• 근관절건강학회지
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• 제7권1호
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• pp.77-88
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• 2000

The arthritis patients suffer from psychological, social and spiritual problems as well as physical problems because the arthritis is not curable and has chronic pain, joint deformity, limitation of activity and physical dysfunction for all of his life. Especially if they do not find the meaning in their lives, they will experience spiritual distress seriously. Therefore, it is important that nurses help the patients to find the meaning in their lives and to reduce spiritual distress. The purpose of this study is to provide a basis for nursing intervention strategies to minimize the arthritis patients' spiritual distress and understand the relationship between the meaning of life and the spiritual distress in arthritis patients. The samples were composed of 157 arthritis patients. Data collection was carried out from October 1, 1998 to February 28, 1999. Data were analyzed using a SAS program for descriptive statistic, Pearson correlation, t-test, ANOVA, linear regression. The results were as follow; 1. The scores on the meaning of life scale ranged from 51 to 130 with a mean of 93. 2. The scores on the spiritual distress scale ranged from 26 to 91 with a mean of 60. 3. There were significant correlations between the meaning of life and the spiritual distress(r=.53, p=.00). 4. The linear regression analysis showed that the meaning of life explained 13% of the spiritual distress. 5. In the degree of the meaning of life and the spiritual distress according to the general characteristics, the level of the meaning of life in arthritis patients was different by the duration of incidence(F=2.71, p=.03). In conclusion, the nursing intervention strategies to reduce the spiritual distress in arthritis patients must take into account the meaning of life.

• 한국육종학회지
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• 제40권2호
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• pp.97-100
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• 2008

Lectin protein and Kunitz trypsin inhibitor (KTI) protein of mature soybean seed are a main antinutritional factor in soybean seed. The Le gene controls a lectin protein and Ti gene controls the KTI protein in soybean. Ti locus has been located on linkage group 9 in the classical linkage map of soybean. Position of Le locus on linkage map was not identified. Genetic relationship between Ti locus and Le locus could be useful in soybean breeding program for the genetic elimination of these factors. The objective of this study was to determine the independent inheritance or linkage between Ti locus and Le locus in soybean seed. Two $F_2$ populations were developed from three parents (Gaechuck#1, T102, and PI548415). The $F_1$ seeds from Gaechuck#1 (titiLeLe) ${\times}$ T102 (TiTilele) and Gaechuck#1 (titiLeLe) ${\times}$ PI548415 (TiTilele) were obtained. The lectin and KTI protein were analysed from $F_2$ seeds harvested from the $F_1$ plants to find independent assortment or linkage between Ti locus and Le locus. The segregation ratios of 3 : 1 for Le locus (129 Le_ : 44 lele) and Ti locus (132 Ti_ : 41 titi) and were observed. The segregation ratios of 9 : 3 : 3 : 1 (95 Le_Li_ : 34 Le_titi: 37 leleTi_ : 7 leletiti) between Le gene and Ti gene in $F_2$ seeds were observed. This data showed that Ti gene was inherited independently with the Le gene in soybean. These results will be helpful in breeding program for selecting the line with lacking both KTI and lectin protein in soybean.

• Toxicological Research
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• 제35권4호
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• pp.395-402
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• 2019

Subcutaneous adipose tissue (SAT) accumulation is a constitutional disorder resulting from metabolic syndrome. Although surgical and non-surgical methods for reducing SAT exist, patients remain non-compliant because of potential adverse effects and cost. In this study, we developed a new minimally-invasive approach to achieve SAT reduction, using a microneedle (MN) patch prepared from gelatin, which is capable of regulating fat metabolism. Four gelatin types were used: three derived from fish (SA-FG, GT-FG 220, and GT-FG 250), and one from swine (SM-PG 280). We applied gelatin-based MN patches five times over 4 weeks to rats with high-fat diet (HD)-induced obesity, and determined the resulting amount of SAT. We also investigated the histological features and determined the expression levels of fat metabolism-associated genes in SAT using hematoxylin and eosin staining and western blotting, respectively. SAT decreased following treatment with all four gelatin MN patches. Smaller adipocytes were observed in the regions treated with SA-FG, GT-FG 250, and SM-PG 280 MNs, demonstrating a decline in fat accumulation. The expression levels of fat metabolism-associated genes in the MN-treated SAT revealed that GT-FG 220 regulates fatty acid synthase (FASN) protein levels. These findings suggest that gelatin MN patches aid in decreasing the quantity of unwanted SAT by altering lipid metabolism and fat deposition.

