• Journal of Soil and Groundwater Environment
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• v.24 no.5
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• pp.42-54
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• 2019

Biodegradation of an explosive compound, glyceryl trinitrate (GTN), was studied with a denitrifying microbial culture grown in a sequencing batch reactor and a GTN acclimated denitrifying culture. The GTN acclimated culture, which were fed on GTN for 1 month, degraded GTN regioselectively via denitration on C1 position as compared to C2 position denitration by denitrifying culture that has never been exposed to GTN. Accumulation of two isomeric glyceryl dinitrates (GDNs) in both culture medium suggests that GDN denitration is the rate-limiting step in GTN biodegradation. The first order GTN degradation rate normalized to cell concentration of the acclimated culture was calculated to be 0.045 (${\pm}0.002$) L/g-hr. Increasing concentration of electron acceptor(nitrate) resulted in discouraged GTN degradation. According to microbial community analysis, prolonged GTN exposure resulted in 25% increase in the genus level of the GTN acclimated culture with the disappearance of two dominating denitrifying microbial species of Methyloversatilis universalis and Hyphomicrobium zavarzinii in the denitrifying culture.

• Fisheries and Aquatic Sciences
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• v.24 no.9
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• pp.297-310
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• 2021

The rockworm gut flora was identified at each growth stage to elucidate the composition of the bacterial community. The source material was Marphysa sanguinea fed regular feed and fed biofloc at the adult stage in parallel. The systematic bacterial community composition was determined based on the next-generation sequencing method, and alpha diversity and beta diversity were conducted to access the species diversity within and between the bacterial communities, respectively. The composition of the gut flora changed considerably as the rockworms developed. The shift in the gut flora was confirmed at the phylum, family, and genera level of the bacterial communities. The Vibrio species associated with high rockworm mortality occupied 7.7% of the gut flora at the larval stage; however, they disappeared in the healthy adult gut. Moreover, different gut flora was observed between adults fed regular feed and those fed biofloc. Specifically in the biofloc-fed adult gut, several immune relevant and water-purifying bacteria were detected. The biofloc-fed adult gut flora could decompose and mineralize organic sediment, and thus be effectively utilized for integrated multitrophic aquaculture. The Venn diagram revealed that only two bacterial species were shared throughout all growth stages, and the biofloc-fed adults exhibited the highest diversity within the bacterial community.

• Journal of Positioning, Navigation, and Timing
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• v.11 no.3
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• pp.147-156
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• 2022

In this paper, we propose Time-Division-Multiplexing Tertiary Offset Carrier (TDMTOC), a novel GNSS modulation based on Tertiary Offset Carrier (TOC) modulation. The TDMTOC modulation multiplexes two three-level signals (i.e., -1, 0, and 1) while crossing over time, and is a type of TOC modulation designed specifically for signal multiplexing. The proposed modulation generates TDMTOC subcarriers of two different phases by simply combining two Binary Offset Carrier (BOC) subcarriers by addition or subtraction. TDMTOC has better correlation and spectral properties than conventional BPSK, BOC, and MBOC modulation techniques, and has good power and spectral efficiency since it can multiplex signals without power loss similar to time division multiplexing. To prove this, we introduce the multiplexing process of TDMTOC, and compare TDMTOC with Binary Phase Shift Keying (BPSK), BOC, Composite BOC (CBOC), and Time Multiplexed BOC (TMBOC) that are currently serviced in GNSS by simulations of various aspects. Through the simulation results, we prove that TDMTOC has better correlation property than modulations currently used in GNSS, less intersystem interference due to its wide spectrum property, and robustness in multipath and noise channel environments.

• Journal of The Korean Association For Science Education
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• v.26 no.5
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• pp.620-636
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• 2006

The purpose of this study was to analyze one science teacher's understanding of student argumentation and his explicit teaching strategies for implementing it in the classroom. One middle school science teacher, Mr. Field, and his students of 54 participated in this study. Data were collected through three semi-structured interviews, 60 hours of classroom observations, and two times of students' lab reports for eight weeks. Coding categories were developed describing the teacher's understanding of scientific argumentation and a description of the main teaching strategy, the Claim-Evidence Approach, was introduced. Toulmin's approach was employed to analyze student discourse as responses to see how much of this discourse was argumentative. The results indicated that Mr. Field defined scientific inquiry as the abilities of procedural skills through experimentation and of reasoning skills through argumentation. The Claim-Evidence Approach provided students with opportunities to develop their own claims based on their readings, design the investigation for evidence, and differentiate pieces of evidence from data to support their claims and refute others. During this approach, the teacher's role of scaffolding was critical to shift students' less extensive argumentation to more extensive argumentation through his prompts and questions. The different level of teacher's involvement, his explicit teaching strategy, and the students' scientific knowledge influenced the students' ability to develop and improve argumentation.

