• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8051-8055
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• 2014

Background: A common genetic variant rs3757318, located in intron of C6orf97, was firstly identified to be associated with breast cancer (BC) risk by a genome-wide association (GWA) study. However, subsequent validation studies with different ethnicities have yielded conflicting results. Materials and Methods: We performed a meta-analysis to synthesize all available data for evaluating the precise effect of this variant on BC susceptibility. Results: A total of 8 articles containing 11 studies with 62,891 cases and 65,635 controls were included in this meta-analysis. When compared to the G allele, the rs3757318-A allele was significantly associated with BC risk with the pooled OR of 1.21 (95% CI=1.15 - 1.29, P<0.001) but with obvious between-study heterogeneity (P=0.040). Stratified analysis suggested that diversity of ethnicity along with control source may explain part of the heterogeneity. Similarly, significant associations were also identified in heterozygote, homozygote, dominant and recessive genetic models. Sensitivity and publication bias analyses indicated robust stability of our results. Conclusions: Our present meta-analysis demonstrated that the variant rs3757318 is associated with increased BC risk. Nevertheless, further studies are needed to clarify the underlying biological mechanisms.

• International Commerce and Information Review
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• v.16 no.3
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• pp.121-138
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• 2014

China and Korea have interacted with each other for 20 years since 1992 when China and Korea established diplomatic relations. During this period, the trade and investment between two countries have increased rapidly. In addition to the enhancement of economic cooperation and the expansion of personal exchange, the relationship between two countries was upgraded to mutual strategic cooperative relationship in 2008 from the 1 friendly and cooperative relations and the economic exchange and cooperation were largely expanded. In this paper, the current situation and characteristics of the trade between China and Korea were figured out. In order to find out the development direction of China and Korea trade, through empirical analysis, the correlation of decisive factors that influence the trade amount of these two countries were analyzed. In terms of dependent variables for the empirical analysis, the trade amount between China and Korea was considered. While the GDP of these countries, the direct investment amount of two countries and the openness of external trade of these countries were considered as independent variables. The degree of economic freedom of these countries was set as policy variable. According to the analysis results, when the GDP of China and Korea is getting higher, there is positive influence on the trade amount of China and Korea. It is showed that the direct investment of Korea has positive influence on the trade amount of China and Korea. Meanwhile, there is negative influence of China's direct investment on the trade amount. When the degree of freedom of these countries is getting higher, the influence of trade amount was showed significantly. Furthermore, when the economic freedom of these countries is getting higher, the insignificant things about trade amount of China and Korea were extracted as insignificant.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3123-3128
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• 2014

The liver is normally the major site of glucose metabolism in intact organisms and the most important target organ for the action of insulin. It has been widely accepted that insulin resistance (IR) is closely associated with postoperative recurrence of hepatocellular carcinoma (HCC). However, the relationship between IR and drug resistance in liver cancer cells is unclear. In the present study, IR was induced in HepG2 cells via incubation with a high concentration of insulin. Once the insulin-resistant cell line was established, the stability of HepG2/IR cells was further tested via incubation in insulin-free medium for another 72h. Afterwards, the biological effects of insulin resistance on adhesion, migration, invasion and sensitivity to cis-platinum (DDP) of cells were determined. The results indicated that glucose consumption was reduced in insulin-resistant cells. In addition, the expression of the insulin receptor and glucose transportor-2 was downregulated. Furthermore, HepG2/IR cells displayed markedly enhanced adhesion, migration, and invasion. Most importantly, these cells exhibited a lower sensitivity to DDP. By contrast, HepG2/IR cells exhibited decreased adhesion and invasion after treatment with the insulin sensitizer pioglitazone hydrochloride. The results suggest that IR is closely related to drug resistance as well as adhesion, migration, and invasion in HepG2 cells. These findings may help explain the clinical observation of limited efficacy for chemotherapy on a background of IR, which promotes the invasion and migration of cancer cells.

