• International Commerce and Information Review
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• v.16 no.2
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• pp.157-183
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• 2014

The aim of this study is to establish a detailed strategic countermeasure for Korean west coast ports(Pyeongtaek Dangjin Port, Incheon Port, and Gwangyang Port) to be developed into core ports in the Pan-Yellow Sea area as the results such as strategic partnership ports analysis through the container volume analysis in Korean ports are comprehensively taken into account between west coast ports and other major ports in the Pan-Yellow Sea area. This study utilized related data which import and export data by Office of Customs Administration and SPIDC by Ministry of Maritime Affairs and Fisheries for analyzing container volume between two ports. Strategic partnership ports were selected based on in-depth analysis on 5 standards such as container volume in 2012, increase rate of trading, occupancy rate, variance rate, and contribution of container volume. As a result of selection strategic partnership port in Pan-Yellow Sea area, Lianyungang, Tianjin, Yantai, Qingdao, Dalian port in Pyeongtaek Dangjin Port, Shidao, Weihai, Qingdao, Tianjin, Dalian port in Incheon, Qingdao, Yantai, Dalian, Lianyungang port in Gwangyang port. Also this study proposed implications of countermeasure to establish strategic partnership ports for each of west coast ports.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.2
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• pp.677-682
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• 2014

Resveratrol has been examined in several model systems for potential effects against cancer. Adenosine monophosphate-activated protein kinase (AMPK) is reported to suppress proliferation in most eukaryocyte cells. Whether resveratrol via AMPK inhibits proliferation of oesophageal adenocarcinoma cells (OAC) is unknown. The aim of this study was to determine the roles of AMPK in the protective effects of resveratrol in OAC proliferation and to elucidate the underlying mechanisms. Treatment of cultured OAC derived from human subjects or cell lines with resveratrol resulted in decreased cell proliferation. Further, inhibition of AMPK by pharmacological reagent or genetical approach abolished resveratrol-suppressed OAC proliferation, reduced the level of $p27^{Kip1}$, a cyclin-dependent kinase inhibitor, and increased the levels of S-phase kinase-associated protein 2 (Skp2) of $p27^{Kip1}$-E3 ubiquitin ligase and 26S proteasome activity reduced by resveratrol. Furthermore, gene silencing of $p27^{Kip1}$ reversed resveratrol-suppressed OAC proliferation. In conclusion, these findings indicate that resveratrol inhibits Skp2-mediated ubiquitylation and 26S proteasome-dependent degradation of $p27^{Kip1}$ via AMPK activation to suppress OAC proliferation.

• Journal of Microbiology and Biotechnology
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• v.32 no.4
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• pp.504-513
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• 2022

Chitin deacetylase (CDA) inhibitors were developed as novel antifungal agents because CDA participates in critical fungal physiological and metabolic processes and increases virulence in soil-borne fungal pathogens. However, few CDA inhibitors have been reported. In this study, 150 candidate CDA inhibitors were selected from the commercial Chemdiv compound library through structure-based virtual screening. The top-ranked 25 compounds were further evaluated for biological activity. The compound J075-4187 had an IC50 of 4.24 ± 0.16 µM for AnCDA. Molecular docking calculations predicted that compound J075-4187 binds to the amino acid residues, including active sites (H101, D48). Furthermore, compound J075-4187 inhibited food spoilage fungi and plant pathogenic fungi, with minimum inhibitory concentration (MIC) at 260 ㎍/ml and minimum fungicidal concentration (MFC) at 520 ㎍/ml. Therefore, compound J075-4187 is a good candidate for use in developing antifungal agents for fungi control.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6649-6655
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• 2014

Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.

• Journal of Korean Society for Atmospheric Environment
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• v.33 no.4
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• pp.411-423
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• 2017

The spacial potential source contribution function (PSCF) method was utilized by considering topography and height of back trajectories based on the measurement of organic typo matter (OM), $NO_3{^-}$, $SO{_4}^{2-}$, and $NH_4{^+}$ at the Baegryungdo Super Site ($37^{\circ}57^{\prime}N$, $124^{\circ}37^{\prime}E$, 135 m a.s.l. (above sea level)) for three selected periods (i.e., January~April, May~August, and September~December) in 2013. The PSCF were calculated on the contributions of trans-boundary transport to the hourly mean concentrations using a high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS). The cluster analysis using back trajectories was performed to identify the major airflows to the sampling site. The upper atmosphere in the Tianjin area of China and the lower atmosphere in the western coast area of Korea can be the major source of trans-boundary pollution to the sampling site during January~April resulted from PSCF. The area in Lianyungang-city and Liaoning-sheng, China can be responsibile for the nitrogen related secondary compounds during May~August, and Shandong Peninsula in China is the major source area during September~December. In addition, relationships between the cluster analysis of back trajectories and PSCF were investigated for the statistically significance level for the source areas.

• Journal of Navigation and Port Research
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• v.39 no.1
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• pp.55-60
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• 2015

The purpose of this study is to suggest a major strategy to become effective for each port in Northeast Asia by analyzing the relative efficiency of each port to determine the current level of efficiency, efficient harbors plan. Individual port of the major 16 ports in Northeast Asia was analysed targeting efficiency and relative efficiency. In this study, DEA technique was used. Of the DEA model, CCR (constant returns to scale) models and BCC (variable return to scale) model was applied to analyze the efficiency and effectiveness of the port. Then the efficiency measured through CCR model is again compared with the efficiency measured by the BCC model. In this way, the empirical analysis includes the input factors of the operating ports such as the number of berths, wharf, depth, total area of the pier, C / C numbers and output elements includes the container throughput. The results of the study show that most of the ports in China is efficient whereas those in Korea and Japan are relatively inefficient. There are some pairs of ports which has the similar input factors, like Busan port and Shanghai port, Lianyungang port and Incheon port, Dalian port and Gwangyang port, but the container throughput of them has a huge difference.