• Journal of Pharmaceutical Investigation
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• v.36 no.2
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• pp.89-95
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• 2006

A selective and sensitive reversed-phase HPLC method for the determination of pentoxifylline in human serum was developed, validated, and applied to the pharmacokinetic study of pentoxifylline. Pentoxifylline and internal standard, chloramphenicol, were extracted from the serum by liquid-liquid extraction with dichloromethane and analyzed on a Luna CI8(2) column with the mobile phase of acetonitrile-0.034 M phosphoric acid (25:75, v/v, adjusted to pH 4.0 with 10 M NaOH). Detection wavelength of 273 nm and flow rate of 0.8 mL/min were used. This method showed linear response over the concentration range of 10-500 ng/mL with correlation coefficients greater than 0.999. The lower limit of quantification using 0.5 mL of the serum was 10 ng/mL, which was sensitive enough for pharmacokinetic studies of pentoxifylline. The overall accuracy of the quality control samples ranged from 89.3 to 92.7% for pentoxifylline with overall precision (% C.V.) being 4.1-9.2%. The relative mean recovery of pentoxifylline for human serum was 105.8%. Stability (stock solution, short and long-term) studies showed that pentoxifylline was not stable during storage. But three freeze-thaw cycles and extracted serum samples were stable. This method showed good ruggedness (within 15% C.V.) and was successfully applied for the analysis of pentoxifylline in human serum samples for the pharmacokinetic studies of orally administered $Trental^{\circledR}$ tablet (400 mg pentoxifylline), demonstrating the suitability of the method.

• Journal of Pharmaceutical Investigation
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• v.37 no.4
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• pp.223-227
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• 2007

A rapid, simple and sensitive LC/MS/MS method for the determination of lercanidipine in human serum was validated and applied to the pharmacokinetic study of lercanidipine. Lercanidipine and internal standard, amlodipine, were extracted from human serum by liquid-liquid extraction with hexan-isoamyl alcohol (100: 1, v/v) and analyzed on a $Symmetry^{(R)}$ MS $C_{18}$ column with the mobile phase of acetonitrile-0.2% aqueous formic acid (70: 30, v/v). Using MS/MS with multiple reaction monitoring (MRM) mode, lercanidipine and amlodipine were detected without severe interferences from human serum matrix. Lercanidipine produced a protonated precursor ion ($[M+H]^+$) at m/z 612.3 and a corresponding product ion at m/z 280.0. Internal standard produced a protonated precursor ion ($[M+H]^+$]) at m/z 409.0 and a corresponding product ion at m/z 238.0. The ruggedness of this method was investigated using quality control (QC) samples. This method showed linear response over the concentration range of 0.05-20 ng/mL with correlation coefficient greater than 0.999. The lower limit of quantitation using 0.5 mL of serum was 0.05 ng/mL, which was sensitive enough for pharmacokinetic studies. The overall accuracy of the developed method ranged from 85.51 to 112.2% for lercanidipine with overall precision (% C.V.) being 3.56-13.1%. This method showed good ruggedness (within 15% C.V.) and was successfully applied for the analysis of lercanidipine in human serum samples for the pharmacokinetic studies, demonstrating the suitability of the method.

• Journal of Korean Society of Environmental Engineers
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• v.38 no.9
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• pp.482-496
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• 2016

Algal blooms of cyanobacteria (blue-green Algae) due to the eutrophication of rivers and lakes can cause not only the damage by its biological toxins but also the economic loss in drinking water treatment. The natural algae coagulant, a commercial product known as W.H. containing the algicidal and allelopathic material derived from oak, can control algal problems proactively through the coagulation flotation process. However, because there have been no applications of the process for pre-treatment in drinking water plants, we could find no report on the optimum injection dose of W.H.. In this study, we have conducted several sets of jar-tests while changing W.H. dose and concentration of chl-a for (1) Han-river samples and (2) subcultured cyanobacteria samples, and monitored the removal mechanisms of algae intensively. Based on these jar-test results, two linear equations with variables of chl-a and turbidity have been deduced to predict the optimal W.H. dose after the multiple regression analysis using IBM-SPSS. Also, prototypes of automatic control logic have been suggested to inject the optimal W.H. dose promptly in response to the variation of water quality.

