• 한국멀티미디어학회논문지
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• 제25권2호
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• pp.345-352
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• 2022

Conducting AI-based fusion business due to the increment of ICT fusion medical device has been expanded. In addition, AI-based medical devices help change existing medical system on treatment into the paradigm of customized treatment such as preliminary diagnosis and prevention. It will be generally promoted to the change of medical device industry. Although the current demand forecasting of medical biotechnology commercialization is based on the method of Delphi and AHP, there is a problem that it is difficult to have a generalization due to fluctuation results according to a pool of participants. Therefore, the purpose of the paper is to predict demand forecasting for identifying promising technology based on building up big data in medical biotechnology. The development method is to employ candidate technologies of keywords extracted from SCOPUS and to use word2vec for drawing analysis indicator, technological distance similarity, and recommended technological similarity of top-level items in order to achieve a reasonable result. In addition, the method builds up academic big data for 5 years (2016-2020) in order to commercialize technology excavation on demand perspective. Lastly, the paper employs global data studies in order to develop domestic and international demand for technology excavation in the medical biotechnology field.

• 대한핵의학회지
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• 제1권2호
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• pp.61-74
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• 1967

In order to confirm whether acquired immunity or resistance can be developed by the repeated hookworm infections, the 150 mature actively moving filariform ancylostoma duodenale larvae obtained from the severe hookworm anemia patients were orally given to 8 healthy volunteers in three divided doses, 50 in each, at 5 day interval. Also the hematological changes as well as several ferrokinetics using $^{59}Fe$ were done and were compared with 10 controls. The clinical symptoms and signs were checked every day for the first 3 weeks and then twice weekly until the end of the experiment. The appearance of the ova in the stool was examined by the formalin ether method and the ova was counted by the Stoll's method. The following laboratory tests were done: 1) Red blood cell count, venous blood hematocrit(micromethod), hemoglobin count (cyanomethemoglobin method) were checked every 5 to 7 day interval. 2) Plasma iron concentration (Barkan's modified method) was determined every 2 to 3 week interval. 3) Radioisotope studies: a) Ferrokinetics: Huff et al and Bothwell's method were applied. Erythropoietic Index (% of normal)=$\frac{Subject's\;turnover/100ml\;whole\;blood{\times}100}{Average\;normal\;turnover/100ml\;whole\;blood}$ of the gastrointestinal absorption of iron: Radioiron($^{59}Fe$) balance b) Quantitative measurement method was applied. c) Determination of the plasma erythropoietin activity: Fried's method was applied. Following were the results: 1) The serum iron level was lower. The red cell volume was decreased, but with relative increase of plasma volume. 2) The plasma iron disappearance time was accelerated and the plasma iron turnover rate was decreased. The red cell iron turnover rate was markedly increased, while all of the red cell iron concentration, circulating red cell iron. plasma iron pool were decreased. The daily iron pool turnover and red cell renewal rate were increased. 3) The erythropoietic index, erythropoietin activity and intestinal absorption of iron($^{59}Fe$) were markedly increased. 4) The infectivity was $9.8{\pm}1.31%$ which was lower than that observed in the single infection. 5) From these observations, it is concluded that the hookworm anemia is essentially iron deficieny in its origin and some immunity acquisition is possible with repeated infections.

• 분석과학
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• 제33권1호
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• pp.42-48
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• 2020

Bromate is a disinfection by-product generated mainly from the oxidation of bromide during the ozonation and disinfection process in order to remove pathogenic microorganism of drinking water, and classified as a possible human carcinogen by International Agency for Research of Cancer (IARC) and World Health Organization (WHO). For the purpose of determining the trace level concentration of bromate, several sensitive techniques are applied mostly based on suppressed conductivity detection and UV/Visible detection after postcolumn reaction (PCR). In this study, the suppressed conductivity detection method and the PCR-UV/Visible detection method through the triiodide reaction were compared to analyze the trace bromate in water samples and estimated for the availability of these analytical methods. In addtion, the state-of-the-art techniques was applied for the determination of trace level bromate in various water matrices, i.e., soft drinking water, hard drinking water, mineral water, swimming pool water, and raw water. In comparison of two analytical methods, it was found that the conductivity detection had the suitable advantage to simultaneously analyze bromate and inorganic anions, however, the bromate might not be precisely quantified due to the matrix effect especially by chloride ion. On the other hand, the trace bromate was analyzed effectively by the method of PCR-UV/Visible detection through triiodide reaction to satisfactorily minimize the matrix interference of chloride ion in various water samples, showing the good linearity and reproducibility. Furthermore, the method detection limit (MDL) and recovery were 0.161 ㎍/L and 101.0-108.1 %, respectively, with a better availability compared to conductivity detection.

