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Review of Randomized Controlled Trials of Traditional Herbal Medicine for Chronic Pelvic Inflammatory Disease (만성 골반염의 한약 치료에 대한 무작위 대조 임상시험 연구 분석)

  • Rho, Eon-Ji;Ahn, Soo-Yeon;Kim, Dong-Chul
    • The Journal of Korean Obstetrics and Gynecology
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    • v.34 no.4
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    • pp.46-61
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    • 2021
  • Objectives: The purpose of this review is to overview the studies of traditional herbal medicine for chronic pelvic inflammatory disease. Methods: We searched relevant studies using seven databases (The Journal of Korean obstetrics & gynecology, National Digital Science Library (NDSL), Research Information Sharing Service (RISS), Oriental Medicine Advanced Searching Integrated System (OASIS), Pubmed, Cochrane, Chinese National Knowledge Infrastructure (CNKI)). Data retrieval was carried out on April 5, 2021 and the papers published from January 1, 2015 to March 31, 2021 were included. The risk of bias was assessed by using Cochrane's risk of bias tool. Results: 524 studies were searched in domestic and foreign databases, and 7 studies were finally selected. In all studies, the treatment group was treated with oral traditional herbal medicine and the control group was treated with western medicine. Although the evaluation index was slightly different for each study, all studies used total efficacy rate index. In all 7 studies, the treatment group was more effective than the control group. Conclusions: Traditional herbal medicine can be an effective option in treating chronic pelvic inflammatory disease. Further high quality studies which include large number should be carried out to confirm the evidence and safety of traditional herbal medicine treatment.

Heart Rate Variability (HRV) Characteristics of Patients with Primary Dysmenorrhea at the Menstrual Phase: A Literature Review and Meta-Analysis (원발성 월경통 환자의 월경기 HRV 특성에 대한 문헌고찰 및 메타분석)

  • Cho, Si-Yoon;Lee, Ji-Yeon
    • The Journal of Korean Obstetrics and Gynecology
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    • v.35 no.3
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    • pp.122-136
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    • 2022
  • Objectives: The aim of this study is to investigate Heart Rate Variability (HRV) characteristics of patients with primary dysmenorrhea at the menstrual phase. Methods: 7 databases (Pubmed, Cochrane library, CNKI, RISS, KISS, OASIS, ScienceON) were searched for eligible studies published before 2021 December. The studies comparing HRV between patients with primary dysmenorrhea and controls were included. A random-effects model was used to evaluate differences of HRV parameters between patients with primary dysmenorrhea and controls. Results: 4 articles were included in this review based on inclusion and exclusion criteria. SDNN (Standard deviation of NN intervals), RMSSD (Square root of the mean squared difference of successive NN intervals), mean PR (Mean of pulse rate), LF (Low frequency), HF (High frequency), was the most frequently used as HRV parameters. RMSSD was significantly lower in patients with primary dysmenorrhea than controls. There was no statistically significant difference of other HRV parameters between patients with primary dysmenorrhea and controls. Conclusions: This study suggests that parasympathetic activity and overall functions of autonomic nervous system might be decreased in patients with primary dysmenorrhea at the menstrual phase. In the future, well-designed clinical studies using HRV and additional meta-analysis should be conducted to obtain a wealth of information about HRV characteristics of patients with primary dysmenorrhea.

The Effect of Electro Acupuncture for Sciatica: A Systematic Review and Meta-analysis (좌골신경통에 대한 전침 치료: 체계적 문헌고찰 및 메타분석)

  • Kim, Ye-Eun;Ahn, Jeong-Hoon;Cha, Yun-Yeop;Han, In-Sik;Heo, In;Park, In-Hwa
    • Journal of Korean Medicine Rehabilitation
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    • v.32 no.2
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    • pp.105-121
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    • 2022
  • Objectives This study was conducted to evaluate the effect of electro-acupuncture for sciatica. Methods We searched 13 online databases (Kmbase, Research Information Sharing Service [RISS], National Digital Science Library [NDSL], Oriental Medicine Advanced Searching Integrated System [OASIS], Koreanstudies, Koreantk, DBpia, PubMed, Cochrane, EMBASE, Medline, China National Knowledge Infrastructure [CNKI], J-stage) to find randomized-controlled clinical trials (RCTs) that used electro-acupuncture for sciatica. Efficacy rate and visual analogue scale (VAS) were mainly analyzed as a main evaluation criteria. Results Among 583 articles that were searched, 24 RCTs were finally selected and 18 RCTs were statistically analyzed. Electro-acupuncture was more effective than acupuncture in terms of efficacy rate (p<0.00001) and VAS (p<0.00001). Also, Electro-acupuncture was more effective than western medication in terms of efficacy rate (p=0.0005). However, the effectiveness of electro-acupuncture was not identified compared to physical therapy (p=0.42). Electro-acupuncture significantly improved efficacy rate when combined with physical therapy than physical therapy alone (p<0.0001). In addition, electro-acupuncture plus Chuna manual therapy compared to Chuna manual therapy alone showed positive results for efficacy rate (p=0.05) and VAS (p<0.0001). Conclusions Based on results, the effectiveness of electro-acupuncture for sciatica was identified. However, this study has limitations because the RCTs included in this study were small in number and published in a particular region. Although this study could be a groundwork for well designed research for sciatica.

