• 대한한방내과학회지
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• 제22권2호
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• pp.193-198
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• 2001

This study was designed to investigate the effects of Korean Lycii Fructus water extract in Pb-administered rats. The Pb exposed rats were given 100 ppm and 200 ppm in the distilled water. Sixty male Sprague-Dawley rats weighing between 90 and 110g were blocked into 6 groups according to body weight. The control group was fed a normal diet, without lead. The experimental groups, which was fed a normal diet plus 100 ppm and 200 ppm lead, and one group received a normal diet plus Lycii Fructus water extracts. The results: the Food intake, the weight gain, and the kidney weight content in the cadmium added groups were lower than those in the Lycii Fructus water extracts group. The contents of Pb in the kidneys of the rats were determined by using ICP(lnductively Coupled Plasma Spectrophotometer). The accumulation of lead in the kidney was lower in the Lycii Fructus water extracts group. The Plasma levels of renin activity was higher in the lead administration groups, as compared with the Lycii Fructus water extracts. Plasma levels of aldosterone activity was higher in the lead administration group, as compared with Lycii Fructus water extracts. These results suggest that Lycii Fructus water extracts has a lowering effects on the accumulation of pb on kidney and it is believed that the Lycii Fructus water extracts have some protective effects on lead-induced nephrotoxicity in rats, but the mechanism of these effects was obscure.

• Journal of Preventive Medicine and Public Health
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• 제31권2호
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• pp.240-248
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• 1998

울산시 초등학교 학생들의 연 폭로에 관한 기초자료를 얻고, 공단지역과 교외지역의 환경적 차이에 따라 혈중 연농도에 차이가 있는지를 알기위하여 공단 지역과 교외지역의 초등학생 448명을 대상으로 이들의 혈중 연농도를 조사하여 다음과 같은 결과를 얻었다. 1. 전체 초등학생들의 평균 혈중 연농도는 $4.90{\mu}g/d\ell$로 나타나 현재 소아들에서 허용가능한 혈중 연농도인 $10{\mu}g/d\ell$보다 낮았으며, 남아가 여아보다 높았으나 통계학적인 유의성은 없었다(P=0.13). 2. 공단지역의 초등학생들의 혈중 연농도는 $5.26{\mu}g/d\ell$로 교외지역의 $3.81{\mu}g/d\ell$보다 통계적으로 유의하게 높았다(P<0.001). 이상의 결과로 보아 울산지역의 초등학생들의 연농도는 허용가능한 혈중 연농도인 $10{\mu}g/d\ell$미만이었으나, 공단지역의 초등학생들은 교외지역의 초등학생들 보다 상대적으로 높은 혈중 연농도를 가지고 있어 이에 대한 지속적인 연구조사가 필요한 것으로 사료된다.

• 생명과학회지
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• 제19권4호
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• pp.472-478
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• 2009

본 연구에서는 도시 지역 주민들과 농촌 지역 주민들을 대상으로 지리적 환경 차이에 따른 혈중 납 및 혈중 카드뮴 농도를 조사하여 노출 정도를 알아보고자 하였다. 연구 대상은 2007년 7월 1일에서 8월 30일 까지 경남의 전형적인 농촌마을(진주) 주민 84명과 부산 인근의 반농촌마을(기장) 주민 64명, 대도시 부산지역 주민 100명을 선정하여 연구를 수행하였으며, Graphite furnace를 갖춘 비불꽃 원자 흡광기를 이용하여 분석하였다. 평균 혈중 납 농도는 대도시 부산지역 주민이 $6.38{\pm}2.86{\mu}g/dl$이었으며, 진주 농촌지역 주민들은 $5.41{\pm}2.16{\mu}g/dl$, 부산 인근의 기장지역 주민들은 $4.50{\pm}2.87{\mu}g/dl$으로 부산지역 주민들의 평균 혈중 납 농도가 가장 높았으며 부산지역 주민의 혈중 납 농도와 부산 인근 기장지역 주민의 혈중 납 농도간 유의한 차이(p<0.01)를 보였다. 평균 혈중 카드뮴 농도는 대도시 부산지역 주민이 $0.85{\pm}0.44{\mu}g/l$이었고, 진주 농촌지역 주민이 $1.57{\pm}0.78{\mu}g/l$, 부산 인근의 기장지역 주민 $0.95{\pm}0.54{\mu}g/l$으로 진주 농촌지역 주민들의 평균 혈중 카드뮴 농도가 가장 높았으며 부산지역 주민과 진주 농촌지역 주민들 간에 통계적 유의한 차이(p<0.01)가 관찰되었다. 본 연구에서는 도시 지역과 농촌 지역 간에 따라 혈중 납 및 혈중 카드뮴의 농도에 차이가 있음을 알 수 있었으나, 일부 지역 주민들의 결과만으로 우리나라 전체 도시와 농촌지역 주민의 혈중 납 및 카드뮴 농도에 대한 차이를 단언하기는 어렵다고 생각된다. 하지만 작업장 내의 직업적 폭로가 아닌 도시와 농촌 간의 지역적 차이에 관한 연구로써 의미 있는 연구라 생각되며, 향후 혈중 납과 카드뮴의 체내 축척을 줄이기 위하여 보다 더 많은 대상자들의 정밀한 조사가 이루어져야 될 것으로 사료된다.

