• 제목/요약/키워드: Liver neoplasm

검색결과 83건 처리시간 0.033초

자녀교육과 수요간의 상관관계에 관한 실증적 고찰 (An Empirical Review of the Relationship between Schooling and Demand for Children on the Basis of Quantity-Quality Interaction Model)

  • Chang-Jin Moon
    • 한국인구학
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    • 제11권1호
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    • pp.197-203
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    • 1988
  • 한국 사망력의 수준 및 특징을 일본과 비교하고자 양국의 1995년 공식통계를 사용하여 사망원인별로 성$\cdot$연령$\cdot$혼인상태별 사망률, 연령표준화사망률, 생존기간손실년수(PYLL) 및 동 측정치의 남녀간 비와 한일간 비를 계산하였다. 사망원인 항목은 모든 사인(총사망), 결핵, 악성신생물, 당뇨병, 고혈압성 질환, 심장 질환, 뇌혈관 질환, 간 진환, 교통사고, 자살을 포함한다. 일본과 비교하여 한국 사망력의 두드러진 특징은 다음과 같다 : (1)자살을 제외한 대부분의 사인에서 한국의 사망률이 일본보다 높은데 , 특히 결핵, 고혈압성 질환, 간 질환 및 교통사고의 경우 한국 생산활동연령층의 사망률이 두드러지게 높다 : (2)결핵, 간질환, 교통사고, 암사망이 한국의 소아에게서도 발생한다 : (3)한국의 생산활동연령층에서 간 질환, 결핵, 교통사고에 의한 성별 사망력 격차가 큰데, 남성의 사망률이 여성의 사망률보다 높기 때문이다 : (4)자살률이 한국생산활동연령층 남성의 경우 일본보다 낮고, 10대와 20대 여성의 자살률은 일본보다 높다 : (5)한국의 45세 미만에서는 사인에 따라 사별이나 이혼상태에서, 45세 이상에서는 모든 사인에 대해 남녀 모두 미혼상태에서 사망력이 가장 높다. : (6)한국은 사별상태에서, 일본은 이혼상태에서 성별 사망력 격차가 가장 크다.

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재일한국인의 생활문화의 이질화와 적응과정에 관한 보건학적 연구(제 1보 한국, 재일한국인, 일본의 사인구조분석 (A comparative Study of Changing Pattern of Cause of Death Analysis of Korean, Korean in Japan and Japanese)

  • 김정근;장창곡;임달오;김무채;이주열
    • 한국인구학
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    • 제15권2호
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    • pp.15-59
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    • 1992
  • After world war II Japanese life expectancy has been improved remarkably, and reached the highest level in the world around late 1970's. The life expectancy of Korean has also shown tremendous improvement in recent years with about 20 year's gap from the Japanese. The reason of rapid improvement of life expectancy can be explained by changes in the structure of cause of death due to health system, living standard, social welfare, health behavior of individuals and so on. Korean in Japan is placed under different situations from both Korean in Korea and Japanese in these regards, and expected to show different picture of cause of death pattern. The objective of this study is the comparision of changing patterns of cause of death of three population groups, Korean in Japan, Korean in Korea and Japanese, and to investigate the reasons which effect to the structural difference of mortality cause with special emphasis on health ecological aspects. One of the major limitations of the Korean causes of death statistics is the under-registration which ranges about 10% of the total events, and inaccuracy of the exact cause of death. Some 20% of registered deaths were unable to classify by ICD. However, it is concluded that the Korean data are evaluated as sufficient to stand for over-viewing of trends of cause of death pattern. The evaluation is done by comparing data from registration and field survey over the same population sample. Population data of Korean in Japan differ between two sources of data; census and foreigner's registration. Correction is done by life table method under the assumption that age-specific mortality pattern would accord with that of the Japanese. The crude death rate was lowest among Korean in Japan, 5.7 deaths per 1,000 population in 1965. The crude death rates of Korean in Japan and Japanese are increasing recently influenced by age structure while Korean in Korea still shows decreasing tendency. The adjusted death rate is lowest among Japanese, followed by Korean in Japan, and Korean in Korea. The leading causes of death of Korean in Korea until 1960's was infectious diseases including pneumonia and tuberculosis. The causes of death structure changed gradually to accidents, neoplasm, hypertensive disease, cerebro-vascular disease in order. The main difference in cause of death between Korean and Japanese if high rate of liver diseases and diabetes for both Korean in Japan and Korea. A special feature of cause of death among Korean in Korea is remakably high rate of hypertensive disease, which is assumed to be caused by physicians tendency in choosing diagnostic categories. The low ischemic heart disease and high vasculo-cerebral disease are the distinctive characteristic of the three population groups compared to western countries. Specific causes of death were selected for detailed sex, age and ethnic group comparisons based on their high death rates. Cancer is the cause of death which showed most dramatical increase in all three population groups. In Korea 20.1% of all death were caused by cancer in 1990 compared with 10.5% in 1981. Cancer of the liver is the leading cause of cancer death among Korean in Japan for both sexes, followed by cancer of the lung and cancer of the stomach, while that of Korean in Korea is cancer of the stomach, followed by cancer of the liver and cancer of the lung for male. Causes of infant mortality were examined among the three population groups since 1980 on yearly bases. For both Japanese and Korean in Japan, leading cause of death ranks as conditions originating in the perinatal period, congenital anomalies, accidents and other violent causes. Trends since 1980 for these two population groups in the leading cause of infant mortality showed no changes. On the contrary, significant changes in leading cause of death structure in Korea were observed : the ranking of leading cause of death in 1981 were congenital asnomalies, pneumonia bronchitis, infectious disease, heart disease, conditions originating in the perinatal period, accident and other violent causes ; in 1990 the ranking shifted to congenital anomalies, accident, pneumonia bronchities, conditions originating in the perinatal period, infectious disease. The mortality rate by congenital anomalies in Korea continuously grew than any other causes. Larger increase ocurred during the 1990's

