• The Journal of Pediatrics of Korean Medicine
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• v.30 no.2
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• pp.96-106
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• 2016

Objectives The purpose of this study is to investigate the effects of Gleditsiae Fructus 70% EtOH extract (JS_E) on anti-inflammatory action in HaCaT cells (A spontaneously immortalized human keratinocyte cell line) and inhibiting triglyceride genesis in SEB-1 cells (Immortalized human sebocyte). Methods The anti-inflammatory effect of JS_E was analyzed by enzyme-linked immunosorbent assays (ELISA) which measured levels of IP-10, RANTES and MDC in HaCaT cells. Also the effect on secretion of sebum of JS_E was analyzed by TG-S kit which measured the quantity of triglyceride in SEB-1 cells. Results JS_E inhibited IP-10, RANTES and MDC expression in a dose dependent manner. IP-10 expression was inhibited significantly in comparison to TNF-${\alpha}$ and IFN-${\gamma}$ recombination (TI) control group at concentration of JS_E $200{\mu}g/ml$ and RANTES and MDC expressions were inhibited significantly at concentration of JS_E 100, $200{\mu}g/ml$. JS_E also inhibited triglyceride secretion of SEB-1 cells significantly in comparison to the control group in a dose dependent manner. Conclusions This study shows that JS_E has the effects of anti-inflammatory action and inhibiting sebum secretion. According to these results, JS_E can be used for treating skin diseases such as acne and dermatitis caused by inflammation and excessive secretion of sebum by controlling the activity of the HaCaT and SEB-1 cells.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.2
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• pp.81-90
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• 2000

The types of $K^+$ channel which determine the pattern of spontaneous action potential (SAP) were investigated using whole-cell variation of patch clamp techniques under current- and voltage-clamp recording conditions in rat clonal pituitary $GH_3$ cells. Heterogeneous pattern of SAP activities was changed into more regular mode with elongation of activity duration and afterhyperpolarization by treatment of TEA (10 mM). Under this condition, exposure of the class III antiarrhythmic agent E-4031 $(5\;{\mu}M)$ to $GH_3$ cells hardly affected SAP activities. On the other hand, the main $GH_3$ stimulator thyrotropin-releasing hormone (TRH) still produced its dual effects (transient hyperpolarization and later increase in SAP frequency) in the presence of TEA. However, addition of $BaCl_2$ (2 mM) in the presence of TEA completely blocked SAP repolarization process and produced membrane depolarization in all tested cells. This effect was observed even in TEA-untreated cells and was not mimicked by higher concentration of TEA (30 mM). Also this barium-induced membrane depolarization effect was still observed after L-type $Ca^{2+}$ channel was blocked by nicardipine $(10\;{\mu}M).$ These results suggest that barium-sensitive current is important in SAP repolarization process and barium itself may have some depolarizing effect in $GH_3$ cells.

• PNF and Movement
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• v.18 no.3
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• pp.393-401
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• 2020

Purpose: In recent years, there has been increasing interest in using blood flow-restricted exercise (BFRE) or KAATSU training. The KAATSU training method, which partially restricts arterial inflow and fully restricts venous outflow in the working musculature during exercise at reduced exercise intensities, has been proven to result in substantial increases in both muscle hypertrophy and strength. The purpose of this study was to investigate the proper level of pressure for KAATSU training using compound muscle action potential (CMAP) analysis. Methods: Twenty-two healthy adults voluntarily participated in this study. CMAP was conducted by measuring the terminal latency and amplitude using a motor nerve conduction velocity test. For reference-line, supramaximal electrical stimulation was applied to the median nerves of the participants to obtain CMAP for the abductor pollicis brevis. For baseline, the intensity of the electrical stimulation was decreased to a level at which the CMAP amplitude was about a third of the CMAP amplitude obtained by the supramaximal electrical stimulation. The pressure levels for the KAATSU were set as a systolic blood pressure (strong pressure), the median values of systolic and diastolic blood pressure (intermediate pressure), and diastolic blood pressure (weak pressure). In the KAATSU condition, CMAP was performed under the same conditions as baseline after low-intensity thumb abduction exercises were performed at the subjects' own pace for one minute. Results: As the pressure increased, the CMAP amplitude was significantly increased, signifying that more muscle fibers were recruited. Conclusion: This study found that KAATSU training recruited more muscle fibers than low-intensity exercise without the restriction of blood flow.

