• Pediatric Infection and Vaccine
• /
• v.19 no.3
• /
• pp.89-110
• /
• 2012

Meningococcal Disease, manifesting as meningitis and septicemia, is a life-threatening bacterial infection that results in significant morbidity and mortality, particularly in childhood. Its epidemic potential and limited opportunities for clinical intervention due to its rapid course present unique public health and clinical challenges. Incidence is highest in infants and young children, with a secondary peak of risk in adolescents. Approximately 10% of cases are fatal and survivors can be left with serious and permanent sequelae including amputations, hearing loss and cognitive impairment. Transmission is only from human-to-human, by infected respiratory tract secretions or saliva and therefore crowding poses a tremendously elevated risk for disease development. Military recruits and university students are at high risk due to the high carriage rate in adolescents, their behavior patterns and close contact. Menveo$^{(R)}$ (Novartis Vaccines and Diagnostics), a novel quadrivalent meningococcal conjugate vaccine directed against meningococcal serogroups A, C, W-135 and Y, has been shown to be immunogenic and well tolerated in all age groups and was recently licensed for use in Korea. Recent cases and deaths among military recruits drew public attention to their elevated risk and the Korean government has recommended vaccination of all new military recruits. Many Korean students seek to attend school, university, or language institutes in countries where routine meningococcal vaccination is required - clinicians should be aware of such requirements to ensure that students are vaccinated prior to arrival in the destination country.

• The Korean Journal of Rehabilitation Nursing
• /
• v.7 no.2
• /
• pp.179-187
• /
• 2004

Purpose: This study was performed to assess the degree of cognitive function of elderly by MMSE-K performances and of that effect. Method: The subjects were 185 aged over 65 in Daejeon Metropolitan city. Data were collected through personal interview using the questionnaire from 10 to 31, Jan. 2003. The measures were Korean version of Mini-Mental State Examination(MMSE-K). Results: The mean score of MMSE-K was $22.60{\pm}5.39$. The prevalence of cognitive impairment was estimated as 48.6% by MMSE-K ${\leq}23$ and significantly age, gender, and education effect. The subtype score of MMSE-K were significantly lower in female group in each items : orientation in time and place, attention/calculation, language except registration and recall. And the scores were significantly lower in the older group and non-educated group in the all items of MMSE-K. Conclusion: Gender, age, and education showed significant effects on total and subtype MMSE-K score. Cognitive function decline were higher in female, older age group, and non-educated group. Therefore, those three factors are thought to be one of important risk factors for development of dementia, also it is assumed to be affected by other variables than age, gender, education effect.

• Speech Sciences
• /
• v.7 no.1
• /
• pp.77-87
• /
• 2000

Distortion Product Otoacoustic Emissions (DPOAEs) can be measured in the external ear canal two fold: amplitude and latency, but most DPOAE studies deal with amplitude aspects. The purpose of this study was to investigate the latency of the 2f1-f2 DPOAEs in ears with hearing losses and to see if it could be a clinically useful method to distinguish normal from abnormal ears. For this purpose, DPOAE latency were measured as a function of frequency from 1 to 8 kHz in 30 ears with conductive and sensorineural hearing losses (SNHLs). DPOAEs were recorded with Otodynamic Analyzer ILO92. Results showed that the latency decreased as the frequency increased up to 8 kHz. The mean values of DPOAE latency for ears of SNHLs were shorter at all frequencies when they were compared to the mean values of normal ears. The latency in ears of conductive hearing losses was shorter than normal ears at the selective frequencies, as well. The results support the hypothesis that latency values are shorter in pathological ears.