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Distinctions Between Clinicopathological Factors and Prognosis of Alpha-fetoprotein Negative and Positive Hepatocelluar Carcinoma Patients

  • Xu, Jia;Liu, Chang;Zhou, Lei;Tian, Feng;Tai, Ming-Hui;Wei, Ji-Chao;Qu, Kai;Meng, Fan-Di;Zhang, Ling-Qiang;Wang, Zhi-Xin;Zhang, Jing-Yao;Chang, Hu-Lin;Liu, Si-Nan;Xu, Xin-Shen;Song, Yan-Zhou;Liu, Jun;Zhang, Peng
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권2호
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    • pp.559-562
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    • 2012
  • Serum alpha-fetoprotein (AFP) is a significant marker for clinical diagnosis and prognosis evaluation in hepatocellular carcinoma (HCC) patients. However, some proportion of liver cancer patients are AFP-negative (AFP ${\leq}$20ng/ml). In order to study the differences between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive patients, a total of 114 cases (41 AFP-negative and 73 AFP-positive) were selected for our research. By systematically statistical analysis, the results demonstrated that compared with AFP-negative patients, AFP-positive examples were more likely to feature cirrhosis nodules, non-complete neoplasm capsules, and a poor Edmondson-steiner grade. Furthermore, AFP-negative patients demonstrated a favorable long-term prognosis. By univariate analysis and multivariate analysis with Cox's proportional hazards model, multiple tumors were found to be independent risk factors for worse survival of AFP negative patients; however, less tumor-free margins, multiple tumors and Edmondson-steiner grades III/IV, proved to be independent risk factors leading to a poor prognosis of AFP positive cases. Finally, we can infer that high levels of AFP signify a highly malignant tumor and unfavorable prognosis.