• Journal of Digital Convergence
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• v.12 no.4
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• pp.461-466
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• 2014

With the popularity of Japan's "Three Kingdoms" series of games, the Three Kingdoms became popular and gave birth to the Three Kingdoms game for the traditional cultural resources and cultural industries. At the same time generate economic benefits and promote the traditional culture of double effect. With Liu Bei, Guan Yu and other roles in the development of cultural industries in each particular historical figure internationalization appearance design to get attention in the digital arts industry. In this thesis, three kingdoms cultures and three kingdoms generals were analyzed based on classic novel Three Kingdoms (三国演义). Guan Yu, China and South Korea in appearing common in the game as the center. Take example of the role of Guan Yu's generals styling, clothing, weapons, color comparison, attempts to explore the international trend of historical figures game character.

• Structural Engineering and Mechanics
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• v.73 no.6
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• pp.613-620
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• 2020

The research study is focuses on a form of all-bolted joint with the external ring stiffening plate in the prefabricated steel structure. The components are bolted at site after being fabricated in the factory. Six specimens were tested under cyclic loading, and the effects of column axial compression ratio, concrete-filled column, beam flange sub plate, beam web angle cleats, and spliced column on the failure mode, hysteretic behavior and ductility of the joints were analyzed. The results shown that the proposed all-bolted joint with external ring stiffening plate performed high bearing capability, stable inflexibility degradation, high ductility and plump hysteretic curve. The primary failure modes were bucking at beam end, cracking at the variable section of the external ring stiffening plate, and finally welds fracturing between external ring stiffening plate and column wall. The bearing capability of the joints reduced with the axial compression ratio increased. The use of concrete-filled steel tube column can increase the bearing capability of joints. The existence of the beam flange sub plate, and beam web angle cleat improves the energy dissipation, ductility, bearing capacity and original rigidity of the joint, but also increase the stress concentration at the variable section of the external reinforcing ring plate. The proposed joints with spliced column also performed desirable integrity, large bearing capacity, initial stiffness and energy dissipation capacity for engineering application by reasonable design.

• Journal of Korean Medical classics
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• v.24 no.6
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• pp.169-186
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• 2011

1. In Sui, Tang and Five Dynasty, a discourse related to sleep was published in various big Fang Shu(方書)'s that later became a valuable historical data. Notably, the importance of good sleep began to be properly discussed in "Bei Ji Qian Jin Yao Fang(備急千金要方)" of 'Sun Si Miao(孫思邈)', etc. 2. During Two Song era, achievements in the previous eras were accepted and diseases related to sleep were explored in more details. 3. In Jin and Yuan(金元) era, Liu He Jian(劉河間), in "Su Wen Xuan Ji Yuan Bing Shi(素問玄機原病式)", recognized 'anger' as the cause for various sleep disorders and Li Dong Yuan(李東垣), in "Pi Wei Lun(脾胃論)", believed 'lethargy' and 'Shi Hou Ji Hun Mao Yu Shui(食後卽昏冒欲睡)' are related to narcolepsy linked with stomach. Zhang Cong Zheng(張從正) observed 'insomnia' as an isolated disease whereas Zhu Dan Xi(朱丹溪), in "Ge Zhi Yu Lun(格致餘論)" argued about somnambulism based on the relationship between Xiang Huo(相火) and Xin huo(心火).

• Geomechanics and Engineering
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• v.23 no.1
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• pp.61-69
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• 2020

The uniaxial compressive strength (UCS) of rock is a basic parameter in underground engineering design. The disadvantages of this commonly employed laboratory testing method are untimely testing, difficulty in performing core testing of broken rock mass and long and complicated onsite testing processes. Therefore, the development of a fast and simple in situ rock UCS testing method for field use is urgent. In this study, a multi-function digital rock drilling and testing system and a digital core bit dedicated to the system are independently developed and employed in digital drilling tests on rock specimens with different strengths. The energy analysis is performed during rock cutting to estimate the energy consumed by the drill bit to remove a unit volume of rock. Two quantitative relationship models of energy analysis-based core drilling parameters (ECD) and rock UCS (ECD-UCS models) are established in this manuscript by the methods of regression analysis and support vector machine (SVM). The predictive abilities of the two models are comparatively analysed. The results show that the mean value of relative difference between the predicted rock UCS values and the UCS values measured by the laboratory uniaxial compression test in the prediction set are 3.76 MPa and 4.30 MPa, respectively, and the standard deviations are 2.08 MPa and 4.14 MPa, respectively. The regression analysis-based ECD-UCS model has a more stable predictive ability. The energy analysis-based rock drilling method for the prediction of UCS is proposed. This method realized the quick and convenient in situ test of rock UCS.

