• 제목/요약/키워드: Left ventricular diastolic function

검색결과 74건 처리시간 0.029초

저대조 혈관 조영상에서 좌심실 기능의 정량화를 위한 지식 기반의 경계선 자동검출 (Knowledge Based Automated Boundary Detection for Quantifying of Left Ventricular Function in Low Contrast Angiographic Images)

  • 전춘기;권용무
    • 대한의용생체공학회:의공학회지
    • /
    • 제17권1호
    • /
    • pp.109-120
    • /
    • 1996
  • Cardiac function is evaluated quantitatively using angiographic images via the analysis of the shape change or the heart wall boundaries. To kin with, boundary defection or ESLV(End Systolic Lert Ventricular) and EDLV(End Diastolic Left Ventricular) is essential for the quantitative analysis of cardiac function. The boundary detection methods proposed in the past were almost semi-automatic. Intervention by a knowledgeable human operator was still required Of con, manual tracing of the boundaries is currently used for subsequent analysis and diagnosis. This method would not cut excessive time, labor, and subjectivity associated with manual intervention by a human operator. EDLV images have noncontiguous and ambiguous edge signal on some boundary regions. In this paper, we propose a new method for automated detection of boundaries in noncontiguous and ambiguous EDLV images. The boundary detection scheme which based on a priori knowledge information is divided into two steps. The first step is to detect the candidate edge points of EDLV using ESLV boundaries. The second step is to correct detected boundaries of EDLV using the LV shape. We developed the algorithm of modifying EDLV boundaries defined adaptive modifier. We experimented the method proposed in this paper and compared our proposed method with the manual method in detecting boundaries of EDLV. In the areas within estimated boundaries of EDLV, the percentage of error was about 1.4%. We verified the useflilness and obtained the satisfying results througll the experiments of the proposed method.

  • PDF

Real- Time Estimation of the Ventricular Relaxation Time Constant

  • Chun Honggu;Kim Hee Chan;Sohn Daewon
    • 대한의용생체공학회:의공학회지
    • /
    • 제26권2호
    • /
    • pp.87-93
    • /
    • 2005
  • A new method for real-time estimating left ventricular relaxation time constant (T) from the left ventricular (LV) pressure waveform, based on the isovolumic relaxation model, is proposed. The presented method uses a recursive least squares (RLS) algorithm to accomplish real-time estimation. A new criterion to detect the end-point of the isovolumic relaxation period (IRP) for the estimation of T is also introduced, which is based on the pattern analysis of mean square errors between the original and reconstructed pressure waveforms. We have verified the performance of the new method in over 4,600 beats obtained from 70 patients. The results demonstrate that the proposed method provides more stable and reliable estimation of τ than the conventional 'off-line' methods.

Effect of Korea Red Ginseng on the Symptoms and Hemodynamics in Healthy Elders

  • Jin En-Yuan;Li Ya-Jun;Yang Lian-Xing;Jin Ming;Wei Yu-Lin;Nam Ki Yeul
    • 고려인삼학회:학술대회논문집
    • /
    • 고려인삼학회 2002년도 학술대회지
    • /
    • pp.27-34
    • /
    • 2002
  • Clinical study on hemodynamics of healthy elders before and after tread mill. Using doubleblind, placebo-controlled study design. Seventy-five 50-70 years old volunteers without organic disease were divided into two groups, Ginseng group and control group. Each subject was received 3 g Korea Red Ginseng (KRG) capsules or placebo per day for 4 weeks. Before and after administration 4 weeks, the symptoms were asked and hemodynamics parameter such as pump function, systolic function, preload and afterload were recorded before and after tread mill 1,5, 10 minutes by the method of thoracic impedance cardiograph. The result showed that Ginseng could improve quality of life, had obvious effect of increasing PEP (pre-ejection period), PEP/LVET (pre-ejection period/left ventricular ejection period), PCWP (wedged pressure pulmonary capillary). The change rate of HR (heart rate), SV (stroke volume) in KRG group were much lowered, while EF (ejection fraction), LVET (left ventricular ejection period), LVEDP (left ventricular end diastolic pressure) was recovered much quickly. The circulation showed Ginseng could improve the quality of life though its promoting circulation function which are increasing both the systolic function and the preload.