• Nuclear Engineering and Technology
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• 제38권1호
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• pp.99-108
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• 2006

SNU-RCCS is a water pool type RCCS (Reactor Cavity Cooling System) developed for VHTR (Very High Temperature Reactor) application by SNU (Seoul National University). Since radiation heat transfer is the major process of passive heat removal in a RCCS, it is important to determine the precise emissivity of the reactor vessel. Review studies have used a constant emissivity in the passive heat removal analysis, even though the emissivity depends on many factors such as temperature, surface roughness, oxidation level, wavelength, direction, atmosphere conditions, etc. Therefore, information on the emissivity of a given material in a real RCCS is essential in order to properly analyze the radiation heat transfer in a VHTR. The objectives of this study are to develop a method for compensation of the factors affecting the emissivity measurement using an infrared thermometer and to estimate the true emissivity from the measured emissivity via the developed method, especially in the SNU-RCCS environment. From this viewpoint, we investigated factors such as the attenuation effect of the window, filling gas, and the effect of background radiation on the emissivity measurements. The emissivity of the vessel surface of the SNU-RCCS facility was then measured using a sight tube. The background radiation was subsequently removed from the measured emissivity by solving a simultaneous equation. Finally, the calculated emissivity was compared with the measured emissivity in a separate emissivity measurement device, yielding good agreement with the emissivity increase with vessel temperature in a range of 0.82 to 0.88.

• 한국전문물리치료학회지
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• 제26권3호
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• pp.106-114
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• 2019

Background: It is difficult to assess whether community-dwelling frail older adults may remain pre-frail status or improve into a robust state without being directly checked by health care professionals. The health information perceived by older adults is considered to be one of best sources of potential concerns in older adult population. An online measurement system combined with item response theory (IRT) and computer adaptive testing (CAT) methods is likely to become a realistic approach to remotely monitor physical activity status of frail older adults. Objects: This article suggests an approach to provide a precise and efficient means of measuring physical activity levels of community-dwelling frail older adults. Methods: Article reviews were reviewed and summarized. Results: In comparison to the classical test theory (CTT), the IRT method is empirically aimed to focus on the psychometric properties of individual test items in lieu of the test as a whole. These properties allow creating a large item pool that can capture the broad range of physical activity levels. The CAT method administers test items by an algorithm that select items matched to the physical activity levels of the older adults. Conclusion: An online measurement system combined with these two methods would allow adequate physical activity measurement that may be useful to remotely monitor the activity level of community-dwelling frail older adults.

• 한국안전학회지
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• 제37권4호
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• pp.129-138
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• 2022

A new method for injecting cooling water into the Korean research reactor (KRR) in the event of beam tube rupture is proposed in this paper. Moreover, the research evaluates the risk to the reactor core in terms of core damage frequency (CDF). The proposed method maintains the cooling water in the chimney at a certain level in the tank to prevent nuclear fuel damage solely by gravitational coolant feeding from the emergency water supply system (EWSS). This technique does not require sump recirculation operations described in the current procedure for resolving beam tube accidents. The reduction in the risk to the core in the event of beam tube rupture that can be achieved by the proposed change in the cooling water injection design is quantified as follows. 1) The total CDF of the KRR for the proposed design change is approximately 4.17E-06/yr, which is 8.4% lower than the CDF of the current design (4.55E-06/yr). 2) The CDF for beam tube rupture is 7.10E-08/yr, which represents an 84.1% decrease compared with that of the current design (4.49E-07/yr). In addition to this quantitative reduction in risk, the modified cooling water injection design maintains a supply of pure coolant to the EWSS tank. This means that the reactor does not require decontamination after an accident. Thermal hydraulic analysis proves that the water level in the reactor pool does not cause damage to the nuclear fuel cladding after beam tube rupture. This is because the amount of water in the chimney can be regulated by the EWSS function. The EWSS supplies emergency water to the reactor core to compensate for the evaporation of coolant in the core, thus allowing water to cover the fuel assemblies in the reactor core over a sufficient amount of time.

