• Archives of Plastic Surgery
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• 제33권4호
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• pp.399-406
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• 2006

Purpose: The authors accessed the anthropometric measurements of fourty non-cleft normal a three-month-old infant and using this obtained data as a basic guideline, authors applied the modified Noordhoff technique for the treatment of bilateral cleft lip. Methods: Over a period of 10 years, a total of 21 bilateral cleft lips were operated. 13 cases of complete and 8 cases of incomplete bilateral cleft lip and palate. In the complete type of bilateral cleft palate, elastic head cap and passive intraoral appliance were applied at 1 to 2 week of age for 2 months duration. The definitive cheiloplasty was performed at 3 months of age using the modified Noordhoff technique. Results: After a follow-up period ranging one to nine years, most patients presented with cosmetically and functionally satisfying results, with an exception of two cases where an undesired peaking effect of the vermilion and dimpling of the vermilion mucosa was encountered. Conclusion: Accessing the anthropometric measurements of fourty non-cleft normal three-month-old infant and using this obtained dara as a guideline, the modified Noordhoff technique can be applied to either complete or incomplete bilaterally cleft lip providing more naturally pleasing and cosmetically satisfying scars that lie in harmony with the philtral ridges, lip tubercle positioned just below the vermilion and a distinct white line and Cupid's bow.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제47권1호
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• pp.3-14
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• 2021

Excessive gingival display is an esthetic issue that is commonly managed by different procedures. Lip repositioning is a modality to address concerns of affected patients. The aim of this review was to investigate the scientific evidence on outcomes and long-term stability of lip repositioning surgery with or without myotomy. The electronic search was conducted in three databases: MEDLINE, Embase, and the Cochrane Library up to October 2019. No publication status, language, or time restrictions were applied. The electronic search was complemented by a manual search of the reference lists. Three hundred thirty-eight studies were screened by title, and 16 articles remained for data extraction. The included studies assessed the lip repositioning procedure in 144 patients aged between 15-59 years (134 females and 10 males). Based on the available data, lip repositioning with myotomy/muscle containment can be a successful treatment for minor discrepancies in gingival display in selected cases. However, further well-organized controlled clinical trials are recommended to derive a conclusion about the long-term stability compared with other alternatives.

• 대한치과교정학회지
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• 제32권3호
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• pp.155-163
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• 2002

치조성 양악 전돌 증례에서 컴퓨터 시뮬레이션을 이용한 연조직 측모의 치료 결과 예측의 객관적 정확성을 상, 하악 제 1소구치 발거를 통해 교정치료를 받은 21명의 성인 여성을 대상으로 $Quick\;Ceph\;Image\;Pro^{TM}\;&\;Quick Eeph\;2000^{TM}$ 을 이용하여 조사, 평가하였다. 치료 전 측모 두부방사선 규격사진 투사도에서 경조직 이동량을 계측하고 Quick Ceph system 상에서 경조직을 동일한 양 이동시켜 컴퓨터시뮬레이 션을 위한 기준으로 삼았다. 이후 프로그램을 통해 연조직 변화를 시뮬레이션하고, 이 자료와 실제 치료 결과로 얻어진 연조직 계측 값을 측정하여 비교해 봄으로써 치료 결과 예측에 대한 정확도를 확인하고 임상에의 적용시 고려할 사항을 알아보았다. 시뮬레이션 결과 계측 항목의 수평 성분은 실제 치료 결과보다 작게, 수직 성분은 치료 결과보다 크게 예측하는 것으로 나타났으며 치료시 의 후방 견인은 실제보다 확대되어 나타나는 경 향을 보였다. 상악에서는 항목간 예측 오차의 방향이 일정하여 예측치가 실제보다 더 후방 이동되어 나타났으나, 하악에서는 증례간 차이가 컸다 Upper Lip Length는 짧게, Upper Vermilion Length는 길게 예측하여 시뮬레이션시 상순이 말려 보이는(rolling)효과를 확인할 수 있었으며 하순에서도 유사한 성향이 나타났으나 상순에 비해서 약하게 나타났다.

• Molecules and Cells
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• 제40권12호
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• pp.935-944
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• 2017

More than 50% of sepsis cases are associated with pneumonia. Sepsis is caused by infiltration of bacteria into the blood via inflammation, which is triggered by the release of cell wall components following lysis. However, the regulatory mechanism of lysis during infection is not well defined. Mice were infected with Streptococcus pneumoniae D39 wild-type (WT) and lipase mutant (${\Delta}lipA$) intranasally (pneumonia model) or intraperitoneally (sepsis model), and survival rate and pneumococcal colonization were determined. LipA and autolysin (LytA) levels were determined by qPCR and western blotting. S. pneumoniae Spd_1447 in the D39 (type 2) strain was identified as a lipase (LipA). In the sepsis model, but not in the pneumonia model, mice infected with the ${\Delta}lipA$ displayed higher mortality rates than did the D39 WT-infected mice. Treatment of pneumococci with serum induced LipA expression at both the mRNA and protein levels. In the presence of serum, the ${\Delta}lipA$ displayed faster lysis rates and higher LytA expression than the WT, both in vitro and in vivo. These results indicate that a pneumococcal lipase (LipA) represses autolysis via inhibition of LytA in a sepsis model.