  • PDF

외과적 심실 복원과 승모판 고리성형 후 좌심실 형태와 기능의 초기 변화: 자기공명영상 (Early Changes of Left Ventricular Geometry and Function after Surgical Ventricular Restoration and Mitral Valve Annuloplasty: Magnetic Resonance Imaging)

  • 최병욱;장병철;김영진;허진;이혜정;김태훈;최규옥
    • Investigative Magnetic Resonance Imaging
    • /
    • 제12권1호
    • /
    • pp.40-48
    • /
    • 2008
  • 목적: 개정 도씨 술식과 승모판 고리성형을 동시에 시행한 후 심실의 형태와 기능의 초기 변화를 자기공명영상을 이용하여 평가하고자 하였다. 대상 및 방법: 총 21명의 확장성 심부전 환자를 대상으로 하여 8명에서 개정 도씨 술식을, 6명에서 승모판 고리성형을, 7명에서 두 수술을 동시에 시행하였다. 영화 자기공명영상을 이용하여 수술 전과 후에 좌심실의 형태와 기능을 평가하였다. 좌심실의 이완기말 용적과 수축기말 용적, 장축과 단축의 길이를 측정하고 이로부터 좌심실의 일회박출량, 박출률, 구형지수를 계산하여 구하였다. 이렇게 구해진 인자들을 분석하고 술식이 서로 다른 3군에서 어떻게 다른지 비교하고 두 수술을 동시에 시행할 때의 효과를 해석하였다. 결과: 자기공명영상은 수술 전 $12\;{\pm}\;15$ 일 (범위 1-58 일)과 수술 후 $38\;{\pm}\;50$ 일 (범위 7- 231 일)에 시행하였다. 두 수술을 동시에 시행한 군에서 다른 군에 비하여 수술 전 좌심실의 확장이 더 심하였고 수축력이 더 감소되어 있었다. 수술 후, 좌심실의 이완기말 용적과 수축기말 용적은 수술 형태와 관계없이 모든 환자에서 유의하게 감소하였다. 박출률은 개정 도씨 술식을 받은 환자 군에서만 유의하게 증가하였다 (25.4% to 40.7%). 구형지수는 개정 도씨 술식을 받은 환자에서는 증가하였고 승모판 고리성형을 받은 환자에서는 감소하였다 (0.65 to 0.78 vs. 0.75 to 0.65). 두 수술을 동시에 시행한 환자에서는 유의한 구형지수의 변화가 없었다. 결론: 개정 도씨 술식과 승모판 고리성형을 동시에 시행받은 확장성 심부전 환자에서 좌심실의 형태와 기능의 초기 변화는 좌심실 용적과 일회박출량의 현저한 저하이다. 승모판 고리성형에 의한 구형지수의 감소는 개정 도씨술식에 의한 구형지수의 증가에 의해 상쇄되어 좌심실의 형태는 변하지 않는다. 두 수술을 동시에 시행한 후 좌심실 박출률의 향상은 조기에 일어나지 않는다.

  • PDF

Effects of alfaxalone on echocardiographic examination in healthy dogs

  • Kim, Ye-Won;Kim, Tae-Jun;Hyun, Changbaig
    • 대한수의학회지
    • /
    • 제55권4호
    • /
    • pp.221-225
    • /
    • 2015
  • This study evaluated the effects of alfaxalone (3 mg/kg, intravenously) on echocardiographic examination in healthy dogs using echocardiography. Six adult Beagle dogs were used for this study. Left ventricular dimensions with systolic indexes, trans-blood flow at all cardiac valvular annulus and trans-mitral tissue Doppler values were measured from routine transthoracic echocardiography. Although the changes were not statistically significant, heart rate, left ventricular end-systolic diameter, left ventricular end-diastolic diameter, peak velocities of tricuspid A-wave and transpulmonic flow were increased after alfaxalone induction, while systolic blood pressure, fractional shortening, left ventricular ejection fraction, peak velocities of mitral E-wave, mitral A wave, tricuspid E-wave, transaortic flow and medial e'-, a'- and s'-peaks decreased after alfaxalone induction. No dogs showed hypoxemia during sedation, regardless of intubation and oxygen supply. Although alfaxalone showed mild cardiovascular depression, this protocol could be a good alternative sedative protocol for echocardiographic examination in healthy dogs because the cardiovascular depression was statistically and clinically insignificant. However, further studies in dogs with heart diseases should be conducted to confirm these findings after alfaxalone induction.

Impact of Pulmonary Arterial Elastance on Right Ventricular Mechanics and Exercise Capacity in Repaired Tetralogy of Fallot