• The Journal of Korean Society for Radiation Therapy
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• v.19 no.1
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• pp.7-17
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• 2007

Purpose: As increasing complexity of modern radiotherapy technique, more developing dosimetry is required. Polymer gel dosimeters offer a wide range of potential applications with high resolution and assured quality in the thee-dimensional verification of complex dose distribution such as intensity-modulated radiotherapy (IMRT). The purpose of this study is to find the most sensitive and suitable gel as a dosimeter by varying its composition ratio and its condition such as temperature during manufacturing. Materials and Methods: Each polymer gel with various ratio of composition was irradiated with the same amount of photon beam accordingly. Various polymer gels were analyzed and compared using a dedicated software written in visual C++ which converts TE images to R2 map images. Their sensitivities to the photon beam depending on their composition ratio were investigated. Results: There is no dependence on beam energy nor dose rate, and calibration curve is linear. Conclusion: The polymer gel dosimeter developed by using anti-oxidant in this study proved to be suitable for dosimetry.

• Journal of Korea Multimedia Society
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• v.10 no.11
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• pp.1367-1383
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• 2007

A sensor network consists of a network of sensors that can perform computation and also communicate with each other through wireless communication. Some important characteristics of sensor networks are that the network should be self administered and the power efficiency should be greatly considered due to the fact that it uses battery power. In sensor networks, when large amounts of various stream data is produced and multiple queries need to be processed simultaneously, the power efficiency should be maximized. This work proposes a technique to create an index on multiple monitoring queries so that the multi-query processing performance could be increased and the memory and power could be efficiently used. The proposed SMILE tree modifies and combines the ideas of spatial indexing techniques such as k-d trees and R+-trees. The k-d tree can divide the dimensions at each level, while the R+-tree improves the R-tree by dividing the space into a hierarchical manner and reduces the overlapping areas. By applying the SMILE tree on multiple queries and using it on stream data in sensor networks, the response time for finding an indexed query takes in some cases 50% of the time taken for a linear search to find the query.

• International Journal of Highway Engineering
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• v.16 no.3
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• pp.43-50
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• 2014

PURPOSES : The dynamic modulus can be determined by applying the various theories from the Impact Resonance Testing(IRT) Method. The objective of this paper is to determine the best theory to produce the dynamic modulus that has the lowest error as the dynamic modulus data obtained from these theories(Complex Wave equation Resonance Method related to either the transmissibility loss or not, Dynamic Stiffness Resonance Method) compared to the results for dynamic modulus determined by using the Universal Testing Machine. The ultimate object is to develop the predictive model for the dynamic modulus of a Linear Visco-Elastic specimen by using the Complex Wave equation Resonance Method(CWRM) came up for an existing study(S. O. Oyadiji; 1985) and the Optimization. METHODS : At the destructive test which uses the Universal Testing Machine, the dynamic modulus results along with the frequency can be used for determining the sigmoidal master curve function related to the reduced frequency by applying Time-Temperature Superposition Principle. RESULTS : The constant to be solved from Eq. (11) is a value of 14.13. The reduced dynamic modulus obtained from the IRT considering the loss factor related to the impact transmissibility has RMSE of 367.7MPa, MPE of 3.7%. When the predictive dynamic modulus model was applied to determine the master curve, the predictive model has RMSE of 583.5MPa, MPE of 3.5% compared to the destructive test results for the dynamic modulus. CONCLUSIONS : Because we considered that the results obtained from the destructive test had the most highest source credibility in this study, the dynamic modulus data obtained respectively from DSRM, CWRM were compared to the results obtained from the destructive test by using th IRT. At the result, the reduced dynamic modulus derived from DSRM has the most lowest error.

• Korean Journal of Soil Science and Fertilizer
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• v.49 no.6
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• pp.751-759
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• 2016

