• Toxicological Research
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• 제18권4호
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• pp.311-324
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• 2002

Toxicokinetic studies are intended to provide critical evaluation of drug disposition at toxico-logical doses and help understand the relationship between blood or tissue levels and the time course of toxic events. Relatively high dose levels wed in toxicokinetics, compared to pharmacokinetics, complicates absorption, protein binding, metabolism and elimination processes. In this mini review, frequently wed toxicokinetic models such as linear compartment models, physiological models, and nonlinear kinetic mod-ec are introduced. In addition, optimization of toxicokinetic studies, their role in the drug development process, and prediction oj human toxicokinetics based on animal data by interspecies scaling are briefly discussed.

• Communications for Statistical Applications and Methods
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• 제19권3호
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• pp.423-432
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• 2012

This paper is concerned with the detection of multiple change-points in linear regression models. The proposed procedure relies on the local estimation for global change-point estimation. We propose a multiple change-point estimator based on the local least squares estimators for the regression coefficients and the split measure when the number of change-points is unknown. Its statistical properties are shown and its performance is assessed by simulations and real data applications.

• Communications for Statistical Applications and Methods
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• 제6권2호
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• pp.375-382
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• 1999

Linear-by-linear association models are commonly used to analyze ordered categorical data. To fit these models appropriate scores need to be chosen. In this paper we perform sensitivity analyses in two-way contingency tables to investigate the effect of scores on goodness-of-fits and on tests of significance. In addition we show that the best score which yields the best fit of data can be selected based on the sensitivity analysis results.

• International Journal of Control, Automation, and Systems
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• 제6권3호
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• pp.306-319
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• 2008

Reaching fault tolerance in technological systems requires to detect malfunctions. This paper presents a diagnostic method that is robust with respect to unknown-but-bounded uncertainties of the dynamical model and the measurements. By using models of the faultless and the faulty behaviours, a state-set observer computes polyhedral sets from which the consistency of the models with the interval measurements is determined. The diagnostic result is proven to be complete, i.e., the set of faults obtained by the diagnostic algorithm includes the actual fault. The algorithm is illustrated by an application example.

• 한국경영과학회지
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• 제27권2호
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• pp.1-13
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• 2002

In this paper, we compares the business failure prediction accuracy among Linear Programming Discriminant Analysis(LPDA) model, Multivariate Discriminant Analysis (MDA) model and logit analysis model. The Data for 417 companies analyzed were gathered from KIS-FAS Published by Korea Information Service in 1999. The result of comparison for four time horizons shows that LPDA Is advantageous in prediction accuracy over the other two models when over all tilt ratio and business failure accuracy are considered simultaneously.

• Journal of the Korean Statistical Society
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• 제21권1호
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• pp.70-79
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• 1992

The generalized linear models with random regrssors case are studied for bootstrapping. Only the natural link functions are considered. It is shown that the bootstrap approximation to the distribution of the maximum likelihood estimators is valid for almost all sample sequences. A slight extension of this model is also considered.

• Communications for Statistical Applications and Methods
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• 제2권2호
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• pp.310-319
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• 1995

We represent graphically the relationship of hierachical log linear models by regarding the values of the likelihood ratio statistics as the squared norm of the corresponding vectors. Right angled triangles, tetrahedrons, and modified polyhedrons are used for graphical description. We find that the angle between the two vectors depends on the coefficient of determination and the partial coefficent of determination. Thess graphical descriptions could be applied to the model selection method.

• Communications for Statistical Applications and Methods
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• 제7권3호
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• pp.687-698
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• 2000

An identification method is proposed in order to detect more than one outlying cells in multi-way contingency tables. The iterative proportional fitting method is applied to get expected values of several suspected outlying cells. Since the proposed method uses minimal sufficient statistics under quasi log-linear models, expected counts of outlying cells could be estimated under any hierarchical log-linear models. This method is an extension of the backwards-stepping method of Simonoff(1988) and requires les iteration to identify outlying cells.

• Communications for Statistical Applications and Methods
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• 제19권6호
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• pp.761-770
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• 2012

We frequently encounter outcomes of count that have extra variation. This paper considers several alternative models for overdispersed count responses such as a quasi-Poisson model, zero-inflated Poisson model and a negative binomial model with a special focus on a generalized linear mixed model. We also explain various goodness-of-fit criteria by discussing their appropriateness of applicability and cautions on misuses according to the patterns of response categories. The overdispersion models for counts data have been explained through two examples with different response patterns.

• Communications for Statistical Applications and Methods
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• 제4권3호
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• pp.795-805
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• 1997

In this paper, we consider a Bayesian forecasting method for the analysis of repeated surveys. It is assumed that the parameters of the superpopulation model at each time follow a stochastic model. We propose Bayesian prediction procedures for the finite population total under dynamic generalized linear models. Some numerical studies are provided to illustrate the behavior of the proposed predictors.