• Journal of Food Hygiene and Safety
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• v.4 no.2
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• pp.133-153
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• 1989

The present study was carried out to investigate the preventive effects of lamprey oil and corn oil on atherosclerotic rats induced by oral administration of cholesterol and vitamin $D_2$. The obtaind results were summarized as fellows; 1. The group, fed only the mixture of cholesterol and vitamin $D_2$ showed the significant increase of total lipid, total cholesterol phospholipid, LDL&HDL-cholesterol in the serum, triglyceride and cholesterol in the heart and the aorta, but the significant decrease of triglyceride in the liver, as comparing with normal control group (p<0.05). The aorta showed the severe damage of disorganization, calcification, necrosis and lipid deposition in the aortic wall. 2. The group, adminstered the mixture of cholesterol and vitamin $D_2$ and fed 15% lamprey oil diet, showed the significant decrease of total lipid, triglyceride, total cholesterol, phospholipid and LDL&VLDL-cholesterol in the serum, triglyceride and cholesterol in the heart and the aorta, but the significant increase of cholesterol in the liver, as comparing with atherogenic control group (p<0.05). The aorta showed slight calcification and no lipid deposition in the aortic wall as comparing with atherogenic control group. 3. The group, administerd the mixture of cholesterol and vitamin $D_2$ and fed 15% corn oil diet, showed the decrease of total lipid, triglyceride and VLDL-cholesterol in the serum, and triglyceride in the heart and the aorta, as comparing with atherogenic control group (p<0.05). The aorta showed calcification and no lipid deposition in the aortic wall. In reviewing above results it was concluded that lamprey oil and corn oil in polyunsaturated fatty acids had the preventive effect on atherosclerotic rats induced by cholesterol and vitamin $D_2$. And the effect of lamprey oil in n-3 polyunsaturated fatty acids was higher than that of corn oil rich in n-6 polyunsturated fatty acids.