• Journal of Information Processing Systems
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• v.13 no.5
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• pp.1243-1258
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• 2017

A new medical materials scheduling system and its modeling method for the complex rescue are presented. Different from other similar system, first both the BeiDou Satellite Communication System (BSCS) and the Special Fiber-optic Communication Network (SFCN) are used to collect the rescue requirements and the location information of disaster areas. Then all these messages will be displayed in a special medical software terminal. After that the bipartite graph models are utilized to compute the optimal scheduling of medical materials. Finally, all these results will be transmitted back by the BSCS and the SFCN again to implement a fast guidance of medical rescue. The sole drug scheduling issue, the multiple drugs scheduling issue, and the backup-scheme selection issue are all utilized: the Kuhn-Munkres algorithm is used to realize the optimal matching of sole drug scheduling issue, the spectral clustering-based method is employed to calculate the optimal distribution of multiple drugs scheduling issue, and the similarity metric of neighboring matrix is utilized to realize the estimation of backup-scheme selection issue of medical materials. Many simulation analysis experiments and applications have proved the correctness of proposed technique and system.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.707-712
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• 2014

Purpose: Anastomotic leakage (AL) is associated with high morbidity and mortality, high reoperation rates, and increased hospital length of stay. Here we investigated the risk factors for AL after anterior resection for rectal cancer with a double stapling technique. Patients and Methods: Data for 460 patients who underwent primary anterior resection with a double stapling technique for rectal carcinoma at a single institution from 2003 to 2007 were prospectively collected. All patients experienced a total mesorectal excision (TME) operation. Clinical AL was defined as the presence of leakage signs and confirmed by diagnostic work-up according to ICD-9 codes 997.4, 567.22 (abdominopelvic abscess), and 569.81 (fistula of the intestine). Univariate and logistic regression analyses of 20 variables were undertaken to determine risk factors for AL. Survival was analysed using the Cox regression method. Results: AL was noted in 35 (7.6%) of 460 patients with rectal cancer. :Median age of the patients was 65 (50-74) and 161 (35%) were male. The diagnosis of AL was made between the 6th and 12th postoperative day (POD; mean 8th POD). After univariate and multivariate analysis, age (p=0.004), gender (p=0.007), tumor site (p<0.001), preoperative body mass index (EMI) (p<0.001), the reduction of TSGF on 5th POD less than 10U/ml (p=0.044) and the pH value of pelvic dranage less than or equal to 6.978 on 3rd POD (p<0.001) were selected as 6 independent risk factors for AL. It was shown that significant differences in survival of the patients were AL-related (p<0.001), high ASA score related (p=0.036), high-level EMI related (p=0.007) and advanced TNM stage related

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1291-1298
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• 2014

Background: Evidence for associations between dietary factors and breast cancer risk is inconclusive among Chinese females. To evaluate this question, we conducted a systematic review of relevant case-control and cohort studies. Methods: Studies were systematically searched among 5 English databases (PudMed, ScienceDirect, Wiley, Clinicaltrials.gov, and Cochrane) and 3 Chinese databases (CNKI, WanFang, and VIP) until November 2012. Random effects models were used to estimate summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Results: Thirty one case-control studies and two cohort studies involving 9,299 cases and 11,413 controls were included. Consumption of both soy and fruit was significantly associated with decreased risk of breast cancer, with summary ORs of 0.65 (95% CIs: 0.43-0.99; I2=88.9%, P<0.001; N=13) and 0.66 (95% CIs: 0.47-0.91; $I^2$=76.7%, P<0.001; N=7), respectively. Consumption of fat was significantly associated with increased risk of breast cancer (OR=1.36; 95% CIs: 1.13-1.63; $I^2$=47.9%, P=0.088; N=6). There was nonsignificant association between consumption of vegetables and breast cancer risk (OR=0.72; 95% CIs: 0.51-1.02; $I^2$= 74.4%, P<0.001; N=9). However, sensitivity analysis based on adjusted ORs showed decreased risk of breast cancer was also associated with consumption of vegetables (OR=0.49; 95% CIs: 0.30-0.67). Conclusion: Both soy food and fruit are significantly associated with decreased risk of breast cancer among Chinese females, and vegetables also seems to be protective while dietary fatexerts a promoting influence.