• 대한한방소아과학회지
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• 제30권2호
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• pp.96-106
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• 2016

Objectives The purpose of this study is to investigate the effects of Gleditsiae Fructus 70% EtOH extract (JS_E) on anti-inflammatory action in HaCaT cells (A spontaneously immortalized human keratinocyte cell line) and inhibiting triglyceride genesis in SEB-1 cells (Immortalized human sebocyte). Methods The anti-inflammatory effect of JS_E was analyzed by enzyme-linked immunosorbent assays (ELISA) which measured levels of IP-10, RANTES and MDC in HaCaT cells. Also the effect on secretion of sebum of JS_E was analyzed by TG-S kit which measured the quantity of triglyceride in SEB-1 cells. Results JS_E inhibited IP-10, RANTES and MDC expression in a dose dependent manner. IP-10 expression was inhibited significantly in comparison to TNF-${\alpha}$ and IFN-${\gamma}$ recombination (TI) control group at concentration of JS_E $200{\mu}g/ml$ and RANTES and MDC expressions were inhibited significantly at concentration of JS_E 100, $200{\mu}g/ml$. JS_E also inhibited triglyceride secretion of SEB-1 cells significantly in comparison to the control group in a dose dependent manner. Conclusions This study shows that JS_E has the effects of anti-inflammatory action and inhibiting sebum secretion. According to these results, JS_E can be used for treating skin diseases such as acne and dermatitis caused by inflammation and excessive secretion of sebum by controlling the activity of the HaCaT and SEB-1 cells.

• The Korean Journal of Physiology and Pharmacology
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• 제4권2호
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• pp.81-90
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• 2000

The types of $K^+$ channel which determine the pattern of spontaneous action potential (SAP) were investigated using whole-cell variation of patch clamp techniques under current- and voltage-clamp recording conditions in rat clonal pituitary $GH_3$ cells. Heterogeneous pattern of SAP activities was changed into more regular mode with elongation of activity duration and afterhyperpolarization by treatment of TEA (10 mM). Under this condition, exposure of the class III antiarrhythmic agent E-4031 $(5\;{\mu}M)$ to $GH_3$ cells hardly affected SAP activities. On the other hand, the main $GH_3$ stimulator thyrotropin-releasing hormone (TRH) still produced its dual effects (transient hyperpolarization and later increase in SAP frequency) in the presence of TEA. However, addition of $BaCl_2$ (2 mM) in the presence of TEA completely blocked SAP repolarization process and produced membrane depolarization in all tested cells. This effect was observed even in TEA-untreated cells and was not mimicked by higher concentration of TEA (30 mM). Also this barium-induced membrane depolarization effect was still observed after L-type $Ca^{2+}$ channel was blocked by nicardipine $(10\;{\mu}M).$ These results suggest that barium-sensitive current is important in SAP repolarization process and barium itself may have some depolarizing effect in $GH_3$ cells.

• PNF and Movement
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• 제18권3호
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• pp.393-401
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• 2020

Purpose: In recent years, there has been increasing interest in using blood flow-restricted exercise (BFRE) or KAATSU training. The KAATSU training method, which partially restricts arterial inflow and fully restricts venous outflow in the working musculature during exercise at reduced exercise intensities, has been proven to result in substantial increases in both muscle hypertrophy and strength. The purpose of this study was to investigate the proper level of pressure for KAATSU training using compound muscle action potential (CMAP) analysis. Methods: Twenty-two healthy adults voluntarily participated in this study. CMAP was conducted by measuring the terminal latency and amplitude using a motor nerve conduction velocity test. For reference-line, supramaximal electrical stimulation was applied to the median nerves of the participants to obtain CMAP for the abductor pollicis brevis. For baseline, the intensity of the electrical stimulation was decreased to a level at which the CMAP amplitude was about a third of the CMAP amplitude obtained by the supramaximal electrical stimulation. The pressure levels for the KAATSU were set as a systolic blood pressure (strong pressure), the median values of systolic and diastolic blood pressure (intermediate pressure), and diastolic blood pressure (weak pressure). In the KAATSU condition, CMAP was performed under the same conditions as baseline after low-intensity thumb abduction exercises were performed at the subjects' own pace for one minute. Results: As the pressure increased, the CMAP amplitude was significantly increased, signifying that more muscle fibers were recruited. Conclusion: This study found that KAATSU training recruited more muscle fibers than low-intensity exercise without the restriction of blood flow.