  • Soo-Jin Kim;Mei Hua Li;Chung Il Noh;Seong-Ho Kim;Chang-Ha Lee;Ja-Kyoung Yoon
    • Korean Circulation Journal
    • /
    • 제53권6호
    • /
    • pp.406-417
    • /
    • 2023
  • Background and Objectives: Pathophysiological changes of right ventricle (RV) after repair of tetralogy of Fallot (TOF) are coupled with a highly compliant low-pressure pulmonary artery (PA) system. This study aimed to determine whether pulmonary vascular function was associated with RV parameters and exercise capacity, and its impact on RV remodeling after pulmonary valve replacement. Methods: In a total of 48 patients over 18 years of age with repaired TOF, pulmonary arterial elastance (Ea), RV volume data, and RV-PA coupling ratio were calculated and analyzed in relation to exercise capacity. Results: Patients with a low Ea showed a more severe pulmonary regurgitation volume index, greater RV end-diastolic volume index, and greater effective RV stroke volume (p=0.039, p=0.013, and p=0.011, respectively). Patients with a high Ea had lower exercise capacity than those with a low Ea (peak oxygen consumption [peak VO2] rate: 25.8±7.7 vs. 34.3±5.5 mL/kg/min, respectively, p=0.003), while peak VO2 was inversely correlated with Ea and mean PA pressure (p=0.004 and p=0.004, respectively). In the univariate analysis, a higher preoperative RV end-diastolic volume index and RV end-systolic volume index, left ventricular end-systolic volume index, and higher RV-PA coupling ratio were risk factors for suboptimal outcomes. Preoperative RV volume and RV-PA coupling ratio reflecting the adaptive PA system response are important factors in optimal postoperative results. Conclusions: We found that PA vascular dysfunction, presenting as elevated Ea in TOF, may contribute to exercise intolerance. However, Ea was inversely correlated with pulmonary regurgitation (PR) severity, which may prevent PR, RV dilatation, and left ventricular dilatation in the absence of significant pulmonary stenosis.

Preliminary study on the effects of pergolide on left ventricular function in the horses with pituitary pars intermedia dysfunction

  • Gehlen, Heidrun;Fisch, Judith;Merle, Roswitha;Trachsel, Dagmar S.
    • Journal of Veterinary Science
    • /
    • 제22권5호
    • /
    • pp.64.1-64.12
    • /
    • 2021
  • Background: Pituitary pars intermedia dysfunction (PPID), a neurodegenerative disease leading to reduced dopamine production, is a common disease in aged horses. The treatment is based on administration of the dopamine agonist pergolide. This drug has been related to valvular fibrosis in humans, but the cardiovascular effect of this drug has not yet been investigated in horses. Objectives: To determine whether pergolide induces valvular disease in horses or affects the cardiac function. Methods: Standard, tissue Doppler (TDE) and two-dimensional speckle tracking (STE) echocardiography were performed in horses with diagnosed PPID based on adrenocorticotropic hormone dosage. Measurements taken in horses treated with pergolide were compared with those from untreated horses with nonparametric t-tests. Furthermore, measurements from follow-up examinations performed at least three months after the initial exam were compared with a Wilcoxon signed rank test for repeated measurements in each group. Results: Twenty-three horses were included. None of the 12 horses under treatment developed valvular regurgitation. Furthermore, no differences in the measurements of the left ventricular systolic or diastolic function could be seen between the group of horses with treatment and those without treatment. Measurements taken in the follow-up exam did not differ compared to those taken in the initial exam in both groups. Conclusions: No changes of the left ventricular function assessed by TDE and STE could be shown in a small population of horses with confirmed PPID. Treatment with pergolide did not affect the ventricular function nor induce valvular disease.

활로씨 4징증의 좌심실용적이 수술후 심장기능에 미치는 영향 (The Effect of Left Ventricular Volume on Postoperative Cardiac Function in Tetralogy of Fallot)

  • 김응중;노준량
    • Journal of Chest Surgery
    • /
    • 제21권2호
    • /
    • pp.211-222
    • /
    • 1988
  • Tetralogy of Fallot is a cyanotic congenital heart disease characterized by large ventricular septal defect[VSD] and stenosis of right ventricular outflow tract[RVOT] and the degree of RVOT stenosis and the state of pulmonary arteries are the major determinant of prognosis of this anomaly after operation. The sum of blood flow through RVOT and collateral flow from systemic arteries determine the total pulmonary blood flow and it is drained to left atrium and left ventricle. Therefore the degree of development of left ventricle not only reflects pulmonary blood flow and the status of peripheral pulmonary arteries but also affects postoperative prognosis as a systemic ventricle. In this article, left ventricular volume and its influence on postoperative cardiac function in tetralogy of Fallot were studied in 34 patients operated on at Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital in 1985. Mean age of the patients was 5 1/12*3 9/12 years[range 9/12 - 14 8/12 years], mean body surface area[BSA] 0.65*0.20m2[range 0.38 - 1.22m2], mean body weight 15.6k6.48kg[range 7.0 - 36kg]and mean hematocrit 50.6*9.77%[range 32.0 - 73.5%]. Left ventricular end-diastolic volume[LVEDV] of them were from 11.2 to 113cc and there was a good linear correlation between BSA[m2, X]and LVEDV[cc, Y][Y= - 20.0+923x, r= 0.84, p < 0.005]. Mean LVEDV/m2 was [57.6 * 18.3 cc / m2[range 28.7 - 95.8 cc / m2] and there was a significant reduction of volume compared with normal value. As body surface increases, there was a increasing tendency in LVEDV/m2 but there was no statistical significance. Mean total amount of postoperatively infused dopamine in these 33 patients[except one who expired postoperatively] was 65.6*74.5mg / kg and it was 40.6*44.0mg / kg in routine RVOT widening group [Group I] and 205*49.3mg / kg in transannular RVOT widening group[Group II]. There was a statistically significant difference between two groups. In group I patients there was a good linear inverse correlation between dopamine total amount[mg / kg, Y] and LV volume[cc / m2, X] [Y = 150 - 1.89 X, r = - 0. 77, p < 0.005]. But there were no correlations between dopamine total amount and Hct, cardiopulmonary bypass time and aorta cross clamp time. In conclusion, the patient with small preoperative left ventricular volume required more amount of dopamine as an inotropic agent for the maintenance of a cardiac function in postoperative period. But this is a result of immediate postoperative period and does not reflect the long term effect of left ventricular volume in tetralogy of Fallot. There must be more study for the evaluation of its long term effect.