• 한국가스학회지
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• 제7권1호
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• pp.19-23
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• 2003

최근 국내에서도 정량적 위험성 평가 기법을 위험시설물에 도입하여 위험도를 관리하면서 LPG 저장탱크에 대한 사고후 피해영향평가에 대한 연구는 다각적으로 이루어지고 있으나 BLEVE(Boiling Liquid Expanding Vapor Explosion, BLEVE)의 조건 및 메커니즘 규명에 대한 연구는 별로 이루어지고 있지 않다. 따라서, 본 고에서는 상대적으로 위험성이 큰 지상식 LPG 저장탱크의 BLEVE 가능성에 대해 외국의 Pilot 탱크 시험 결과 및 BLEVE 발생을 위한 소요입열량 계산값을 이용한 연역적 계산방법을 통해 BLEVE 조건 및 가능성을 정량화하여 규명코자 하였다. 또한, 산출된 탱크의 파열압력(burst pressure)과 충전량에 의해 보정된 액 온도를 사용해서 그려진 BLEVE map을 이용하여 BLEVE 조건에서 액위($\%$)가 BLEVE에 어떤 영향을 미칠 것인가를 규명하였다. 계산결과, 탱크 plate 온도가 $600^{\circ}C$이고, 탱크내부 액온도가 $53^{\circ}C$ 일 때 액충전량은 $43.68\%$ 이상일 경우에 BLEVE의 발생이 가능하다는 결과를 얻었다. 또한, 부천 대성에너지 LPG 충전소와 동일한 사양인 15톤 프로판 탱크를 모델로 하여 BLEVE가 발생하기 위한 외부 누출 및 외부화재 조건을 PHAST(Version 6.00) 및 EFFECTS(Version 2.1) 프로그램을 이용해 계산한 결과 액상 누출시 누출상당직경은 7.2mm, 이상 누출시 누출상당직경은 17.6mm 이상일 경우에 BLEVE가 발생 가능한 최소한의 풀화재 생성조건이 되었고, 풀화재의 크기는 최소 직경 3.3m, 높이 10.4m 이상의 풀화재가 전제되어야 한다는 결과를 얻을 수 있었다.

• 경영정보학연구
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• 제16권1호
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• pp.37-50
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• 2014

사례기반 추론기법(case-based reasoning)은 수많은 데이터 속에서 현재 문제와 유사한 과거데이터를 실시간으로 탐색하고 복원해내야 하기 때문에, 과거에 축적된 데이터의 양이 방대하거나 또는 데이터의 축적 속도가 빠를 경우 계산비용(computational cost)이 급격히 높아지는 확장성(scalability) 문제를 갖는다. 이러한 문제를 해결하기 위하여, 기존의 일부 연구들은 클러스터링(clustering) 기법을 적용하여, 전체 데이타를 사전에 몇 개의 그룹으로 분류한 후, 특정 클러스터 내에서만 과거 사례를 탐색하도록 하는 클러스터링과 사례기반 추론의 하이브리드 기법을 제안하였다. 그러나 이러한 기법은 클러스터 수를 얼마로 설정했는지에 따른 성능편차가 심하고, 또한 기본적인 사례기반 추론기법에 비해 일반적으로 낮은 예측성능을 도출하는 문제점이 있다. 본 연구는 이러한 기존의 클러스터-사례기반추론기법의 문제점을 실증적으로 분석하고, 이를 극복할 수 있는 새로운 하이브리드(hybrid) 사례기반 추론기법을 제안한다. 제안된 기법은 실제 심장병환자를 예측하는 문제에 적용하였으며, 그 결과 제안된 기법이 기존의 사례기반 추론기법에 비해 현격하게 낮은 계산비용을 사용하면서도, 유사한 수준의 예측성능을 도출할 수 있음을 확인하였다.

• Journal of Applied Biological Chemistry
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• 제50권4호
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• pp.211-214
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• 2007

A solid-phase microextraction and gas chromatography-mass spectrometry utilizing $^{13}C$-formate as an internal standard for the determination of formate was proved to be applicable as a reliable quantitative method in several plants. We were the first to discover that trees contain larger pool sizes of formate than herbs. Our data also showed that the formate level of the leaves increased after the methanol-spraying, suggesting that methanol oxidation could convert formaldehyde into formate. In addition, drought and chilling led to the increase of endogenous formate in Arabidospsis thaliana. These results confirmed that formate is a universal stress signal in plants.

• 대기
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• 제21권2호
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• pp.143-149
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• 2011

A new multi-timescale analysis method, Ensemble Empirical Mode Decomposition (EEMD), is used to diagnose the variation of the MJO activity determined by 850hPa and 200hPa zonal winds from the National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) Reanalysis data for the 56-yr period from 1950 to 2005. The results show that MJO activity can be decomposed into 9 quasi-periodic oscillations and a trend. With each level of contribution of the quasi-periodic oscillation discussed, the bi-seasonal oscillation, the interannual oscillation and the trend of the MJO activity are the most prominent features. The trend increases almost linearly, so that prior to around 1978 the activity of the MJO is lower than that during the latter part. This may be related to the tropical sea surface temperature(SST). It is speculated that the interdecadal change in the MJO activity appeared in around 1978 is related to the warmer SST in the equatorial warm pool, especially over the Indian Ocean.