• Proceedings of the Materials Research Society of Korea Conference
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• 2007.11a
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• pp.89.2-89.2
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• 2007

• Bulletin of the Korean Chemical Society
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• v.31 no.12
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• pp.3788-3790
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• 2010

• 대한예방의학회:학술대회논문집
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• 1994.02b
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• pp.336-341
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• 1994

Multicenter controlled clinical trials require It synthesis of the scientific method and the precepts of modern management. The management tasks associated with these studies are akin to those found in other kinds of complex corporate endeavors. It is recommended that clinical investigators become more knowledgeable about management concepts and methods and management specialists be given a major role in the planning and conduct of large-scale clinical trials.

• Journal of the Korean Crystal Growth and Crystal Technology
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• v.23 no.6
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• pp.296-301
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• 2013

Carbon coils could be synthesized using $C_2H_2/H_2$ as source gases and $SF_6$ as an incorporated additive gas under the thermal chemical vapor deposition system. A 304-type stainless steel was used as a substrate with nickel powders as the catalyst. The surface of the substrate was pretreated using a sand paper or a mechanical drill to enhance the production yield of the carbon coils. The characteristics of the deposited carbon nanomaterials on the substrates were investigated according to the surface state on the stainless steel substrate. The protrusion induced by the grooves on the substrate surface could enhance the formation of the carbon nanomaterials having the coils geometries. The cause for the enhancement of the carbon coils formation by the grooves was suggested and discussed with the surface energies for the interaction between as-growing carbon elements. Finally, we could obtain the massive production yield of the carbon coils by the surface pretreatment using SiC sand papers on the several tens grooved stainless steel substrate.

• Proceedings of the Materials Research Society of Korea Conference
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• 2011.05a
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• pp.21.1-21.1
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• 2011

Controlling the morphology of a metal nanocrystal is critical to modern materials chemistry because its physical and chemical properties can be easily and widely tuned by tailoring the size and shape. Combined with ease of synthesis and processing, metal nanocrystals with desired morphologies and thus properties are promising candidates for a wide variety of applications in catalysis, sensing, imaging, electronics, and photonics, and medicine. In this talk, I would like to introduce my recent research results on the shape-controlled synthesis of metal nanocrystals using a simple aqueous method. This water-based system provides a number of merits such as simplicity, convenience, and the potential for large-scale production and enables us to synthesize metal nanocrystals with a rich variety of shapes such as truncated octahedron, cubes, bars, octahedrons, and thin plates. The ability to control the shape of metal nanocrystals provides a great opportunity to systematically investigate their catalytic and optical properties.

• Archives of Pharmacal Research
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• v.28 no.9
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• pp.1019-1022
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• 2005

Risperidone has been reported to have neuroleptic activity. In this study, risperidone was synthesized using a new method involving a stille reaction, in which 2-methyl-3-vinyl-6,7,8,9-tet­rahydropyrido[1 ,2-a]pyrimidin-4-one was synthesized (5). The chemical synthesis process was found to be simple and produced risperidone in a high yield. In addition, can be easily scaled up for large scale synthesis.

• Bulletin of the Korean Chemical Society
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• v.35 no.9
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• pp.2726-2732
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• 2014

The promoting effect of rhodium on the structure and activity of the supported Cu-Co based catalysts for CO hydrogenation was investigated in detail. The samples were characterized by DRIFTS, $N_2$-adsorption, XRD, $H_2$-TPR, $H_2$-TPD and XPS. The results indicated that the introduction of rhodium to Cu-Co catalysts resulted in modification of metal dispersion, reducibility and crystal structure. DRIFTS results of CO hydrogenation at reaction condition (P=2 MPa, $T=260^{\circ}C$) indicated the addition of 1 wt % rhodium improved hydrogenation ability of Cu-Co catalysts. The ethanol selectivity and CO conversion were both improved by 1 wt % Rh promoted Cu-Co based catalysts. The alcohol distribution over un-promoted and rhodium promoted Cu-Co based catalysts obeys A-S-F rule and higher chain growth probability was got on rhodium promoted catalyst.

• Proceedings of the Materials Research Society of Korea Conference
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• 2010.05a
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• pp.3.2-3.2
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• 2010

There have been many efforts to utilize the outstanding properties of graphene for macroscopic applications such as transparent conducting films useful for flexible/stretchable electronics. However, the lack of efficient synthesis, transfer, and doping methods limited the scale and the quality needed for the practical production of graphene films. In this presentation, we introduce ultra-large scale (~30 inch) synthesis, roll-to-roll transfer, and chemical doping of graphene films showing excellent electrical and physical properties suitable for practical applications. Considering the outstanding scalability/processibility of roll-to-roll and CVD methods and the extraordinary flexibility/conductivity of graphene films, we expect the commercial production and application electrodes replacing the use of ITO can be realized in near future.

• Journal of Microbiology and Biotechnology
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• v.34 no.5
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• pp.1154-1163
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• 2024

Glucosylation is a well-known approach to improve the solubility, pharmacological, and biological properties of flavonoids, making flavonoid glucosides a target for large-scale biosynthesis. However, the low yield of products coupled with the requirement of expensive UDP-sugars limits the application of enzymatic systems for large-scale. C. glutamicum is a Gram-positive and generally regarded as safe (GRAS) bacteria frequently employed for the large-scale production of amino acids and biofuels. Due to the versatility of its cell factory system and its non-endotoxin producing properties, it has become an attractive system for the industrial-scale biosynthesis of alternate products. Here, we explored the cell factory of C. glutamicum for efficient glucosylation of flavonoids using apigenin as a model flavonoid, with the heterologous expression of a promiscuous glycosyltransferase, YdhE from Bacillus licheniformis and the endogenous overexpression of C. glutamicum genes galU1 encoding UDP-glucose pyrophosphorylase and pgm encoding phosphoglucomutase involved in the synthesis of UDP-glucose to create a C. glutamicum cell factory system capable of efficiently glucosylation apigenin with a high yield of glucosides production. Consequently, the production of various apigenin glucosides was controlled under different temperatures yielding almost 4.2 mM of APG1(apigenin-4'-O-β-glucoside) at 25℃, and 0.6 mM of APG2 (apigenin-7-O-β-glucoside), 1.7 mM of APG3 (apigenin-4',7-O-β-diglucoside) and 2.1 mM of APG4 (apigenin- 4',5-O-β-diglucoside) after 40 h of incubation with the supplementation of 5 mM of apigenin and 37℃. The cost-effective developed system could be used to modify a wide range of plant secondary metabolites with increased pharmacokinetic activities on a large scale without the use of expensive UDP-sugars.

• Journal of Hydrogen and New Energy
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• v.20 no.5
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• pp.416-423
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• 2009

High-temperature steam electrolysis (HTSE) using solid oxide cell is a challenging method for highly efficient large-scale hydrogen production as a reversible process of solid oxide fuel cell (SOFC). The overall efficiency of the HTSE hydrogen and synthesis gas production system was analyzed thermo-electrochemically. A thermo-electrochemical model for the hydrogen and synthesis gas production system with solid oxide electrolysis cell (SOEC) and very high temperature gas-cooled reactor (VHTR) was established. Sensitivity analyses with regard to the system were performed to investigate the quantitative effects of key parameters on the overall efficiency of the production system. The overall efficiency with SOEC and VHTR was expected to reach a maximum of 58% for the hydrogen production system and to 62% for synthesis gas production system by improving electrical efficiency, steam utilization rate, waste heat recovery rate, electrolysis efficiency, and thermal efficiency. Therefore, overall efficiency of the synthesis production system has higher efficiency than that of the hydrogen production system.