• 한국환경보건학회지
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• 제8권1호
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• pp.31-43
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• 1982

Seventy-seven Mugil cephalus of spinal deformation, living in Hanam, Nogsan, and Myeongji area, the downstreams of the Nagdong River, were collected in order to determine their forms and the levels of heavy metal contamination between March and October, 1981. The specimens were examined by X-ray and content of cadmium, lead, copper, and zinc by atomic absorption spectrophotometer. The results were summarized as follows: 1. The rate of appearance of deformational fish to the total Mugil cephflus were 4.3% (13 fish), 5.7% (17 fish), relatively high in May and June (dry season). Meanwhile during March and October they were low by 1.0% (3 fish), 2.0% (6 fish). As far as the research areas are concerned, they appeared in larger numbers in downstreams than in upper streams Myeongji (39), Nogsan (25), and Hanam (13). 2. Concerning with fractured parts of vertebraes,86 percent (66 out of 77) had their caudal regions fractured and 72 percent (55) their first to seventh caudal regions fractured. 3. The average levels of cadmium, lead, copper, zinc detected from flesh were 0.26ppm, 2.06ppm, 6.35ppm, 0.85ppm on the other hand, they were 0.22ppm, 1.84ppm, 5.03ppm, 0.93ppm in normal fish. 4. The average levels of cadmium, lead, copper, zinc measured in the bones were 0.39ppm, 2.55ppm, 8.97ppm, 2.73ppm. Meanwhile, from normal fish they were 0.33ppm, 2.25ppm, 7.24ppm, 2.42ppm. 5. Compared with regional heavy metal contamination such as cadium, lead, zinc, Myeongji area had higher contamination content than Nogsan area Nogsan area than Hanam area. 6. Compared with heavy metal contamination level in their tissues, cadmium was highly found in bones Lead and copper were highly detected in viscera. Particularly in skeleton cadmium was 560 times, zinc 160 times in proportion to those in the downstreams of the Nagdong River.

• 대한수의학회지
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• 제25권2호
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• pp.145-148
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• 1985

Nickel toxicity and interactions of nickel with zinc, copper, and lead were studied in glowing chicks fed supplemented diet. Feed intake and growth rate of the chick were reduced by 250mg nickel as a sulfate salt per kg of feed. The toxicity of nickel was decreased by zinc or copper supplementation, but not lead. High nickel feed increased nickel level in kidney and decreased zinc levels in tibia and plasma. However, low zinc levels in tibia and in plasma were reversed by zinc supplementation. Hemoglobin, packed cell volume, and aortic elastin content were increased in chicks fed nickel. These results suggest that nickel toxicity is induced by interference with zinc metabolism.

• Nuclear Engineering and Technology
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• 제51권5호
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• pp.1272-1278
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• 2019

A lumped kinetic modeling platform is developed to investigate the coupled nuclear/thermo-fluid features of the closed natural circulation loop in a low power lead cooled fast reactor. This coolant material serves a reliable choice with noticeable thermo-physical safety characteristics in terms of natural convection. Boussienesq approximation is resorted to appropriately reduce the governing partial differential equations (PDEs) for the fluid flow into a set of ordinary differential equations (ODEs). As a main contributing step, the coolant circulation speed is accordingly correlated to the loop operational power and temperature levels. Further temporal analysis and control synthesis activities may thus be carried out within a more consistent state space framework. Nyquist stability criterion is thereafter employed to carry out a sensitivity analysis for the system stability at various power and heat sink temperature levels and results confirm a widely stable natural circulation loop.

• 한국환경보건학회지
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• 제45권5호
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• pp.541-555
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• 2019

Objectives: The aim of this study is to examine heavy metal exposure levels in the blood and urine of a nationally representative adult population in Korea, and to identify the major influence factors for exposure through linkage analysis using questionnaire data. Methods: Biological samples and questionnaire data were collected from adults aged 18 and over who had participated in the Korean National Environmental Health Survey from 2009 to 2017. Lead, mercury, and cadmium exposure levels were presented with geometric mean and 95th percentiles. Multiple regression analysis was performed to determine the factors affecting heavy metal concentrations. Results: Blood lead levels increased slightly in Cycle 2 compared to Cycle 1, but decreased in Cycle 3. Blood and urinary mercury and urinary cadmium levels decreased over time. The main influence factors included gender, age, and smoking status for blood lead levels; gender, age, and intake of fish at least once a week for blood mercury levels; and age for urinary cadmium levels. Conclusion: The Korean National Environmental Health Survey is an effective tool for confirming over-time changes in exposure to lead, mercury, and cadmium in Korean adults and to identify its influence factors. The results of this study are expected to present basic data for calculating reference values and baseline exposure levels for environmental chemicals in Korean adults.