Gamma Knife Radiosurgery for Metastatic Brain Tumors with Exophytic Hemorrhage

  • Park, Eun Suk;Lee, Eun Jung;Yun, Jung-Ho;Cho, Young Hyun;Kim, Jeong Hoon;Kwon, Do Hoon
    • Journal of Korean Neurosurgical Society
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    • 제61권5호
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    • pp.592-599
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    • 2018
  • Objective : Metastatic brain tumors (MBTs) often present with intracerebral hemorrhage. Although Gamma Knife surgery (GKS) is a valid treatment option for hemorrhagic MBTs, its efficacy is unclear. To achieve oncologic control and reduce radiation toxicity, we used a radiosurgical targeting technique that confines the tumor core within the hematoma when performing GKS in patients with such tumors. We reviewed our experience in this endeavor, focusing on local tumor control and treatment-associated morbidities. Methods : From 2007 to 2014, 13 patients with hemorrhagic MBTs were treated via GKS using our targeting technique. The median marginal dose prescribed was 23 Gy (range, 20-25). GKS was performed approximately 2 weeks after tumor bleeding to allow the patient's condition to stabilize. Results : The primary sites of the MBTs included the liver (n=7), lung (n=2), kidney (n=1), and stomach (n=1); in two cases, the primary tumor was a melanoma. The mean tumor volume was $4.00cm^3$ (range, 0.74-11.0). The mean overall survival duration after GKS was 12.5 months (range, 3-29), and three patients are still alive at the time of the review. The local tumor control rate was 92% (tumor disappearance 23%, tumor regression 46%, and stable disease 23%). There was one (8%) instance of local recurrence, which occurred 11 months after GKS in the solid portion of the tumor. No GKS-related complications were observed. Conclusion : Our experience shows that GKS performed in conjunction with our targeting technique safely and effectively treats hemorrhagic MBTs. The success of this technique may reflect the presence of scattered metastatic tumor cells in the hematoma that do not proliferate owing to the inadequate microenvironment of the hematoma. We suggest that GKS can be a useful treatment option for patients with hemorrhagic MBTs that are not amenable to surgery.

전신질환으로 입원한 환자의 구강질환과 전신질환의 상관관계(I) (Interrelationship between the Oral Disease and the Systemic Disease to Inpatient(I))

  • 전양현;어규식;홍정표
    • Journal of Oral Medicine and Pain
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    • 제33권2호
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    • pp.111-120
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    • 2008
  • 다양한 전신질환으로 입원한 환자들의 전신질환별 구강질환의 주소와 치료내용을 조사하여 기본적인 구강질환의 실태를 파악하고자 본 연구를 시행하였는데, 전신질환으로 입원하여 구강질환의 진단과 치료를 위하여 내원한 환자를 대상으로 연구한 결과 다음과 같은 결론을 얻었다. 1. 주된 전신질환인 내분비, 영양 및 대사 질환의 경우 구강질환은 치은염 및 치주질환 44.9%, 타액선의 질환 22.4%, 치아우식증 12.2%, 치수 및 치근단주위의 질환 4.1%, 매몰치와 매복치, 치아경조직의 기타질환 각각 2% 순서로 나타났다. 2. 주된 구강질환인 치은 및 치주질환의 경우 전신질환은 인슐린-비의존성 당뇨 39.2%, 뇌경색 29.4%, 신경근 및 신경총장애 5.6%, 뇌내출혈 3.9%, 위의 악성 신생물, 갑상선기능항진증, 정신분열증, 알콜성 간질환, 신증후군 각각 2% 순서로 나타났다. 이상의 결과로 전신질환이 있는 환자의 구강질환과 구강질환이 있는 환자의 전신질환에 대해서는 일정부분 파악이 되었으나 향후 전신질환으로 입원한 환자의 구강질환과 전신질환과의 상관관계에 대한 연구가 이루어져야 한다고 사료된다.

혈관주위세포종의 폐전이 1례 (A Case of Metastatic Hemangiopericytoma in Lung)

  • 변민광;이정은;정우영;박무석;문진욱;한창훈;강신명;임범진;박영년;김영삼;김세규;장준;김성규
    • Tuberculosis and Respiratory Diseases
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    • 제59권5호
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    • pp.551-555
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    • 2005
  • 혈관주위세포종은 혈관주위세포에 발생하는 드문 종양으로 폐나 뼈로의 전이가 가능하다. 저자들은 좌측 서혜부에서 원발하여 완치판정 5년 후에 원발 부위의 재발 없이 폐로 전이된 혈관주위세포종 1례를 경험하였기에 임상적 증상, 방사선 소견, 병리학적 소견들을 문헌 고찰과 함께 보고하는 바이다.

