• Journal of Korean Neurosurgical Society
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• 제53권5호
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• pp.303-304
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• 2013

Rhabdomyolysis is a rare but potentially life-threatening disorder caused by the release of injured skeletal muscle components into the circulation. The authors report a case of severe head injury, in which a hyperosmolar state and continuous seizure complicated by severe rhabdomyolysis and acute renal failure evolved during the course of treatment resulted in a fatal outcome despite intensive supportive treatment. Our bitter experience suggests that rhabdomyolysis should be born in mind in patients with severe head injury who may develop hyperosmolar state and continuous seizure.

• Journal of Korean Biological Nursing Science
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• 제22권3호
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• pp.172-175
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• 2020

Purpose: The purpose of this paper is to provide nurses with a concise review on neurodegenrative dementias. This review includes pathophysiology, clinical course, and tips on management of dementias from Alzheimer's disease (AD), Parkinson disease (PD) and lewy body dementia (LBD). Considering increasing numbers of dementia cases among older adults, nurses who are cognizant about dementia care are instrumental in maximizing daily activities and quality of life of patients with cognitive impairment and dementia.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2000년도 가을 학술발표회 논문집(II)
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• pp.1091-1094
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• 2000

An experimental study is carried out to estimate the way of applying the granulated blast furnace slag[GBFS] to the lean concrete subbase of concrete pavement. According to the test results, this application seems promising. For this application, mixing percent of GBFS ranging from 30 to 45 is recommendable at this stage. Expected benefits using GGBFS in the field of concrete pavement include reduced shrinkage crack, reduced pavement thickness, and extended service life.

• Journal of Chest Surgery
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• 제16권3호
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• pp.381-385
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• 1983

Congenital bronchoesophageal fistula without esophageal atresia is very rare and often has an insidious clinical course that occasionally persists into adult life. Here are presented five cases of congenital bronchoesophageal fistula without esophageal atresia in adults treated successfully in the Seoul National University Hospital. The patients included two women and three men in the range of 16 and 45 years old. [mean age: 32 years old] Three of five cases could be diagnosed preoperatively by esophagogram and bronchogram but two of them could only be found in operative field. Cineesophagogram is recommended, on review of the literature, to be the most rewarding diagnostic procedure.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 추계 학술발표회 제20권2호
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• pp.969-974
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• 2008

본 연구는 철근콘크리트 구조물의 사용을 증진하기 위한 성능중심형 고내구성 콘크리트의 배합설계를 위해 환경 조건 및 사용목적에 따른 설계요소를 알아보고 대표적인 성능검증 방법에 관하여 언급하고자 한다. 일반적인 콘크리트의 성능은 주로 강도, 내구성, 유동성의 3요소를 의미하지만 성능중심형 콘크리트는 연구자의 소견과 환경에 따라서 많은 차이를 보일 수 있다. 따라서 콘크리트 배합설계시 사용 기간 내에는 구조체 및 부재에 대하여 요구 성능을 만족하여야 하며, 콘크리트 배합설계자는 구조물의 용도, 기능 및 사회적 중요도를 바탕으로 설계 년수를 결정하여야 한다. 성능중심형 콘크리트는 반드시 배합시험을 통하여 결정하는 것을 원칙으로 하며, 사용자로부터 요구되는 내용연수 및 요구성능과 법적, 사회적 제약조건을 만족하는 설계내용년수를 설정해야 한다. 또한 현장조사를 통하여 구조물이 위치하는 환경적 요인을 충분히 고려하고 부재의 설계 강도, 타설시기,타설물량등 제반조사 및 시험이 완료되어야 할 시점을 결정하여 전체실험 계획을 수립하여야 한다.본 연구에서는 다양한 열화 환경요소 중 콘크리트의 내구성에 관한 기본적인 요소로써 기온, 온도, 일사열, 중성화, 동해 및 염해 등 일반적인 구조물에 작용한다고 판단되는 요인만을 산정하였다. 또한 대표적인 성능중심형 고내구성 콘크리트의 성능 검증방법으로 탄산화, 동해, 염해 및 화학약품에 대한 성능검증 방법에 대해 언급하였다. 아직까지 국내에서는 콘크리트 구조물의 성능중심형 고내구설계 시공지침으로서 표준적인 시방이 정해지지 않았으나 향후 양질의 사회자본을 축척하고 이를 계승발전하기 위해서는 국내의 콘크리트 구조물에 대한 고내구성 콘크리트의 배합설계를 위한 연구는 필수적이라고 판단된다.

• Journal of Microbiology and Biotechnology
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• 제10권3호
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• pp.423-428
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• 2000

Bacteriocins are classified as proteins which are produced by heterogeneous groups of bacteria, having and antimicrobial effect of the closely related organisms. Recently, bacteriocins derived from lactic acid bacteria and other food-related organisms have been the subject of much research on potential food biopreservatives. The goal of this study was to screen and characterize the bacteriocinogenic lactic acid bacteria from Jeot-gal(commercial fermented fish foods). All bacteriocinogenic isolates were identified as lactic acid bacteria. Isolates NK24, NK34, and SA72 were tentatively identified as Lactobacillus brevis, according to the API 50 CHL kit database. All antimicrobial substances produced from four lactic acid bacteria isolates completely lost their antibacterial activity after being treated with some proteases, indicating to their proteinaceous nature. The bacteriocin produced from isolates NK24, NK34, and SA72 showed a broad spectrum of activity when compared to those produced from isolate SA131. All bacteriocins isolated during the course of this study showed a bactericidal mode of inhibition.

