• 공업화학
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• 제8권4호
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• pp.582-588
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• 1997

고체산 촉매인 헤테로폴리산 촉매를 이용하여 대기오염 방지를 위한 옥탄가 향상제인 TAME, ETBE 및 MTBE 합성반응에 대한 실험을 고정층 상압유통식 반응장치에서 수행하였다. 일반적으로 TAME, ETBE 및 MTBE 합성반응에서 헤테로폴리산에 hetero원자와 poly원자를 치환시켜 비교한 결과, 배위된 poly원자가 W, hetero원자가 Si인 $H_4SiW_{12}O_{40}$ 촉매의 활성이 가장 우수하였고, 또한 치환된 금속에 따라 촉매의 활성이 달랐으며 이는 촉매의 산성질과 관련이 있음을 알 수 있었다. 헤테로폴리산 촉매를 이용한 합성반응에서 TAME 경우는 $FeHPW_{12}O_{40}$과 $K_3PM_{o12}O_{40}$이 비교적 활성이 좋았으나, ETBE나 MTBE 경우에 비해서는 다소 활성이 낮았다. 그리하여 본 연구에서는 활성이 좋은 헤테로폴리산 촉매들을 선정하여 각각에 대하여 1:1로 다음과 같이 혼합하여 $H_4SiW_{12}O_{40}$ : $Sr_2SiW_{12}O_{40}$, $H_4SiW_{12}O_{40}$ : $NaH_2PW_{12}O_{40}$, $Fe_{1.5}PW_{12}O_{40}$ : $Mg_2SiW_{12}O_{40}$ 및 $Mg_2SiW_{12}O_{40}$ : $Ba_2SiW_{12}O_{40}$ 실험한 결과, 혼합촉매들이 각각의 단일성분 촉매때보다 TBA의 전화율과 ETBE나 MTBE의 선택율이 더욱 향상되었음을 알 수 있었다.

• Journal of Periodontal and Implant Science
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• 제41권5호
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• pp.227-233
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• 2011

Purpose: The aim of this study was to compare osteoblast behavior on zirconia and titanium under conditions cultured with bone morphogenetic protein-2. Methods: MC3T3-E1 cells were cultured on sandblasted zirconia and sandblasted/etched titanium discs. At 24 hours after seeding MC3T3-E1, the demineralized bone matrix (DBM) gel alone and the DBM gel with bone morphogenetic protein-2 (BMP-2) were added to the culture medium. The surface topography was examined by confocal laser scanning microscopy. Cellular proliferation was measured at 1, 4, and 7 days after gel loading. Alkaline phosphatase activity was measured at 7 days after gel loading. The mRNA expression of ALPase, bone sialoprotein, type I collagen, runt-related transcription factor 2 (Runx-2), osteocalcin, and osterix were evaluated by real-time polymerase chain reaction at 4 days and 7 days. Results: At 1, 4, and 7 days after loading the DBM gel alone and the DBM gel with BMP-2, cellular proliferation on the zirconia and titanium discs was similar and that of the groups cultured with the DBM gel alone and the DBM gel with BMP-2 was not significantly different, except for titanium with BMP-2 gel. ALPase activity was higher in the cells cultured with BMP-2 than in the other groups, but there was no difference between the zirconia and titanium. In ALPase, bone sialoprotein, osteocalcin, Runx-2 and osterix gene expression, that of cells on zirconia or titanium with BMP-2 gel was much more highly increased than titanium without gel at day 7. The gene expression level of cells cultured on zirconia with BMP-2 was higher than that on titanium with BMP-2 at day 7. Conclusions: The data in this study demonstrate that the osteoblastic cell attachment and proliferation of zirconia were comparable to those of titanium. With the stimulation of BMP-2, zirconia has a more pronounced effect on the proliferation and differentiation of the osteoblastic cells compared with titanium.