Efficacy of First-Line Targeted Therapy in Real-World Korean Patients with Metastatic Renal Cell Carcinoma: Focus on Sunitinib and Pazopanib

  • Kim, Myung Soo;Chung, Ho Seok;Hwang, Eu Chang;Jung, Seung Il;Kwon, Dong Deuk;Hwang, Jun Eul;Bae, Woo Kyun;Park, Jae Young;Jeong, Chang Wook;Kwak, Cheol;Song, Cheryn;Seo, Seong Il;Byun, Seok-Soo;Hong, Sung-Hoo;Chung, Jinsoo
    • Journal of Korean Medical Science
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    • 제33권51호
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    • pp.325.1-325.10
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    • 2018
  • Background: To evaluate survival outcomes and prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received sunitinib (SU) and pazopanib (PZ) as first-line therapy in real-world Korean clinical practice. Methods: Data of 554 patients with mRCC who received SU or PZ at eight institutions between 2012 and 2016 were retrospectively reviewed. Based on the targeted therapy, the patients were divided into SU (n = 293) or PZ (n = 261) groups, and the clinicopathological variables and survival rates of the two groups were compared. A multivariable Cox proportional hazard model was used to determine the prognostic factors for OS. Results: The median follow-up was 16.4 months (interquartile range, 8.3-31.3). Patients in the PZ group were older, and no significant difference was observed in the performance status (PS) between the two groups. In the SU group, the dose reduction rate was higher and the incidence of grade 3 toxicity was more frequent. The objective response rates were comparable between the two groups (SU, 32.1% vs. PZ, 36.4%). OS did not differ significantly between the two groups (SU, 36.5 months vs. PZ, 40.2 months; log-rank, P = 0.955). Body mass index, Eastern Cooperative Oncology Group PS > 2, synchronous metastasis, poor Heng risk criteria, and liver and bone metastases were associated with a shorter OS. Conclusion: Our real-world data of Korean patients with mRCC suggested that SU and PZ had similar efficacies as first-line therapy for mRCC. However, PZ was better tolerated than SU in Korean patients.

간전이를 동반한 대장 상피모양혈관육종: 증례 보고 (Primary Colonic Epithelioid Angiosarcoma with Hepatic Metastasis: A Case Report)

  • 임지윤;홍성숙;황지영;김현주;진소영
    • 대한영상의학회지
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    • 제83권2호
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    • pp.432-438
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    • 2022
  • 대장 혈관육종은 매우 드문 악성 종양이며 빠르게 진행하고 나쁜 예후를 보인다. 우리는 장 폐쇄를 일으킨 대장 상피모양혈관육종의 빠르게 진행한 간전이가 있었던 44세 여자 환자의 사례를 경험하여 이를 보고하고자 한다. 복부 CT에서 불균질하게 조영증강되는 상행결장의 종괴로 인한 근위부 장 확장 소견이 있었고 수술 후 병리적으로 저분화암종으로 보고되었다. 4개월 후 추적 간 MRI에서 테두리 및 결절성의 현저한 동맥기 조영증강을 보이는 수많은 작은 간 결절들이 새로 생겼으며 간 혈관육종이 의심되는 형태로 보였다. 추가 면역조직화학검사 병리적 이차 의견에서 대장 상피모양혈관육종이 진단되었다. 환자는 6개월 후 추적 복부 CT에서 빠른 진행성 간 전이를 보였으며 8개월 후 사망하였다. 빠른 진행을 보이는 혈관육종의 간 전이의 영상 소견을 통해 혈관육종을 의심하고 재진단할 수 있었던 드문 대장 혈관육종의 교훈적인 사례로 생각된다.

Effect of Stent Placement on Survival in Patients with Malignant Portal Vein Stenosis: A Propensity Score-Matched Study

