• 제목/요약/키워드: Lacrimal gland

검색결과 44건 처리시간 0.032초

Influence of Ribosomal Protein L39-L in the Drug Resistance Mechanisms of Lacrimal Gland Adenoid Cystic Carcinoma Cells

  • Ye, Qing;Ding, Shao-Feng;Wang, Zhi-An;Feng, Jie;Tan, Wen-Bin
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권12호
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    • pp.4995-5000
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    • 2014
  • Background: Cancer constitutes a key pressure on public health regardless of the economy state in different countries. As a kind of highly malignant epithelial tumor, lacrimal gland adenoid cystic carcinoma can occur in any part of the body, such as salivary gland, submandibular gland, trachea, lung, breast, skin and lacrimal gland. Chemotherapy is one of the key treatment techniques, but drug resistance, especially MDR, seriously blunts its effects. As an element of the 60S large ribosomal subunit, the ribosomal protein L39-L gene appears to be documented specifically in the human testis and many human cancer samples of different origins. Materials and Methods: Total RNA of cultured drug-resistant and susceptible lacrimal gland adenoid cystic carcinoma cells was seperated, and real time quantitative RT-PCR were used to reveal transcription differences between amycin resistant and susceptible strains of lacrimal gland adenoid cystic carcinoma cells. Viability assays were used to present the amycin resistance difference in a RPL39-L transfected lacrimal gland adenoid cystic carcinoma cell line as compared to control vector and null-transfected lacrimal gland adenoid cystic carcinoma cell lines. Results: The ribosomal protein L39-L transcription level was 6.5-fold higher in the drug-resistant human lacrimal gland adenoid cystic carcinoma cell line than in the susceptible cell line by quantitative RT-PCR analysis. The ribosomal protein L39-L transfected cells revealed enhanced drug resistance compared to plasmid vector-transfected or null-transfected cells as determined by methyl tritiated thymidine (3H-TdR) incorporation. Conclusions: The ribosomal protein L39-L gene could possibly have influence on the drug resistance mechanism of lacrimal gland adenoid cystic carcinoma cells.

Clinical and Radiological Features of Diffuse Lacrimal Gland Enlargement: Comparisons among Various Etiologies in 91 Biopsy-Confirmed Patients

  • Sae Rom Chung;Gye Jung Kim;Young Jun Choi;Kyung-Ja Cho;Chong Hyun Suh;Soo Chin Kim;Jung Hwan Baek;Jeong Hyun Lee;Min Kyu Yang;Ho-Seok Sa
    • Korean Journal of Radiology
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    • 제23권10호
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    • pp.976-985
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    • 2022
  • Objective: To compare the clinical and radiological features of various etiologies of chronic diffuse lacrimal gland enlargement. Materials and Methods: We retrospectively reviewed 91 consecutive patients who underwent surgical biopsy for chronic diffuse lacrimal gland enlargement and were diagnosed with non-specific dacryoadenitis (DA) (n = 42), immunoglobulin G4-related dacryoadenitis (IgG4-RD) (n = 33), and lymphoma (n = 16). Data on patient demographics, clinical presentation, and CT imaging findings (n = 73) and MRI (n = 43) were collected. The following radiologic features of lacrimal gland enlargement were evaluated: size, unilaterality, wedge sign, angle with the orbital wall, heterogeneity, signal intensity, degree of enhancement, patterns of dynamic contrast-enhanced, and apparent diffusion coefficient value. Radiological features outside the lacrimal glands, such as extra-lacrimal orbital involvement and extra-orbital head and neck involvement, were also evaluated. The clinical and radiological findings were compared among the three diseases. Results: Compared to the DA and IgG4-RD groups, the lymphoma group was significantly older (mean 59.9 vs. 46.0 and 49.4 years, respectively; p = 0.001) and had a higher frequency of unilateral involvement (62.5% vs. 31.0% and 15.2%, respectively; p = 0.004). Compared to the IgG4-RD and lymphoma groups, the DA group had significantly smaller lacrimal glands (2.3 vs. 2.8 and 3.3 cm, respectively; p < 0.001) and a lower proportion of cases with a wedge sign (54.8% vs. 84.8% and 87.5%, respectively; p = 0.005). The IgG4-RD group showed more frequent involvement of the extra-orbital head and neck structures, including the infraorbital nerve (36.4%), paranasal sinus (72.7%), and salivary gland (58.6%) compared to the DA and lymphoma groups (4.8%-28.6%) (all p < 0.005). Conclusion: Patient age, unilaterality, lacrimal gland size, wedge sign, and extra-orbital head and neck involvement differed significantly different between lymphoma, DA, and IgG4-RD. Our results will be useful for the differential diagnosis and proper management of chronic lacrimal gland enlargement.