• The Journal of Pediatrics of Korean Medicine
• /
• v.18 no.2
• /
• pp.143-160
• /
• 2004

Objective: There were few reports on the treatment of Hypoxic ischemic encephalopathy. We treated a hypoxic ischemic encephalopathic patient after accident with Oriental medical approach, and get a significant result. this treatment shows the possibility of healing Hypoxic ischemic encephalopathy, So we are reporting that case. Method : The acupuncture, herb medication. rehabilitation therapy was applied for treting patient's chife symptom(involuntary movement, dystonia, aphasia, dysuria, constipation) Results : 1. Generally patients with Hypoxic ischemic encephalopathy show language impairment and cognition disorder for several weeks to months. After coma stage, first they recover consciousness but have various degree of confusional mentality, visual agnosia, extrapyramidal stiffness and motor disturbance. 2. Consciousness loss in acute stage of Hypoxic ischemic encephalopathy can be considered as Mental Confusion due to Phlegm(Dammisimgyu) in veiw point of Oriental medicine. 3. After oriental medical treatment, patient's chief symptoms were improved. Conclusion: We treated a hypoxic ischemic encephalopathic patient with Oriental medical approach and patient's chief symptoms were improved. this treatment shows the possibility of healing Hypoxic ischemic encephalopathy.

• Research in Community and Public Health Nursing
• /
• v.22 no.4
• /
• pp.377-388
• /
• 2011

Purpose: This study was to examine the relation between diabetes and cognitive function in older adults. Methods: Eighty community-dwelling patients with diabetes and 506 subjects without diabetes were studied with cognitive function test. Cognitive function was measured by Full-scale IQ, Basic IQ, Executive IQ, Attention Function Index, Working Memory Index, Language Function Index, Visuospatial Function Index, Memory Function Index, and MMSE-K1. Results: In model controlling for education, the diabetic group showed significantly lower scores than the non-diabetic group in in Full-scale IQ (p=.012), Basic IQ (p=.034), Executive IQ (p=.014), Attention Function Index (p=.002), Working Memory Index (p=.037), and Memory Function Index (p=.043). The diabetic and non-diabetic groups that were matched for gender, age, and education showed similar differences in 7 out of 9 cognitive measures. The impairments of Full-scale IQ and Memory Function Index in the diabetic group were, respectively, 2.7 and 2.8 times greater than that in the diabetic group. Conclusion: These results showed that diabetes should be considered to a factor of cognitive impairment in older adults.

• Phonetics and Speech Sciences
• /
• v.7 no.3
• /
• pp.37-44
• /
• 2015

This study investigated the effects of the age of Korean speakers, place of articulation, and phonation types on voice onset time (VOT) of stops. Twenty-five preschoolers, 25 schoolers, and 25 adults who had no history of speech and language impairment produced plosives in /VCV/ words in isolation. A three-way ($3{\times}3{\times}3$) mixed design was used with the age of speakers (preschoolers, schoolers, adults) as a between-subject factor, the place of articulation (bilabials, alveolars, velars) and phonation types (plain, tense, aspirated consonants) as a within-subject factor. The dependent measure was the VOT values. Results revealed that three main effects were statistically significant. Preschoolers exhibited longer VOTs than adults (p<.05). There were significant differences in VOTs among the place of articulation, showing that speakers had the longest VOTs for velars (velars > alvelars > bilabials) (all p<.05). In addition, the VOTs for aspirated consonants were longer than those for plain and tense consonants, and the differences were significant among three phonation types (aspirated > tense > plain) (all p<.05). The current results suggested that VOTs would be linked to age and development, and schoolers over the age of 11 years had achieved adult-like VOTs. Moreover, the place of articulation and phonation types in Korean stops showed marked factors in normal speakers' VOT patterns.