• 한국환경보건학회지
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• 제35권3호
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• pp.153-161
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• 2009

The purpose of this paper is to evaluate 1) blood lead levels of workers at auto repair shops as Biological Exposure Indices (BEI) of toxic substances such as lead and toluene that are produced during automotive painting process, 2) the differences depending on personal characteristics of workers who have been exposed to toluene by using urine hippuric acid concentration as a marker and 3) the correlation between the concentration of hazardous chemicals in each workplace and the BEL. All subjects were male with a mean age of 36.2 years. In terms of age, most were in the 30 to 40 age group (13 persons, 48.1%). In relation to the length of work experience, the highest proportion had experience of 10 years of less (18 persons, 66.7%). Twenty three workers were cigarette smokers (85.2%) while 4 (14.8%) were non-smokers. In addition, more than 80% of the workers drank alcohol. Dust concentration and toluene exposure during automotive painting showed no significant difference with age, length of work experience, smoking and drinking while a significant difference (p<0.05) has been detected between lead concentration and smoking. The geometric mean of dust concentration, lead concentration and toluene concentration were $0.38mg/m^3,\;0.0021mg/m^3$ and 1.08ppm respectively. In addition, the geometric mean of blood lead levels and urine hippuric acid concentration were $1.70{\mu}g/dl$ and 0.25g/g respectively, which were lower than the standard levels suggested by the Ministry of Labor. To determine the influential factors on blood lead and urine hippuric acid concentrations, a correlation analysis has been conducted with variables of air, lead and toluene concentrations, age, length of work experience and amount of cigarette smoking. According to the analysis, a relatively high correlation (p<0.01) has been observed between air lead concentration and biological sample concentration.

• Journal of Nutrition and Health
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• 제29권6호
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• pp.597-607
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• 1996

This study has been investigated the potenial of increased dietary cysteine to alter the effects of cadmium and lead on tissure and bone metal concentrations, excretion and tissue metallothionein(MT) concentrations. Fifty-four male rats of Sprgue-Dawley strain weighing 149$\pm$17g were divided into 9 groups according to body weight. Nine experimental diets with different cadmium (0ppm, 400ppm), lead(0ppm, 710ppm) and cysteine (0.06%, 0.45%, 0.90%) levels were given to rats for 30 days ; Food intake, weight gain, F.E.R, and weights of liver, kidney and femur were decreased in cadmium supplied groups than in cadmium free groups. Urinary and fecal cadmium excretions were increased and MT synthesis we induced in liver, kidney and small intestine in cadmium supplied groups. In lead supplied groups, weight gain and F.E.R were decreased. With cysteine supplementation in cadmium supplied groups, weight gain and F.E.R, and weights of liver, kidney and femur were increased. Cadmium excretion in feces and MT concentrations in liver and kidney were also increased with cysteine supplementation. In lead supplied groups, there was no significant increase in food intake, weight gain and F.E.R with cysteine supplementation. Lead excretion in feces was increased in cysteine supplemented groups. In conclusion, effect of cadmium administration was more toxic than lead adminstration. Cysteine alleviated cadmium and lead toxicity by increasing metallothionein concentration and fecal excretions of heavy metals. Especially, effect of cysteine supplementation was more effective in cadmium groups than in lead groups. Effect of cysteine supplementation was not different with level of cysteine supplementation in both cadmium and lead groups.

• 대한지역사회영양학회지
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• 제12권6호
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• pp.773-781
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• 2007

The objective of this study was to investigate the nutritional and health status of women industrial workers by working fields. One hundred forty eight (105 lead and 43 office) workers were recruited from March 2005 to October 2005. Information on age, education, smoking and drinking status were collected using questionnaire and nutrient intake and diet quality of workers were assessed by average of two-day 24 hr recall method. Biochemical indexes including blood lead level (PbB), indexes for iron status, serum calcium (Ca) and serum lipid profiles were analyzed from fasting venous blood or serum. Results showed that education level of lead workers was lower than that of office workers (p<0.05), but nutrient intake levels were not significantly different by working fields. Overall nutritional status of the subject were good except for calcium, vitamin $B_2$, C and folic acid intakes. PbB of lead workers were significantly higher than that of office workers while mean corpuscular hemoglobin concentration (MCHC) and serum Ca levels were significantly lower in lead workers. MCHC was positively correlated with zinc intake (r=0.166) and serum Ca was positively correlated with vitamin C intake (r=0.179). This study confirms that lead workers need extra care to keep their health and nutritional management especially for the nutrients known to interact with lead. Tailored nutrition education for workers at specific working fields needs to be more focused for the improvement of health status of industrial workers.