• Toxicological Research
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• 제31권4호
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• pp.331-337
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• 2015

Synthetic pyrethroids (SPs) are the most common pesticides which are recently used for indoor pest control. The widespread use of SPs has resulted in the increased exposure to wild animals and humans. Recently, some SPs are suspected as endocrine disrupting chemicals (EDCs) and have been assessed for their potential estrogenicity by adopting various analyzing assays. In this study, we examined the estrogenic effects of lambda-cyhalothrin (LC) and cypermethrin (CP), the most commonly used pesticides in Korea, using BG-1 ovarian cancer cells expressing estrogen receptors (ERs). To evaluate the estrogenic activities of two SPs, LC and CP, we employed MTT assay and reverse-transcription polymerase chain reaction (RT-PCR) in LC or CP treated BG-1 ovarian cancer cells. In MTT assay, LC ($10^{-6}M$) and CP ($10^{-5}M$) significantly induced the growth of BG-1 cancer cells. LC or CP-induced cell growth was antagonized by addition of ICI 182,720 ($10^{-8}M$), an ER antagonist, suggesting that this effect appears to be mediated by an ER-dependent manner. Moreover, RT-PCR results showed that transcriptional level of cyclin D1, a cell cycle-regulating gene, was significantly up-regulated by LC and CP, while these effects were reversed by co-treatment of ICI 182,780. However, p21, a cyclin D-ckd-4 inhibitor gene, was not altered by LC or CP. Moreover, $ER{\alpha}$ expression was not significantly changed by LC and CP, while down-regulated by E2. Finally, in xenografted mouse model transplanted with human BG-1 ovarian cancer cells, E2 significantly increased the tumor volume compare to a negative control, but LC did not. Taken together, these results suggest that LC and CP may possess estrogenic potentials by stimulating the growth of BG-1 ovarian cancer cells via partially ER signaling pathway associated with cell cycle as did E2, but this estrogenic effect was not found in in vivo mouse model.

• 방송공학회논문지
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• 제22권2호
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• pp.193-206
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• 2017

본 논문에서는 4K UHD 입력 영상을 실시간으로 부호화하기 위해 GOP 단위 또는 IDR 주기 단위의 병렬 부호화 구조를 지원하는 $R-{\lambda}$ 모델 기반의 율 제어 방법을 제안한다. 제안하는 $R-{\lambda}$ 모델 기반의 율 제어 방법에서는 순차적 프레임 부호화가 아닌 병렬 부호화를 위한 슬라이스 레벨 비트 분배(bit allocation) 방법을 제안한다. GOP 단위 또는 IDR 주기 단위의 병렬 부호화에서 율 제어기를 작동시키는 경우, 계층적 B구조에서 최하위 프레임 계층을 제외한 동일 계층에 속한 프레임 간에는 상호간에는 부호화 수행 이후 각 소모된 비트양에 대한 정보를 공유 할 수 없기 때문에 기존의 비트량 분배 방식으로는 비트 예산(bit budget) 관리가 불가능하다. 이를 해결하기 위해 본 논문에서는, 기존의 $R-{\lambda}$ 모델 기반 율 제어 방법인 프레임 부호화 순서에 따라 각 프레임별로 목표 비트량 분배하던 방식으로부터, GOP 별로 비트량을 할당한 후, 각 GOP 내의 계층적 B 구조에서 계층이 깊어지는 방향으로 순차적으로 비트 예산을 갱신하여 비트량을 분배하는 방식으로 율 배분 방식을 개선하였다. 뿐만 아니라, 입력 영상의 전처리 과정을 통해 획득된 영상의 복잡도 정보를 고려하여 비트를 분배하여 영상의 주관적인 화질을 향상시켰다. 실험을 통해 제안 방법이 병렬 구조의 HEVC 부호화기에서 잘 작동함을 확인 할 수 있었고, 전처리 결과를 활용하여 율 제어기의 성능을 향상 시킬 수 있음을 확인하였다.

• 정보처리학회논문지B
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• 제11B권6호
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• pp.625-632
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• 2004

H.264 부호화 기법은 단방향 및 양방향 예측 모드를 채택하고 있으며, 가변 길이 부호화를 사용하기 때문에 비디오 부호기에서 발생되는 데 이터량은 시간에 따라 변한다. 전송채널 용량이 제한된 고정 비트율 부호기에서는 출력 비트량을 제어하기 위해 버퍼가 사용되는데, 버퍼가 넘치거나(overflow) 고갈되는 것(underflow)을 막기 위해 발생 비트량을 적절한 영역 내에서 제한해야 한다. 기존의 비트량 제어방법 에서는 영상데이터의 왜곡 값과 양자화 계수간의 $\lambda_{MODE}$가 정규 값을 벗어나기 때문에 화질이 열화 된다. 본 논문에서는 H.264 동영상의 왜곡 값에 대한 새로운 양자화 계수론 도출하여 피드백 함으로써 버퍼의 넘침이나 고갈을 방지할 수 있는 알고리즘을 제안하였다. 제안한 기법을 6개의 실험데이터에 적용한 견과 PSNR 값은 기존 방법에서와 비슷하면서도 비트율은 최대 8%까지 감소하였다.

