• 농업과학연구
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• 제13권1호
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• pp.139-146
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• 1986

과망간산카리움법(法)을 이용(利用)하여 자연발생(自然發生)아밀로이드증(症)의 소(15례(例)), 개(1례(例)), 및 고양이 (1례(例)) 그리고 인공유발(人工誘發)아밀로이드증(症) (토끼, 1례(例))으로부터 채취(採取)한 아밀로이드단백(蛋白)의 침착장기(沈着臟器)에 대하여 침착(沈着)아밀로이드의 성상(性狀)을 조직화학적(組織化學的)으로 검사(檢査)하였다. 그 결과(結果), 소, 개 및 인공유발 토끼의 아밀로이드증(症)에서 각(各) 장기(臟器) 모두 적갈색(赤褐色)의 형광(螢光)및 녹색(綠色)의 편광(扁光)이 소실(消失)되어 과망간산카리움의 처리(處理)에 대해 감수성(感受性)이었다. 이 사실(事實)로 보아 소, 개 및 인공유발아밀로이드증례(症例) 모두 amyloid protein A(AA 단백(蛋白))에 상당(相當)하는 것으로 판명(判明)되었다. 반면 고양이 1증례(症例)에서는 과망간산카리움처리(處理) 후(後)에도 침착(沈着)아밀로이드의 Congo red에 대한 친화성(親和性)이 잔존(殘存)하였고 또한 신장(腎臟)의 사구체(絲球體)에 면역(免疫) 글리부린의 침착(沈着)이 인정(認定)된 점으로 보아, 본(本) 증례(症例)의 아밀로이드 단백(蛋白)은 amyloid light chain related protein (AL 단백(蛋白))에 상당(相當)하는 것으로 사료(思料)되었다.

• Korean Journal of Radiology
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• 제25권5호
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• pp.426-437
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• 2024

Objective: Cardiac magnetic resonance (CMR) is a diagnostic tool that provides precise and reproducible information about cardiac structure, function, and tissue characterization, aiding in the monitoring of chemotherapy response in patients with light-chain cardiac amyloidosis (AL-CA). This study aimed to evaluate the feasibility of CMR in monitoring responses to chemotherapy in patients with AL-CA. Materials and Methods: In this prospective study, we enrolled 111 patients with AL-CA (50.5% male; median age, 54 [interquartile range, 49-63] years). Patients underwent longitudinal monitoring using biomarkers and CMR imaging. At follow-up after chemotherapy, patients were categorized into superior and inferior response groups based on their hematological and cardiac laboratory responses to chemotherapy. Changes in CMR findings across therapies and differences between response groups were analyzed. Results: Following chemotherapy (before vs. after), there were significant increases in myocardial T2 (43.6 ± 3.5 ms vs. 44.6 ± 4.1 ms; P = 0.008), recovery in right ventricular (RV) longitudinal strain (median of -9.6% vs. -11.7%; P = 0.031), and decrease in RV extracellular volume fraction (ECV) (median of 53.9% vs. 51.6%; P = 0.048). These changes were more pronounced in the superior-response group. Patients with superior cardiac laboratory response showed significantly greater reductions in RV ECV (-2.9% [interquartile range, -8.7%-1.1%] vs. 1.7% [-5.5%-7.1%]; P = 0.017) and left ventricular ECV (-2.0% [-6.0%-1.3%] vs. 2.0% [-3.0%-5.0%]; P = 0.01) compared with those with inferior response. Conclusion: Cardiac amyloid deposition can regress following chemotherapy in patients with AL-CA, particularly showing more prominent regression, possibly earlier, in the RV. CMR emerges as an effective tool for monitoring associated tissue characteristics and ventricular functional recovery in patients with AL-CA undergoing chemotherapy, thereby supporting its utility in treatment response assessment.