• Nuclear Engineering and Technology
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• v.56 no.4
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• pp.1431-1440
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• 2024

The study aimed to develop a laser-based distance meter (LDM) to improve water surface identification for clinical MeV electron beam dosimetry, as inaccurate water surface determination can lead to imprecise positioning of ionization chambers (ICs). The LDM consisted of a laser ranging sensor, a signal processing microcontroller, and a tablet PC for data acquisition. I₅₀ (the water depth at which ionization current drops to 50 % of its maximum) measurements of electron beams were performed using six different types of ICs and compared to other water surface identification methods. The LDM demonstrated reproducible I₅₀ measurements with a level of 0.01 cm for all six ICs. The uncertainty of water depth was evaluated at 0.008 cm with the LDM. The LDM also exposed discrepancies between I₅₀ measurements using different ICs, which was partially reduced by applying an optimum shift of IC's point of measurement (POM) or effective point of measurement (EPOM). However, residual discrepancies due to the energy dependency of the cylindrical chamber's EPOM caused remained. The LDM offers straightforward and efficient means for precision water surface identification, minimizing reliance on individual operator skills.

• IMMUNE NETWORK
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• v.22 no.1
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• pp.7.1-7.20
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• 2022

Recently, there have been impressive advancements in understanding of the immune mechanisms underlying cutaneous inflammatory diseases. To understand these diseases on a deeper level and clarify the therapeutic targets more precisely, numerous studies including in vitro experiments, animal models, and clinical trials have been conducted. This has resulted in a paradigm shift from non-specific suppression of the immune system to selective, targeted immunotherapies. These approaches target the molecular pathways and cytokines responsible for generating inflammatory conditions and reinforcing feedback mechanisms to aggravate inflammation. Among the numerous types of skin inflammation, psoriasis and atopic dermatitis (AD) are common chronic cutaneous inflammatory diseases. Psoriasis is a IL-17-mediated disease driven by IL-23, while AD is predominantly mediated by Th2 immunity. Autoimmune bullous diseases are autoantibody-mediated blistering disorders, including pemphigus and bullous pemphigoid. Alopecia areata is an organ-specific autoimmune disease mediated by CD8⁺ T-cells that targets hair follicles. This review will give an updated, comprehensive summary of the pathophysiology and immune mechanisms of inflammatory skin diseases. Moreover, the therapeutic potential of current and upcoming immunotherapies will be discussed.

• Geomechanics and Engineering
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• v.38 no.1
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• pp.69-77
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• 2024

The development of shield-driven cross-river tunnels in China is witnessing a notable shift towards larger diameters, longer distances, and higher water pressures due to the more complex excavation environment. Complex geological formations, such as fault and karst cavities, pose significant construction risks. Real-time adjustment of shield tunneling parameters based on parameter prediction is the key to ensuring the safety and efficiency of shield tunneling. In this study, prediction models for the torque and thrust of the cutter plate of ultra-large diameter slurry shield TBMs is established based on integrated learning algorithms, by analyzing the real data of Heyan Road cross-river tunnel. The influence of geological complexities at the excavation face, substantial burial depth, and high water level on the slurry shield tunneling parameters are considered in the models. The results reveal that the predictive models established by applying Random Forest and AdaBoost algorithms exhibit strong agreement with actual data, which indicates that the good adaptability and predictive accuracy of these two models. The models proposed in this study can be applied in the real-time prediction and adaptive adjustment of the tunneling parameters for shield tunneling under complex geological conditions.

