• Title/Summary/Keyword: Lee Sung-min

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Protective effect of Shenqi-wan and its fractions on N-methyl-D-aspartate-induced excitotoxicity in rat hippocampus

  • Lee, Joung-Hun;Kim, Youn-Sub;Kim, Young-Sick;Kim, Sung-Eun;Sung, Yun-Hee;Kim, Bo-Kyun;Lee, Jin-Woo;Ham, Dae-Hyun;Lee, Hye-Jung;Kim, Chang-Ju
    • Advances in Traditional Medicine
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    • v.7 no.5
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    • pp.534-539
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    • 2008
  • Shenqi-wan, Oriental herbal medicine formulation, has traditionally been used for the treatment of delayed mental and physical development in children, complications of diabetes, and glomerulonephritis. In the present study, we investigated the protective effect of the aqueous extract of Shenqi-wan and its fractions against N-methyl-D-aspartate (NMDA)-induced exitotoxicity in rat hippocampal CA1 neurons. Fractions were elucidated at 0 - 10 min, 11 - 20 min, and 21 - 30 min by using gravity column chromatography method. In the present results, treatment with NMDA on cultured hippocampal slices induced neuronal death in the hippocampal CA1 region. Pretreatment with the Shenqi-wan did not exerted protective effect, however its fractions suppressed NMDA-induced neuronal damage. The fraction elucidated at 11 - 20 min showed the most potent protective effect. These results revealed that effective substances of the Shenqi-wan against NMDA-induced excitotoxicity may exist mainly in the fraction elucidated at 11 - 20 min.

Determination of voice phishing based on deep learning and sentiment analysis (딥러닝과 감성 분석에 따른 보이스피싱 여부 판별)

  • Kim, Won-Woong;Kang, Yea-Jun;Kim, Hyun-Ji;Yang, Yu-Jin;Oh, Yu-Jin;Lee, Min-Woo;Lim, Se-Jin;Seo, Hwa-Jeong
    • Proceedings of the Korea Information Processing Society Conference
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    • 2021.11a
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    • pp.811-814
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    • 2021
  • 본 논문에서는 점차 진화되어가는 보이스피싱 수법에 대하여 딥러닝 기반 네트워크인 DNN(Deep Neural Network)를 통한 보이스피싱 여부 판별할 뿐만 아니라, CNN, Bi-LSTM을 활용한 다양한 관점에서의 감성 분석을 통하여 보이스피싱 조직원의 감성 상태를 파악하여 판별된 결과에 신뢰도를 높여주는 모델을 제안하였다.

Changes in drug metabolism during hypoxia/reoxygenation in isolated perfused rat

  • Seo, Min-Young;Cho, Tai-Soon;Lee, Sun-Mee
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1997.04a
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    • pp.98-98
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    • 1997
  • This study was done to investigate the effect of vitamin E on hypoxia/reoxygenation-induced hepatic injury in isolated perfused rat liver. Rats were pretreated with vitamin E or vehicle(soybean oil). Isolated livers from fasted 18 hours were subjected to 45min of low flow hypoxia or N$_2$ hypoxia followed by reoxygenation for 30min. The perfusion medium used was KHBB(pH 7.4) and 50${\mu}$㏖/$\ell$ of ethoxycoumarin was added to the perfusate to determine the ability of hepatic drug-metabolizing systems, In low flow hypoxia model, total glutathione and oxidised glutathione levels were significantly increased by hepoxia/reoxygenation with slight increase in LDH levels. These increases were prevented by vitamin E pretreatment. In N$_2$ hypoxia model, LDH, total glutathione and oxidized glutathione levels were increased significantly by hypoxia but restored to normal level by reoxygenation. Vitamin E had little effect on this hypoxic damage. There were no significant changes in the rate of hepatic oxidation of 7-EC to 7-HC in both hepoxic models. But, the subsequent conjugation of 7-HC by sulfate or glucuronic acid were significantly decreased by hypoxia, but restored by reoxygenation in both hypoxia models. As opposed to our expectation, treatment with vitamin E aggrevated the decrease of the rate of conjugation and even inhibited the restoration by reoxygenation. Our findings suggest that hypoxia/reoxygenation diminishes phase II drug metabolizing function and this is, in part, related to decreased energy level.

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Analysis and Performance Test for the Fan of a Wide Area Sprayer of Livestock Farm (축산 농가용 광역방제기 팬의 성능실험 및 분석)

  • Hong, J.T.;Min, B.R.;Kim, D.W.;Seo, K.W.;Kim, W.;Lee, S.K.;Kim, S.Y.;Lee, D.W.
    • Journal of Animal Environmental Science
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    • v.13 no.2
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    • pp.105-112
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    • 2007
  • This research was carried out to test and analyse the capability of a fan for development of a sprayer in actual livestock farm. A fan was designed and made to be able to spray agricultural chemicals within 140mm in a maximum scattering range and 100m in an effective scattering range. Accordingly, its' flow rate was $3,600\;m^3/min$, and static pressure was 100 mmAq for a wide area sprayer to be sprayed widely and far. Fan performance, which was given $600\;m^3/min$ flow rate and 500 mmAq total pressure, was tested fur basic experiment. As the result, the axial power showed minimum error, which be designed to keep the fan performance. And power efficiency was the maximum. Sound level was 92.1dB that wasn't enough to environmental standard. If we take the sealed place into consideration, sound level is suitable for environmental standard.

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