• 한국해양환경ㆍ에너지학회지
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• 제17권3호
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• pp.224-235
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• 2014

본 연구는 낙동강 진우도 자연 해빈에 내습하는 해양파랑, 해안표착물(해양쓰레기), 배후 식생대 전선의 변화 과정에 대한 상호작용에 대해서 고찰하고자 하였다. 이를 위해 해빈단면 측량, 입사파랑 수치모의실험, 해안표착물 분포 현장 조사, 자연해빈 식생대선 현장 조사 등을 수행하였다. 연구결과를 요약하면 다음과 같다. (1) 진우도 자연해빈의 지반고는 상승하고 있으며 이에 따라서 해안사구 식생대 전선도 전진하는 경향을 나타내고 있다. 지반고가 표고 1.5 m이상이 되는 상황에서 대체적으로 식생대의 전선이 외해방향으로 발달하는 경향이 강하게 나타났다. (2) 진우도 전면 수심에 의해 파랑변형된 입사파랑이 공간상으로 상이하고 소상대에서의 처오름 현상도 공간상으로 복잡한 변화를 야기할 것으로 생각할 수 있다. 해양쓰레기는 파의 처오름이 큰 경우 배후 식생대 전선에 표착물이 도달하고 그렇지 못한 경우에는 해빈상에 독립적인 섬의 형태로 표착물을 침적/퇴적시킬 가능성이 있다. 따라서 이렇게 침적된 표착물은 배후 식생대전선의 전진과 후퇴를 결정짓게 하는 요인이라 할 수 있다. 최종적으로 본 연구에서는 조사결과를 바탕으로 해안표착물과 식생대 전선의 상호작용에 대한 개념적 모식도를 제시하였다.

• 한국정보과학회논문지:소프트웨어및응용
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• 제30권11호
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• pp.1054-1061
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• 2003

강화학습의 대표적인 알고리즘인 Q-Learning은 상태공간의 모든 상태-행동 쌍(state-action pairs)의 평가값이 수렴할 때까지 반복해서 경험하여 최적의 전략(policy)을 얻는다. 상태공간을 구성하는 요소(feature)들이 많거나 요소의 데이타 형태가 연속형(continuous)인 경우, 상태공간은 지수적으로 증가하게 되어, 모든 상태들을 반복해서 경험해야 하고 모든 상태-행동 쌍의 Q값을 저장하는 것은 시간과 메모리에 있어서 어려운 문제이다. 본 논문에서는 온라인으로 학습을 진행하면서 비슷한 상황의 상태들을 클러스터링(clustering)하고 새로운 경험에 적응해서 클러스터(cluster)의 수정(update)을 반복하여, 분류된 최적의 전략(policy)을 얻는 새로운 함수근사(function approximation)방법인 Q-Map을 소개한다. 클러스터링으로 인해 정교한 제어가 필요한 상태(state)는 규칙(rule)으로 추출하여 보완하였다. 미로환경과 마운틴 카 문제를 제안한 Q-Map으로 실험한 결과 분류된 지식을 얻을 수 있었으며 가시화된(explicit) 지식의 형태인 규칙(rule)으로도 쉽게 변환할 수 있었다.

• 한국도로학회논문집
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• 제11권4호
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• pp.79-85
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• 2009

국내의 줄눈 콘크리트 포장설계에 주로 사용되는 다웰바 설계 기준은 국외 기준과 검증되지 않은 경험에 의해 사용되고 있다. 또한 다웰바의 설치는 길어깨나 하부층의 조건 등을 고려하지 못한 상태에서 슬래브 폭에 대하여 일률적으로 적용되고 있다. 이에 다웰바를 합리적으로 설계하기 위해서는 다웰바 거동에 대한 고찰이 요구되며, 이를 3차원 유한요소해석을 이용하여 수행하였다. 다웰바의 거동에 대한 3차원 유한요소해석 결과의 타당성을 검토하기 위하여 Timoshenko이론의 다웰바 거동을 비교하였다. 또한 실제 도로에서 교통하중이 여러 개의 다웰바에 분산 전달하는 다웰바의 그룹작용(Dowel Group Action)을 3차원 유한요소해석을 통하여 다웰바 그룹작용 적용범위를 산정하였다. 본 연구에서 제시된 다웰바 그룹작용 범위는 Friberg의 그룹작용 범위와는 상이한 결과가 나타났으며, 비교적 최근 연구 결과인 Tabatabaie의 그룹작용 범위의 연구결과와 유사한 결과가 도출되었다.

• Archives of Plastic Surgery
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• 제32권3호
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• pp.311-313
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• 2005

Generally, many Asian women tend to dislike the square jaw, as they believe it makes the face look wider, giving a stubborn and strong impression. Contouring of the mandible is therefore a relatively common aesthetic procedure among Asians. These days, the use of botulinum toxin for contouring of the lower face offer simple alternative to surgery. Motor point, which is the site over a muscle where its contraction may be elicited by a minimal intensity short duration electrical stimulus, is the optimal injection point of botulinum toxin. Study was undertaken to identify the location of motor point of the masseter muscle and the skin surface landmark. First, the thickest point of the masseter muscle was inspected through palpation and inspection by 3 different individual plastic surgeons and then compound muscle action potentials(CMAPs) of masseter muscle in 15 health volunteers were recorded using EMG. For the localization of the measured points, line between lateral canthus to the mandibular angle was used. Location of motor points were mapped to skin surface from lateral canthus in a percentage of the distance along the landmark line and in distance in millimeters. The clinical injection point was located at 71.69 percentile and 7.3 mm of the landmark line. The motor point test was located at 72.54 percentile and 7.1 mm of the landmark line. The depth of motor point was 16mm. There was no statistically significant difference between the clinical injection point and the motor point. We conclude that surface mapping of motor point of the masseter muscle would increase accessibility and accuracy in botulinum toxin injection for contouring of the lower face.

