• Journal of Radiopharmaceuticals and Molecular Probes
• /
• v.9 no.1
• /
• pp.3-8
• /
• 2023

Parkinson's disease is a neurodegenerative disease caused by damage to brain neurons related to dopamine. Non-clinical animal models mainly used in Parkinson's disease research include drug-induced models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine, and genetically modified transgenic animal models. Parkinson's diagnosis can be made using brain imaging of the substantia nigra-striatal dopamine system and using a radiotracer that specifically binds to the dopamine transporter. In this study, ¹⁸F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane was used to confirm the image evaluation cutoff between normal and parkinson's disease models, and to confirm model persistence over time. In addition, the efficacy of single or combined administration of clinically used therapeutic drugs in parkinson's animal models was evaluated. Image analysis was performed using the PMOD software. Converted to standardized uptake value, and analyzed by standardized uptake value ratio by dividing the average value of left striatum by the average value of right striatum obtained by applying positron emission tomography images to the atlas magnetic resonance template. The image cutoff of the normal and the parkinson's disease model was calculated as SUVR=0.829, and it was confirmed that it was maintained during the test period. In the three-drug combination administration group, the right and left striatum showed a high symmetry of more than 0.942 on average and recovered significantly. Images using ¹⁸F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane are thought to be able to diagnose and evaluate treatment efficacy of non-clinical Parkinson's disease.

• Journal of the Korean Home Economics Association
• /
• v.35 no.4
• /
• pp.95-110
• /
• 1997

According to the design method for constructing the crotch angle of traditional Korean men's trousers there are differences in from after its completion. Since there is no standardization of visual & aesthetic pattern for the construction method which is stablished by the calculation formular of waist girth hip girth pantleg end and upper outer leg length it is difficult to be used for educational use or for teaching materials. Therefore the purpose of this project according to five models in proportion to the physical standard of Korea in ages from 24 to 29 years old is to establish a design criterion and the standardization of construction methods by introduction the pant construction method of the crotch angle by converting the sitting posture length to seaming crotch center point both knees width in the Korean way of sitting. The production method for the pattern design is as follow: (1) The waist girth formular is {{{{ { w} over {4 } }}}}+{{{{ {w} over {10 } }}}}(2) The hip girth formular is {{{{ {H } over { 4} }}}}+{{{{ {H } over {5 } }}}}(3) The pantleg end formular is {{{{ {H } over {4 } }}}}(4) A crotch angle is fixed at 70 degress.(5) The ratio of outer leg length to leg width is 5:8 (6) The component ratio of the upper outer leg length to the pant length in 5:8(7) The ratio of the division point of front / right inner leg length and left inner leg width to upper outer leg length is 5 : 8

• Steel and Composite Structures
• /
• v.39 no.4
• /
• pp.383-399
• /
• 2021

In the study, three 1:3-scale unequal span steel-concrete composite substructures with top-seat angle and double web angle connection were designed and identified as specimens GTSDWA-0.6, GTSDWA-1.0, and GTSDWA-1.4. Pseudo-static tests and refined numerical model analysis were conducted to examine the anti-progressive collapse performance of a semi-rigid steel-concrete composite substructure. The results indicated that the failure modes of the three specimens revealed that the fracture occurred in the root of the long leg of the top/seat angle in tension at the connection. With increases in the span ratio of the left and right composite beams, the bearing capacities of the composite substructures decreased, and the corresponding displacement increased. With respect to GTSDWA-0.6 and GTSDWA-1.4, the resistance due to the short composite beam corresponded to 62% and 60%, respectively, and the total resistance provided by the short composite beam exceeded that of the long composite beam. With respect to GTSDWA-1.0, the resistance due to the left and right composite beams was similar. All three specimens underwent the flexure mechanism and flexure-axial mixed mechanism stages. They resisted the external load mainly via the flexure mechanism. Moreover, the addition of stiffeners on both sides of the top and seat angles is advantageous in terms of improving the collapse resistance and ductility of unequal span composite substructures.

• Korean Journal of Digital Imaging in Medicine
• /
• v.12 no.2
• /
• pp.119-125
• /
• 2010