• 생약학회지
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• 제30권2호
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• pp.202-206
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• 1999

The MeOH extracts obtained from the leaves of Eucommia ulmoides were solvent-fractionated with EtOAc, n-BuOH, and $H_20$, successively. From the EtOAc extract showing Grab2-Shc inhibitory activity, a flavonol and a lignan compounds were isolated through repeated silica gel column chromatographies. By interpretation of several spectral data and adaptation of acetylation method, the chemical structures of the compounds were determined as 5,7,3',4'-tetrahydroxy-flavonol (quercetin), and 4,4',8',9-tetrahydroxy-3,3'-dimethoxy-7,9'-cyclolignan {(-)-olivil)}, respectively. The compounds exhibited $IC_{50}$ values in Grb2-Shc inhibitory activity to be 93 and $210\;{\mu}mole/l$, respectively.

• Journal of Microbiology and Biotechnology
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• 제20권2호
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• pp.397-402
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• 2010

A Gram-negative, rod-shaped, gliding, aerobic bacterium, designated $12157^T$, was isolated from the desert of Xinjiang, China and subjected to a polyphasic taxonomic study. The strain $12157^T$ grew optimally at pH 7.0 and $30^{\circ}C$. MK-7 was the predominant respiratory menaquinone. The DNA G+C content was 42.0 mol%. Phylogenetic analysis based on the 16S rRNA gene sequences showed that the isolate was mostly related to members of the genus Pedobacter, with similarities ranging from 90.0% to 93.7%. Phylogenetic evidence and the results of phenotypic and genotypic analyses support the establishment of a novel species, Pedobacter xinjiangensis sp. nov., with strain $12157^T$ (=CCTCC AB $208092^T$=NRRL B-$51338^T$) as the type strain.

• 성인간호학회지
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• 제21권3호
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• pp.339-348
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• 2009

Purpose: We aimed to describe and compare the cognitive function, anxiety, and quality of life for the demented elderly in day care centers or nursing homes. Methods: We selected 44 subjects from day care centers and 63 subjects from nursing homes by performing convenience sampling. The Korean version of Mini Mental Status Examination was used for measuring cognitive status; Rating Anxiety in Dementia, for assessing anxiety; Korean Version of Quality of Life-Alzheimer's Disease, for assessing the quality of life. The data were collected from May to June 2008 and analyzed by SPSS/WIN 14.0. Results: 1) The cognitive function of the subjects in the day care center was higher than that of the subjects in the nursing home. Anxiety in the subjects in the nursing home was higher than that in the subjects in the day care center. 2) The cognitive function and quality of life of the subjects in the day care center showed statistically significant correlation, 3) The anxiety and quality of life of the subjects in the nursing home showed statistically significant correlation. Conclusions: Nursing interventions that improve the quality of life of the demented elderly should be considered and applied according to the degree of cognitive function and anxiety.

• 대한가정학회지
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• 제40권7호
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• pp.53-68
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• 2002

The purpose of this study is to clarify the influence of positive interactions between the low-income female householders and children on the mothers'psychological well-being and quality of life. The major findings are as following: First, there were high level of life satisfaction and low level of depression among the low-income female householders who perceived high level of children's emotional support. The difference from the existence of the low-income female householder\`s husband was not found in the life satisfaction and depression. After controling for the low-income female householder's health, the differences were maintained. Second, the low-income female householders who communicated with their children open-heartedly felt higher level of life satisfaction and lower level of depression than those who had less communication with their children. The difference from the existence of the low-income female householder's husband was not found in the life satisfaction and depression. After controlling for the low-income female householder\`s educational level and health, the differences were maintained. finally, the low-income female householders felt higher level of life satisfaction and lower level of depression when they listened to their children closely, and were satisfied with mother-child communication.