Optimization of the Number of Filter in CNN Noise Attenuator (CNN 잡음감쇠기에서 필터 수의 최적화)

  • Lee, Haeng-Woo
    • The Journal of the Korea institute of electronic communication sciences
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    • v.16 no.4
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    • pp.625-632
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    • 2021
  • This paper studies the effect of the number of filters in the CNN (Convolutional Neural Network) layer on the performance of a noise attenuator. Speech is estimated from a noised speech signal using a 64-neuron, 16-kernel CNN filter and an error back-propagation algorithm. In this study, in order to verify the performance of the noise attenuator with respect to the number of filters, a program using Keras library was written and simulation was performed. As a result of simulation, it can be seen that this system has the smallest MSE (Mean Squared Error) and MAE (Mean Absolute Error) values when the number of filters is 16, and the performance is the lowest when there are 4 filters. And when there are more than 8 filters, it was shown that the MSE and MAE values do not differ significantly depending on the number of filters. From these results, it can be seen that about 8 or more filters must be used to express the characteristics of the speech signal.

Valid Data Conditions and Discrimination for Machine Learning: Case study on Dataset in the Public Data Portal (기계학습에 유효한 데이터 요건 및 선별: 공공데이터포털 제공 데이터 사례를 통해)

  • Oh, Hyo-Jung;Yun, Bo-Hyun
    • Journal of Internet of Things and Convergence
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    • v.8 no.1
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    • pp.37-43
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    • 2022
  • The fundamental basis of AI technology is learningable data. Recently, the types and amounts of data collected and produced by the government or private companies are increasing exponentially, however, verified data that can be used for actual machine learning has not yet led to it. This study discusses the conditions that data actually can be used for machine learning should meet, and identifies factors that degrade data quality through case studies. To this end, two representative cases of developing a prediction model using public big data was selected, and data for actual problem solving was collected from the public data portal. Through this, there is a difference from the results of applying valid data screening criteria and post-processing. The ultimate purpose of this study is to argue the importance of data quality management that must be most fundamentally preceded before the development of machine learning technology, which is the core of artificial intelligence, and accumulating valid data.

Nonlinear Noise Attenuator by Adaptive Wiener Filter with Neural Network (신경망 구조의 적응 Wiener 필터를 이용한 비선형 잡음감쇠기)

  • Haeng-Woo Lee
    • The Journal of the Korea institute of electronic communication sciences
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    • v.18 no.1
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    • pp.71-76
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    • 2023
  • This paper studied a method of attenuating nonlinear noise using a Wiener filter of a neural network structure in an acoustic noise attenuator. This system improves nonlinear noise attenuation performance with a deep learning algorithm using a neural network Wiener filter instead of using a conventional adaptive filter. A voice is estimated from a single input voice signal containing nonlinear noise using a 128-neuron, 8-neuron hidden layer and an error back propagation algorithm. In this study, a simulation program using the Keras library was written and a simulation was performed to verify the attenuation performance for nonlinear noise. As a result of the simulation, it can be seen that the noise attenuation performance of this system is significantly improved when the FNN filter is used instead of the Wiener filter even when nonlinear noise is included. This is because the complex structure of the FNN filter expresses any type of nonlinear characteristics well.

Review of Indicators and Tools used to Assess Korean Medicine Infertility Treatment (한의 난임 치료에 활용되는 평가지표와 평가도구 사용 현황 조사 및 고찰)

  • Soo-Jin Lee;Dong-Il Kim;Su-Ji Choi
    • The Journal of Korean Obstetrics and Gynecology
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    • v.36 no.3
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    • pp.173-195
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    • 2023
  • Objectives: To investigate and analyze the assessment indicators and tools used in clinical practice to assess Korean medicine (KM) treatment for infertility, and to establish a basis for assessment tools to diagnose and assess infertility. Methods: Relevant studies published until March 2023 were extracted from Pubmed, Research Information Sharing Service, and National Digital Science Library databases. Results: Sixty-four studies comprising 4,105 patients were included. We investigated pregnancy outcomes, and assessed pregnancy- and childbirth-related factors, overall health, reproductive health, and mental health. Pregnancy result was most common primary outcome. Ongoing pregnancy, stillbirth, miscarriage, and ectopic pregnancy rates were suggested as indicators of pregnancy and childbirth-related assessment. Overall health was most commonly assessed with Likert and Visual analogue scale (VAS). Among reproductive health variables, menstrual history was most frequently assessed. Moreover, indicators such as reproductive function, sexual intercourse, and gynecological disease were assessed. The Infertility Stress Scale and the Fertility Quality of Life tool (FertiQoL) were used to assess mental health. Conclusions: Subjective scales and objective assessment tools, such as the Likert scale and blood tests/ultrasonography, respectively, are used to assess KM infertility treatment. Inconsistent assessment tools make quantitative analyses more challenging. The development of a standardized mental and physical function assessment questionnaire with confirmed reliability and validity ensure the effectiveness of KM infertility treatment, and promote future studies on infertility treatment.