In order to demonstrate the value of long-distance radiography, we have studied how distance affects images in chest frontal radiography and compared short-distance and long-distance images in chest lateral radiography. Cardiothoracic ratio(CTR %) of 50 patients with no disease in the chest(10 each at the age of 20~60) were evaluated in Supine AP(100 cm), Sitting AP(100 cm), Sitting AP(180 cm), and Erect PA(180 cm). In lateral radiography, we evaluated and compared left lateral radiography(100 cm and 180 cm) of the patients based on the horizontal maximum of the heart. The average value of CTR(%) were 0.48 in Erect PA(180 cm), 0.52 in Supine AP(100 cm), 0.50 in Sitting AP(100 cm), 0.49 in Sitting AP(180 cm), which were Supine AP(100 cm) > Sitting AP(100 cm) > Sitting AP(180 cm) > Erect PA(180 cm). The average value of Maximum transverse diameter of left of the cardiac(MLD), which showed how much axis of spine was slanted to the left, was 90.67 mm in Erect PA(180 cm), 103.92 mm in Supine AP(100 cm), 93.54 mm in Sitting(100 cm), 89.84 mm in Sitting AP(180 cm), 58.11 mm in the minimum value and 118.79 mm in the maximum value. The average value of Maximum transverse diameter of right side of the cardiac(MRD), which suggested how much axis of spine was slanted to the right, was 47.18 mm in Erect PA(180 cm), 48.12 mm in Supine AP(100 cm), 44.98 mm in Sitting AP(180 cm), and the minimum value 26.84 mm and the maximum value 65.30 mm. There was no standard method to calculate; therefore, the horizontal maximum of the heart was used for lateral radiography. The average value was 121.07 mm in 100 cm and 109.76 mm in 180 cm. Sitting AP(180 cm) among the types was closest to C-PA(180 cm). As a result, during C-AP radiography, long-distance radiography lessened shadow of the heart more than that of short distance, Sitting position more than Supine position.

• Journal of Korean Physical Therapy Science
• /
• v.10 no.1
• /
• pp.74-82
• /
• 2003

The purpose of this study is to provide guideline of muscle strengthening exercise for preparing ambulation by presenting suitable ratio of muscle power of agonist & antagonist, and that of concentric & eccentric contraction on behalf of amputee's normal ambulation training and it's strenthening as well. 7 Subjects who have femur amputee for experimental group were able to ambulate naturally without inconvenience and 20 adult subjects of comparison group for comparison were considered to be free from disturbance of ambulation. The method of study was to measure the muscle power of hip pint, was to figure out the ratio of agonist & antagonist, concentric contraction & eccentric contraction, and was to find out mean and standard deviation of each measurement. Every numerical value of comparison was tested by Mann-whitney and comparison group's comparison between left & right value was done with t-test. Results are as followings : 1) Extension force was stronger than flexor force and had no remarkable difference(p<0.05) 2) For normal adults, adduction farce was stronger than abduction force and for amputees, abduction force was stronger while adduction force was the same as the normal without showing remarkable difference(p<0.05) According the result above, I make an assumption that maintaining a proper ratio of muscle power on strengthening exercise for amputee's ambulation training & rehabilitation and finally bring out an improvement of transfer and ambulation.

• Journal of Convergence for Information Technology
• /
• v.8 no.6
• /
• pp.59-66
• /
• 2018

The utilized coefficient of friction (UCOF) as a ratio of the shear force to the normal force on the ground during walking is used to identify the point at which slip is likely to occur. Shoe walking will change the utilized coefficient of friction by shoe design such as sole thickness and hardness, heel shape, and outsole pattern. In this study, subjects are 21 adults (10 female, 11 male, age: $25.2{\pm}2.3yrs$, height: $165.6{\pm}7.2cm$), analysis variables were walking speed, GRF, when the UCOF is maximal, and Tangent of CoP-CoM angle, and correlation analysis with the utilized friction coefficient (UCOF). As a result, First, for the shod walking the time point which UCOF is maximum about heel strike was faster and the magnitude was larger than for barefoot walking. Second, the correlation between the tangent of CoP-CoM and UCOF of right foot was higher at the left heel striking point (UCOF2_h) which occurred in the post propulsion phase than at the right heel striking point (UCOF1_h). This suggests that the right foot UCOF is related to the braking phase of left foot( which is the propulsion phase of right foot) rather than the braking phase of right foot.

• Journal of the Korean Society of Physical Medicine
• /
• v.6 no.3
• /
• pp.361-368
• /
• 2011

Purpose : The aims of this study was to identify the activation of the mirror neuron system during action observation in people with stroke and the difference between left hemisphere and right hemisphere and to provide possibility of the use of action observation as a clinical method for improving motor function after stroke. Methods : Seventeen participants were asked to observe 3 different stimulation conditions for 80 seconds. A 30 second rest period was given between stimulations. Electroencephalogram(EEG) signals from electrodes on the participant's scalp were recorded during action observation. The activation of the mirror neuron system(MNS) between the picture observation condition and action observation condition was compared with a paired t-test. An independent t-test was used to compare difference between C3 and C4 on the activation of the mirror neuron system in the action observation condition. Results : Result of paired t-test showed a significantly decreased log ratio in the activation of the mirror neuron system in the action observation condition compared to the picture observation condition. Result of the independent t-test indicated no significant differences in the activation of the mirror neuron system in the right and left hemisphere. Conclusion : The mirror neuron system showed greater activation in the action observation condition than in the picture observation condition and activation in the both hemisphere during action observation. We conclude that these findings suggest that this may possibly be an efficient clinical intervention method for improving motor function.