• Journal of Periodontal and Implant Science
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• 제44권2호
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• pp.79-84
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• 2014

Purpose: While single-species biofilms have been studied extensively, we know notably little regarding multispecies biofilms and their interactions. The purpose of this study was to develop and evaluate an in vitro multispecies dental biofilm model that aimed to mimic the environment of chronic periodontitis. Methods: Streptococcus gordonii KN1, Fusobacterium nucleatum ATCC23726, Aggregatibacter actinomycetemcomitans ATCC33384, and Porphyromonas gingivalis ATCC33277 were used for this experiment. The biofilms were grown on 12-well plates with a round glass slip (12 mm in diameter) with a supply of fresh medium. Four different single-species biofilms and multispecies biofilms with the four bacterial strains listed above were prepared. The biofilms were examined with a confocal laser scanning microscope (CLSM) and scanning electron microscopy (SEM). The minimum inhibitory concentrations (MIC) for four different planktonic single-species and multispecies bacteria were determined. The MICs of doxycycline and chlorhexidine for four different single-species biofilms and a multispecies biofilm were also determined. Results: The CLSM and SEM examination revealed that the growth pattern of the multispecies biofilm was similar to those of single-species biofilms. However, the multispecies biofilm became thicker than the single-species biofilms, and networks between bacteria were formed. The MICs of doxycycline and chlorhexidine were higher in the biofilm state than in the planktonic bacteria. The MIC of doxycycline for the multispecies biofilm was higher than were those for the single-species biofilms of P. gingivalis, F. nucleatum, or A. actinomycetemcomitans. The MIC of chlorhexidine for the multispecies biofilm was higher than were those for the single-species biofilms of P. gingivalis or F. nucleatum. Conclusions: To mimic the natural dental biofilm, a multispecies biofilm composed of four bacterial species was grown. The 24-hour multispecies biofilm may be useful as a laboratory dental biofilm model system.

• The Journal of Advanced Prosthodontics
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• 제5권4호
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• pp.471-478
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• 2013

PURPOSE. The aim of the study was to evaluate the effect of annealing on the nanostructure and hardness of Co-Cr metal ceramic samples that were fabricated with a direct metal laser sintering (DMLS) technique. MATERIALS AND METHODS. Five groups of Co-Cr dental alloy samples were manufactured in a rectangular form measuring $4{\times}2{\times}2$ mm. Samples fabricated by a conventional casting technique (Group I) and prefabricated milling blanks (Group II) were examined as conventional technique groups. The DMLS samples were randomly divided into three groups as not annealed (Group III), annealed in argon atmosphere (Group IV), or annealed in oxygen atmosphere (Group V). The nanostructure was examined with the small-angle X-ray scattering method. The Rockwell hardness test was used to measure the hardness changes in each group, and the means and standard deviations were statistically analyzed by one-way ANOVA for comparison of continuous variables and Tukey's HSD test was used for post hoc analysis. P values of <.05 were accepted as statistically significant. RESULTS. The general nanostructures of the samples were composed of small spherical entities stacked atop one another in dendritic form. All groups also displayed different hardness values depending on the manufacturing technique. The annealing procedure and environment directly affected both the nanostructure and hardness of the Co-Cr alloy. Group III exhibited a non-homogeneous structure and increased hardness ($48.16{\pm}3.02$ HRC) because the annealing process was incomplete and the inner stress was not relieved. Annealing in argon atmosphere of Group IV not only relieved the inner stresses but also decreased the hardness ($27.40{\pm}3.98$ HRC). The results of fitting function presented that Group IV was the most homogeneous product as the minimum bilayer thickness was measured (7.11 ${\AA}$). CONCLUSION. After the manufacturing with DMLS technique, annealing in argon atmosphere is an essential process for Co-Cr metal ceramic substructures. The dentists should be familiar with the materials that are used in clinic for prosthodontics treatments.

• The Journal of Advanced Prosthodontics
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• 제5권4호
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• pp.452-456
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• 2013