누액선에 발생한 Adenoid Cytic Carcinoma - 증 례 보 고 - (Lacrimal Gland Adenoid Cystic Carcinoma - A Case Report -)

  • 서대희;백정환;김윤덕;하범준;박익성;남도현;박관;김종현
    • Journal of Korean Neurosurgical Society
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    • 제29권8호
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    • pp.1089-1093
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    • 2000
  • Adenoid cystic carcinoma(ACC) is a rare malignant tumor that occurs in exocrine glands such as major and minor salivary glands, lacrimal glands, ceruminal glands. It has a tendency for delayed distant metastasis and long clinical course. ACC of the lacrimal gland is generally found in adults and is usually managed by radical orbitectomy and supplemental external beam irradiation. The authors present two cases of recurrent lacrimal gland ACC with review of the literature.

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Extensive and aggressive growth of adenoid cystic carcinoma in the lacrimal gland

  • Park, Jonghyun;Kim, Han Koo;Kim, Woo Seob;Bae, Tae Hui
    • 대한두개안면성형외과학회지
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    • 제21권2호
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    • pp.114-118
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    • 2020
  • Adenoid cystic carcinoma (ACC) in the lacrimal gland is a very rare disease with poor overall prognosis. Its primary treatment is surgical excision, including orbital exenteration and radical orbitectomy, which is combined with radiotherapy and chemotherapy. Age, histopathologic type, bone invasion, and tumor extent are known factors that affect the prognosis of ACC. Furthermore, perineural invasion is highly associated with local tumor recurrence and tumor base invasion. Here, we report a rare case of ACC in the lacrimal gland with superior sagittal sinus invasion that repeatedly recurred after the surgical excision.

재발된 누선과 안와 선양낭포암에 대한 전안와제거술 - 증례보고 - (En Bloc Orbitectomy for Recurred Adenoid Cystic Carcinoma of the Lacrimal Gland - A Case Report -)

  • 박정현;김영수;최희윤;고용;오성훈;오석전
    • Journal of Korean Neurosurgical Society
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    • 제30권3호
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    • pp.376-380
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    • 2001
  • A 54-year-old woman presented with an exophthalmos and a mass on her right eye, which proved to be recurred adenoid cystic carcinoma of the lacrimal gland. Orbital CT and MRI showed that tumor was located in the right orbit, but skin over right eye brow was also involved. There was no visualization of tumor extension into the intracranial compartment. The authors have performed an en bloc orbitectomy. Although en bloc orbitectomy is known to be useful in reducing recurrence, this case showed the tumor recurrence and even distant metastasis that occurred after total tumor removal via en bloc orbitectomy. As adenoid cystic carcinoma of lacrimal gland is known to have high rate of recurrence and metastasis, en bloc orbitectomy should be performed to reduce local advancement and distant metastasis. In case of distant metastasis, radiotherapy could be useful strategy in selected case.

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흰쥐 눈물샘의 Prolactin 존재에 관한 면역전자현미경적 연구 (Immunoelectron Microscopic Localization of Prolactin in Rat Exolacrimal gland)

  • 박경호
    • Applied Microscopy
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    • 제23권1호
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    • pp.25-34
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    • 1993
  • Prolactin has been reported to be present in the tear film of humans and prolactin-like immunoreactivity has been detected by immunofluorescence in acinar cells of the lacrimal glands of humans and rats. The present study was aimed at clarifying the intracellular distribution of the prolactin-like immunoreactivity, using the electron microscope immunogold technique. The lacrimal gland acinar cells have two types of secretory granules: 1) Secretory granules containing flocculent materials irregularly shaped and are often coalesced. 2) Secretory granules are fairly round and contain homogenous materials of a moderate electron density. The density of the granular content varies even within a single cell. We found prolactin-like reactivity in secretory granules, some smaller cytosolic vesicles, Golgi cisternae and nuclei in acinar cells from intact glands of rat. Our present results are consistent with the conclusion that prolactin is present in lacrimal cells. The presence of prolactin reactivity in the nucleus suggests that prolactin may be a regulatory factor modulating gene expression.