• Journal of Family Resource Management and Policy Review
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• v.16 no.1
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• pp.85-101
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• 2012

This study aims to identify the propensity to consume and housing characteristics according to life cycle as the main independent variable. It also tries to understand the consumption power and housing style of each cycle and analyze whether there are differences between each life cycle, ultimately aiming to match the propensity to consume and housing style with each cycle. For empirical analysis, on and off-line surveys of 488 people were collected and analyzed by cross analysis, factor analysis and analysis of variance. The prime research findings are as follows: First of all, factor analysis on propensity to consume showed four main sub-factors as rational consumption, conspicuous consumption, trend consumption, and status consumption. Secondly, current and preferred housing styles ranked from modern, natural, casual, classic and romantic, which proved that people are currently housed in preferred housing styles. Thirdly, in case of housing-related characteristics of life cycles, the size of the house increased as the levels progressed, and then decreased at level 6 when the children grew into adulthood. The majority of the population was paying a monthly rent, a few were leasing, and a very few owned their housing. 58% were living in apartments, but in levels 1-2, more were living in row houses and high-rise residential buildings, while in level 6 it was detached houses. Fourthly, the propensity to consume according to life cycle tended to shift from conspicuous and trend-based consumption to rational consumption as the cycles progressed. Fifthly, the preferred housing styles were modern and natural styles, regardless of life cycle. These study results can be applied to product development and marketing activities based on their accurate analysis of customers' needs, which can thus bring further customer satisfaction.

• Proceedings of the Korean Vacuum Society Conference
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• 2012.08a
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• pp.340-341
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• 2012

In this work, we investigated the effects of temperature stress on flatband voltage (VFB) shifts of HfO2-SiO2 double gate dielectrics devices. Fig. 1 shows a high frequency C-V of the device when a positive bias for 10 min and a subsequent negative bias for 10 min were applied at room temperature (300 K). Fig. 2 shows the corresponding plot when the same positive and negative biases were applied at a higher temperature (473.15 K). These measurements are based on the BTS (bias temperature stress) about mobile charge in the gate oxides. These results indicate that the positive bias stress makes no difference, whereas the negative bias stress produces a significant difference; that is, the VFB value increased from ${\Delta}0.51$ V (300 K, Fig. 1) to ${\Delta}14.45$ V (473.15 K, Fig. 2). To explain these differences, we propose a mechanism on the basis of oxygen vacancy in HfO2. It is well-known that the oxygen vacancy in the p-type MOS-Cap is located within 1 eV below the bottom of the HfO2 conduction band (Fig. 3). In addition, this oxygen vacancy can easily trap the electron. When heated at 473.15 K, the electron is excited to a higher energy level from the original level (Fig. 4). As a result, the electron has sufficient energy to readily cross over the oxide barrier. The probability of trap about oxygen vacancy becomes very higher at 473.15 K, and therefore the VFB shift value becomes considerably larger.

• Therapeutic Science for Rehabilitation
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• v.6 no.2
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• pp.37-45
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• 2017

Background: The presence of visuospatial impairment can make patients slow functional recovery and impede the rehabilitation process in TBI patients. Objective: The aim of this study is to investigate effects of prism adaptation treatment for functional outcomes in patients following traumatic brain injury. Methods: The subject received prism adaptation treatment for 2 weeks additionally during traditional rehabilitation for 4 weeks. The Patient has prism adaptation treatment while wearing wedge prisms that shift the external environment about $12^{\circ}$ leftward. The patient received 10 sessions, 15-20min each session. Outcome measures were visuospatial deficit(line bisection, latter cancellation), Visual and spatial perception(LOTCA-visual perception and spatial perception), motor function of upper extremity(FMA U/E; Fugl-Meyer motor assessment upper extremity, ARAT; Action research arm test), balance(BBS; Berg Balance Scale), mobility(FAC; Functional ambulation classification) and functional level(FIM; Functional independent measure). All Assessments took place on study entry and post-treatment assessments were performed at discharge from the hospital. Results: After prism adaptation, the visuospatial impairment scores improved as indicated in the line bisection(-15.2 to -6.02), latter cancellation(2 to 0) and LOTCA- spatial perception scores(7 to 9). The upper motor function improved as indicated in the scores of affected FMA U/E(21 to 40) and ARAT(4 to 22). Ambulation and balance improved as indicated in the BBS scores(25 to 38) and FAC scores(0 to 4). ADL function improved as indicated in the FIM total scores 54 to 70(motor 34 to 61, cognition 20 to 29). Conclusion: Prism adaptation did improve functional level such as motor functions and ADL abilities in TBI patient. Further research is recommended.