  • PDF

Subclinical left ventricular dysfunction in children after hematopoietic stem cell transplantation for severe aplastic anemia: a case control study using speckle tracking echocardiography

  • Kim, Beom Joon;Moon, Kyung Pil;Yoon, Ji-Hong;Lee, Eun-Jung;Lee, Jae Young;Kim, Seong Koo;Lee, Jae Wook;Chung, Nack Gyun;Cho, Bin;Kim, Hack Ki
    • Clinical and Experimental Pediatrics
    • /
    • 제59권4호
    • /
    • pp.190-195
    • /
    • 2016
  • Purpose: Severe aplastic anemia (SAA), a fatal disease, requires multiple transfusion, immunosuppressive therapy, and finally, hematopoietic stem cell transplantation (HSCT) as the definitive treatment. We hypothesized that iron overloading associated with multiple transfusions and HSCT-related complications may adversely affect cardiac function. Left ventricular (LV) function was assessed in children after HSCT for SAA. Methods: Forty-six consecutive patients with a median age of 9.8 years (range, 1.5-18 years), who received HSCT for SAA and who underwent comprehensive echocardiography before and after HSCT, were included in this study. The data of LV functional parameters obtained using conventional echocardiography, tissue Doppler imaging (TDI), and speckle-tracking echocardiography (STE) were collected from pre- and post-HSCT echocardiography. These data were compared to those of 40 age-matched normal controls. Results: In patients, the LV ejection fraction, shortening fraction, end-diastolic dimension, mitral early diastolic E velocity, TDI mitral septal E' velocity, and STE LV longitudinal systolic strain rate (SSR) decreased significantly after HSCT. Compared to normal controls, patients had significantly lower post-HSCT early diastolic E velocity and E/A ratio. On STE, patients had significantly decreased LV deformational parameters including LV longitudinal systolic strain (SS), SSR, and diastolic SR (DSR), and circumferential SS and DSR. Serum ferritin levels showed weak but significant correlations (P<0.05) with LV longitudinal SS and SSR and circumferential SS and DSR. Conclusion: Subclinical LV dysfunction is evident in patients after HSCT for SAA, and was associated with increased iron load. Serial monitoring of cardiac function is mandatory in this population.

관상동맥질환에서 Gated Blood Pool Scan을 이용한 좌심실 확장기능의 분석 (Analysis of Left Ventricular Diastolic Function in Coronary Artery Disease with Gated Blood Pool Scan)

  • 최창운;임상무;정준기;이명철;박영배;서정돈;이영우;고창순
    • 대한핵의학회지
    • /
    • 제20권2호
    • /
    • pp.39-45
    • /
    • 1986
  • Resting gated blood pool scan was used to derive left ventricular functional changes in normals (N=13, mean age=43) and in patients with coronary artery disease (N=50, mean age=53). Peak filling rates, average filling rates, and ejection fractions were significantly depressed in coronary artery disease. (p<0.0005, each other). And in coronary artery disease with normal ejection fraction (N=21), peak filling rates and average filling rates were depressed also, and peak filling rates of coronary artery disease with normal ejection fraction were abnormal in 61.2% and average fillin rates were abnormal in 71.4%. It appears that (1) resting peak filling rates and average filling rates were sensitive and easily obtainable parameters of the diastolic dysfunction assosiated with coronary artery disease, (2) a significant proportion of coronary artery disease patients without any evidence of abnormal systolic function have depressed resting peak filling rates and average filling rates of the left ventricle.

  • PDF