• Safety and Health at Work
• /
• v.8 no.4
• /
• pp.329-336
• /
• 2017

A review study was conducted to examine the adverse effects of styrene, styrene mixtures, or styrene and/or styrene mixtures and noise on the auditory system in humans employed in occupational settings. The search included peer-reviewed articles published in English language involving human volunteers spanning a 25-year period (1990-2015). Studies included peer review journals, caseecontrol studies, and case reports. Animal studies were excluded. An initial search identified 40 studies. After screening for inclusion, 13 studies were retrieved for full journal detail examination and review. As a whole, the results range from no to mild associations between styrene exposure and auditory dysfunction, noting relatively small sample sizes. However, four studies investigating styrene with other organic solvent mixtures and noise suggested combined exposures to both styrene organic solvent mixtures may be more ototoxic than exposure to noise alone. There is little literature examining the effect of styrene on auditory functioning in humans. Nonetheless, findings suggest public health professionals and policy makers should be made aware of the future research needs pertaining to hearing impairment and ototoxicity from styrene. It is recommended that chronic styrene-exposed individuals be routinely evaluated with a comprehensive audiological test battery to detect early signs of auditory dysfunction.

• Journal of Korean Academy of Medicine & Therapy Science
• /
• v.10 no.2
• /
• pp.39-45
• /
• 2018

Objective: The aimes of this study is to analyze the effects of presbycusis on the quality of life. Method: 47-elderly were participated. The participants were divided into the suspected hearing impaired group (N=18) and the within normal limits (WNL) group (N=29). One-way ANOVA was performed to determine the association between the HHIE and WHOQOL-BREF scores by age group, and independent t-test was carried out to analyze the inter-group relations. Results: The scores in WHOQOL-BREF differed significantly by age group (p=.011): people in their sixties scored $3.7{\pm}.62$, those in their seventies $3.3{\pm}.56$, and those in their eighties $2.8{\pm}.60$, with significant differences observed. There were statistically significant inter-group differences (p=.000), with significant differences observed. Conclusion: The quality of life of the elderly were lowered depending on age and hearing impairment.

• Psychiatry investigation
• /
• v.15 no.12
• /
• pp.1144-1153
• /
• 2018

Objective One of the areas of social cognition is Theory of Mind (ToM) is defined as the capacity to interpret, infer and explain mental states underlying the behavior of others. When social cognition studies on neurodevelopmental disorders are examined, it can be seen that this skill has not been studied sufficiently in children with Specific Learning Disorder (SLD). Methods In this study, social cognition skills in children diagnosed with attention deficit hyperactivity disorder (ADHD), SLD or Autism Spectrum Disorder (ASD) evaluated before puberty and compared with controls. To evaluate the ToM skills, the first and second-order false belief tasks, the Hinting Task, the Faux Pas Test and the Reading the Mind in the Eyes Task were used. Results We found that children with neurodevelopmental disorders as ADHD, ASD, and SLD had ToM deficits independent of intelligence and language development. There was a significant correlation between social cognition deficits and problems experienced in many areas such as social communication and interaction, attention, behavior, and learning. Conclusion Social cognition is an important area of impairment in SLD and there is a strong relationship between clinical symptoms and impaired functionality.

• Journal of Genetic Medicine
• /
• v.17 no.2
• /
• pp.79-82
• /
• 2020

In epilepsy-aphasia spectrum (EAS) disorders, mutations in the glutamate receptor ionotropic N-methyl-D-aspartate type subunit 2A (GRIN2A) have become important for screening the disease. Research into the phenotypic variability of several types of neurologic impairment involving these mutations is in progress. However, the non-neurological problems related to these mutations are poorly understood. EAS disorders usually have epileptic, cognitive, or behavioral manifestations. In this case report, we present a female patient with epilepsy, delay in expressive language and social development, and intellectual disability with low intelligence quotient and memory quotient, but normal motor development. Through genetic analysis, she was found to have a missense and a nonsense mutation in GRIN2A (c.1770A>C; p.Lys509Asn and c.3187G>T; p.Glu1063∗, respectively) and we consider the nonsense mutation as 'pathogenic variant'. She was also discovered to have congenital hypothyroidism, growth hormone deficiency and Rathke's cleft cyst in the brain, which were previously unknown features of GRIN2A mutation. Our findings should widen understanding of the spectrum of GRIN2A phenotypes, and emphasize the need for more research into the association between GRIN2A mutations and non-neurologic clinical presentations.