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Skull Base Invasion of Adenoid Cystic Carcinoma of the Lacrimal Gland : A Case Report

  • Lee, Jae-Il;Kim, Young-Zoon;Lee, Eun-Hee;Kim, Kyu-Hong
    • Journal of Korean Neurosurgical Society
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    • 제44권4호
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    • pp.273-276
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    • 2008
  • Although adenoid cystic carcinoma (ACC) of the lacrimal gland is a rarely encountered orbital tumor, it invades intracranially more frequently than carcinomas of other glands in the head and neck. A 52-year-old man underwent orbital exenteration and resection of intracranially extended tumor via a fronto-orbito-zygomatic approach in combination with a transfacial approach. Histopathologically, the tumor showed perineural, vascular, and lymphatic invasion. Additionally, he received radiotherapy (60 Gy) and adjuvant systemic cisplatin and 5-fluorouracil chemotherapy due to residual tumor in the orbit and systemic metastases (lung, ribs, and spines). He was free of progression and recurrence at 6 months after treatment. The authors report a case of skull base invasion by an ACC of the lacrimal gland to remind neurosurgeons planning intervention that this disease shows a tendency to invade intracranially.

Pleomorphic Adenoma with Sarcomatous Change in a Lacrimal Gland

  • Sung, Kyoung-Su;Kim, Dae-Cheol;Ahn, Hee-Bae;Song, Young-Jin
    • Journal of Korean Neurosurgical Society
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    • 제57권6호
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    • pp.473-477
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    • 2015
  • A 69-year-old man was referred with left exophthalmos. Computed tomographic (CT) findings detected a well-circumscribed mass in the left side of the intraorbital cavity. At that time, he refused the further evaluation and treatment. About three years later, the size of the mass had enlarged, and the patient's symptoms were getting worse. The mass was completely removed with frontotemporal craniotomy and superolateral orbitotomy. In operative findings, the mass had originated in the lacrimal gland and was well-encapsulated without invasion to the surrounding tissue. In the pathologic findings, the tumor consisted of pleomorphic adenoma with osteosarcomatous change of stromal components. Postoperatively, the adjuvant radiotherapy was done four weeks later. The patient's symptoms were improved. The pleomorphic adenoma with osteosarcomatous change is extremely rare and appropriate treatment is not clearly established. We would like to report this rare case with a review of the literature.

토끼 아래눈물샘의 미세구조에 관한 전자현미경적 연구 (Electron Microscopic Study on the Rabbit Inferior Lacrimal Glands)