  • Dong Jae Shim;Jong Woo Kim;Doyoung Kim;Gi-Young Ko;Dong Il Gwon;Ji Hoon Shin;Yun-Jung Yang
    • Korean Journal of Radiology
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    • 제23권1호
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    • pp.68-76
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    • 2022
  • Objective: Percutaneous portal vein (PV) stent placement can be an effective treatment for symptoms associated with portal hypertension. This study aimed to evaluate the effect of PV stenting on the overall survival (OS) in patients with malignant PV stenosis. Materials and Methods: Two groups of patients with malignant PV stenosis were compared in this retrospective study involving two institutions. A total of 197 patients who underwent PV stenting between November 2016 and August 2019 were established as the stent group, whereas 29 patients with PV stenosis who were treated conservatively between July 2013 and October 2016 constituted the no-stent group. OS was compared between the two groups before and after propensity score matching (PSM). Risk factors associated with OS were evaluated using the Cox proportional hazards model. Procedure-associated adverse events were also evaluated. Results: The stent group finally included 100 patients (median age, 65 [interquartile range, 58-71] years; 64 male). The no-stent group included 22 patients (69 [61-75] years, 13 male). Stent placement was successful in 95% of attempted cases, and the 1- and 2-year stent occlusion-free survival rate was 56% (95% confidence interval, 45%-69%) and 44% (32%-60%), respectively. The median stent occlusion-free survival time was 176 (interquartile range, 70-440) days. OS was significantly longer in the stent group than in the no-stent group (median 294 vs. 87 days, p < 0.001 before PSM, p = 0.011 after PSM). The 1- and 3-year OS rates before PSM were 40% and 11%, respectively, in the stent group. The 1-year OS rate after PSM was 32% and 5% in the stent and no-stent groups, respectively. Anemia requiring transfusion (n = 2) and acute thrombosis necessitating re-stenting (n = 1) occurred in three patients in the stent group within 1 week. Conclusion: Percutaneous placement of a PV stent may be effective in improving OS in patients with malignant PV stenosis.

다형성 암종의 임상적 고찰 (Clinical Characteristics of Pleomorphic Carcinoma)

  • 이덕헌;박훈;박창권;권건영;박남희;최세영;이광숙;유영선
    • Journal of Chest Surgery
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    • 제36권6호
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    • pp.397-403
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    • 2003
  • 폐의 다형성 암종은 일반적으로 드문 폐암종의 아형으로 알려져 있다. 1999년 WHO 폐암분류의 기준을 적용하여 계명대학교 동산의료원에서 진단된 42예의 다형성 암종에 대한 임상적 특징에 대해 알아보고자 하였다. 대상 및 방법: 1992년 1월부터 2001년 12월까지 본원에서 폐암으로 폐 절제술을 시행한 256예 중, 광학현미경적 재검색과 면역조직화학염색을 실시하여 다형성 암종으로 진단한 42예를 대상으로, 연구를 시행하였다. 결과: 42예 중 남자는 31예, 여자는 11예였고, 나이는 26세부터 77세까지였다. 임상증상은 기침, 객혈, 객담이 주로 나타났으며, 진단 시 병기는 Ia 3예, (7%), Ib 16예(38%), IIa 1예 (2%), IIb 8예(19%), IIIa 15예(35%), IIIb 1예(2%)였고, 이 중 림프절 전이가 없는 N0 경우는 23예(54%), 림프절 전이가 있는 N1과 N2인 경우는 19예(46%)로 나타났다. 원격전이가 발생한 환자는 총 19예로 뇌 5예(26%),뼈 4예(21%),근육 4예(21%), 림프절 2예(10%), 간, 난소, 편측 폐, 부신이 각 1예씩 발생하였다. 종양의 크기는 1 cm부터 11 cm까지 분포하였고 평균 5.85 cm이었다. 42예의 환자에서 조사 기간 중 생존자는 11예(26%), 사망자는 31예(74%)이었다. Kaplan-Meier method에 의한 이들의 전체 2년, 5년 생존율은 각각 26%와 13%로 조사대상 256예에서 다형성암종을 제외한 증례의 2년생존율 44%와 5년 생존율 34%에 비해서 유의하게 낮은 것으로 조사되었다(p<0.002). 나이와 종양의 크기, 병기 I과 병기 II 이상, N0 N1 이상의 생존율 비교에서는 유의한 차이는 없었다. 술 후 원격전이가 발생한 증례는 모두 사망하였고 이들은 원격전이가 없는 증례에 비하여 생존율이 유의하게 낮게 나타났다(p<0.002). 걸론: 1999년 WHO 폐암분류에 따른 새로운 진단 기준을 적용할 경우 다형성 암종은 이전의 WHO 폐암분류에서보다 높은 발생률을 보이며, 술 후 이들의 생존율은 다른 비소세포암종의 유형보다 유의하게 낮은 것을 확인할 수 있었다.