PURPOSE. The aim of this study was to evaluate the repeatability of the digitizing of silicon rubber impressions of abutment teeth by using a white light scanner and compare differences in repeatability between different abutment teeth types. MATERIALS AND METHODS. Silicon rubber impressions of a canine, premolar, and molar tooth were each digitized 8 times using a white light scanner, and 3D surface models were created using the point clouds. The size of any discrepancy between each model and the corresponding reference tooth were measured, and the distribution of these values was analyzed by an inspection software (PowerInspect 2012, Delcamplc., Birmingham, UK). Absolute values of discrepancies were analyzed by the Kruskal-Wallis test and multiple comparisons (${\alpha}$=.05). RESULTS. The discrepancy between the impressions for the canine, premolar, and molar teeth were $6.3{\mu}m$ (95% confidence interval [CI], 5.4-7.2), $6.4{\mu}m$ (95% CI, 5.3-7.6), and $8.9{\mu}m$ (95% CI, 8.2-9.5), respectively. The discrepancy of the molar tooth impression was significantly higher than that of other tooth types. The largest variation (as mean [SD]) in discrepancies was seen in the premolar tooth impression scans: $26.7{\mu}m$ (95% CI, 19.7-33.8); followed by canine and molar teeth impressions, $16.3{\mu}m$ (95% CI, 15.3- 17.3), and $14.0{\mu}m$ (95% CI, 12.3-15.7), respectively. CONCLUSION. The repeatability of the digitizing abutment teeth's silicon rubber impressions by using a white light scanner was improved compared to that with a laser scanner, showing only a low mean discrepancy between $6.3{\mu}m$ and $8.9{\mu}m$, which was in an clinically acceptable range. Premolar impression with a long and narrow shape showed a significantly larger discrepancy than canine and molar impressions. Further work is needed to increase the digitizing performance of the white light scanner for deep and slender impressions.

• Journal of Periodontal and Implant Science
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• 제47권4호
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• pp.219-230
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• 2017

Purpose: The purpose of this study was to compare the characteristics of single- and dualspecies in vitro oral biofilms made by static and dynamic methods. Methods: Hydroxyapatite (HA) disks, 12.7 mm in diameter and 3 mm thick, were coated with processed saliva for 4 hours. The disks were divided into a static method group and a dynamic method group. The disks treated with a static method were cultured in 12-well plates, and the disks in the dynamic method group were cultured in a Center for Disease Control and Prevention (CDC) biofilm reactor for 72 hours. In the single- and dual-species biofilms, Fusobacterium nucleatum and Porphyromonas gingivalis were used, and the amount of adhering bacteria, proportions of species, and bacterial reduction of chlorhexidine were examined. Bacterial adhesion was examined with scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). Results: Compared with the biofilms made using the static method, the biofilms made using the dynamic method had significantly lower amounts of adhering and looser bacterial accumulation in SEM and CLSM images. The proportion of P. gingivalis was higher in the dynamic method group than in the static method group; however, the difference was not statistically significant. Furthermore, the biofilm thickness and bacterial reduction by chlorhexidine showed no significant differences between the 2 methods. Conclusions: When used to reproduce periodontal biofilms composed of F. nucleatum and P. gingivalis, the dynamic method (CDC biofilm reactor) formed looser biofilms containing fewer bacteria than the well plate. However, this difference did not influence the thickness of the biofilms or the activity of chlorhexidine. Therefore, both methods are useful for mimicking periodontitis-associated oral biofilms.

• Journal of Radiation Protection and Research
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• 제41권2호
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• pp.167-171
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• 2016

Background: TlBr is of considerable technological importance for radiation detection applications where detecting high-energy photons such as X-rays and ${\gamma}$-rays are of prime importance. However, there were few reports on investigating optical properties of TlBr itself for deeper understandings of this material and for making better radiation detection devices. Thus, in this paper, we report on the optical characterizations of TlBr single crystals. Spectroscopic ellipsometry (SE) and photoluminescence (PL) measurements at RT were performed for this work. Materials and Methods: A 2-inch TlBr single crystalline ingot was grown by using the vertical Bridgman furnace. SE measurements were performed at RT within the photon energy range from 1.1 to 6.5 eV. PL measurements were performed at RT by using a home-made PL system equipped with a 266 nm-laser and a spectrometer. Results and Discussion: Dielectric responses from SE analysis were shown to be slightly different among the different samples possibly due to the different structural/optical properties. Also from the PL measurements, it was observed that the peak intensities of the middle samples were significantly higher than those of the other two samples. With the given values for permittivity of free space (${\varepsilon}_0=8.854{\times}10^{-12}F{\cdot}m^{-1}$), thickness (d = 1 mm), and area ($A=10{\times}10mm^2$) of the TlBr sample, capacitances of TlBr were 6.9 pF (at $h{\nu}=3eV$) and 4.4 pF (at $h{\nu}=6eV$), respectively. Conclusion: SE and PL measurement and analysis were performed to characterize TlBr samples from the optical perspective. It was observed that dielectric responses of different TlBr samples were slightly different due to the different material properties. PL measurements showed that the middle sample exhibited much stronger PL emission peaks due to the better material quality. From the SE analysis, optical, dielectric constants were extracted, and calculated capacitances were in the few pF range.