  • 박영희;안의태;고정식;박대균;김명수;박경호
    • Applied Microscopy
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    • 제37권1호
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    • pp.23-33
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    • 2007
  • 눈물샘은 주위환경으로부터 눈의 표면을 보호해주는 눈물막(tear film)을 구성하는 데 중요한 작용을 한다. 포유동물의 종에 따라 눈물샘의 구조와 구성요소는 차이가 있다. 포유류의 눈물샘에는 크게 두 가지 종류 즉, 위눈물샘 (superior lacrimal gland)과 아래눈물샘 (inferior lacrimal gland)으로 나눌 수 있다. 위눈물샘은 사람, 토끼, 개, 말, 낙타, 소등에 있는데, 안구의 위쪽에 위치하며, 아래눈물샘은 설치류, 토끼, 식충류 등에 존재하며, 안구의 아래쪽에 위치하고 있다. 토끼는 두 종류의 눈물샘 즉, 위눈물샘과 아래눈물샘을 모두 갖고 있는 데, 본 실험에서는 아래 눈물샘의 전자현미경적 구조를 관찰하였다. 토끼의 아래 눈물샘을 광학현미경으로 관찰한 일반구조는, 눈물샘은 전체적으로 피막에 싸여있었고, 샘실질은 결합조직에 의해 소엽으로 나뉘어지고, 소엽에는 분비부, 소엽속관 및 소엽사이관이 있다. 샘포세포는 아주 좁은 속공간을 가지고 있으며, 사이관(intercalated duct)은 샘포와 소엽속관을 연결한다. 소엽속관은 단층의 입방상피로 구성되어 있으며, 배출관인 소엽사이관이 결합조직 안에 잘 발달되어 있다. 눈물샘의 미세구조는 눈물샘 샘포세포는 피라밋형으로, 세포사이는 잘 발달된 연접복합체로 연접하였으며, 좁은 꼭대기 부분은 약간의 미세융모들이 샘의 내강쪽으로 향해 있다. 세포들의 가쪽면 사이에는 세포사이세관이 형성되었고, 그 속에도 상당수의 미세융모들이 관찰된다. 눈물샘분비세포는 세 종류로서 장액세포(serous cell), 장점액세포(seromucous cell)와 점액세포(mucous cell)로 이루어졌다. 장액세포는 샘포의 바닥 쪽에 많고, 세포질에는 전형적인 골지복합체와 전자밀도가 높은 분비과립이 있으며, 둥글둥글한 소포상의 과립형질내세망이 특징적인 구조이다. 한편 장점액세포는 전형적인 납작한 과립형질내세망이 조밀하고, 리보소체도 많아서 매우 어둡게 보이며, 분비과립에는 전자밀도가 높은 장액분비과립, 미세먼지같은 중등도의 전자밀도를 지닌 과립, 전자밀도가 낮으며 가끔은 융합되는 점액 분비과립을 갖고 있다. 점액세포의 과립세포질세망은 세포질전체에 퍼져 있으며, 관모양의 사립체들이 드물게 관찰된다. 점액세포에서는 세 가지 종류의 분비과립 즉, 전자밀도가 낮은 분비과립, 전자밀도가 비교적 높으며 빈도가 낮은 과립과 중간정도의 전자밀도를 가진 과립이 있으며, 전자밀도가 낮은 과립은 서로 융합된 모습을 보이기도 한다. 과립세포질세망은 주로 세포의 바닥부분에 위치하며, 골지복합체는 세포의 중간부분인 핵상부에 주로 위치한다. 점액세포의 가쪽벽에는 세포사이공간이 있어 가쪽주름(lateral fold)과 내강에 미세융모를 지닌 세포사이세관(intercellular canaliculi)이 관찰된다. 분비관을 구성하고 있는 세포들에는 세포질이 어두운 세포와 밝은 세포가 있었으며, 세포질내에는 전자밀도가 높은 분비과립이 관찰되었다. 전체적인 특징은 눈물샘분비세포 중 장액세포의 것과 비슷하였으나, 과립의 크기는 작았다. 분비관을 구성하는 세포들 사이에도 연접복합체가 매우 잘 발달되어 있었다. 샘포에서 사이관으로 이행되는 곳에서도 샘포세포와 사이관세포 사이에서도 연접복합체가 관찰되었다. 분비관세포의 분비과립 가운데는 중심부분에 전자밀도가 더 높은 중심을 가진 다른 모양의 과립이 관찰되기도 하였다.

Age-related Autoimmune Changes in Lacrimal Glands

  • Rodrigo G. de Souza;Cintia S. de Paiva;Milton R. Alves
    • IMMUNE NETWORK
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    • 제19권1호
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    • pp.3.1-3.17
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    • 2019
  • Aging is a complex process associated with dysregulation of the immune system and low levels of inflammation, often associated with the onset of many pathologies. The lacrimal gland (LG) plays a vital role in the maintenance of ocular physiology and changes related to aging directly affect eye diseases. The dysregulation of the immune system in aging leads to quantitative and qualitative changes in antibodies and cytokines. While there is a gradual decline of the immune system, there is an increase in autoimmunity, with a reciprocal pathway between low levels of inflammation and aging mechanisms. Elderly C57BL/6J mice spontaneously show LGs infiltration that is characterized by Th1 but not Th17 cells. The aging of the LG is related to functional alterations, reduced innervation and decreased secretory activities. Lymphocytic infiltration, destruction, and atrophy of glandular parenchyma, ductal dilatation, and secretion of inflammatory mediators modify the volume and composition of tears. Oxidative stress, the capacity to metabolize and eliminate toxic substances decreased in aging, is also associated with the reduction of LG functionality and the pathogenesis of autoimmune diseases. Although further studies are required for a better understanding of autoimmunity and aging of the LG, we described anatomic and immunology aspects that have been described so far.