• BMB Reports
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• 제29권1호
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• pp.88-91
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• 1996

The anaerobically expressed gene aeg-46.5, which had been identified by the operon fusion technique with a hybrid bacteriophage of ${\lambda}$ and Mu, ${\lambda}$placMu53, was studied for its expression pattern and growth. The expression of aeg-46.5 was studied in the wild-type cell and mutant cells that have mutation (s) in the control gene of anaerobic respiration (fnr) and nitrate response (narL and narP). The ${\beta}$-galactosidase reporter gene showed maximum expression in narL host after two hours of aerobic to anaerobic switch in M9-Glc-nitrate medium. Both 40 mM and 100 mM concentrations of nitrate ion in the medium had little effect on expression level. We propose that aeg-46.5 is subject to multiple regulations of anaerobic activation by Fnr, nitrate activation by NarP and repression mediated by NarL.

• 한국자동차공학회논문집
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• 제11권2호
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• pp.40-47
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• 2003

This paper presents a new evaporative system monitoring method using a virtual HC sensor for an automotive on-board diagnosis. A development was made at providing mathematical expressions from the lambda control information to estimate the HC mass flow purged into the intake manifold from the canister for implementing a virtual HC sensor. The change of the lambda averagevalue reflected the influence of the additional fuel from purging results the sensor estimation of the purged HC amount. Based on this virtual HC sensor, a new evaporative system monitoring method was proposed comparing the amount of purged HC amount with the amount of the HC gas evaporated from the fuel tank and absorbed into the canister. Finally, the method was validated with a simulation using the data logged from the retail car.

• Journal of electromagnetic engineering and science
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• 제6권3호
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• pp.165-170
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• 2006

In this paper, magneto-dielectric material is proposed to use for minimizing antenna size. One examle of very small antenna is presented to prove this with antenna's area of $0.078\lambda_0\times0.016\lambda_0$, and just moderate values of permittivity and permeability while the return loss can reach - 38 dB at the resonant frequency. The parameters of dielectric material for that best performance are $\varepsilon_r=1.71-j0.004$, and $\mu_r=2.39-j2.58$. Besides, this material also has ability to control the trade-off between the gain and bandwidth while keeping the antenna size unchanged.

• 산업경영시스템학회지
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• 제34권4호
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• pp.189-196
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• 2011

In this paper, we propose a logical control-based actor-critic algorithm as an efficient approach for the approximation of the capacitated fab scheduling problem. We apply the average reward temporal-difference learning method for estimating the relative value functions of system states, while avoiding deadlock situation by Banker's algorithm. We consider the Intel mini-fab re-entrant line for the evaluation of the suggested algorithm and perform a numerical experiment by generating some sample system configurations randomly. We show that the suggested method has a prominent performance compared to other well-known heuristics.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2008년도 추계학술발표대회
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• pp.1383-1386
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• 2008

분산된 자원의 실시간 정보교환과 그리드를 통한 효율적인 자원 재구성을 위해서는 기존의 단일 도메인에서 구성되는 네트워크와는 다르게 대규모 가상도메인(Large-Scale Multi-domain)을 위한 네트워크의 성능과 기능 향상이 필요하다. 그리드네트워크를 기반으로 활발히 진행 중인 글로벌한 연구자원을 대상으로 공유된 자원의 성능 개선과 자원 간 데이터전달의 효율 개선을 위해 TDM(Time Division Multiplexing)기반의 Multi-Point Lambda-Path Ring 구현 기술을 제안하고 이를 Multi-Domain 간 Control Plane하에서 최적의 가상도메인으로 구성 할 수 있는 기법을 제안한다.

• International Journal of Control, Automation, and Systems
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• 제6권4호
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• pp.468-476
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• 2008

This paper presents a novel approach to economic dispatch (ED) with nonconvex fuel cost function as combinatorial optimization problems (COP) while most of the conventional researches have been developed as function optimization problems (FOP). One nonconvex fuel cost function can be divided into several convex fuel cost functions, and each convex function can be regarded as a generation type (G-type). In that case, ED with nonconvex fuel cost function can be considered as COP finding the best case among all feasible combinations of G-types. In this paper, a genetic algorithm is applied to solve the COP, and the $\lambda$-P table method is used to calculate ED for the fitness function of GA. The $\lambda$-P table method is reviewed briefly and the GA procedure for COP is explained in detail. This paper deals with three kinds of ED problems, namely ED considering valve-point effects (EDVP), ED with multiple fuel units (EDMF), and ED with prohibited operating zones (EDPOZ). The proposed method is tested for all three ED problems, and the test results show an improvement in solution cost compared to the results obtained from conventional algorithms.

• 약학회지
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• 제36권4호
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• pp.370-378
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• 1992

A simple and sensitive high performance liquid chromatographic method to quantitate ${\alpha}-keto$ acids in serum and urine was investigated. ${\alpha}-Keto$ acids react with 1,2-diamino-4,5-methylenedioxybenzene (DMB) in the presence of 2-mercapto-ethanol and sodium hydrogen sulfite to form highly fluorescent derivatives, substituted 6,7-methylenedioxyquinoxalinol. The derivatization procedure was performed in water bath at $100^{\circ}C$, and completed within 50 min. By the use of a reversed-phase column and multi-step gradient with two solvents, a mixture containing twelve of these derivatives were efficiently resolved within 35 minutes. The optimal wavelengh of the fluorescence detector are ${\lambda}_{ex}=364\;nm$ and ${\lambda}_{em}=445\;nm$. The quantitation of the individual ${\alpha}-Keto$ acids was reproducible with relative standard deviation of $3.0{\sim}7.9%$ and had a detection limits of $10{\sim}60$ fmol, except for p-hydroxyphenylpyruvic acid (960 fmol).