• 대한생식의학회:학술대회논문집
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• 2007.11a
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• pp.124.1-124.1
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• 2007

• 대한생식의학회:학술대회논문집
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• 2007.11a
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• pp.118.1-118.1
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• 2007

• Communications of Mathematical Education
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• v.2
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• pp.55-85
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• 1997

• 대한예방의학회:학술대회논문집
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• 1998.10b
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• pp.52-55
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• 1998

• Korean Journal of Pharmacognosy
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• v.47 no.3
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• pp.258-263
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• 2016

In this study, we tested anti-fatigue effect of Kyung-Ok-Ko (KOK). We examined the exercise performance effects of KOK (600 mg/kg) at 2nd, 3rd and 4th week. The exercise performance of KOK treated group was significantly improved than that of vehicle control (VC) group on grip strength (2nd week), exhausted time of treadmill (3rd week) and exhausted time of weight loaded swimming (4th week). We also investigated the effects of KOK on the change of fatigue parameters in blood, skeletal muscle and liver after swimming exercise. KOK significantly reduced lactate level and enhanced glucose level in blood. Equally KOK significantly increased glycogen in skeletal muscle. However, the glycogen level of KOK in the liver was not significantly increased compared to VC group. These results show that supplementation of KOK may improve the anti-fatigue activity and exercise capacity.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.1798-1805
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• 2010

The Railroad Safety Technology R&D Program has been supported by the Ministry of Land, Transport and Maritime Affairs. The Program consists of dozen or more projects and thus is quite complex, which requires effective project management. This paper is discussing how to effectively manage the railroad safety technology R&D program based on systems engineering management plan (SEMP). The key issues dealt in this paper include the SE management, requirements management, verification and validation, integrated data base management, and traceability management. To achieve the goal, we first defined an appropriate SE process to be adopted in the program and the result was documented in the systems engineering management plan. According to the process defined, we set up the environmental frame in database. Using the database and SEMP, each project of the program was verified with respect to the corresponding requirements utilizing the traceability. All these efforts were carried out using a computer-aided SE tool, which enables efficient management of complex database.

• The Korean Journal of Physiology and Pharmacology
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• v.23 no.4
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• pp.281-289
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• 2019

Vascular endothelial growth factor (VEGF)-C and its receptor, vascular endothelial growth factor receptor (VEGFR)-3, are responsible for lymphangiogenesis in both embryos and adults. In epilepsy, the expression of VEGF-C and VEGFR-3 was significantly upregulated in the human brains affected with temporal lobe epilepsy. Moreover, pharmacologic inhibition of VEGF receptors after acute seizures could suppress the generation of spontaneous recurrent seizures, suggesting a critical role of VEGF-related signaling in epilepsy. Therefore, in the present study, the spatiotemporal expression of VEGF-C and VEGFR-3 against pilocarpine-induced status epilepticus (SE) was investigated in C57BL/6N mice using immunohistochemistry. At 1 day after SE, hippocampal astrocytes and microglia were activated. Pyramidal neuronal death was observed at 4 days after SE. In the subpyramidal zone, VEGF-C expression gradually increased and peaked at 7 days after SE, while VEGFR-3 was significantly upregulated at 4 days after SE and began to decrease at 7 days after SE. Most VEGF-C/VEGFR-3-expressing cells were pyramidal neurons, but VEGF-C was also observed in some astrocytes in sham-manipulated animals. However, at 4 days and 7 days after SE, both VEGFR-3 and VEGF-C immunoreactivities were observed mainly in astrocytes and in some microglia of the stratum radiatum and lacunosum-moleculare of the hippocampus, respectively. These data indicate that VEGF-C and VEGFR-3 can be upregulated in hippocampal astrocytes and microglia after pilocarpine-induced SE, providing basic information about VEGF-C and VEGFR-3 expression patterns following acute seizures.

• The Korea Journal of Herbology
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• v.31 no.6
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• pp.1-9
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• 2016

Objectives : Gamisoyosan (GMS) is a useful prescription for treating insomnia, dysmenorrhea and infertility induced by a stress. Also, GMS has been used traditionally to improve systemic circulation and biological energy production. The purpose of this study was to assess the anti-oxidant activity and anti-inflammatory effects of Gamisoyosan Formulation (Soft extract, GMS-SE). Methods : The biological activities such as anti-oxidant and anti-inflammatory effects were measured through cell line-based in vitro assay. We investigated the anti-oxidant properties of GMS-SE on the 1,1-diphenyl-2-picryhydrazyl (DPPH) radical, contents of total flavonoid and polyphenol. GMS-SE compared to butyl hydroxy anizole (BHA). Furthermore, based on this result the anti-inflammatory effects of GMS-SE have verified by mechanism from LPS- treated Raw264.7 macrophages. Results : The anti-oxidant activities of GMS-SE increased markedly, in a dose-dependent manner. The GMS-SE showed significant scavenging activity (GMS-SE $500{\mu}g/m{\ell}$ : $32.77{\pm}1.65%$, GMS-SE $1000{\mu}g/m{\ell}$ : $45.06{\pm}1.04%$ and BHA $100{\mu}g/m{\ell}$ : $39.25{\pm}2.41%$ for DPPH assay). and, The total phenolic compound and flavonoids contents of GMS-SE were $73.93{\pm}6.87{\mu}g/mg$ and $698.75{\pm}6.78{\mu}g/mg$. GMS-SE which is LPS has diminished in the LPS-induced release of inflammatory mediators (NO, iNOS, COX2 and PGE2) and pro-inflammatory cytokines (TNF-${\alpha}$, IL-6 and IL-$1{\beta}$) from the RAW264.7 macrophages. Moreover, GMS-SE inhibited the activation of phosphorylation of p38 and ERK MAPKs by induced LPS. Conclusion : The present results indicate that GMS-SE has an anti-oxidant and anti-inflammatory properties, therefore may be beneficial in diseases which related to oxidative stress-mediated inflammatory disorders.

• Proceedings of the KIEE Conference
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• 2004.11c
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• pp.562-564
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• 2004

The containment leakage rate test performed on the nuclear power plants consists of following phases : pressurizing the containment, stabilizing the atmosphere, conducting a Type A test, conducting a verification test, depressurizing the containment. It takes more than 48 hours from the pressurization to the depressurization and the prediction of the results will help to prepare the next test phase. In this paper, to predict the leakage rate, the prediction methods based on the least square method are evaluated according to the input variables and the measurement period.

• Proceedings of the KIEE Conference
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• 2004.11c
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• pp.638-640
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• 2004

The gas stripper system of a nuclear power plant provides gas-free water to a reactor and a turbine system. The gas tripper unit has two control systems to regulate pressure and level independently. Because the level and the pressure interact as a control disturbance each other, continuous operation of the system is difficult. In this paper, We describe the controllability evaluation of the gas stripper system and the results of the optimally tuned control gains.