• BMB Reports
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• 제38권5호
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• pp.577-583
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• 2005

Subtilisin QK, which is newly identified as a fibrinolytic enzyme from Bacillus subtilis QK02, has the ability of preventing nitrotyrosine formation in bovine serum albumin induced by nitrite, hydrogen peroxide and hemoglobin in vitro verified by ELISA, Western-blot and spectrophotometer assay. Subtilisin QK also attenuates the fluorescence emission spectra of bovine serum albumin in the course of oxidation caused by nitrite, hydrogen peroxide and hemoglobin. Furthermore, subtilisin QK could suppress the transformation of oxy-hemoglobin to met-hemoglobin caused by sodium nitrite, but not the heat-treated subtilisn QK. Compared with some other fibrinolytic enzymes and inactivated subtilisin QK treated by phenylmethylsulfonylfluoride, the ability of inhibiting met-hemoglobin formation of subtilisin QK reveals that the anti-oxidative ability of subtilisin QK is not concerned with its fibrinolytic function. Additionally, nitrotyrosine formation in proteins from brain, heart, liver, kidney, and muscle of mice that is intramuscular injected the mixture of nitrite, hydrogen peroxide and hemoglobin is attenuated by subtilisin QK. Subtilisin QK can also protect Human umbilical vein endothelial cell (ECV-304) from the damage caused by nitrite and hydrogen peroxide.

• Clinical and Experimental Pediatrics
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• 제59권9호
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• pp.347-354
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• 2016

An apparent life-threatening event (ALTE) is defined as the combination of clinical presentations such as apnea, marked change in skin and muscle tone, gagging, or choking. It is a frightening event, and it predominantly occurs during infancy at a mean age of 1-3 months. The causes of ALTE are categorized into problems that are: gastrointestinal (50%), neurological (30%), respiratory (20%), cardiovascular (5%), metabolic and endocrine (2%-5%), or others such as child abuse. Up to 50% of ALTEs are idiopathic, where the cause cannot be diagnosed. Infants with an ALTE are often asymptomatic at hospital and there is no standard workup protocol for ALTE. Therefore, a detailed initial history and physical examination are important to determine the extent of the medical evaluation and treatment. Regardless of the cause of an ALTE, all infants with an ALTE should require hospitalization and continuous cardiorespiratory monitoring and evaluation for at least 24 hours. The natural course of ALTEs has seemed benign, and the outcome is generally associated with the affected infants' underlying disease. In conclusion, systemic diagnostic evaluation and adequate treatment increases the survival and quality of life for most affected infants.

• Advances in Computational Design
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• 제3권2호
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• pp.201-212
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• 2018

Decrease in availability of suitable subbase and base course materials for highway construction leads to a search for economic method of converting locally available troublesome soil to suitable one for highway construction. Present study insights on evaluation of benefits of stabilization of subgrade soils in term of extension in service life (TBR) and layer thickness reduction (LTR). Laboratory investigation consisting of Atterberg limit, Compaction, California Bearing Ratio, unconfined compressive strength and triaxial shear strength tests were carried out on two types of soil for varying percentages of stabilizers. Vertical compressive strains at the top of unstabilized and stabilized subgrade soils were found out by elastoplastic finite element analysis using commercial software ANSYS. The values of vertical compressive strains at the top of unstabilized and stabilized subgrade, were further used to estimate layer thickness reduction or extension in service life of the pavement due to stabilization. Finite element modeling of the flexible pavement layered structure provides modern technology and sophisticated characterization of materials that can be accommodated in the analysis and enhances the reliability for the prediction of pavement response for improved design methodology. If the pavement section is kept same for unstabilized and stabilized subgrade soils, pavement resting on lime, fly ash and fiber stabilized subgrade soil B will have service life 2.84, 1.84 and 1.67 times than that of unstabilized pavement respectively. The flexible pavement resting on stabilized subgrade is beneficial in reducing the construction material. Actual savings would depend on the option exercised by the designer for reducing the thickness of an individual layer.

• The Korean journal of internal medicine
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• 제33권6호
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• pp.1039-1049
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• 2018

The populations of Asian countries are expected to age rapidly in the near future, with a dramatic increase in the number of heart failure (HF) patients also anticipated. The need for palliative and end-of-life care for elderly patients with advanced HF is currently recognized in aging societies. However, palliative care and active treatment for HF are not mutually exclusive, and palliative care should be provided to reduce suffering occurring at any stage of symptomatic HF after the point of diagnosis. HF patients are at high risk of sudden cardiac death from the early stages of the disease onwards. The decision of whether to perform cardiopulmonary resuscitation in the event of an emergency is challenging, especially in elderly HF patients, because of the difficulty in accurately predicting the prognosis of the condition. Furthermore, advanced HF patients are often fitted with a device, and device deactivation at the end of life is a complicated process. Treatment strategies should thus be discussed by multi-disciplinary teams, including palliative experts, and should consider patient directives to address the problems discussed above. Open communication with the HF patient regarding the expected prognosis, course, and treatment options will serve to support the patient and aid in future planning.