• Bulletin of the Korean Chemical Society
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• v.33 no.2
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• pp.692-694
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• 2012

• Proceedings of the Korean Geotechical Society Conference
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• 2010.09c
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• pp.86-95
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• 2010

Ground movements during tunnelling have the potential for major impact on nearby buildings, utilities and streets. The impacts on buildings are assessed by linking the magnitude of ground loss at the source of ground loss around tunnel to the lateral and vertical displacements on the ground surface, and then to the lateral strain and angular distortion, and resulting damage in the building. To prevent or mitigate the impacts on nearby buildings, it is important to understand the whole mechanism from tunnelling to building damage. This paper discusses tunneling-induced ground movements and their impacts on nearby buildings, including the importance of the soil-structure interactions. In addition, a building damage criterion, which is based on the state of strain, is presented and discussed in detail and the overall damage assessment procedure is provided for the estimation of tunnelling-induced building damage considering the effect of soil-structure interaction.

• Journal of Korean Society for Atmospheric Environment
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• v.28 no.5
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• pp.581-594
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• 2012

The goal of this study is to investigate the effects of the chemical lateral boundary conditions (CLBCs) on Community Multi-scale Air Quality (CMAQ) simulations of tropospheric ozone for East Asia. We developed linking tool to produce CLBCs of CMAQ from Goddard Earth Observing System-Chemistry (GEOS-Chem) as a global chemistry model. We examined two CLBCs: the fixed CLBC in CMAQ (CLBC-CMAQ) and the CLBC from GEOS-Chem (CLBC-GEOS). The ozone fields by CMAQ simulation with these two CLBCs were compared to Tropospheric Emission Spectrometer (TES) satellite data, ozonesonde and surface measurements for May and August in 2008. The results with CLBC-GOES showed a better tropospheric ozone prediction than that with CLBC-CMAQ. The CLBC-GEOS simulation led to the increase in tropospheric ozone concentrations throughout the model domain, due to be influenced high ozone concentrations of upper troposphere and near inflow western and northern boundaries. Statistical evaluations also showed that the CLBC-GEOS case had better results of both the index of Agreement (IOA) and mean normalized bias. In the case of IOA, the CLBC-GEOS simulation was improved about 0.3 compared to CLBC-CMAQ due to the better predictions for high ozone concentrations in upper troposphere.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.37 no.3
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• pp.325-331
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• 2013

In this study, a complex eigenvalue analysis is implemented to verify the unstable mode of a brake system using ABAQUS software. The component participation factors and component modal participation factors are used to analyze the total contributions from each component and each component mode to a particular unstable system mode. This study shows that the 1.4-kHz unstable system mode comes from mode coupling between the 2nd nodal diametric mode and 3rd lateral axial mode (LAM) in the baseline model. A sensitivity analysis with a linking index is performed to prevent the mode coupling of the component modes. This linking index analysis shows the optimum mass loading position to move away the natural frequency of the 3rd LAM, which contributes to the unstable mode. Finally, a complex eigenvalue analysis is implemented with mass loading in the tie bar position, and no unstable system mode is generated in the low-frequency range (below 2 kHz).

• Korean Journal of Microbiology
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• v.39 no.2
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• pp.114-117
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• 2003

In molecular biology, it is necessary to develop an easy and rapid method to identify a specific DNA sequence. Though Southern and Northern blot techniques have been used widely for the analysis of gene structure and function, those methods are inconvenient in the points that we need to control incubation temperature, time, and other parameters to get the final result. In this study, we report a new method for the rapid analysis of specific DNA sequence with the modification of an immunochromatographic method. The lateral flow DNA analysis strip is composed of a sample pad, a nitrocellulose membrane for the separation and propagation of analytes, and an absorption pad for the generation of capillary action. Capture DNA was immobilized on the membrane by UV cross-linking and target DNA was labeled with Cy-5 for signaling. The samples containing target DNA were applied onto the sample pad, incubated for 15 min for separation, and scanned with a GSI fluorescence scanner. Though the hybridization reaction occurs in a short time without any washing steps, there appears to be little cross hybridization between the different sequences. The result showed a possibility that the new method can be used for the rapid identification of specific DNA sequence among the samples.

• The Journal of Korean Academy of Sensory Integration
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• v.14 no.1
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• pp.50-59
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• 2016

Objective : The goal of this study was to investigate neurological mechanism of emotional regulation and to examine the relationship between the regulation and sensory processing. Subjective : Emotional regulations are mainly processed in limbic system, particularly the basal-lateral group of amygdala takes on a major role in the regulations. The basal-lateral group of amygdala links to thalamus directly and/or indirectly which processes sensory information together. This sensory information connects to orbital and medial prefrontal cortex. Inadequate sensory processing may cause difficulties in emotional regulations and behaviors because of a circuit linking the amygdala, the thalamus, and the orbital and medial prefrontal cortex. These difficulties and impairments has been reported in neurological studies for children with ASD and ADHD. Conclusion : Neurological states are different between the normal children and children with ASD and ADHD and these represent various aspects in sensory processing, emotional regulations and behaviors. Thus, therapists working with children with ASD and ADHD need to understand mechanisms of sensory processing and emotional regulations in order to provide adequate treatments.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.19 no.4 s.74
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• pp.357-367
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• 2006