It is known that the poor soil fertility of newly reclaimed saline soils is due to the lack of organic matter and available mineral nutrients for crop production. The effect of green manuring with Sesbania aculeata in combination with five rates of urea-N treatments (N0. N25, N50, N75, N100) on the productivity of a subsequent whole-crop barley and the fertility of the reclaimed saline soil in Saemangeum was evaluated in the field during 2013-2014 growing season. Sesbania was grown during summer season (June to October). The amount of Sesbania incorporated was $16.2Mg\;ha^{-1}$. Sesbania contributed to $393kg\;N\;ha^{-1}$ to the soils when ploughed down and incorporated before whole-crop barley cultivated. The performances of whole-crop barley following sesbania incorporation were significantly affected by a combination of Sesbania manuring and different N rates. The N fertilizer equivalence without N fertilizer following Sesbania was 42.6% ($63.9kg\;N\;ha^{-1}$), compared with N100 ($150kg\;N\;ha^{-1}$) in fallow soils. The whole-crop barley yield responded to N fertilizer rates in both sesbania-amended and fallow soil. The yield response to nitrogen rates in fallow soil was linear (Y=0.0586X+3.3011, $R^2=0.9534$), whereas that in sesbania-amended soils was quadratic (Y= -0.001X2+0.1322X+5.7143, $R^2=0.9576$). The yield of whole-crop barley in sesbania-amended with increasing N rates was increased up to SN75 (115 kgN) $10.3Mg\;ha^{-1}$. Apparent N recovery (ANR) of whole-crop barely showed decreased with sesbania plus increasing rates of N fertilizer. Despite higher yield with sesbania manuring plus increasing N rates, the contributions of N from Sesbania with increasing N rates to whole-crop barley were decreased, whereas those from fertilizer increment due to excessively mineralized Nitrogen. Considering yield, ANR, N contribution from Sesbania and nitrogen fertilizer, the optimum N rate was N50 rate following sesbania incorporation.

• Journal of the Earthquake Engineering Society of Korea
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• v.9 no.3 s.43
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• pp.51-58
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• 2005

Many RC building structures of multiple uses constructed in Korea have the Irregularities of torsion and soft story at bottom stories simultaneously. Seismic design codes generally require dynamic analysis and to take into account the effect or earthquake excitations in the orthogonal direction using the approximate methods of 100/30 and SRSS for type of building structures. And ail buildings should be designed to be safe in any direction of earthquake input. But, most of designers have difficulty in considering the orthogonal and directional effect of earthquake. The objective of the study stated herein is to verily 1) the effect of the choice of the reference axes on the seismic design member forces by comparing the analytical results on member forces using the principal axes suggested by Wilson and the global axes generally adopted in design office, 2) the validity or the 100/30 and SRSS methods by comparing the member forces obtained through linear elastic time history analysis with those obtained through using response spectrum analysis and 100/30 (or SRSS) methods. Based on the observations on the analytical results, it is concluded as follows; 1) The values of member forces by principal axes can be about $15\%$ smaller than those by the global axes in the example structure. 2) Though the values of member forces given by time history analysis are generally within the peak values predicted by 100/30 and SRSS methods, many member force vectors $(P,\;M_y,\;and\;M_z)$ by lime history analysis were located outside the boundaries predicted by the approximate method such as the 100/30 method.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.27 no.5
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• pp.437-450
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• 2014

In this study, we developed a methodology to determine the reference parameter for an aircraft impact induced risk assessment of nuclear power plant (NPP) using finite element impact analysis of containment building. The target structure used to develop the method of reference parameter selection is one of the typical Korean PWR type containment buildings. We composed a three-dimensional finite element model of the containment building. The concrete damaged plasticity model was used for the concrete material model. The steels in the tendon, rebar, and liner were modeled using the piecewise-linear stress-strain curves. To evaluate the correlations between structural response and each candidate parameter, we developed Riera's aircraft impact force-time history function with respect to the variation of the loading parameters, i.e., impact velocity and mass of the remaining fuel. For each force-time history, the type of aircraft is assumed to be a Boeing 767 model. The variation ranges of the impact velocity and remaining fuel percentage are 50 to 200m/s, and 30 to 90%, respectively. Four parameters, i.e., kinetic energy, total impulse, maximum impulse, and maximum force are proposed for candidates of the reference parameter. The wellness of the correlation between the reference parameter and structural responses was formulated using the coefficient of determination ($R^2$). From the results, we found that the maximum force showed the highest $R^2$ value in most responses in the materials. The simplicity and intuitiveness of the maximum force parameter are also remarkable compared to the other candidate parameters. Therefore, it can be concluded that the maximum force is the most proper candidate for the reference parameter to assess the aircraft impact induced risk of NPPs.

• Journal of The Korean Association For Science Education
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• v.22 no.4
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• pp.892-905
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• 2002

There are an increasing emphasis on affective domain, for example interest or belief, in science education. But decreasing interest on learning science and tendency to avoid science-related job are serious problems of secondary science education, especially in case of vocational high school students. However there are few researches for vocational high school students. In this study, preference for science is assumed to be a multidimensional property that reveals ones' behavioral volition and valuation as well as emotional response upon learning science. To investigate vocational high school students' preference for science and its causal factors, a Likert style questionnaire was developed through factor analysis. Students' preference for science was analyzed by 3 categories, and its causal factors are investigated by path analysis using structural equation model.