• Elastomers and Composites
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• 제54권4호
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• pp.351-358
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• 2019

To evaluate the aging of a rubber pad in power window switch which is the part of a vehicle, the accelerated thermal aging test of rubber pad material is performed. Finite element analysis was performed using the nonlinear material constants of the rubber pad to calculate the operating force, and the Arrhenius relationship was derived from the aging temperature and time. The aging test was performed at 150, 180, 210, or 240 ℃ for 1 to 60 days. When the operating force of the rubber pad is changed by 10% from the initial value, the service life is expected to be 113 years, which is much longer than the life of the vehicle. This indicates that the aging life of the rubber pad is sufficiently safe and the operating force of the rubber pad during the life of the vehicle (20 years) was decreased by approximately 8.4%. By examining the correlation between the shear elastic modulus and operating force calculated from finite element analysis under each aging test condition, the changes in the operating force of the rubber pad and the shear elastic modulus showed good linear relationship. The aging life could be predicted by the change in shear elastic modulus and a process for predicting the aging life of automotive power window switch rubber pad parts is described herein.

• Journal of Preventive Medicine and Public Health
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• 제55권5호
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• pp.444-454
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• 2022

Objectives: We aimed to identify the factors related to depression and quality of life in patients with hypertension by using multilevel regression analysis. Methods: In 2019, 229 043 participants in the Korean Community Health Survey were selected as the study group. Individual factors were identified using data from the 2019 Community Health Survey. Regional factors were identified using data from the National Statistical Office of Korea. Multilevel regression analysis was conducted to find individual and local factors affecting depression and quality of life in patients with hypertension and to determine any associated interactions. Results: As individual factors in patients with hypertension, women, those with lower education-levels, recipients of basic livelihood benefits, and those with poor dietary conditions showed stronger associations with depression and quality of life. As regional factors and individual-level variables in patients with hypertension, lower gross regional personal income, fewer doctors at medical institutions, and lower rates of participation in volunteer activities presented stronger associations with depression and quality of life. In addition, the associations of depression with gross regional personal income, the number of doctors at medical institutions, and dietary conditions were significantly stronger in patients with hypertension than in patients without hypertension. The associations of gender and employment status with quality of life were also significantly greater. Conclusions: Policy interventions are needed to adjust health behaviors, prevent depression, and improve quality of life for patients with hypertension, especially for those with the risk factors identified in this study.

• 사회복지연구
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• 제42권2호
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• pp.275-302
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• 2011

본 연구의 목적은 이야기성에 주목한 생애사연구를 위해 남성노인의 생애사를 재구성하는 데에 있다. 이에 해당 생애사를 내러티브-생애사 인터뷰 분석방법에 따라 재구성한 결과, 이야기된 생애사는 '독자로서의 의무가 이끄는 삶으로 엮여 들어가 "독자 행세" 를 하지 않을 수 없었던 삶' 이라는 생애사적 관점에 따라 구성되고 있는 반면, 체험된 생애사는 '자기주도적인 삶의 의지' 를 관철시키는 삶을 살아온 것으로 구성되는 차이가 있음을 조절메커니즘에 의거해 도출하였다. 그리고 이러한 양 생애사 간 차이는 생애사적 자기평가와 생애사적 실재성 간에 괴리가 있음을 의미하는 것으로 해석하였다. 이러한 결과에 의거해, 이야기성에 주목한 생애사연구가 노인복지실천과 노인복지학 분야 생애사연구 방법에 함의하는 점을 논의하였다.