• Journal of the Korean Society for Marine Environment & Energy
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• v.17 no.3
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• pp.224-235
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• 2014

Changes in the interactions among incident ocean water waves, coastal debris (marine debris), and the back vegetation zone line on a natural sandy beach on the island of Jinu-do in the Nakdong river estuary were investigated. The study involved a cross-sectional field survey of the beach, numerical modeling of incident ocean water waves, field observations of the distribution of coastal debris, and vegetation zone line tracking using GPS. The conclusions of this study can be summarized as follows: (1) The ground level of the swash zone (sandy beach) on Jinu-do is rising, and the vegetation zone line, which is the boundary of the coastal sand dunes, shows a tendency to move forward toward the open sea. The vegetation zone line is developing particularly strongly in the offshore direction in areas where the ground level is elevated by more than 1.5 m. (2) The spatial distributions of incident waves differed due to variations in the water depth at the front of the beach, and the wave run-up in the swash zone also displayed complex spatial variations. With a large wave run-up, coastal debris may reach the vegetation zone line, but if the run-up is smaller, coastal debris is more likely to deposit in the form of an independent island on the beach. The deposited coastal debris can then become a factor determining which vegetation zone line advances or retreats. Finally, based on the results of this investigation, a schematic concept of the mechanisms of interaction between the coastal debris and the coastal vegetation zone line due to wave action was derived.

• Journal of KIISE:Software and Applications
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• v.30 no.11
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• pp.1054-1061
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• 2003

Q-Learning, a representative algorithm of reinforcement learning, experiences repeatedly until estimation values about all state-action pairs of state space converge and achieve optimal policies. When the state space is high dimensional or continuous, complex reinforcement learning tasks involve very large state space and suffer from storing all individual state values in a single table. We introduce Q-Map that is new function approximation method to get classified policies. As an agent learns on-line, Q-Map groups states of similar situations and adapts to new experiences repeatedly. State-action pairs necessary for fine control are treated in the form of rule. As a result of experiment in maze environment and mountain car problem, we can achieve classified knowledge and extract easily rules from Q-Map

• International Journal of Highway Engineering
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• v.11 no.4
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• pp.79-85
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• 2009

Dowel-bar in the jointed concrete pavement has been designed and constructed by Foreign standard and experience in Korea. Timoshenko solution was evaluated for dowel bar design. However, various assumptions, Timoshenko solution evaluated only single dowel bar. Therefore, This study object is evaluated the guide line dowel size and arrangement that using the 3Dimensional Finite Element Method. Dowel bar behavior, Timoshenko solution and 3D FEM estimated used result. Dowel allowable stress and Friberg bearing stress estimated using result. The effects of Dowel Group Action were analyzed using Timoshenko range and Friberg range and 3D FEM.

• Archives of Plastic Surgery
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• v.32 no.3
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• pp.311-313
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• 2005

Generally, many Asian women tend to dislike the square jaw, as they believe it makes the face look wider, giving a stubborn and strong impression. Contouring of the mandible is therefore a relatively common aesthetic procedure among Asians. These days, the use of botulinum toxin for contouring of the lower face offer simple alternative to surgery. Motor point, which is the site over a muscle where its contraction may be elicited by a minimal intensity short duration electrical stimulus, is the optimal injection point of botulinum toxin. Study was undertaken to identify the location of motor point of the masseter muscle and the skin surface landmark. First, the thickest point of the masseter muscle was inspected through palpation and inspection by 3 different individual plastic surgeons and then compound muscle action potentials(CMAPs) of masseter muscle in 15 health volunteers were recorded using EMG. For the localization of the measured points, line between lateral canthus to the mandibular angle was used. Location of motor points were mapped to skin surface from lateral canthus in a percentage of the distance along the landmark line and in distance in millimeters. The clinical injection point was located at 71.69 percentile and 7.3 mm of the landmark line. The motor point test was located at 72.54 percentile and 7.1 mm of the landmark line. The depth of motor point was 16mm. There was no statistically significant difference between the clinical injection point and the motor point. We conclude that surface mapping of motor point of the masseter muscle would increase accessibility and accuracy in botulinum toxin injection for contouring of the lower face.