Cryopreservation of mesenchymal stem cells derived from dental pulp: a systematic review

  • Sabrina Moreira Paes;Yasmine Mendes Pupo;Bruno Cavalini Cavenago;Thiago Fonseca-Silva;Carolina Carvalho de Oliveira Santos
    • Restorative Dentistry and Endodontics
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    • v.46 no.2
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    • pp.26.1-26.15
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    • 2021
  • Objectives: The aim of the present systematic review was to investigate the cryopreservation process of dental pulp mesenchymal stromal cells and whether cryopreservation is effective in promoting cell viability and recovery. Materials and Methods: This systematic review was developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement and the research question was determined using the population, exposure, comparison, and outcomes strategy. Electronic searches were conducted in the PubMed, Cochrane Library, Science Direct, LILACS, and SciELO databases and in the gray literature (dissertations and thesis databases and Google Scholar) for relevant articles published up to March 2019. Clinical trial studies performed with dental pulp of human permanent or primary teeth, containing concrete information regarding the cryopreservation stages, and with cryopreservation performed for a period of at least 1 week were included in this study. Results: The search strategy resulted in the retrieval of 185 publications. After the application of the eligibility criteria, 21 articles were selected for a qualitative analysis. Conclusions: The cryopreservation process must be carried out in 6 stages: tooth disinfection, pulp extraction, cell isolation, cell proliferation, cryopreservation, and thawing. In addition, it can be inferred that the use of dimethyl sulfoxide, programmable freezing, and storage in liquid nitrogen are associated with a high rate of cell viability after thawing and a high rate of cell proliferation in both primary and permanent teeth.

Electroacupuncture for Lumbar Spinal Stenosis: A Systematic Review and Meta-Analysis (요추 척추관 협착증에 대한 전침 치료의 효과: 체계적 문헌고찰 및 메타분석)

  • Bok-Yeon Na;Woo-Seok Shon;Young-Jun Kim;Chang-Hoon Woo
    • Journal of Korean Medicine Rehabilitation
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    • v.33 no.3
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    • pp.67-78
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    • 2023
  • Objectives To evaluate the evidence supporting the efficacy and safety of electroacupuncture for lumbar spinal stenosis. Methods We searched eight electronic databases (PubMed, EMBASE, Cochrane Library, Chinese Academic Journals, Research Information Sharing Service, ScienceOn, KMBASE, DBpia) and related two journals up to March 2023. We included randomized controlled trials of testing electroacupuncture for lumbar spinal stenosis patients. The methodological quality of relevant randomized controlled trials assessed by the Cochrane risk of bias tool. Results Among 90 articles that were searched, seven randomized controlled trials involving 474 participants were finally selected in this systematic review. Electroacupuncture was more effective on lumbar spinal stenosis compared with other treatments including analgesics, acupuncture, bed rest and exercise therapy, but showed ambiguous effect compared with physical therapy. Most of the side effects and adverse reactions were reported as minor and temporary. Conclusions Electroacupuncture for lumbar spinal stenosis was more effective than analgesics, acupuncture, bed rest and exercise therapy. In terms of safety, it was limited because there are many papers that do not mention side effects and adverse reactions related to electroacupuncture. Additional studies are needed to determine the effect of electroacupuncture on lumbar spinal stenosis.

Efficacy of Herbal Medicine on Sleep Disorders in Parkinson's Disease: A Review of Randomized Controlled Trials (파킨슨병에 동반된 수면장애의 한약 치료에 대한 임상 연구 동향 : 무작위 대조연구를 중심으로)

  • Ji-hyeon Kang;Kyungmin Baek
    • The Journal of Internal Korean Medicine
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    • v.44 no.4
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    • pp.603-620
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    • 2023
  • Objectives: This study reviewed randomized controlled trials (RCTs) investigating the efficacy of herbal medicine on sleep disorders associated with Parkinson's disease and suggests a better research process. Methods: We searched for RCTs for herbal medicine treatments for sleep disorders related to Parkinson's disease on July 31, 2023 using eight databases (PubMed, Embase, the Cochrane library, China National Knowledge Infrastructure [CNKI], the Research Information Service System [RISS], Science ON, the Oriental Medicine Advanced Searching Integrated System [OASIS], and the Korea Citation Index [KCI]). Cochrane's risk of bias tool was used to assess the quality of the RCTs. Results: A total of 16 RCTs met all the inclusion criteria, and in most reports, the treatment group showed a significant improvement in sleep disorders compared to the control group. Total effective rate (TER), Pittsburgh Sleep Quality Index (PSQI), Unified Parkinson's Disease Rating Scale (UPDRS), TCM Symptom Score (TSS), Parkinson's Disease Sleep Scale (PDSS), etc., were used as evaluation indicators. Conclusion: Herbal medicine is a potential treatment for sleep disorders associated with Parkinson's disease. However, the selected RCTs were of poor quality, and it is necessary to perform more systematic studies.