population and local industry Municipalities were integrated based on the addressing system 市(Shi), 町(Chome), 村(Village) of Japan. As a result, an actual increase of the population could not be seen in the new municipalities formed by the integration of the basic municipalities. It is also found that the shipping volumes, number of companies, and the number of people employed by local industry, attracted by such municipalities, has steadily decreased. However, even though the proportion of industry-sharing in the local municipalities is not significant, it was found that the number of tourists has increased. Therefore, it is concluded that the strengthening of the connectivity between local industry and the tourism industry can be one of the principal methods to strengthen the competitiveness of these municipalities. In addition, it has been found that scientific research from a variety of perspectives and verification of data related to the effectiveness of integration of local municipalities is necessary.

• 감성과학
• /
• 제16권1호
• /
• pp.11-28
• /
• 2013

This article aims to explore the interactive roles of types of primed identity (local versus global identity) and types of ad framing on brand evaluations. The authors designed 2 experiments in which each experiment followed a $2{\times}2$ between-subject design. The empirical results showed that a gain-framed ad induced more positive emotional responses than a loss-framed ad, and the positive affective responses lead to more favorable brand evaluation. Furthermore, the results showed that there were interactive effects of primed identity and types of advertisement frame on brand evaluation. In the additional analysis, the results showed that when people with local identity were exposed to the gain-framed ad, they would engage in a higher level of integration processing than those in the control group, which in turn induced more favorable evaluation to the local brand. That is, the integration processing mode played a mediating role between the interaction (local id priming ${\times}$ ad frame) and the local brand evaluation. However, in the case of global brand evaluation, the integration processing mode did not play such a mediating role.

• 한국항해항만학회:학술대회논문집
• /
• 한국항해항만학회 2006년도 Asia Navigation Conference
• /
• pp.203-212
• /
• 2006

The purpose of this research is to suggest the activation plan of Busan port. In the past years, Busan port enjoyed the golden days because of the China's rapid economic growth. But China's continuous development of ports, the trend of increasing container ship size and increasing direct call to China are coming threats to Busan port. So Korea needs to revise the 'Northeast Logistics Hub' strategy because it is considered that Korea ports continuously will handle China's transshipment cargoes. But now China's transshipment cargo share has decreased by direct call to China ports. It means that China has a lot of its local cargoes, so many ship companies change liner service route to handle China cargoes except Bussan ports although Busan port is included in the main trunk route. In the future, Bussan port will not be able to compete again about throughput with China ports if Busan port's transshipment cargo share decreases. So we must find out and develop Busan port's strength which is the competitive edge. By good luck, Busan port has a few opportunities such as the developed feeder network service and geographical advantages. Busan port has many feeder network service like spider's web in any northeast countries so we can suggest that if Japanese shippers use Busan port to distribute their cargoes to Japanese local areas, its transport costs are cheaper than when they use Japan's main ports. In this paper analyzed side of cost when they use Bussan port like hub to distribute their cargo to their local areas. Because most companies tried to reduce the total cost about logistics. Finally, this paper suggests when northeast shippers(China, Japan) use Bussan port which is more economical than their local main ports.

• 농촌계획
• /
• 제28권2호
• /
• pp.21-32
• /
• 2022

Since the village maintenance type public housing project was introduced in 2015, the resident needs for regional revitalization and pleasant living conditions are not being met due to the poor performance of the public housing complexes that reflect the surrounding area maintenance plan (village plan) and regional characteristics. The purpose of this study is to suggest a plan to revitalize the village maintenance type public housing project in consideration of regional characteristics as a result of analyzing the needs of local residents through the problems of the village maintenance type public housing project being promoted so far and resident satisfaction. As a result of the analysis based on the public housing project implementation status analysis and resident satisfaction, the plans to activate the village maintenance type public housing project are as follows. First, in order to secure the effectiveness of the village plan, it is desirable to promote the public housing project and the village plan at the same time. It is necessary to secure a budget according to the selection of public offering projects in the village plan, such as promoting public housing projects without setbacks by prioritizing land purchases for public housing sites and establishing specialized strategies considering regional characteristics. Second, a public housing project that responds to local demand is required. The evaluation factors such as continuous promotion of the urban architecture integration plan and strengthening of regional linkage plans such as specialization of regionally tailored designs should be supplemented so that regional resources and village plans are linked with the public housing specialization plan. Third, surrounding area maintenance plan (village plan) should be secured by the strengthen of the legal status or establishing related provisions. It is also necessary to promote system improvement for area maintenance plan (village plan) when selecting a publicly funded public project.