• Journal of Fashion Business
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• v.6 no.5
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• pp.27-40
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• 2002

The purpose of this thesis is presenting desirable design of uniform which could reflect high school girls' demands with the researches on their consciousness of fashion and actual state of uniforms. Methods to accomplish this research include first, examinationson characteristics of high school girls and their consciousness of fashion with relevant articles, second, interviews with designers from major domestic uniform brands - ELITE, IVY, SMART - and third, analysis on related internet sites. Practical researches are followed by design analysis and proposal of improvement on high school girls' uniform, accompanied by collection of photographs from field studies, major uniform brands' shops and uniform related internet sites. Korean high school girls in the digital era are able to express themselves in each different fashion with own individuality, preference or intention, as they are particularly interested in clothes or their appearances. Their consciousness of fashion became visible in a shape of negative attitude and dissatisfaction with uniforms due to its out-of-date design, lack of features and inconvenience in action. Besides more than half of high school girls already experienced reforming it for better looks. As a result of current analysis on references of uniform designs, various levels of refinement were noticed even in uniform of similar details, design, fabric textile and color due to differences on size & length of jacket collar, dart, cutting line, size of details, decorative line, easiness in fit, length of clothes, and etc. To provide students of more refined and desired designs which reflect their demands, current uniforms are to begin acquiring delicate changes with present vogue and feature such as size of details, silhouette, cutting line, decorative line and etc. In addition newly designed uniforms are to present desirable design with image of refinement and neat as they actively comprehend students' needs within its symbolic, functional, economic and aesthetic characteristics by nature.

• International Commerce and Information Review
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• v.8 no.2
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• pp.141-162
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• 2006

This paper focuses on the phenomenon that international payment system is essential as reverse action of delivery or supply of digital goods in global transactions. In order to impose the customs duties on imported goods in global on-line transactions, the imposition of tariff by tracing the payment process when business transaction is occurring is recommended. The purpose of this study is to review the countermeasures for effective tariff imposition system by using the model of the main payment tools in global transactions. Some models reviewed in this paper are as follows : i) a model of withholding taxes at the source by the credit company ii) a model of self declaration by the importer iii)a model of registering by overseas company iv) a model of negotiating after the taxation at the export country This study is different from existing preceding research at the point of view of presenting 4 models and doing appraisal by each model. It should be done more in depth and various study on the model of the tariff imposition system about the models reviewed at this paper. Systematic and reasonable alternatives which are actually adoptable at the system should also be studied and examined carefully. Because it is required that tariff imposition system on the digital goods should be harmonized with that of traditional business in order to obtain effectiveness and rightfulness, and especially, in order to get justness for the imposition a tariff on digital goods, the process of tax imposition should be predictable and be sure to get the fairness by enhancing the equilibrium, impartiality and transparency.

• KIEE International Transactions on Power Engineering
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• v.4A no.4
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• pp.171-177
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• 2004

In the current age of the information oriented society in which we live, many people use PCs and are dependant on the databases provided by the network server. However, online data can be missed during the occurrence of a blackout and furthermore, power failure can greatly effect Power Quality. This has resulted in the trend of using interruption-free live-line work when trouble occurs in a power system. However, 83% of the population receives an electric shock experience when a laborer is performing interruption-free live-line work. In the interruption-free method, education and training problems have been pinpointed. However, there are few instructors to implement the necessary training. Furthermore, the trainees undergo only a short training period of just 4 weeks. In this paper, to develop a method with no restrictions on time and place and to ensure a reduction in the misuse of materials, immersion type virtual reality (or environment) technology is used. The users of a 3D immersion type VR training system can interact with the system by performing the equivalent action in a safe environment. Thus, it can be valuable to apply this training system to such dangerous work as 'Interruption-free live-line work exchanging COS (Cut-Out-Switch)'. In this program, the user carries out work according to instructions displayed through the window and speaker and cannot perform other tasks until each part of the task is completed in the proper sequence. The workers using this system can utilize their hands and viewpoint movement since they are in a real environment but the trainee cannot use all parts and senses of a real body with the current VR technology. Despite these weak points, when we consider the trends of improvement in electrical devices and communication technology, we can say that 3D graphic VR application has high potentiality.