• 전기학회논문지
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• 제57권11호
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• pp.2035-2040
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• 2008

The electrical discharge of high voltage direct current(HVDC) overhead transmission line generate audible noise, radio noise, electric field, ion current and induced voltage on the ground. These items are major factors to design environmentally friendly configuration of DC transmission line. Therefore, HVDC transmission lines must be designed to keep all these corona effects within acceptable levels. Several techniques have been used to assess interference caused by ions on HVDC overhead transmission line. In this study, to assess the ion characteristic of DC line, the ion current density and induced voltage caused by ion flow were measured by plate electrodes manufactured from a metal flat board and charged bodies, respectively. The charged body has two types of cylinder and cylindrical plate. From the results of calibration experiments, the sensitivity of flat electrode and charged body can be obtained. At present, the developed system is used to investigate the ion generation characteristics of Kochang DC ${\pm}500kV$ test line.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 하계학술대회 논문집 A
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• pp.559-561
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• 2001

본 연구에서는 총괄비용법 가운데 선로의 이용정도에 따른 송전요금의 결정에서 활용될 수 있는 모선에 대한 선로의 조류 민감도를 유도하였다. 또한, 발전기 및 부하의 증가에 대한 조류 민감도를 일반화하였으며, 기존의 반복적인 조류계산 수행 전략과 결과를 비교하였다. 제안된 방법론은 샘플 및 실계통에 적용하여 호주 빅토리아주의 선로 민감도 방법론과 비교 분석하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2115-2120
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• 2012

The presence of lung cancer cells in anoxic zones is a key cause od chemotherapeutic resistance. Thus, it is necessary to enhance the sensitivity of such lung cancer cells. However, loss of efficient gene therapeutic targeting and inefficient objective gene expression in the anoxic zone in lung cancer are dilemmas. In the present study, a eukaryotic expression plasmid pUC57-HRE-JAB1 driven by a hypoxia response elements promoter was constructed and introduced into lung cancer cell line A549. The cells were then exposed to a chemotherapeutic drug cis-diamminedichloroplatinum (C-DDP). qRT-PCR and western blotting were used to determine the mRNA and protein level and flow cytometry to examine the cell cycle and apoptosis of A549 transfected pUC57-HRE-JAB1. The results showed that JAB1 gene in the A549 was overexpressed after the transfection, cell proliferation being arrested in G1 phase and the apoptosis ratio significantly increased. Importantly, introduction of pUC57-HRE-JAB1 significantly increased the chemotherapeutic sensitivity of A549 in an anoxic environment. In conclusion, JAB1 overexpression might provide a novel strategy to overcome chemotherapeutic resistance in lung cancer.

• 한국산학기술학회논문지
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• 제18권2호
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• pp.6-13
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• 2017

본 연구에서는 혼화기의 혼화성능과 압력손실을 개선하기 위해 오리피스의 형상과 개수에 따른 영향을 해석하였다. 물의 정수에서 중요한 과정은 물속의 이물질을 포집하는 응집 과정이고 응집제가 얼마나 물속에 고른 분포를 가지고 물속에 혼화되어 있는 지가 정수에 큰 영향을 미친다. 기계식 혼화방식이 갖는 정수과정에서의 긴 체류시간, 기계 소음, 과다한 에너지의 소비 및 높은 유지관리 비용 등의 단점을 보완하기 위해서 최근에는 응집제가 원수에 주입됨과 동시에 가능한 한 빠르게 수중에 확산시킬 수 있는 장치로서 관내혼화장치의 도입이 증가추세에 있다. 본 연구에서는 관내 혼화기의 혼화성능과 압력손실을 개선하기 위해 오리피스의 유무, 형상과 개수에 따른 약품의 체적분률, 관내 압력손실 등 유동특성과 체적분률이 수치해석에 의해 계산된다. 관내 혼화장치에 장착된 오리피스는 혼화정도를 향상시키나 압력손실이 증가되므로 오리피스의 개수를 제한하여야 한다. 주요 인자에 대한 민감도 분석을 통해 가이드 베인을 장착한 오리피스 1개를 사용하여 약품의 체적분률과 압력손실이 개선된 관내 혼화장치를 제안하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6517-6521
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• 2012

To analyze the growth, proliferation, apoptosis, invasiveness and chemotherapy sensitivity of EC9706 cells after K-Ras gene silencing, an expression carrier pSilencer-siK-Ras was constructed, and the EC9706 cell line was transfected using a liposome technique. Six groups were established: Control, siRNA NC (transfected with empty vector pSilencer2.1); Ras siRNA (transfected with pSilencer-siK-Ras2); Paclitaxel; Paclitaxel + siRNA NC; and Ras siRNA + Paclitaxel. After the treatment, RT-PCR, Western blotting, MTT assay, flow cytometry and the Transwell technique were used to assess expression of K-Ras mRNA and protein in EC9706 cells, as well as cell growth, proliferation, apoptosis and invasiveness. The effect of Paclitaxel chemotherapy was also tested. pSilencer-siK-Ras2 effectively down-regulated expression of K-Ras mRNA and protein in EC9706 cells, growth being significantly inhibited. Flow cytometry indicated obvious apoptosis of cells in the experimental group, with arrest in the G1 phase; cell migration ability was also reduced. After pSilencer-siK-Ras2 transfection or the addition of Paclitaxel, EC9706 cells were suppressed to different extents; the suppressive effect was strengthened by combined treatment. The results suggested that RNAi-induced K-Ras gene silencing could enhance chemotherapy sensitivity of esophageal cancer.