• Korean Journal of Applied Biomechanics
• /
• v.27 no.3
• /
• pp.211-217
• /
• 2017

Objective: The purpose of this study was to investigate the effect of a 12-week professional body massage program (PMP) on forward head posture, neck pain, and plantar foot pressure balance in men in their 20s. Method: A total of 20 men with musculoskeletal diseases were recruited for this study. The participants were asked to take part in a PMP twice a week for 12 weeks. The cranial vertical angle (CVA) for forward head posture and visual analogue scale (VSC) for neck pain and right/left foot plantar pressure balances were extracted to compare between pre- and post-program differences. Results: CVAs before ($56.86{\pm}4.55^{\circ}$) and after ($62.72{\pm}4.57^{\circ}$) and VSCs before ($6.95{\pm}1.70$) and after ($1.70{\pm}1.56$) PMP revealed statistically significant differences. The right foot, after PMP, showed a significant increase in the plantar pressure balance from $46.17{\pm}2.95$ to $49.44{\pm}1.29%$, while the left foot decreased significantly from $53.83{\pm}2.95%$ to $50.56{\pm}1.29%$. Therefore, based on these results, it may be said that the foot pressure balance abilities were improved after PMP because the ideal foot pressure ratio is 50%. Conclusion: Consequently, it was suggested that a 12-week PMP could be utilized for improvement of forward head posture, neck pain, and foot plantar pressure balance in men in the 20s with musculoskeletal diseases.

• The Journal of Korean Physical Therapy
• /
• v.7 no.1
• /
• pp.33-42
• /
• 1995

The purposes of this study were 1) to compare weight distribution and ratio of the extremities between normal and hemiplegic children in quadruped position and 2) to compare the effect of ATNR on weight bearing of the extremities between normal and hemiplegic children. The subjects fer the study were 48 children(24 normal, 24 hemiplegic) between the ages 3 to 6. They were teated weight distribution and ratio of the extremities in the neutral position of head and by passive right and left rotation of the head in the quadruped position. The data wert analized by paired t-test. The results were as follows: 1. In the neutral position of head, normal group was not difference on weight distribution and ratio of the extremities and hemiplegic group was more weight bearing on the sound upper extremity than the affected upper extremity(p<.01). 2. When the head rotated to the dominant side or sound side passively, there was not a significant difference between normal and hemiplegic group. 3. When the head rotated to the nondominant side or affected side passively, there was a significant difference between nondominant upper extremity nf normal and affected upper extremity of hemiplegic group(p<.05).

• Journal of Oral Medicine and Pain
• /
• v.25 no.1
• /
• pp.87-97
• /
• 2000

This study was performed to investigate the effects of repetitive mandibular opening movement and change of head posture on the vibration of temporomandibular(TM) joint. For this study, 23 patients with internal derangement of TM joint were selected. All they had clinically noticeable TM joint sound. Observation of the joint vibration were performed in four head postures, namely, natural head posture (NHP), forward head posture(FHP), upward head posture(UHP), and downward head posture(DHP). For recording of joint sound vibration, Sonopak of Biopak system(Bioresearch Inc., Milwaukee, USA) was used, The author could take results related to integral higher than 300Hz, integral lower than 300Hz, ratio of integral higher than 300Hz to integral lower than 300Hz, total integral which was sum of higher and lower integral, peak amplitude, and peak frequency in each opening movement, which was carried out three times in each head posture. Integral means amount of vibration. The data obtained were analysed by SPSS windows program and the results of this study were as follows : 1. In NHP, total integral in right TM joint was 5O.3Hz in the first opening, 67.9Hz in the second opening, and 74.0Hz in the third opening movement, bur there was no significant increase of total integral with repetitive opening movement. This finding was similar in left TM joint. Integral lower than 300Hz were higher than integral higher than 300Hz in almost every opening movement. 2. There was no significant difference of total integral between right and left side of TM joint, but there was a tendency of higher total integral in right TM joint than that in left TM joint except for results in DHP. 3. Peak amplitude in NHP ranged from 2.0 to 4.7, and peak frequency in NHP were 101.4-170.0Hz. And there was no consistent findings related to increase or decrease of these value according to repetitive opening in each head posture. 4. Change of head posture did not result any difference in integral, peak amplitude, and peak frequency. In conclusion, change of head posture and repetitive mandibular opening movement did not make any significant effect on the vibration of temporo-mandibular joint, especially, on total integral, peak amplitude, and peak frequency.