• 대한두개안면성형외과학회지
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• 제25권2호
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• pp.62-70
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• 2024

Background: The management of cleft lip and palate aims at improving the patient's aesthetic and functional outcomes. Delaying primary repair can disrupt the patient's functional status. Long-term follow-up is essential to evaluate the need for secondary repair or revision surgery. This article presents the epidemiology of cleft lip and palate, including comprehensive patient characteristics, the extent of delay, and secondary repair at our institutional center, the Bandung Cleft Lip and Palate Center, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia. Methods: This retrospective study aimed to determine the epidemiology and recurrence rates of cleft lip and palate at the Bandung Cleft Lip and Palate Center, Indonesia, from January 2007 to December 2021. The inclusion criteria were patients diagnosed with cleft lip and/or palate. Procedures such as labioplasty, palatoplasty, secondary lip and nasal repair, and alveolar bone grafting were performed, and data on recurrence were available. Results: In total, there were 3,618 patients with cleft lip and palate, with an age range of 12 months to 67 years. The mean age was 4.33 years, and the median age was 1.35 years. Males predominated over females in all cleft types (60.4%), and the cleft lip was on the left side in 1,677 patients (46.4%). Most cases were unilateral (2,531; 70.0%) and complete (2,349; 64.9%), and involved a diagnosis of cleft lip and palate (1,981; 54.8%). Conclusion: Delayed primary labioplasty can affect daily functioning. Primary repair for patients with cleft lip and palate may be postponed due to limited awareness, socioeconomic factors, inadequate facilities, and varying adherence to treatment guidelines. Despite variations in the timing of primary cleft lip repair (not adhering to the recommended protocol), only 10% of these patients undergo reoperation. Healthcare providers should prioritize the importance of the ideal timing for primary repair in order to optimize physiological function without compromising the aesthetic results.

• 대한치과교정학회지
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• 제27권3호
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• pp.411-420
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• 1997

본 교정 치료에 의한 경조직과 측모 연조직의 변화를 정량화하고 그들 상호간의 관계를 규명하기 위하여 원광대학교 치과대학 교정과에서 내원한 교정환자중 성장이 완료된 40명(발치군 20명, 비발치군 20명)의 여자 환자를 대상으로 치료 전후의 두부방사선계측사진을 채득하여, 경조직과 연조직 항목의 변화를 계측하고 계수공제영상 측정법을 이용하여 구순의 변화면적을 산출한 다음과 같은 결론을 얻었다. 발치군에서의 상순과 하순부위의 연조직 변화(UL, LL)는 $558.60\pm355.17,\;941.15\pm364.07$ pixels이었으며 , 비 발치 군에서의 상순과 하순 부위의 연조직 변화(UL)는 상악 중절치의 이동량(${\Delta}UIP$)과 높은 상관성이 있으며, 하순부위의 연조직 변화(LL)는 상악 중절치의 이동량(${\Delta}UIP$), FH평면에 대한 상악중절치의 각도의 변화(${\Delta}FUIA$), 절치간 각도(${\Delta}IIA$)와 높은 상관성을 보였다. 상악중절치 변화(${\Delta}UIP$)와 상순변화(${\Delta}LS$)의 비율은 1.68, 하악중절치 변화(${\Delta}LIP$)와 하순변화(${\Delta}LI$)의 비율은 1.19, 상악중절치 변화(${\Delta}UIP$)와 상순의 두께 증가량(${\Delta}TUL$)의 비율은 1.95이었다. 비발치군에서는 상순부위의 연조직 변화(UL)와 상악중절치의 변화(${\Delta}UIP$)간에 유의한 상관성이 인정되었다.

• 대한두개안면성형외과학회지
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• 제24권3호
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• pp.111-116
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• 2023