• 패션비즈니스
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• 제6권5호
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• pp.27-40
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• 2002

The purpose of this thesis is presenting desirable design of uniform which could reflect high school girls' demands with the researches on their consciousness of fashion and actual state of uniforms. Methods to accomplish this research include first, examinationson characteristics of high school girls and their consciousness of fashion with relevant articles, second, interviews with designers from major domestic uniform brands - ELITE, IVY, SMART - and third, analysis on related internet sites. Practical researches are followed by design analysis and proposal of improvement on high school girls' uniform, accompanied by collection of photographs from field studies, major uniform brands' shops and uniform related internet sites. Korean high school girls in the digital era are able to express themselves in each different fashion with own individuality, preference or intention, as they are particularly interested in clothes or their appearances. Their consciousness of fashion became visible in a shape of negative attitude and dissatisfaction with uniforms due to its out-of-date design, lack of features and inconvenience in action. Besides more than half of high school girls already experienced reforming it for better looks. As a result of current analysis on references of uniform designs, various levels of refinement were noticed even in uniform of similar details, design, fabric textile and color due to differences on size & length of jacket collar, dart, cutting line, size of details, decorative line, easiness in fit, length of clothes, and etc. To provide students of more refined and desired designs which reflect their demands, current uniforms are to begin acquiring delicate changes with present vogue and feature such as size of details, silhouette, cutting line, decorative line and etc. In addition newly designed uniforms are to present desirable design with image of refinement and neat as they actively comprehend students' needs within its symbolic, functional, economic and aesthetic characteristics by nature.

• 통상정보연구
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• 제8권2호
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• pp.141-162
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• 2006

This paper focuses on the phenomenon that international payment system is essential as reverse action of delivery or supply of digital goods in global transactions. In order to impose the customs duties on imported goods in global on-line transactions, the imposition of tariff by tracing the payment process when business transaction is occurring is recommended. The purpose of this study is to review the countermeasures for effective tariff imposition system by using the model of the main payment tools in global transactions. Some models reviewed in this paper are as follows : i) a model of withholding taxes at the source by the credit company ii) a model of self declaration by the importer iii)a model of registering by overseas company iv) a model of negotiating after the taxation at the export country This study is different from existing preceding research at the point of view of presenting 4 models and doing appraisal by each model. It should be done more in depth and various study on the model of the tariff imposition system about the models reviewed at this paper. Systematic and reasonable alternatives which are actually adoptable at the system should also be studied and examined carefully. Because it is required that tariff imposition system on the digital goods should be harmonized with that of traditional business in order to obtain effectiveness and rightfulness, and especially, in order to get justness for the imposition a tariff on digital goods, the process of tax imposition should be predictable and be sure to get the fairness by enhancing the equilibrium, impartiality and transparency.

• KIEE International Transactions on Power Engineering
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• 제4A권4호
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• pp.171-177
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• 2004

In the current age of the information oriented society in which we live, many people use PCs and are dependant on the databases provided by the network server. However, online data can be missed during the occurrence of a blackout and furthermore, power failure can greatly effect Power Quality. This has resulted in the trend of using interruption-free live-line work when trouble occurs in a power system. However, 83% of the population receives an electric shock experience when a laborer is performing interruption-free live-line work. In the interruption-free method, education and training problems have been pinpointed. However, there are few instructors to implement the necessary training. Furthermore, the trainees undergo only a short training period of just 4 weeks. In this paper, to develop a method with no restrictions on time and place and to ensure a reduction in the misuse of materials, immersion type virtual reality (or environment) technology is used. The users of a 3D immersion type VR training system can interact with the system by performing the equivalent action in a safe environment. Thus, it can be valuable to apply this training system to such dangerous work as 'Interruption-free live-line work exchanging COS (Cut-Out-Switch)'. In this program, the user carries out work according to instructions displayed through the window and speaker and cannot perform other tasks until each part of the task is completed in the proper sequence. The workers using this system can utilize their hands and viewpoint movement since they are in a real environment but the trainee cannot use all parts and senses of a real body with the current VR technology. Despite these weak points, when we consider the trends of improvement in electrical devices and communication technology, we can say that 3D graphic VR application has high potentiality.