Drift design methods using resizing algorithms have been presented as a practical drift design method since the resizing algorithms proposed easily find drift contribution of each member, called member displacement participation factor, to lateral drift to be designed without calculation of sensitivity coefficient or re-analysis. Weight of material to be redistributed for minimization of the lateral drift is determined according to the member displacement participation factors. However, resizing algorithms based on energy theorem must consider loading conditions because they have different displacement contribution according to different loading conditions. Furthermore, to improve practicality of resizing algorithms, structural member grouping is required in application of resizing algorithms to drift control of high-rise buildings. In this study, three resizing algorithms on considering load condition and structural member grouping are developed and applied to drift design of a 20-story steel-frame shear-wall structure and a 50-story frame shear-wall system with outriggers.

• Korean Institute of Interior Design Journal
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• v.18 no.2
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• pp.61-70
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• 2009

Architectural color would be understood as a essential tool to be reflected the architect's value criteria, thinking process and the specific methodology. This study was established the characteristics of color use correlated with Eisenman's architectural features based on his point of view. At first, it could be organized with data and use the color in view points with the becomming process. Especially it would be expressed the color as a trace of unsynchronized formation. Second, it was introduced the color by graphics engaged with form, to be expressed the dividing, folding, reiteration for deliver of escape from graphic thinking process. Third, it was analyzed to be imported the color to have a multi-lateral space experience in center of user's space recognition and behavior by introduction of color. Finally, it could be inducted the consistent color by viewpoint of interfacial between interior and exterior environment, communicated with strong meaning by conversion from interior elements to color from these processes. A characteristics of Eisenman's architecture color is reflected his thinking process in architecture color as it is and can be understand of 'becomming process use of color' as a tool that is corresponded in form creation. Specially, it would be kept continuous viewpoint of interior and exterior space, giving user color as a viewpoint of linking space, enable many-sidedness experiences through space.

• BMB Reports
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• v.51 no.1
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• pp.5-13
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• 2018

Formation of toxic protein aggregates is a common feature and mainly contributes to the pathogenesis of neurodegenerative diseases (NDDs), which include amyotrophic lateral sclerosis (ALS), Alzheimer's, Parkinson's, Huntington's, and prion diseases. The transglutaminase 2 (TG2) gene encodes a multifunctional enzyme, displaying four types of activity, such as transamidation, GTPase, protein disulfide isomerase, and protein kinase activities. Many studies demonstrated that the calcium-dependent transamidation activity of TG2 affects the formation of insoluble and toxic amyloid aggregates that mainly consisted of NDD-related proteins. So far, many important and NDD-related substrates of TG2 have been identified, including $amlyoid-{\beta}$, tau, ${\alpha}-synuclein$, mutant huntingtin, and ALS-linked trans-activation response (TAR) DNA-binding protein 43. Recently, the formation of toxic inclusions mediated by several TG2 substrates were efficiently inhibited by TG2 inhibitors. Therefore, the development of highly specific TG2 inhibitors would be an important tool in alleviating the progression of TG2-related brain disorders. In this review, the authors discuss recent advances in TG2 biochemistry, several mechanisms of molecular regulation and pleotropic signaling functions, and the presumed role of TG2 in the progression of many NDDs.

• Structural Engineering and Mechanics
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• v.18 no.5
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• pp.645-669
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• 2004

In seismic analysis of moment-resisting frames, beam-column connections are often modeled with rigid joint zones. However, it has been demonstrated that, in ductile reinforced concrete (RC) moment-resisting frames designed based on current codes (to say nothing of older non-ductile frames), the joint zones are in fact not rigid, but rather undergo significant shear deformations that contribute greatly to global drift. Therefore, the "rigid joint" assumption may result in misinterpretation of the global performance characteristics of frames and could consequently lead to miscalculation of strength and ductility demands on constituent frame members. The primary objective of this paper is to propose a rational method for estimating the hysteretic joint shear behavior of RC connections and for incorporating this behavior into frame analysis. The authors tested four RC edge beam-column-slab connection subassemblies subjected to earthquake-type lateral loading; hysteretic joint shear behavior is investigated based on these tests and other laboratory tests reported in the literature. An analytical scheme employing the modified compression field theory (MCFT) is developed to approximate joint shear stress vs. joint shear strain response. A connection model capable of explicitly considering hysteretic joint shear behavior is then formulated for nonlinear structural analysis. In the model, a joint is represented by rigid elements located along the joint edges and nonlinear rotational springs embedded in one of the four hinges linking adjacent rigid elements. The connection model is able to well represent the experimental hysteretic joint shear behavior and overall load-displacement response of connection subassemblies.