Background: In Indonesia, the prevalence of cleft lip and palate increased from 0.08% to 0.12% between 2013 and 2018. Children with cleft deformities typically undergo staged surgery. However, the coronavirus disease 2019 (COVID-19) pandemic has had negative impacts on the healthcare sector, including the suspension of elective procedures; this has raised concerns about the safety of performing surgery and the functional consequences of delaying treatment, the latter of which is associated with poor prognosis. The purpose of this study was to report the characteristics of clefts treated by the Bandung Cleft Lip and Palate Center team during the pandemic period. Methods: This brief comparative study based on a chart review was conducted at the Bandung Cleft Lip and Palate Center. We statistically evaluated data from all patients treated between September 2018 and August 2021. Frequency analysis was performed to analyze the average number of each procedure by age before and during the COVID-19 pandemic. Results: Data from 18-month periods before (n= 460) and during (n= 423) the pandemic were compared. Cheiloplasty procedures were examined (pre-pandemic, n= 230; pandemic, n= 248); before the pandemic, 86.1% were performed according to the treatment protocol (patient < 1 year old), and this proportion non-significantly dropped to 80.6% during the pandemic (p= 0.904). Palatoplasty procedures were also compared (pre-pandemic, n= 160; pandemic, n= 139); the treatment protocol (patient 0.5-2 years old) was followed for 65.5% of procedures before the pandemic and 75.5% during the pandemic (p= 0.509). Additionally, 70 (mean age, 7.94 years) revision and other procedures were performed before the pandemic and 36 (mean age, 8.52 years) during the pandemic. Conclusion: The cleft procedures performed at the Bandung Cleft Lip and Palate Center did not significantly change during the COVID-19 pandemic.

• Archives of Plastic Surgery
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• 제47권5호
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• pp.483-486
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• 2020

Midline clefts of the upper lip are rare, and it is therefore important that surgeons have access to a methodical approach for when these presentations are encountered. We adapted principles of the anatomic subunit approximation for unilateral cleft lip, to the repair of midline clefts. The overt use of anatomic landmarks to define the repair results in a design that inherently adjusts to varying degrees of clefts and can accommodate asymmetries. The "measure twice, cut once" style is an advantage to new surgeons and to surgeons who seldom encounter this presentation. We describe the details of surgical repair in the context of a patient with Pai syndrome and associated nasal hamartomas that resulted in nasolabial asymmetry. This is the first report of surgical outcome following treatment of Pai syndrome and includes early and 5-year follow-up. The system of repair that we describe is applicable to both symmetric and asymmetric midline clefts.

• Archives of Plastic Surgery
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• 제49권1호
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• pp.55-58
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• 2022

In Van der Woude syndrome (VWS), a rare congenital disease, lower lip pits (LLPs) can cause an aesthetically significant deformity. Surgical treatment of LLPs is necessary if they cause recurrent inflammation or aesthetic problems. Intraoperatively, surgeons should keep in mind the possibility of deep extension of the sinus tract and the relative deficiency of the midline in VWS, which increases the risk of lip disfigurement. Herein, we emphasize the importance of using a tissue-preserving technique to improve aesthetic results in VWS patients with a sinus tract.

• 대한치과교정학회지
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• 제31권1호
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• pp.63-69
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• 2001

구순열 및 구개열은 두개 악안면 부위에서 가장 자주 발생되는 선천성 기형으로 적절한 의료진의 확보와 의료 정책의 수립을 위해서 정착한 환자 수를 파악하는 것이 필요하다. 그러나, 기존의 국내 발생률 추정 연구는 표본선정의 문제점과 이 질환이 갖는 높은 유산율과 사산율 및 다양한 형태로 인한 분류의 어려움과 한국 내에서의 특수성 중 하나인 장애아들의 해외 입양으로 인해 정확한 환자 수의 파악이 어려웠다. 따라서, 한국인에서의 체계적인 유병률 연구가 필요하리라 사료되며, 대부분의 구순열 및 구개열 환자에서 필요한 교정 치료의 수혜 정도를 파악할 필요성이 있다고 사료된다. 이에 본 연구에서는 한국 성인 남자에서 구순열 및 구개열 환자에 대한 유병률과 이들에 대한 교정치료 수혜율을 조사하고자, 1998년도 병무청 징병 검사자 중 1979년도에 출생한 자만을 연구대상으로 하여 서울, 광주, 대구 부산의 성인 남자 218,322명에 대해 3단계 검사를 실시한 후 다음과 같은 결과를 얻었다. 1. 1979년 생 한국 성인남자에서 구순열 및 구개열 환자의 유병률은 1000명당 0.65명이었다. 2. 전후방적 심도에 따라 1000명당 각각의 유병률은 구순열이 0.26명, 구순구개열이 0.36명,구개열이 0.03명이었다. 구순열과 구순구개열은 비슷한 정도의 유병률을 보였으나, 구개열은 이에 비해 낮은 유병률을 보였다. 3. 횡적 심도에 따라 1000명당 각각의 유병률은 좌측 파열이 0.35명, 우측 파열이 0.16명, 양측 파열이 0.12명이었다. 좌측 파열은 우측 파열에 비해 매우 뚜렷하게 높은 유병률을 보였으며, 양측 파열은 편측 파열에 비해 낮게 나타났다. 4. 구순열 및 구개열 환자 중 성인남자에서의 한국 내 교정치료 수혜율은 $35\%$였으며, 구순열, 구개열, 구순구개열의 순으로 $28\%,\;29\%\;67\%$였다. 구순열이나 구개열과 같이 단독 발생된 경우보다 파열의 심도가 심한 구순구개열의 경우에서 교정치료 수혜율이 높게 나타났다.