• 한국유체기계학회 논문집
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• 제17권6호
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• pp.13-20
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• 2014

It is necessary to design a compressor with high pressure ratio that satisfies the IMO(international maritime organization) NOx emission regulation for the marine diesel engine. Impeller was designed using the modified slip factor with the flow coefficient. The main purpose of this study is to investigate the sensitivity of the compressor performance by the vaned diffuser geometries. The first vaned diffuser type was based on a NACA airfoil, the second was channel diffuser, and the third was conformally transformated configuration of a NACA65(4A10)06 airfoil. The sensitivity of the performance was calculated using a commercial CFD program for three different diffuser geometries. The channel diffuser showed the wide range of operation and higher pressure characteristics, comparing with the others. This is attributed to the flow stability at diffuser. Combined with this results with impeller design, the optimized compressor was designed and verified by the test results.

• The Journal of Asian Finance, Economics and Business
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• 제8권10호
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• pp.305-315
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• 2021

This study aims to investigate the relationship between the difference in gender of top executives and corporate investment. In addition, this study also extends to how the sensitivity of investment to cash flow varies with the gender of leaders. Finally, the effect of the gender of leaders on firm investment is also tested across firm types (state firms vs. private firms and high-growth firms vs. low-growth firms). Based on the dataset of Vietnamese listed firms over 2007-2017, the fixed-effect model is used to test the hypotheses. The results show that women as chairs of the board tend to lower corporate investment, whereas the gender of CEOs (Chief Executive Officers) does not influence the investment level. Moreover, top female executives are associated with a decrease in the sensitivity of investment to cash flow. These regression results also show that top female executives only have an impact on the rate of investment in private and low-growth firms. The findings of this study are useful for the board of directors in selecting a chairperson in line with the firm's strategies. Furthermore, the findings of this study are also meaningful for policymakers who should monitor the separate role of the CEO and chair of the board in a company.

• Journal of Advanced Marine Engineering and Technology
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• 제28권5호
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• pp.837-846
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• 2004

This paper presents a screening technique for greatly reducing the computation involved in determining the optimal location and types of Flexible AC Transmission System (FACTS) devices in a large power system. The first-order sensitivities of the generation cost for various FACTS devices are derived. This technique requires solving only one optimal power flow (OPF) to obtain sensitivities with respect to FACTS device control variables for every transmission line To implement a sensitivity-based screening technique, we used a new UPFC model, which consists of an ideal transformer with a complex turns ratio and a variable shunt admittance. A S-bus system based on the IEEE 14-bus system was used to illustrate the technique.

• 에너지공학
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• 제13권1호
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• pp.60-67
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• 2004

규제완화된 경쟁적 전력시장으로의 이행은 전력계통의 운영 및 계획에 있어서 기존의 중앙급전방식과는 다른 새로운 개념을 필요로 하고 있다. 경쟁적 전력시장에서의 전력계통 운영은 경제적 측면을 충분히 고려하여 보다 적은 여유로 운영될 것으로 예상된다. 따라서 SCOPF(Security Constrained Optimal Power Flow서 역할이 커지면서 실시간 안전도 처리에 대한 중요성이 보다 부각되고 있다. 본 논문은 On-Line 상의 적용을 가능하게 하는 SCOP떠 응용을 다룬다. 전력계통의 안전도 여유는 계통의 조건과 부하상황에 따라 시시각각 변화한다. 따라서 안전도 처리를 위한 민감도 계수 역시 전력계통 상태에 따라 재계산되고 적용 시에 갱신 처리되어야 한다. 본 논문의 목적은 안전도 처리를 위한 민감도 계수의 효율적인 사용을 통해 적정 안전도를 확보하여 이 알고리즘을 계통운영상에 실시간으로 적용 가능토록 하기 위함이다. 사례연구에서는 제안된 메커니즘을 간단한 예제계통에 적용하여, 상정사고에 대한 보다 안정적인 결과가 나타남을 보였다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.895-901
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• 2013

Resistance to induction of apoptosis is a major obstacle for bladder cancer treatment. Bcl-2 is thought to be involved in anti-apoptotic signaling. In this study, we investigated the effect of Bcl-2 overexpression on apoptotic resistance and intracellular reactive oxygen species (ROS) generation in bladder cancer cells. A stable Bcl-2 overexpression cell line, BIU87-Bcl-2, was constructed from human bladder cancer cell line BIU87 by transfecting recombinant Bcl-2 [pcDNA3.1(+)-Bcl-2]. The sensitivity of transfected cells to adriamycin (ADR) was assessed by MTT assay. Apoptosis was examined by flow cytometry and acridine orange fluorescence staining. Intracellular ROS was determined using flow cytometry, and the activities of superoxide dismutase (SOD) and catalase (CAT) were also investigated by the xanthinoxidase and visible radiation methods using SOD and CAT detection kits. The susceptibility of BIU87-Bcl-2 cells to ADR treatment was significantly decreased as compared with control BIU87 cells. Enhanced expression of Bcl-2 inhibited intracellular ROS generation following ADR treatment. Moreover, the suppression of SOD and CAT activity induced by ADR treatment was blocked in the BIU87-Bcl-2 case but not in their parental cells. The overexpression of Bcl-2 renders human bladder cancer cells resistant to ADR-induced apoptosis and ROS might act as an important secondary messenger in this process.