• Tuberculosis and Respiratory Diseases
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• 제55권2호
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• pp.198-205
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• 2003

원발성 폐 림프종은 매우 드문 질환으로 전세계적으로 보고된 바가 흔하지 않고 특히 폐 실질의 침범 없이 기관에서 원발성으로 발생한 경우는 극히 드물며 그 대부분은 BALT 기원의 저등급 B-세포 림프종으로 알려져 있다. BALT 림프종은 오랜 기간 동안 한 곳에 국한되어 존재하고, 예후가 좋고, 얌전한 조직학적 소견을 보이는 것이 특징이다. 아직 전세계적으로 그 예가 많지 않아 표준적인 치료지침은 정해져 있지 않으나 외과적 절제, 국소 방사선 치료나 항암제 치료 등이 있으며 특히 국소성 방사선 조사는 확실히 전이가 되지 않았을 때 일차적 치료로 선택할 수 있다. 저자들은 호흡곤란을 주소로 내원한 환자에서 경기관지 조직 검사상 기관 원발성 BALT 림프종을 진단 후 경기관지 레이저 소작술 및 국소 방사선 조사치료를 시행하고 2년간의 추적관찰 기간동안 재발의 소견없이 안정적인 임상경과를 보이고 있는 기관 원발성 BALT 림프종 1예를 경험하였기에 문헌고찰과 함께 이를 보고 하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제70권6호
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• pp.521-525
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• 2011

Bronchial carcinoid tumors are relatively uncommon neoplasms that are considered to be malignant tumors of low to intermediate grade. They are classified by pathologic features as typical or atypical carcinoids and have distinctly different prognoses and therapeutic options. Surgery is the treatment of choice in typical and atypical carcinoid tumors but the approach has been changing. Recently, several studies have described experiences using other technologies as adjuncts to bronchoscopic resection, technologies such as laser and cryotherapy with curative intent in endoluminal typical carcinoids. Here we present a case of atypical bronchial carcinoid that was treated with bronchoscopic cryotherapy.

• 한국게임학회 논문지
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• 제10권6호
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• pp.157-168
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• 2010

게임 캐릭터와 객체들이 상호작용하는 지형은 가상세계를 구성하기 위한 필수 요소이다. 지형을 제작할 때 많은 갱신 작업과 시간이 들어가는 문제점이 발생한다. 본 논문에서는 실제 지형을 촬영한 데이터로부터 가상 공간의 3D 지형을 생성하기 위한 3D 지형 재구축 시스템을 제안한다. 제안시스템에서는 스테레오 카메라로 촬영하고, 레이져 스캐너로 실측한 3차원 지형 데이터를 기반으로 생성된 그리드 기반의 높이 맵(Height Map)과 로봇의 항법정보 중 z축과 x축 방향 벡터를 이용해 가상공간의 중심인 월드좌표계에 맞게 로테이션을 수행하여 축의 방향을 일치시키고, 로봇 중심의 좌표계에서 월드 좌표계로의 이동 벡터를 각 포인트에 더하여 최종적으로 월드좌표계에 맞게 변환한다. 이후 무방향성 그래프를 사용하여 지형 데이터를 관리하면서 가상공간에서 필요한 부분에만 동적으로 지형 메쉬를 생성한다. 이때 지형 데이터의 오류를 보정하여 메쉬를 올바르게 갱신한다. 실험에서는 제안 시스템이 지형 재구축을 완료할 때까지 일정한 주기로 FPS를 확인하고, 완성된 지형을 가시화하여 품질을 검토하였다. 지형의 전체 크기를 알 수 없거나, 실시간으로 지형의 크기가 변화하는 환경에서는, 제안된 시스템이 쿼드트리를 사용한 지형 관리보다 지형 크기가 작을 때 3배정도의 높은 FPS를 보이나, 지형이 아주 클 때는 평균 40% 정도 나은 실행 성능을 가진다. 최종적으로는, 실측한 지형의 모양을 그대로 유지하면서 가시화하고 있다. 본 연구에서 제안한 시스템을 이용하여 게임에 이용할 지형 데이터를 실시간으로 자동 생성하여 게임에 이용하거나, 실제 지형을 배경으로 필요한 영화의 CG 작업에 활용하는 등의 응용 방안을 고려해 볼 수 있다.